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NMDA Neurotransmission

NMDA receptors are one of the subsets of glutaminergic receptors, involved in mediating the effects of the main stimulatory neurotransmitter glutamate and, to a lesser extent, glycine. NMDA receptor activation appears to be a positive regulator of synaptic plasticity.

Our evidence-based analysis on nmda neurotransmission features 19 unique references to scientific papers.

Research analysis lead by Kamal Patel
All content reviewed by Examine.com Team.
Last Updated:

Scientific Research on NMDA Neurotransmission

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  1. Hardingham GE, Bading H. Synaptic versus extrasynaptic NMDA receptor signalling: implications for neurodegenerative disorders. Nat Rev Neurosci. (2010)
  2. Harris AZ, Pettit DL. Extrasynaptic and synaptic NMDA receptors form stable and uniform pools in rat hippocampal slices. J Physiol. (2007)
  3. Scimemi A, et al. NR2B-containing receptors mediate cross talk among hippocampal synapses. J Neurosci. (2004)
  4. Tovar KR, Westbrook GL. The incorporation of NMDA receptors with a distinct subunit composition at nascent hippocampal synapses in vitro. J Neurosci. (1999)
  5. Petralia RS, et al. Organization of NMDA receptors at extrasynaptic locations. Neuroscience. (2010)
  6. Cottrell JR, et al. Distribution, density, and clustering of functional glutamate receptors before and after synaptogenesis in hippocampal neurons. J Neurophysiol. (2000)
  7. Groc L, Bard L, Choquet D. Surface trafficking of N-methyl-D-aspartate receptors: physiological and pathological perspectives. Neuroscience. (2009)
  8. Tovar KR, Westbrook GL. Mobile NMDA receptors at hippocampal synapses. Neuron. (2002)
  9. Groc L, et al. NMDA receptor surface mobility depends on NR2A-2B subunits. Proc Natl Acad Sci U S A. (2006)
  10. Yamagata K, et al. Expression of a mitogen-inducible cyclooxygenase in brain neurons: regulation by synaptic activity and glucocorticoids. Neuron. (1993)
  11. Stark DT, Bazan NG. Synaptic and extrasynaptic NMDA receptors differentially modulate neuronal cyclooxygenase-2 function, lipid peroxidation, and neuroprotection. J Neurosci. (2011)
  12. Bliss TV, Collingridge GL. A synaptic model of memory: long-term potentiation in the hippocampus. Nature. (1993)
  13. Aamodt SM, Constantine-Paton M. The role of neural activity in synaptic development and its implications for adult brain function. Adv Neurol. (1999)
  14. Hewett SJ, et al. Cyclooxygenase-2 contributes to N-methyl-D-aspartate-mediated neuronal cell death in primary cortical cell culture. J Pharmacol Exp Ther. (2000)
  15. Strauss KI, Marini AM. Cyclooxygenase-2 inhibition protects cultured cerebellar granule neurons from glutamate-mediated cell death. J Neurotrauma. (2002)
  16. Carlson NG. Neuroprotection of cultured cortical neurons mediated by the cyclooxygenase-2 inhibitor APHS can be reversed by a prostanoid. J Neurosci Res. (2003)
  17. Li SQ, et al. Activation of NMDA receptor is associated with up-regulation of COX-2 expression in the spinal dorsal horn during nociceptive inputs in rats. Neurochem Res. (2009)
  18. Bosetti F. Arachidonic acid metabolism in brain physiology and pathology: lessons from genetically altered mouse models. J Neurochem. (2007)
  19. Toscano CD, et al. NMDA-induced seizure intensity is enhanced in COX-2 deficient mice. Neurotoxicology. (2008)