Last Updated: September 28 2022

Eleutherococcus senticosus is an adaptogen and herb that may increase work capacity during strenuous aerobic activity. It also has anti-stress and potential immunity-boosting effects.

Eleuthero is most often used for


Eleutherococcus senticosus, commonly known as Siberian ginseng, is an herb used in traditional medicine to combat fatigue. It is an adaptogen compound.

Preliminary evidence suggests that Eleutherococcus senticosus can improve physical performance during periods of high intensity exercise. Unfortunately, this effect is not very reliable. The studies that showed the most promise for Eleutherococcus senticosus also had the worst methodology. Though additional research is needed to confirm Eleutherococcus senticosus’s ergogenic effect, it cannot be disproven either.

Preliminary in vitro (outside the body) and animal research suggests Eleutherococcus senticosus supplementation can provide a variety of protective effects for cognition, meaning it can protect the brain from harm. Again, further research is needed to confirm these effects.

What else is Eleuthero known as?
Note that Eleuthero is also known as:
  • Siberian Ginseng
  • Ciwujia
  • Acanthopanax Senticosus
  • Eleuthero
  • Eleutherococcus Senticosus
Dosage information

The standard dose for Eleutherococcus senticosus is 300-1,200mg, though the 2-4g range and more have been traditionally recommended.

The most common form of Eleutherococcus senticosus supplements are root and stem extracts, though leaf extracts have been used as well.

