Zinc

Last Updated: September 27, 2023

Zinc is an essential mineral that is critical for the function of hundreds of enzymes. Consequently, it plays many roles, including in antioxidant enzymes, brain function, and the immune system. Zinc is most commonly taken to reduce the duration of respiratory infections and the common cold.

Zinc is most often used for

What is zinc?

Zinc is an essential mineral and has a multitude of biological roles because it is a functional component of over 300 hundred enzymes that rely on zinc to be able to catalyze chemical reactions. Zinc also participates in the structure of important proteins and is involved in the regulation of gene expression.[1][2]

Zinc is obtained from the diet. Oysters contain substantially more zinc than any other food, although red meat (e.g., beef, pork) and poultry provide the majority of zinc in the American diet. Other good sources of zinc are legumes, nuts, and dairy products.[3] In some countries, the flours used in cereals are fortified with zinc.[4]

What are zinc’s main benefits?

The potential benefits of supplementation with zinc are largely dependent on the individual’s zinc status. Therefore, supplementation with zinc is unlikely to provide a benefit if zinc levels are already adequate and the person is not zinc deficient.[5] One exception to this rule may be respiratory tract infections and the common cold, conditions in which supplementation with zinc has been shown to reduce the duration of illness.[6][7][8] In children, zinc may help prevent pneumonia.[9][10] However, further high-quality studies are needed to bolster the evidence in this field.

Supplementation with zinc has been shown to improve depressive symptoms[11][12] and markers of glycemic control and blood lipids, particularly in people with chronic disease.[13][14][15] Supplementation with zinc may also improve severe acne, but higher-quality trials are needed to bolster the current evidence.[16][17]

What are zinc’s main drawbacks?

In the short term, consuming zinc in excess of the recommended upper limit (40 mg/day)[1] can result in gastrointestinal symptoms (e.g., abdominal pain, nausea, vomiting, diarrhea).[1][18] In the long term, excessive zinc intake has been associated with copper deficiency and iron deficiency, as well as suppression of the immune system.[19][20][21] Also, the application of intranasal zinc has been reported to cause a loss of smell in some people.[22]

How does zinc work?

The potential benefits derived from supplementation with zinc seem to be at least partly attributable to zinc’s anti-inflammatory and antioxidant properties.[2][23][24][25]

Adequate dietary intake of zinc is essential for proper growth and development during pregnancy and throughout infancy, childhood, and adulthood.[2][26] Additionally, zinc is required for normal development, activity, and function of both innate and adaptive immune cells;[19][27] proper function of pancreatic beta-cells and glucose uptake;[28] and spermatogenesis and normal sperm physiology (e.g., sperm motility).[29]

In the brain, zinc ions inhibit N-methyl-D-aspartate (NMDA) receptors,[30] which is relevant to depression because this condition is characterized by elevated glutamatergic neurotransmission (to which NMDA receptors contribute).[31] Zinc may also benefit depression by increasing brain-derived neurotrophic factor levels.[32][33]

Dosage information

Zinc supplements vary in their dosages from 5–10 milligrams (mg) up to 25–45 mg, and sometimes higher. Dosages in the lower range are typically used as a daily preventative, whereas dosages in the higher range are typically used to treat chronic conditions and zinc deficiency.

Zinc supplements contain different forms of zinc. Each of these forms contains different amounts of elemental zinc, which refers to the weight of the zinc molecule by itself, for example:

  • Zinc acetate is approximately 36% zinc by weight; therefore, 140 mg of zinc acetate contains 50 mg of elemental zinc.
  • Zinc picolinate is approximately 21% zinc by weight; therefore, 237 mg of zinc picolinate contains 50 mg of elemental zinc.
  • Zinc citrate is approximately 11% zinc by weight; therefore, 439 mg of zinc citrate contains 50 mg of elemental zinc.
  • The content of zinc sulfate depends on which form is used. The anhydrous, monohydrate, and heptahydrate forms of zinc sulfate are 41%, 36%, and 23% zinc by weight, respectively; therefore, 123 mg of anhydrous zinc sulfate, 137 mg of zinc sulfate monohydrate, and 220 mg of zinc sulfate heptahydrate each contain 50 mg of elemental zinc.
  • Zinc gluconate is approximately 14% zinc by weight; therefore, 348 mg of zinc gluconate contains 50 mg of elemental zinc.
  • Zinc monomethionine is approximately 31% zinc by weight; therefore, 163 mg of zinc monomethionine contains 50 mg of elemental zinc.

This can be confusing, but most zinc product labels indicate the elemental weight of zinc that each dose provides. For example, if a label says “Zinc (as picolinate) 50 mg”, this means that each dose provides 50 mg of elemental zinc.

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Update History
2023-09-27 00:30:05

Tweak to relationship between zinc and ADHD

minor

The wording of the effect of zinc supplementation on ADHD was slightly modified. It now says that there is a slight chance zinc may help with ADHD symptoms, but the research on this topic isn't consistent.

