Japanese Knotweed, or Polygonum cuspidatum, is a Traditional Chinese Medicine used for circulation and heart health. It is a very good source of resveratrol, and most benefits of Japanese Knotweed may actually just be benefits of resveratrol.
Japanese Knotweed is most often used for
Polygonum Cuspidatum var. Japonicus is the species of plant most commonly referred to as Japanese Knotweed. This plant is an invasive species yet has been used traditionally in Chinese and Japanese medicine for its benefits on gastrointestinal health and circulatory health (among some other claims such as cancer prevention). Composition analysis of Japanese Knotweed reveals it to be a vessel for Resveratrol (as well as a few other compounds structurally similar to resveratrol and may act in the same way) and anthraquinone compounds that possess slight laxative effects; like Senna root but less potent.
Most of the effects of Japanese Knotweed can be traced back to either the stilbenes (resveratrol) or the anthraquinones (emodin) for the circulatory and gastrointestinal help, respectively.
Most research on Japanese Knotweed has been pertaining to either suppressing its invasive tendencies, or controlling it to become a large scale producer of Resveratrol for medical or supplemental usage. Limited trials have been conducted in humans, but it appears to have similar effects to resveratrol due to the resveratrol content.
- Polygonum Cuspidatum
- Polygonum Japonicus
- Polygonum Multiforum (different composition from a related plant)
- Pueraria lobata (also called Kudzu)
The only current human study used Japanese Knotweed at 200mg daily and standardized to 40mg Resveratrol which was effective.
Although there are other bioactives in Japanese Knotweed, it may be prudent to dose it in accordance to the dosing guidelines on the resveratrol page.