Examine Database
1.^Huang L, Zhao H, Huang B, Zheng C, Peng W, Qin LAcanthopanax senticosus: review of botany, chemistry and pharmacologyPharmazie.(2011 Feb)
3.^[No authors listedMonograph. Eleutherococcus senticosusAltern Med Rev.(2006 Jun)
4.^Bleakney TLDeconstructing an adaptogen: Eleutherococcus senticosusHolist Nurs Pract.(2008 Jul-Aug)
6.^Hartz AJ, Bentler S, Noyes R, Hoehns J, Logemann C, Sinift S, Butani Y, Wang W, Brake K, Ernst M, Kautzman HRandomized controlled trial of Siberian ginseng for chronic fatiguePsychol Med.(2004 Jan)
7.^Załuski D, Smolarz HD, Szpilewska MEleutherosides in aerial parts of Eleutherococcus species cultivated in PolandJ AOAC Int.(2011 Sep-Oct)
8.^Li XC, Barnes DL, Khan IAA new lignan glycoside from Eleutherococcus senticosusPlanta Med.(2001 Nov)
11.^Jiang W, Li W, Han L, Liu L, Zhang Q, Zhang S, Nikaido T, Koike KBiologically active triterpenoid saponins from Acanthopanax senticosusJ Nat Prod.(2006 Nov)
13.^Li F, Li W, Fu H, Zhang Q, Koike KPancreatic lipase-inhibiting triterpenoid saponins from fruits of Acanthopanax senticosusChem Pharm Bull (Tokyo).(2007 Jul)
15.^Tolonen A, Joutsamo T, Mattlla S, Kämäräinen T, Jalonen JIdentification of isomeric dicaffeoylquinic acids from Eleutherococcus senticosus using HPLC-ESI/TOF/MS and 1H-NMR methodsPhytochem Anal.(2002 Nov-Dec)
23.^Donovan JL, DeVane CL, Chavin KD, Taylor RM, Markowitz JSSiberian ginseng (Eleutheroccus senticosus) effects on CYP2D6 and CYP3A4 activity in normal volunteersDrug Metab Dispos.(2003 May)
25.^Jin L, Wu F, Li X, Li H, Du C, Jiang Q, You J, Li S, Xu YAnti-depressant Effects of Aqueous Extract from Acanthopanax senticosus in MicePhytother Res.(2013 Feb 18)
26.^Fujikawa T, Soya H, Hibasami H, Kawashima H, Takeda H, Nishibe S, Nakashima KEffect of Acanthopanax senticosus Harms on biogenic monoamine levels in the rat brainPhytother Res.(2002 Aug)
27.^Fujikawa T, Miguchi S, Kanada N, Nakai N, Ogata M, Suzuki I, Nakashima KAcanthopanax senticosus Harms as a prophylactic for MPTP-induced Parkinson's disease in ratsJ Ethnopharmacol.(2005 Feb 28)
28.^Soya H, Deocaris CC, Yamaguchi K, Ohiwa N, Saito T, Nishijima T, Kato M, Tateoka M, Matsui T, Okamoto M, Fujikawa TExtract from Acanthopanax senticosus harms (Siberian ginseng) activates NTS and SON/PVN in the rat brainBiosci Biotechnol Biochem.(2008 Sep)
30.^Yamazaki M, Hirota K, Chiba K, Mohri TPromotion of neuronal differentiation of PC12h cells by natural lignans and iridoidsBiol Pharm Bull.(1994 Dec)
32.^Panossian A, Wikman G, Kaur P, Asea AAdaptogens stimulate neuropeptide y and hsp72 expression and release in neuroglia cellsFront Neurosci.(2012)
35.^Panossian A, Wikman G, Kaur P, Asea AAdaptogens exert a stress-protective effect by modulation of expression of molecular chaperonesPhytomedicine.(2009 Jun)
36.^Huang LZ, Wei L, Zhao HF, Huang BK, Rahman K, Qin LPThe effect of Eleutheroside E on behavioral alterations in murine sleep deprivation stress modelEur J Pharmacol.(2011 May 11)
37.^Provalova NV, Skurikhin EG, Pershina OV, Suslov NI, Minakova MY, Dygai AM, Gol'dberg EDMechanisms underling the effects of adaptogens on erythropoiesis during paradoxical sleep deprivationBull Exp Biol Med.(2002 May)
38.^Jin ML, Park SY, Kim YH, Park G, Lee SJAcanthopanax senticosus exerts neuroprotective effects through HO-1 signaling in hippocampal and microglial cellsEnviron Toxicol Pharmacol.(2013 Mar)
41.^Lee SE, Jeong SI, Yang H, Jeong SH, Jang YP, Park CS, Kim J, Park YSExtract of Salvia miltiorrhiza (Danshen) induces Nrf2-mediated heme oxygenase-1 expression as a cytoprotective action in RAW 264.7 macrophagesJ Ethnopharmacol.(2012 Jan 31)
44.^Tohda C, Ichimura M, Bai Y, Tanaka K, Zhu S, Komatsu KInhibitory effects of Eleutherococcus senticosus extracts on amyloid beta(25-35)-induced neuritic atrophy and synaptic lossJ Pharmacol Sci.(2008 Jul)
45.^Lee D, Park J, Yoon J, Kim MY, Choi HY, Kim HNeuroprotective effects of Eleutherococcus senticosus bark on transient global cerebral ischemia in ratsJ Ethnopharmacol.(2012 Jan 6)
46.^Bu Y, Jin ZH, Park SY, Baek S, Rho S, Ha N, Park SK, Kim H; Sun Yeo KimSiberian ginseng reduces infarct volume in transient focal cerebral ischaemia in Sprague-Dawley ratsPhytother Res.(2005 Feb)
48.^Bhattacharya A, Leonard S, Tardif S, Buffenstein R, Fischer KE, Richardson A, Austad SN, Chaudhuri ARAttenuation of liver insoluble protein carbonyls: indicator of a longevity determinantAging Cell.(2011 Aug)