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References
  1. ^Institute of Medicine (US) Panel on MicronutrientsDietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc
  2. ^Vallee BL, Falchuk KHThe biochemical basis of zinc physiology.Physiol Rev.(1993-Jan)
  3. ^FoodData Central Search ResultsU.S. Department of Agriculture, Agricultural Research Service.(2023)
  4. ^Brown KH, Hambidge KM, Ranum P,Zinc fortification of cereal flours: current recommendations and research needs.Food Nutr Bull.(2010-Mar)
  5. ^Seet RC, Lee CY, Lim EC, Quek AM, Huang H, Huang SH, Looi WF, Long LH, Halliwell BOral zinc supplementation does not improve oxidative stress or vascular function in patients with type 2 diabetes with normal zinc levelsAtherosclerosis.(2011 Nov)
  6. ^Jennifer Hunter, Susan Arentz, Joshua Goldenberg, Guoyan Yang, Jennifer Beardsley, Stephen P Myers, Dominik Mertz, Stephen LeederZinc for the prevention or treatment of acute viral respiratory tract infections in adults: a rapid systematic review and meta-analysis of randomised controlled trialsBMJ Open.(2021 Nov 2)
  7. ^Min Xian Wang, Shwe Sin Win, Junxiong PangZinc Supplementation Reduces Common Cold Duration among Healthy Adults: A Systematic Review of Randomized Controlled Trials with Micronutrients SupplementationAm J Trop Med Hyg.(2020 Jul)
  8. ^Harri HemiläZinc lozenges may shorten the duration of colds: a systematic reviewOpen Respir Med J.(2011)
  9. ^Wang L, Song YEfficacy of zinc given as an adjunct to the treatment of severe pneumonia: A meta-analysis of randomized, double-blind and placebo-controlled trials.Clin Respir J.(2018-Mar)
  10. ^Lassi ZS, Moin A, Bhutta ZAZinc supplementation for the prevention of pneumonia in children aged 2 months to 59 months.Cochrane Database Syst Rev.(2016-Dec-04)
  11. ^Somaye Yosaee, Cain C T Clark, Zahra Keshtkaran, Mahkameh Ashourpour, Parisa Keshani, Sepideh SoltaniZinc in depression: From development to treatment: A comparative/ dose response meta-analysis of observational studies and randomized controlled trialsGen Hosp Psychiatry.(Jan-Feb 2022)
  12. ^Sawada T, Yokoi KEffect of zinc supplementation on mood states in young women: a pilot studyEur J Clin Nutr.(2010 Mar)
  13. ^Laura M Pompano, Erick BoyEffects of Dose and Duration of Zinc Interventions on Risk Factors for Type 2 Diabetes and Cardiovascular Disease: A Systematic Review and Meta-AnalysisAdv Nutr.(2020 Jul 28)
  14. ^Kelishadi R, Hashemipour M, Adeli K, Tavakoli N, Movahedian-Attar A, Shapouri J, Poursafa P, Rouzbahani AEffect of zinc supplementation on markers of insulin resistance, oxidative stress, and inflammation among prepubescent children with metabolic syndromeMetab Syndr Relat Disord.(2010 Dec)
  15. ^Hashemipour M, Kelishadi R, Shapouri J, Sarrafzadegan N, Amini M, Tavakoli N, Movahedian-Attar A, Mirmoghtadaee P, Poursafa PEffect of zinc supplementation on insulin resistance and components of the metabolic syndrome in prepubertal obese childrenHormones (Athens).(2009 Oct-Dec)
  16. ^Brittany E Yee, Phillip Richards, Jennifer Y Sui, Amanda Fleming MarschSerum zinc levels and efficacy of zinc treatment in acne vulgaris: A systematic review and meta-analysisDermatol Ther.(2020 Aug 29)
  17. ^Liu H, Yu H, Xia J, Liu L, Liu GJ, Sang H, Peinemann FTopical azelaic acid, salicylic acid, nicotinamide, sulphur, zinc and fruit acid (alpha-hydroxy acid) for acne.Cochrane Database Syst Rev.(2020-May-01)
  18. ^Singh M, Das RRZinc for the common coldCochrane Database Syst Rev.(2011 Feb 16)
  19. ^Dorota Skrajnowska, Barbara Bobrowska-KorczakRole of Zinc in Immune System and Anti-Cancer Defense MechanismsNutrients.(2019 Sep 22)
  20. ^Bjørklund G, Aaseth J, Skalny AV, Suliburska J, Skalnaya MG, Nikonorov AA, Tinkov AAInteractions of iron with manganese, zinc, chromium, and selenium as related to prophylaxis and treatment of iron deficiency.J Trace Elem Med Biol.(2017-May)
  21. ^Chandra RKExcessive intake of zinc impairs immune responsesJAMA.(1984 Sep 21)
  22. ^Terence M Davidson, Wendy M SmithThe Bradford Hill criteria and zinc-induced anosmia: a causality analysisArch Otolaryngol Head Neck Surg.(2010 Jul)
  23. ^Prasad ASZinc in human health: effect of zinc on immune cells.Mol Med.(2008)
  24. ^Ananda S PrasadClinical, immunological, anti-inflammatory and antioxidant roles of zincExp Gerontol.(2008 May)
  25. ^Bao B, Prasad AS, Beck FW, Fitzgerald JT, Snell D, Bao GW, Singh T, Cardozo LJZinc decreases C-reactive protein, lipid peroxidation, and inflammatory cytokines in elderly subjects: a potential implication of zinc as an atheroprotective agentAm J Clin Nutr.(2010 Jun)
  26. ^Recommended Dietary Allowances: 10th Edition(1989)
  27. ^Maria Maares, Hajo HaaseZinc and immunity: An essential interrelationArch Biochem Biophys.(2016 Dec 1)
  28. ^Anatoly V Skalny, Michael Aschner, Alexey A TinkovZincAdv Food Nutr Res.(2021)
  29. ^Kinga Skoracka, Piotr Eder, Liliana Łykowska-Szuber, Agnieszka Dobrowolska, Iwona Krela-KaźmierczakDiet and Nutritional Factors in Male (In)fertility-Underestimated FactorsJ Clin Med.(2020 May 9)
  30. ^Stacy A Amico-Ruvio, Swetha E Murthy, Thomas P Smith, Gabriela K PopescuZinc effects on NMDA receptor gating kineticsBiophys J.(2011 Apr 20)
  31. ^Adejoke Yetunde Onaolapo, Olakunle James OnaolapoGlutamate and depression: Reflecting a deepening knowledge of the gut and brain effects of a ubiquitous moleculeWorld J Psychiatry.(2021 Jul 19)
  32. ^Jafari F, Amani R, Tarrahi MJEffect of Zinc Supplementation on Physical and Psychological Symptoms, Biomarkers of Inflammation, Oxidative Stress, and Brain-Derived Neurotrophic Factor in Young Women with Premenstrual Syndrome: a Randomized, Double-Blind, Placebo-Controlled TrialBiol Trace Elem Res.(2019 Jun 2)
  33. ^Solati Z, Jazayeri S, Tehrani-Doost M, Mahmoodianfard S, Gohari MRZinc monotherapy increases serum brain-derived neurotrophic factor (BDNF) levels and decreases depressive symptoms in overweight or obese subjects: A double-blind, randomized, placebo-controlled trialNutr Neurosci.(2014 Jan 7)
