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Total Cholesterol

Total cholesterol refers to all the cholesterol in your blood (HDL-C and LDL-C). It is distinct from Triglycerides.

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Human Effect Matrix

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The Human Effect Matrix looks at human studies to tell you what supplements affect Total Cholesterol.

Full details on all Total Cholesterol supplements are available to Examine members.
Grade Level of Evidence
Robust research conducted with repeated double-blind clinical trials
Multiple studies where at least two are double-blind and placebo controlled
Single double-blind study or multiple cohort studies
Uncontrolled or observational studies only
Level of Evidence
? The amount of high quality evidence. The more evidence, the more we can trust the results.
Supplement Magnitude of effect
? The direction and size of the supplement's impact on each outcome. Some supplements can have an increasing effect, others have a decreasing effect, and others have no effect.
Consistency of research results
? Scientific research does not always agree. HIGH or VERY HIGH means that most of the scientific research agrees.
Notes
grade-a Notable Very High See all 17 studies
Garlic supplementation or the raw garlic bulb appears to reduce cholesterol (total cholesterol, mostly due to LDL reductions) reliably and in the range of 10-15%
grade-a Minor Moderate See all 30 studies
A small reduction has been found overall. There is a greater effect of doses 2 g or more than lower doses, and healthy participants seem to benefit more than those with diabetes or on hemodialysis, while those who are overweight but not obese saw the greatest reduction.
grade-a Minor Moderate See all 12 studies
There may be some limited efficacy of policosanol on cholesterol (when excluding the studies from cuba, which are highly suspicious, there is still some scattered but unreliable evidence) whereas it does not appear to be potent in any way.

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