50.^Salmon AB, Leonard S, Masamsetti V, Pierce A, Podlutsky AJ, Podlutskaya N, Richardson A, Austad SN, Chaudhuri ARThe long lifespan of two bat species is correlated with resistance to protein oxidation and enhanced protein homeostasisFASEB J.(2009 Jul)
51.^Wiegant FA, Surinova S, Ytsma E, Langelaar-Makkinje M, Wikman G, Post JAPlant adaptogens increase lifespan and stress resistance in C. elegansBiogerontology.(2009 Feb)
52.^Cicero AF, Derosa G, Brillante R, Bernardi R, Nascetti S, Gaddi AEffects of Siberian ginseng (Eleutherococcus senticosus maxim.) on elderly quality of life: a randomized clinical trialArch Gerontol Geriatr Suppl.(2004)
53.^Maslov LN, Lishmanov YB, Arbuzov AG, Krylatov AV, Budankova EV, Konkovskaya YN, Burkova VN, Severova EAAntiarrhythmic activity of phytoadaptogens in short-term ischemia-reperfusion of the heart and postinfarction cardiosclerosisBull Exp Biol Med.(2009 Mar)
62.^Huang LZ, Huang BK, Ye Q, Qin LPBioactivity-guided fractionation for anti-fatigue property of Acanthopanax senticosusJ Ethnopharmacol.(2011 Jan 7)
65.^Szołomicki J, Samochowiec L, Wójcicki J, Droździk MThe influence of active components of Eleutherococcus senticosus on cellular defence and physical fitness in manPhytother Res.(2000 Feb)
66.^Asano K, Takahashi T, Miyashita M, Matsuzaka A, Muramatsu S, Kuboyama M, Kugo H, Imai JEffect of Eleutherococcus senticosus extract on human physical working capacityPlanta Med.(1986 Jun)
67.^Goulet ED, Dionne IJAssessment of the effects of eleutherococcus senticosus on endurance performanceInt J Sport Nutr Exerc Metab.(2005 Feb)
68.^Cheuvront SN, Moffatt RJ, Biggerstaff KD, Bearden S, McDonough PEffect of ENDUROX on metabolic responses to submaximal exerciseInt J Sport Nutr.(1999 Dec)
69.^Plowman SA, Dustman K, Walicek H, Corless C, Ehlers GThe effects of ENDUROX on the physiological responses to stair-stepping exerciseRes Q Exerc Sport.(1999 Dec)
70.^Dowling EA, Redondo DR, Branch JD, Jones S, McNabb G, Williams MHEffect of Eleutherococcus senticosus on submaximal and maximal exercise performanceMed Sci Sports Exerc.(1996 Apr)
71.^Eschbach LF, Webster MJ, Boyd JC, McArthur PD, Evetovich TKThe effect of siberian ginseng (Eleutherococcus senticosus) on substrate utilization and performanceInt J Sport Nutr Exerc Metab.(2000 Dec)
76.^Jung CH, Jung H, Shin YC, Park JH, Jun CY, Kim HM, Yim HS, Shin MG, Bae HS, Kim SH, Ko SGEleutherococcus senticosus extract attenuates LPS-induced iNOS expression through the inhibition of Akt and JNK pathways in murine macrophageJ Ethnopharmacol.(2007 Aug 15)
77.^Jeong HJ, Koo HN, Myung NI, Shin MK, Kim JW, Kim DK, Kim KS, Kim HM, Lee YMInhibitory effects of mast cell-mediated allergic reactions by cell cultured Siberian GinsengImmunopharmacol Immunotoxicol.(2001 Feb)
78.^Yi JM, Hong SH, Kim JH, Kim HK, Song HJ, Kim HMEffect of Acanthopanax senticosus stem on mast cell-dependent anaphylaxisJ Ethnopharmacol.(2002 Mar)
80.^Steinmann GG, Esperester A, Joller PImmunopharmacological in vitro effects of Eleutherococcus senticosus extractsArzneimittelforschung.(2001 Jan)
82.^Di Carlo G, Pacilio M, Capasso R, Di Carlo REffect on prolactin secretion of Echinacea purpurea, hypericum perforatum and Eleutherococcus senticosusPhytomedicine.(2005 Sep)
83.^Leem K, Park SY, Lee DH, Boo YM, Cho KH, Lim J, Jeon H, Park HJ, Chung JH, Kim HEffects of Jaoga-Yukmiwon(R), a Korean herbal medicine, on chondrocyte proliferation and longitudinal bone growth in adolescent male ratsPhytother Res.(2003 Nov)
84.^Kim MY, Park Y, Pandit NR, Kim J, Song M, Park J, Choi HY, Kim HThe herbal formula HT042 induces longitudinal bone growth in adolescent female ratsJ Med Food.(2010 Dec)
85.^Kim MY, Kim JY, Lim D, Lee D, Kim Y, Chang GT, Choi HY, Kim HSkeletal growth and IGF levels in rats after HT042 treatmentPhytother Res.(2012 Dec)
88.^Aslanyan G, Amroyan E, Gabrielyan E, Nylander M, Wikman G, Panossian ADouble-blind, placebo-controlled, randomised study of single dose effects of ADAPT-232 on cognitive functionsPhytomedicine.(2010 Jun)
89.^Narimanian M, Badalyan M, Panosyan V, Gabrielyan E, Panossian A, Wikman G, Wagner HImpact of Chisan (ADAPT-232) on the quality-of-life and its efficacy as an adjuvant in the treatment of acute non-specific pneumoniaPhytomedicine.(2005 Nov)