  34. ^Ebben M, Lequerica A, Spielman AEffects of pyridoxine on dreaming: a preliminary studyPercept Mot Skills.(2002 Feb)
  35. ^De Souza MC, Walker AF, Robinson PA, Bolland KA synergistic effect of a daily supplement for 1 month of 200 mg magnesium plus 50 mg vitamin B6 for the relief of anxiety-related premenstrual symptoms: a randomized, double-blind, crossover studyJ Womens Health Gend Based Med.(2000 Mar)
  36. ^Hambidge MHuman zinc deficiency.J Nutr.(2000-May)
  37. ^Nazanin Roohani, Richard Hurrell, Roya Kelishadi, Rainer SchulinZinc and its importance for human health: An integrative reviewJ Res Med Sci.(2013 Feb)
  38. ^Maxfield L, Shukla S, Crane JSZinc DeficiencyStatPearls.(2022-11)
  39. ^K Ryan Wessells, Kenneth H BrownEstimating the global prevalence of zinc deficiency: results based on zinc availability in national food supplies and the prevalence of stuntingPLoS One.(2012)
  40. ^Shay NF, Mangian HFNeurobiology of zinc-influenced eating behavior.J Nutr.(2000-May)
  41. ^Gupta S, Brazier AKM, Lowe NMZinc deficiency in low- and middle-income countries: prevalence and approaches for mitigation.J Hum Nutr Diet.(2020-Oct)
  42. ^Vreugdenhil M, Akkermans MD, van der Merwe LF, van Elburg RM, van Goudoever JB, Brus FPrevalence of Zinc Deficiency in Healthy 1-3-Year-Old Children from Three Western European Countries.Nutrients.(2021-Oct-22)
  43. ^Kerksick CM, Wilborn CD, Roberts MD, Smith-Ryan A, Kleiner SM, Jäger R, Collins R, Cooke M, Davis JN, Galvan E, Greenwood M, Lowery LM, Wildman R, Antonio J, Kreider RBISSN exercise & sports nutrition review update: research & recommendationsJ Int Soc Sports Nutr.(2018 Aug 1)
  44. ^Brilla et alEffects of a Novel Zinc-Magnesium Formulation on Hormones and StrengthJournal of Exercise Physiology.(2020)
  45. ^Wilborn CD, Kerksick CM, Campbell BI, Taylor LW, Marcello BM, Rasmussen CJ, Greenwood MC, Almada A, Kreider RBEffects of Zinc Magnesium Aspartate (ZMA) Supplementation on Training Adaptations and Markers of Anabolism and CatabolismJ Int Soc Sports Nutr.(2004 Dec 31)
  46. ^Koehler K, Parr MK, Geyer H, Mester J, Schänzer WSerum testosterone and urinary excretion of steroid hormone metabolites after administration of a high-dose zinc supplementEur J Clin Nutr.(2009 Jan)
  47. ^Yamaguchi S, Miura C, Kikuchi K, Celino FT, Agusa T, Tanabe S, Miura TZinc is an essential trace element for spermatogenesis.Proc Natl Acad Sci U S A.(2009-Jun-30)
  48. ^Croxford TP, McCormick NH, Kelleher SLModerate zinc deficiency reduces testicular Zip6 and Zip10 abundance and impairs spermatogenesis in mice.J Nutr.(2011-Mar)
  49. ^Merrells KJ, Blewett H, Jamieson JA, Taylor CG, Suh MRelationship between abnormal sperm morphology induced by dietary zinc deficiency and lipid composition in testes of growing rats.Br J Nutr.(2009-Jul)
  50. ^Te L, Liu J, Ma J, Wang SCorrelation between serum zinc and testosterone: A systematic review.J Trace Elem Med Biol.(2023-Mar)
  51. ^C D Hunt, P E Johnson, J Herbel, L K MullenEffects of dietary zinc depletion on seminal volume and zinc loss, serum testosterone concentrations, and sperm morphology in young menAm J Clin Nutr.(1992 Jul)
  52. ^A Taravati, F TohidiAssociation between seminal plasma zinc level and asthenozoospermia: a meta-analysis studyAndrologia.(2016 Aug)
  53. ^Jiang Zhao, Xingyou Dong, Xiaoyan Hu, Zhou Long, Liang Wang, Qian Liu, Bishao Sun, Qingqing Wang, Qingjian Wu, Longkun LiZinc levels in seminal plasma and their correlation with male infertility: A systematic review and meta-analysisSci Rep.(2016 Mar 2)
  54. ^Netter A, Hartoma R, Nahoul KEffect of zinc administration on plasma testosterone, dihydrotestosterone, and sperm countArch Androl.(1981 Aug)
  55. ^Prasad AS, Mantzoros CS, Beck FW, Hess JW, Brewer GJZinc status and serum testosterone levels of healthy adultsNutrition.(1996 May)
  56. ^Shahid MN, Khan TM, Neoh CF, Lean QY, Bukhsh A, Karuppannan MEffectiveness of Pharmacological Intervention Among Men with Infertility: A Systematic Review and Network Meta-Analysis.Front Pharmacol.(2021)
  57. ^Clara Y Jones, Alice M Tang, Janet E Forrester, Jinyong Huang, Kristy M Hendricks, Tamsin A Knox, Donna Spiegelman, Richard D Semba, Margo N WoodsMicronutrient levels and HIV disease status in HIV-infected patients on highly active antiretroviral therapy in the Nutrition for Healthy Living cohortJ Acquir Immune Defic Syndr.(2006 Dec 1)
  58. ^Baum MK, Campa A, Lai S, Lai H, Page JBZinc status in human immunodeficiency virus type 1 infection and illicit drug use.Clin Infect Dis.(2003)
  59. ^N M Graham, D Sorensen, N Odaka, R Brookmeyer, D Chan, W C Willett, J S Morris, A J SaahRelationship of serum copper and zinc levels to HIV-1 seropositivity and progression to AIDSJ Acquir Immune Defic Syndr (1988).(1991)
  60. ^Baum MK, Lai S, Sales S, Page JB, Campa ARandomized, controlled clinical trial of zinc supplementation to prevent immunological failure in HIV-infected adults.Clin Infect Dis.(2010-Jun-15)
  61. ^Mocchegiani E, Veccia S, Ancarani F, Scalise G, Fabris NBenefit of oral zinc supplementation as an adjunct to zidovudine (AZT) therapy against opportunistic infections in AIDS.Int J Immunopharmacol.(1995-Sep)
  62. ^Zeng L, Zhang LEfficacy and safety of zinc supplementation for adults, children and pregnant women with HIV infection: systematic review.Trop Med Int Health.(2011-Dec)
  63. ^Olivares M, Pizarro F, Ruz MZinc inhibits nonheme iron bioavailability in humansBiol Trace Elem Res.(2007 Summer)
  64. ^Olivares M, Pizarro F, Ruz MNew insights about iron bioavailability inhibition by zincNutrition.(2007 Apr)
  65. ^Marena Ceballos-Rasgado, Nicola M Lowe, Simonette Mallard, Andrew Clegg, Victoria H Moran, Catherine Harris, Jason Montez, Maria XipsitiAdverse Effects of Excessive Zinc Intake in Infants and Children Aged 0-3 Years: A Systematic Review and Meta-AnalysisAdv Nutr.(2022 Dec 22)
  66. ^Donangelo CM, Woodhouse LR, King SM, Viteri FE, King JCSupplemental zinc lowers measures of iron status in young women with low iron reservesJ Nutr.(2002 Jul)
  67. ^Rossander-Hultén L, Brune M, Sandström B, Lönnerdal B, Hallberg LCompetitive inhibition of iron absorption by manganese and zinc in humans.Am J Clin Nutr.(1991-Jul)
  68. ^Olivares M, Wiedeman A, Bolívar L, López de Romaña D, Pizarro FEffect of increasing concentrations of zinc on the absorption of iron from iron-fortified milkBiol Trace Elem Res.(2012 Dec)
  69. ^Olivares M, Pizarro F, Ruz M, de Romaña DLAcute inhibition of iron bioavailability by zinc: studies in humansBiometals.(2012 Aug)
  70. ^Palsa Kondaiah, Puneeta Singh Yaduvanshi, Paul A Sharp, Raghu PullakhandamIron and Zinc Homeostasis and Interactions: Does Enteric Zinc Excretion Cross-Talk with Intestinal Iron Absorption?Nutrients.(2019 Aug 13)
  71. ^Fischer Walker C, Kordas K, Stoltzfus RJ, Black REInteractive effects of iron and zinc on biochemical and functional outcomes in supplementation trials.Am J Clin Nutr.(2005-Jul)
  72. ^Travison TG, Morley JE, Araujo AB, O'Donnell AB, McKinlay JBThe relationship between libido and testosterone levels in aging menJ Clin Endocrinol Metab.(2006 Jul)
  73. ^Chrysohoou C, Panagiotakos D, Pitsavos C, Siasos G, Oikonomou E, Varlas J, Patialiakas A, Lazaros G, Psaltopoulou T, Zaromitidou M, Kourkouti P, Tousoulis D, Stefanadis CLow total testosterone levels are associated with the metabolic syndrome in elderly men: the role of body weight, lipids, insulin resistance, and inflammation; the Ikaria studyRev Diabet Stud.(2013 Spring)
  74. ^Westley CJ, Amdur RL, Irwig MSHigh Rates of Depression and Depressive Symptoms among Men Referred for Borderline Testosterone LevelsJ Sex Med.(2015 Aug)
  75. ^Giltay EJ, Enter D, Zitman FG, Penninx BW, van Pelt J, Spinhoven P, Roelofs KSalivary testosterone: associations with depression, anxiety disorders, and antidepressant use in a large cohort studyJ Psychosom Res.(2012 Mar)
  76. ^Feldman HA, Longcope C, Derby CA, Johannes CB, Araujo AB, Coviello AD, Bremner WJ, McKinlay JBAge trends in the level of serum testosterone and other hormones in middle-aged men: longitudinal results from the Massachusetts male aging studyJ Clin Endocrinol Metab.(2002 Feb)
  77. ^Wu FC, Tajar A, Pye SR, Silman AJ, Finn JD, O'Neill TW, Bartfai G, Casanueva F, Forti G, Giwercman A, Huhtaniemi IT, Kula K, Punab M, Boonen S, Vanderschueren D, European Male Aging Study GroupHypothalamic-pituitary-testicular axis disruptions in older men are differentially linked to age and modifiable risk factors: the European Male Aging StudyJ Clin Endocrinol Metab.(2008 Jul)
  78. ^Handelsman DJ, Yeap B, Flicker L, Martin S, Wittert GA, Ly LPAge-specific population centiles for androgen status in menEur J Endocrinol.(2015 Dec)
  79. ^Cote KA, McCormick CM, Geniole SN, Renn RP, MacAulay SDSleep deprivation lowers reactive aggression and testosterone in menBiol Psychol.(2013 Feb)
  80. ^Leproult R, Van Cauter EEffect of 1 week of sleep restriction on testosterone levels in young healthy menJAMA.(2011 Jun 1)
  81. ^Penev PDAssociation between sleep and morning testosterone levels in older menSleep.(2007 Apr)
  82. ^González-Santos MR, Gajá-Rodríguez OV, Alonso-Uriarte R, Sojo-Aranda I, Cortés-Gallegos VSleep deprivation and adaptive hormonal responses of healthy menArch Androl.(1989)
  83. ^Cortés-Gallegos V, Castañeda G, Alonso R, Sojo I, Carranco A, Cervantes C, Parra ASleep deprivation reduces circulating androgens in healthy menArch Androl.(1983 Mar)
  84. ^Nedeltcheva AV, Kilkus JM, Imperial J, Schoeller DA, Penev PDInsufficient sleep undermines dietary efforts to reduce adiposityAnn Intern Med.(2010 Oct 5)
  85. ^O'Leary CB, Hackney ACAcute and chronic effects of resistance exercise on the testosterone and cortisol responses in obese males: a systematic reviewPhysiol Res.(2014)
  86. ^Kraemer WJ, Ratamess NAHormonal responses and adaptations to resistance exercise and trainingSports Med.(2005)
  87. ^Daly W, Seegers CA, Rubin DA, Dobridge JD, Hackney ACRelationship between stress hormones and testosterone with prolonged endurance exerciseEur J Appl Physiol.(2005 Jan)
  88. ^Hackney AC, Aggon EChronic Low Testosterone Levels in Endurance Trained Men: The Exercise- Hypogonadal Male ConditionJ Biochem Physiol.(2018)
  89. ^Grossmann MLow testosterone in men with type 2 diabetes: significance and treatmentJ Clin Endocrinol Metab.(2011 Aug)
  90. ^Tajar A, Forti G, O'Neill TW, Lee DM, Silman AJ, Finn JD, Bartfai G, Boonen S, Casanueva FF, Giwercman A, Han TS, Kula K, Labrie F, Lean ME, Pendleton N, Punab M, Vanderschueren D, Huhtaniemi IT, Wu FC, EMAS GroupCharacteristics of secondary, primary, and compensated hypogonadism in aging men: evidence from the European Male Ageing StudyJ Clin Endocrinol Metab.(2010 Apr)
  91. ^Hall SA, Esche GR, Araujo AB, Travison TG, Clark RV, Williams RE, McKinlay JBCorrelates of low testosterone and symptomatic androgen deficiency in a population-based sampleJ Clin Endocrinol Metab.(2008 Oct)
  92. ^Grossmann M, Matsumoto AMA Perspective on Middle-Aged and Older Men With Functional Hypogonadism: Focus on Holistic ManagementJ Clin Endocrinol Metab.(2017 Mar 1)
  93. ^Corona G, Rastrelli G, Monami M, Saad F, Luconi M, Lucchese M, Facchiano E, Sforza A, Forti G, Mannucci E, Maggi MBody weight loss reverts obesity-associated hypogonadotropic hypogonadism: a systematic review and meta-analysisEur J Endocrinol.(2013 May 2)
  94. ^Camacho EM, Huhtaniemi IT, O'Neill TW, Finn JD, Pye SR, Lee DM, Tajar A, Bartfai G, Boonen S, Casanueva FF, Forti G, Giwercman A, Han TS, Kula K, Keevil B, Lean ME, Pendleton N, Punab M, Vanderschueren D, Wu FC, EMAS GroupAge-associated changes in hypothalamic-pituitary-testicular function in middle-aged and older men are modified by weight change and lifestyle factors: longitudinal results from the European Male Ageing StudyEur J Endocrinol.(2013 Feb 20)
  95. ^Pilz S, Frisch S, Koertke H, Kuhn J, Dreier J, Obermayer-Pietsch B, Wehr E, Zittermann AEffect of vitamin D supplementation on testosterone levels in menHorm Metab Res.(2011 Mar)
  96. ^Wehr E, Pilz S, Boehm BO, März W, Obermayer-Pietsch BAssociation of vitamin D status with serum androgen levels in menClin Endocrinol (Oxf).(2010 Aug)
  97. ^Institute of Medicine (US) Committee to Review Dietary Reference Intakes for Vitamin D and Calcium, A Catharine Ross, Christine L Taylor, Ann L Yaktine, Heather B Del ValleDietary Reference Intakes for Calcium and Vitamin D
  98. ^Heaney R, Garland C, Baggerly C, French C, Gorham ELetter to Veugelers, P.J. and Ekwaru, J.P., A statistical error in the estimation of the recommended dietary allowance for vitamin D. Nutrients 2014, 6, 4472-4475; doi:10.3390/nu6104472Nutrients.(2015 Mar 10)
  99. ^Veugelers PJ, Ekwaru JPA statistical error in the estimation of the recommended dietary allowance for vitamin DNutrients.(2014 Oct 20)
  100. ^Chang CS, Choi JB, Kim HJ, Park SBCorrelation between serum testosterone level and concentrations of copper and zinc in hair tissueBiol Trace Elem Res.(2011 Dec)
  101. ^Tang YM, Wang DG, Li J, Li XH, Wang Q, Liu N, Liu WT, Li YXRelationships between micronutrient losses in sweat and blood pressure among heat-exposed steelworkersInd Health.(2016 Jun 10)
  102. ^Valentiner-Branth P, Shrestha PS, Chandyo RK, Mathisen M, Basnet S, Bhandari N, Adhikari RK, Sommerfelt H, Strand TAA randomized controlled trial of the effect of zinc as adjuvant therapy in children 2-35 mo of age with severe or nonsevere pneumonia in Bhaktapur, NepalAm J Clin Nutr.(2010 Jun)
  103. ^Willis MS, Monaghan SA, Miller ML, McKenna RW, Perkins WD, Levinson BS, Bhushan V, Kroft SHZinc-induced copper deficiency: a report of three cases initially recognized on bone marrow examinationAm J Clin Pathol.(2005 Jan)
  104. ^Afrin LBFatal copper deficiency from excessive use of zinc-based denture adhesiveAm J Med Sci.(2010 Aug)
  105. ^Maggio M, De Vita F, Lauretani F, Nouvenne A, Meschi T, Ticinesi A, Dominguez LJ, Barbagallo M, Dall'aglio E, Ceda GPThe Interplay between Magnesium and Testosterone in Modulating Physical Function in MenInt J Endocrinol.(2014)
  106. ^Uwitonze AM, Razzaque MSRole of Magnesium in Vitamin D Activation and FunctionJ Am Osteopath Assoc.(2018 Mar 1)
  107. ^Costello RB, Moser-Veillon PBA review of magnesium intake in the elderly. A cause for concern?Magnes Res.(1992 Mar)
  108. ^Nielsen FH, Lukaski HCUpdate on the relationship between magnesium and exerciseMagnes Res.(2006 Sep)
  109. ^Institute of Medicine (US) Committee on Military Nutrition Research; Marriott BM, editor. Washington (DC)Nutritional Needs in Hot Environments, “Influence of Exercise and Heat on Magnesium Metabolism”National Academies Press (US).(1993)
  110. ^Consolazio CF, Matoush LO, Nelson RA, Harding RS, Canham JEExcretion of sodium, potassium, magnesium and iron in human sweat and the relation of each to balance and requirementsJ Nutr.(1963 Apr)
  111. ^Institute of Medicine (US) Standing Committee on the Scientific Evaluation of Dietary Reference IntakesDietary Reference Intakes for Calcium, Phosphorus, Magnesium, Vitamin D, and Fluoride
  112. ^Yoshimura Y, Fujisaki K, Yamamoto T, Shinohara YPharmacokinetic Studies of Orally Administered Magnesium Oxide in RatsYakugaku Zasshi.(2017 May 1)
  113. ^Firoz M, Graber MBioavailability of US commercial magnesium preparationsMagnes Res.(2001 Dec)
  114. ^Gonzales-Arimborgo C, Yupanqui I, Montero E, Alarcón-Yaquetto DE, Zevallos-Concha A, Caballero L, Gasco M, Zhao J, Khan IA, Gonzales GFAcceptability, Safety, and Efficacy of Oral Administration of Extracts of Black or Red Maca (Lepidium meyenii) in Adult Human Subjects: A Randomized, Double-Blind, Placebo-Controlled StudyPharmaceuticals (Basel).(2016 Aug 18)
  115. ^Zenico T, Cicero AF, Valmorri L, Mercuriali M, Bercovich ESubjective effects of Lepidium meyenii (Maca) extract on well-being and sexual performances in patients with mild erectile dysfunction: a randomised, double-blind clinical trialAndrologia.(2009 Apr)
  116. ^Gonzales GF, Córdova A, Vega K, Chung A, Villena A, Góñez C, Castillo SEffect of Lepidium meyenii (MACA) on sexual desire and its absent relationship with serum testosterone levels in adult healthy menAndrologia.(2002 Dec)
  117. ^Dording CM, Schettler PJ, Dalton ED, Parkin SR, Walker RS, Fehling KB, Fava M, Mischoulon DA double-blind placebo-controlled trial of maca root as treatment for antidepressant-induced sexual dysfunction in womenEvid Based Complement Alternat Med.(2015)
  118. ^G. D’Aniello, S. Ronsini, T. Notari, N. Grieco, V. Infante, N. D’Angel, F. Mascia, M. Fiore, G. Fisher and A. D’AnielloD-asparate, a key element for the improvement of sperm qualityAdvances in Sexual Medicine.(2012 Oct)
  119. ^Topo E, Soricelli A, D'Aniello A, Ronsini S, D'Aniello GThe role and molecular mechanism of D-aspartic acid in the release and synthesis of LH and testosterone in humans and ratsReprod Biol Endocrinol.(2009 Oct 27)
  120. ^Melville GW, Siegler JC, Marshall PWThree and six grams supplementation of d-aspartic acid in resistance trained menJ Int Soc Sports Nutr.(2015 Apr 1)
  121. ^Willoughby DS, Leutholtz BD-aspartic acid supplementation combined with 28 days of heavy resistance training has no effect on body composition, muscle strength, and serum hormones associated with the hypothalamo-pituitary-gonadal axis in resistance-trained menNutr Res.(2013 Oct)
Examine Database References
  1. PMS Symptoms - Jafari F, Amani R, Tarrahi MJEffect of Zinc Supplementation on Physical and Psychological Symptoms, Biomarkers of Inflammation, Oxidative Stress, and Brain-Derived Neurotrophic Factor in Young Women with Premenstrual Syndrome: a Randomized, Double-Blind, Placebo-Controlled TrialBiol Trace Elem Res.(2019 Jun 2)
  2. PMS Symptoms - Siahbazi S, Behboudi-Gandevani S, Moghaddam-Banaem L, Montazeri AEffect of zinc sulfate supplementation on premenstrual syndrome and health-related quality of life: Clinical randomized controlled trialJ Obstet Gynaecol Res.(2017 May)
  3. Apolipoprotein A - Kelishadi R, Hashemipour M, Adeli K, Tavakoli N, Movahedian-Attar A, Shapouri J, Poursafa P, Rouzbahani AEffect of zinc supplementation on markers of insulin resistance, oxidative stress, and inflammation among prepubescent children with metabolic syndromeMetab Syndr Relat Disord.(2010 Dec)
  4. Cell Adhesion Factors - Bao B, Prasad AS, Beck FW, Fitzgerald JT, Snell D, Bao GW, Singh T, Cardozo LJZinc decreases C-reactive protein, lipid peroxidation, and inflammatory cytokines in elderly subjects: a potential implication of zinc as an atheroprotective agentAm J Clin Nutr.(2010 Jun)
  5. Iron Absorption - Olivares M, Pizarro F, Ruz MNew insights about iron bioavailability inhibition by zincNutrition.(2007 Apr)
  6. Testosterone - Kilic MEffect of fatiguing bicycle exercise on thyroid hormone and testosterone levels in sedentary males supplemented with oral zincNeuro Endocrinol Lett.(2007 Oct)
  7. Rosacea Symptoms - Bamford JT, Gessert CE, Haller IV, Kruger K, Johnson BPRandomized, double-blind trial of 220 mg zinc sulfate twice daily in the treatment of rosaceaInt J Dermatol.(2012 Apr)
  8. Rosacea Symptoms - Sharquie KE, Najim RA, Al-Salman HNOral zinc sulfate in the treatment of rosacea: a double-blind, placebo-controlled studyInt J Dermatol.(2006 Jul)
  9. Upper Respiratory Tract Infection Symptoms - Al-Nakib W, Higgins PG, Barrow I, Batstone G, Tyrrell DAProphylaxis and treatment of rhinovirus colds with zinc gluconate lozengesJ Antimicrob Chemother.(1987 Dec)
  10. Upper Respiratory Tract Infection Symptoms - Hemilä HZinc lozenges and the common cold: a meta-analysis comparing zinc acetate and zinc gluconate, and the role of zinc dosageJRSM Open.(2017 May 2)
  11. Upper Respiratory Tract Infection Symptoms - Petrus E, Lawson K, Bucci L, Blum KRandomized, double-masked, placebo-controlled clinical study of the effectiveness of zinc acetate lozenges on common cold symptoms in allergy-tested subjectsCurr Ther Res.()
  12. Upper Respiratory Tract Infection Symptoms - Farr BM, Conner EM, Betts RF, Oleske J, Minnefor A, Gwaltney JM JrTwo randomized controlled trials of zinc gluconate lozenge therapy of experimentally induced rhinovirus coldsAntimicrob Agents Chemother.(1987 Aug)
  13. Upper Respiratory Tract Infection Symptoms - Godfrey JC, Conant Sloane B, Smith DS, Turco JH, Mercer N, Godfrey NJZinc gluconate and the common cold: a controlled clinical studyJ Int Med Res.(1992 Jun)
  14. Upper Respiratory Tract Infection Symptoms - Prasad AS, Beck FW, Bao B, Snell D, Fitzgerald JTDuration and severity of symptoms and levels of plasma interleukin-1 receptor antagonist, soluble tumor necrosis factor receptor, and adhesion molecules in patients with common cold treated with zinc acetateJ Infect Dis.(2008 Mar 15)
  15. Upper Respiratory Tract Infection Symptoms - Hemilä H, Haukka J, Alho M, Vahtera J, Kivimäki MZinc acetate lozenges for the treatment of the common cold: a randomised controlled trialBMJ Open.(2020 Jan 23)
  16. Upper Respiratory Tract Infection Symptoms - Mossad SB, Macknin ML, Medendorp SV, Mason PZinc gluconate lozenges for treating the common cold. A randomized, double-blind, placebo-controlled studyAnn Intern Med.(1996 Jul 15)
  17. Upper Respiratory Tract Infection Symptoms - Turner RB, Cetnarowski WEEffect of treatment with zinc gluconate or zinc acetate on experimental and natural coldsClin Infect Dis.(2000 Nov)
  18. Upper Respiratory Tract Infection Symptoms - Eby GA, Davis DR, Halcomb WWReduction in duration of common colds by zinc gluconate lozenges in a double-blind studyAntimicrob Agents Chemother.(1984 Jan)
  19. Upper Respiratory Tract Infection Symptoms - Weismann K, Jakobsen JP, Weismann JE, Hammer UM, Nyholm SM, Hansen B, Lomholt KE, Schmidt KZinc gluconate lozenges for common cold. A double-blind clinical trialDan Med Bull.(1990 Jun)
  20. Upper Respiratory Tract Infection Symptoms - Prasad AS, Fitzgerald JT, Bao B, Beck FW, Chandrasekar PHDuration of symptoms and plasma cytokine levels in patients with the common cold treated with zinc acetate. A randomized, double-blind, placebo-controlled trialAnn Intern Med.(2000 Aug 15)
  21. Upper Respiratory Tract Infection Risk - Prasad AS, Beck FW, Bao B, Fitzgerald JT, Snell DC, Steinberg JD, Cardozo LJZinc supplementation decreases incidence of infections in the elderly: effect of zinc on generation of cytokines and oxidative stressAm J Clin Nutr.(2007 Mar)
  22. Mucositis Symptoms - Ertekin MV, Koç M, Karslioglu I, Sezen OZinc sulfate in the prevention of radiation-induced oropharyngeal mucositis: a prospective, placebo-controlled, randomized studyInt J Radiat Oncol Biol Phys.(2004 Jan 1)
  23. IGF-1 - Rodondi A, Ammann P, Ghilardi-Beuret S, Rizzoli RZinc increases the effects of essential amino acids-whey protein supplements in frail elderlyJ Nutr Health Aging.(2009 Jun)
  24. Serum BDNF - Ranjbar E, Shams J, Sabetkasaei M, M-Shirazi M, Rashidkhani B, Mostafavi A, Bornak E, Nasrollahzadeh JEffects of zinc supplementation on efficacy of antidepressant therapy, inflammatory cytokines, and brain-derived neurotrophic factor in patients with major depressionNutr Neurosci.(2014 Feb)
  25. Serum BDNF - Solati Z, Jazayeri S, Tehrani-Doost M, Mahmoodianfard S, Gohari MRZinc monotherapy increases serum brain-derived neurotrophic factor (BDNF) levels and decreases depressive symptoms in overweight or obese subjects: A double-blind, randomized, placebo-controlled trialNutr Neurosci.(2014 Jan 7)
  26. Depression Symptoms - Sawada T, Yokoi KEffect of zinc supplementation on mood states in young women: a pilot studyEur J Clin Nutr.(2010 Mar)
  27. Depression Symptoms - Siwek M, Dudek D, Paul IA, Sowa-Kućma M, Zieba A, Popik P, Pilc A, Nowak GZinc supplementation augments efficacy of imipramine in treatment resistant patients: a double blind, placebo-controlled studyJ Affect Disord.(2009 Nov)
  28. Reaction Time - Tupe RP, Chiplonkar SAZinc supplementation improved cognitive performance and taste acuity in Indian adolescent girlsJ Am Coll Nutr.(2009 Aug)
  29. DHT - Netter A, Hartoma R, Nahoul KEffect of zinc administration on plasma testosterone, dihydrotestosterone, and sperm countArch Androl.(1981 Aug)
  30. IGF-1 - Blostein-Fujii A, DiSilvestro RA, Frid D, Katz C, Malarkey WShort-term zinc supplementation in women with non-insulin-dependent diabetes mellitus: effects on plasma 5'-nucleotidase activities, insulin-like growth factor I concentrations, and lipoprotein oxidation rates in vitroAm J Clin Nutr.(1997 Sep)
  31. Glycemic Control - Ghaedi K, Ghasempour D, Jowshan M, Zheng M, Ghobadi S, Jafari AEffect of zinc supplementation in the management of type 2 diabetes: A grading of recommendations assessment, development, and evaluation-assessed, dose-response meta-analysis of randomized controlled trials.Crit Rev Food Sci Nutr.(2023-May-15)
  32. Fasting Glucose - Laura M Pompano, Erick BoyEffects of Dose and Duration of Zinc Interventions on Risk Factors for Type 2 Diabetes and Cardiovascular Disease: A Systematic Review and Meta-AnalysisAdv Nutr.(2020 Jul 28)
  33. Total cholesterol - Asbaghi O, Sadeghian M, Fouladvand F, Panahande B, Nasiri M, Khodadost M, Shokri A, Pirouzi A, Sadeghi OEffects of zinc supplementation on lipid profile in patients with type 2 diabetes mellitus: A systematic review and meta-analysis of randomized controlled trials.Nutr Metab Cardiovasc Dis.(2020-Jul-24)
  34. Insulin - Hashemipour M, Kelishadi R, Shapouri J, Sarrafzadegan N, Amini M, Tavakoli N, Movahedian-Attar A, Mirmoghtadaee P, Poursafa PEffect of zinc supplementation on insulin resistance and components of the metabolic syndrome in prepubertal obese childrenHormones (Athens).(2009 Oct-Dec)
  35. Anti-Oxidant Enzyme Profile - Kara E, Gunay M, Cicioglu I, Ozal M, Kilic M, Mogulkoc R, Baltaci AKEffect of zinc supplementation on antioxidant activity in young wrestlersBiol Trace Elem Res.(2010 Apr)
  36. General Oxidation - Seet RC, Lee CY, Lim EC, Quek AM, Huang H, Huang SH, Looi WF, Long LH, Halliwell BOral zinc supplementation does not improve oxidative stress or vascular function in patients with type 2 diabetes with normal zinc levelsAtherosclerosis.(2011 Nov)
  37. Body Fat - C S Mantzoros, A S Prasad, F W Beck, S Grabowski, J Kaplan, C Adair, G J BrewerZinc may regulate serum leptin concentrations in humansJ Am Coll Nutr.(1998 Jun)
  38. Wart Severity - Al-Gurairi FT, Al-Waiz M, Sharquie KEOral zinc sulphate in the treatment of recalcitrant viral warts: randomized placebo-controlled clinical trialBr J Dermatol.(2002 Mar)
  39. Wart Severity - Sharquie KE, Khorsheed AA, Al-Nuaimy AATopical zinc sulphate solution for treatment of viral wartsSaudi Med J.(2007 Sep)
  40. Wart Severity - Mun JH, Kim SH, Jung DS, Ko HC, Kim BS, Kwon KS, Kim MBOral zinc sulfate treatment for viral warts: an open-label studyJ Dermatol.(2011 Jun)
  41. Pneumonia Symptoms - Valavi E, Hakimzadeh M, Shamsizadeh A, Aminzadeh M, Alghasi AThe efficacy of zinc supplementation on outcome of children with severe pneumonia. A randomized double-blind placebo-controlled clinical trialIndian J Pediatr.(2011 Sep)
  42. Pneumonia Symptoms - Wadhwa N, Chandran A, Aneja S, Lodha R, Kabra SK, Chaturvedi MK, Sodhi J, Fitzwater SP, Chandra J, Rath B, Kainth US, Saini S, Black RE, Santosham M, Bhatnagar SEfficacy of zinc given as an adjunct in the treatment of severe and very severe pneumonia in hospitalized children 2-24 mo of age: a randomized, double-blind, placebo-controlled trialAm J Clin Nutr.(2013 Jun)
  43. Pneumonia Symptoms - Chandyo RK, Shrestha PS, Valentiner-Branth P, Mathisen M, Basnet S, Ulak M, Adhikari RK, Sommerfelt H, Strand TATwo weeks of zinc administration to Nepalese children with pneumonia does not reduce the incidence of pneumonia or diarrhea during the next six monthsJ Nutr.(2010 Sep)
  44. Pneumonia Symptoms - Shah GS, Dutta AK, Shah D, Mishra OPRole of zinc in severe pneumonia: a randomized double bind placebo controlled studyItal J Pediatr.(2012 Aug 2)
  45. Pneumonia Symptoms - Ganguly A, Chakraborty S, Datta K, Hazra A, Datta S, Chakraborty JA randomized controlled trial of oral zinc in acute pneumonia in children aged between 2 months to 5 yearsIndian J Pediatr.(2011 Sep)
  46. Pneumonia Symptoms - Srinivasan MG, Ndeezi G, Mboijana CK, Kiguli S, Bimenya GS, Nankabirwa V, Tumwine JKZinc adjunct therapy reduces case fatality in severe childhood pneumonia: a randomized double blind placebo-controlled trialBMC Med.(2012 Feb 8)
  47. Pneumonia Symptoms - Valentiner-Branth P, Shrestha PS, Chandyo RK, Mathisen M, Basnet S, Bhandari N, Adhikari RK, Sommerfelt H, Strand TAA randomized controlled trial of the effect of zinc as adjuvant therapy in children 2-35 mo of age with severe or nonsevere pneumonia in Bhaktapur, NepalAm J Clin Nutr.(2010 Jun)
  48. Pneumonia Symptoms - Basnet S, Shrestha PS, Sharma A, Mathisen M, Prasai R, Bhandari N, Adhikari RK, Sommerfelt H, Valentiner-Branth P, Strand TA; Zinc Severe Pneumonia Study GroupA randomized controlled trial of zinc as adjuvant therapy for severe pneumonia in young childrenPediatrics.(2012 Apr)
  49. Cognition - Aquilani R, Baiardi P, Scocchi M, Iadarola P, Verri M, Sessarego P, Boschi F, Pasini E, Pastoris O, Viglio SNormalization of zinc intake enhances neurological retrieval of patients suffering from ischemic strokesNutr Neurosci.(2009 Oct)
  50. Tinnitus Symptoms - Arda HN, Tuncel U, Akdogan O, Ozluoglu LNThe role of zinc in the treatment of tinnitusOtol Neurotol.(2003 Jan)
  51. Testosterone - Kilic M, Baltaci AK, Gunay M, Gökbel H, Okudan N, Cicioglu IThe effect of exhaustion exercise on thyroid hormones and testosterone levels of elite athletes receiving oral zincNeuro Endocrinol Lett.(2006 Feb-Apr)
  52. Acne Symptoms - Dreno B, Moyse D, Alirezai M, Amblard P, Auffret N, Beylot C, Bodokh I, Chivot M, Daniel F, Humbert P, Meynadier J, Poli F; Acne Research and Study GroupMulticenter randomized comparative double-blind controlled clinical trial of the safety and efficacy of zinc gluconate versus minocycline hydrochloride in the treatment of inflammatory acne vulgarisDermatology.(2001)
  53. Acne Symptoms - Verma KC, Saini AS, Dhamija SKOral zinc sulphate therapy in acne vulgaris: a double-blind trialActa Derm Venereol.(1980)
  54. Acne Symptoms - Dreno B, Amblard P, Agache P, Sirot S, Litoux PLow doses of zinc gluconate for inflammatory acneActa Derm Venereol.(1989)
  55. Acne Symptoms - Göransson K, Lidén S, Odsell LOral zinc in acne vulgaris: a clinical and methodological studyActa Derm Venereol.(1978)
  56. Acne Symptoms - Brittany E Yee, Phillip Richards, Jennifer Y Sui, Amanda Fleming MarschSerum zinc levels and efficacy of zinc treatment in acne vulgaris: A systematic review and meta-analysisDermatol Ther.(2020 Aug 29)
  57. Upper Respiratory Tract Infection Symptoms - Smith DS, Helzner EC, Nuttall CE Jr, Collins M, Rofman BA, Ginsberg D, Goswick CB, Magner AFailure of zinc gluconate in treatment of acute upper respiratory tract infectionsAntimicrob Agents Chemother.(1989 May)
  58. Iron Absorption - J K Friel, R E Serfass, P V Fennessey, L V Miller, W L Andrews, B S Simmons, G F Downton, P G KwaElevated intakes of zinc in infant formulas don not interfere with iron absorption in premature infantsJ Pediatr Gastroenterol Nutr.(1998 Sep)
  59. Spontaneous Birth Risk - Carducci B, Keats EC, Bhutta ZAZinc supplementation for improving pregnancy and infant outcome.Cochrane Database Syst Rev.(2021-Mar-16)
  60. Infant Growth - Lassi ZS, Kurji J, Oliveira CS, Moin A, Bhutta ZAZinc supplementation for the promotion of growth and prevention of infections in infants less than six months of age.Cochrane Database Syst Rev.(2020-Apr-08)
  61. Infant Growth - Belal Alshaikh, Moaaz Abo Zeed, Kamran Yusuf, Madhusudan Guin, Tanis FentonEffect of enteral zinc supplementation on growth and neurodevelopment of preterm infants: a systematic review and meta-analysisJ Perinatol.(2021 May 18)
  62. Cirrhosis Severity - Somi MH, Rezaeifar P, Ostad Rahimi A, Moshrefi BEffects of low dose zinc supplementation on biochemical markers in non-alcoholic cirrhosis: a randomized clinical trialArch Iran Med.(2012 Aug)
  63. Mucositis Symptoms - Mansouri A, Hadjibabaie M, Iravani M, Shamshiri AR, Hayatshahi A, Javadi MR, Khoee SH, Alimoghaddam K, Ghavamzadeh AThe effect of zinc sulfate in the prevention of high-dose chemotherapy-induced mucositis: a double-blind, randomized, placebo-controlled studyHematol Oncol.(2012 Mar)
  64. Psoriasis Symptoms - Sadeghian G, Ziaei H, Nilforoushzadeh MATreatment of localized psoriasis with a topical formulation of zinc pyrithioneActa Dermatovenerol Alp Panonica Adriat.(2011)
  65. Subjective Well-Being - Stewart-Knox BJ, Rae G, Simpson EE, McConville C, O'Connor J, Polito A, Andriollo-Sanchez M, Coudray C, Strain JJSupplemented zinc does not alter mood in healthy older European adults--a randomised placebo-controlled trial: the Zenith studyPublic Health Nutr.(2011 May)
  66. Testosterone - Ghanbarali Raeis Jalali, Jamshid Roozbeh, Azam Mohammadzadeh, Maryam Sharifian, Mohammad Mahdi Sagheb, Alireza Hamidian Jahromi, Sanaz Shabani, Fariborz Ghaffarpasand, Raha AfsharianiImpact of oral zinc therapy on the level of sex hormones in male patients on hemodialysisRen Fail.(2010 May)
  67. C-Reactive Protein (CRP) - Rashidi AA, Salehi M, Piroozmand A, Sagheb MMEffects of zinc supplementation on serum zinc and C-reactive protein concentrations in hemodialysis patientsJ Ren Nutr.(2009 Nov)
  68. ADHD Symptoms - Arnold LE, Disilvestro RA, Bozzolo D, Bozzolo H, Crowl L, Fernandez S, Ramadan Y, Thompson S, Mo X, Abdel-Rasoul M, Joseph EZinc for attention-deficit/hyperactivity disorder: placebo-controlled double-blind pilot trial alone and combined with amphetamineJ Child Adolesc Psychopharmacol.(2011 Feb)
  69. ADHD Symptoms - Talebi S, Miraghajani M, Ghavami A, Mohammadi HThe effect of zinc supplementation in children with attention deficit hyperactivity disorder: A systematic review and dose-response meta‑analysis of randomized clinical trials.Crit Rev Food Sci Nutr.(2022)
  70. Mucositis Symptoms - Sangthawan D, Phungrassami T, Sinkitjarurnchai WA randomized double-blind, placebo-controlled trial of zinc sulfate supplementation for alleviation of radiation-induced oral mucositis and pharyngitis in head and neck cancer patientsJ Med Assoc Thai.(2013 Jan)
  71. Mucositis Symptoms - Arbabi-kalati F, Arbabi-kalati F, Deghatipour M, Ansari Moghadam AEvaluation of the efficacy of zinc sulfate in the prevention of chemotherapy-induced mucositis: a double-blind randomized clinical trialArch Iran Med.(2012 Jul)
  72. OCD Symptoms - Sayyah M, Olapour A, Saeedabad Ys, Yazdan Parast R, Malayeri AEvaluation of oral zinc sulfate effect on obsessive-compulsive disorder: a randomized placebo-controlled clinical trialNutrition.(2012 Sep)
  73. Dysgeusia - Lyckholm L, Heddinger SP, Parker G, Coyne PJ, Ramakrishnan V, Smith TJ, Henkin RIA randomized, placebo controlled trial of oral zinc for chemotherapy-related taste and smell disordersJ Pain Palliat Care Pharmacother.(2012 Jun)
  74. Dental Health Metrics - Uçkardeş Y, Tekçiçek M, Ozmert EN, Yurdakök KThe effect of systemic zinc supplementation on oral health in low socioeconomic level childrenTurk J Pediatr.(2009 Sep-Oct)
  75. Itching - Najafabadi MM, Faghihi G, Emami A, Monghad M, Moeenzadeh F, Sharif N, Davarpanah Jazi AHZinc sulfate for relief of pruritus in patients on maintenance hemodialysisTher Apher Dial.(2012 Apr)
  76. Dysgeusia - R I Henkin, B M Martin, R P AgarwalEfficacy of exogenous oral zinc in treatment of patients with carbonic anhydrase VI deficiencyAm J Med Sci.(1999 Dec)
  77. Iron Absorption - Olivares M, Pizarro F, Ruz MZinc inhibits nonheme iron bioavailability in humansBiol Trace Elem Res.(2007 Summer)
  78. Iron Absorption - Olivares M, Wiedeman A, Bolívar L, López de Romaña D, Pizarro FEffect of increasing concentrations of zinc on the absorption of iron from iron-fortified milkBiol Trace Elem Res.(2012 Dec)
  79. Diarrhea Symptoms - Lazzerini M, Wanzira HOral zinc for treating diarrhoea in children.Cochrane Database Syst Rev.(2016-Dec-20)
  80. Diarrhea Symptoms - Lamberti LM, Walker CL, Chan KY, Jian WY, Black REOral zinc supplementation for the treatment of acute diarrhea in children: a systematic review and meta-analysis.Nutrients.(2013-Nov-21)
  81. Diarrhea Symptoms - Galvao TF, Thees MF, Pontes RF, Silva MT, Pereira MGZinc supplementation for treating diarrhea in children: a systematic review and meta-analysis.Rev Panam Salud Publica.(2013-May)