Last Updated: September 28 2022

Garcinia Cambogia is a fruit that is known to enhance the culinary experience of food, and enhances satiety from a meal (possibly by enhancing the flavor experience). Its usage as a fat burner does not appear to extend to humans.

Garcinia is most often used for


Garcinia Cambogia (Malabar Tamarind) is a small fruit that has some traditional usage to enhance the culinary experience of a meal, but beyond that has limited medicinal usage. It is a very good source of hydroxycitric acids (structurally related to citric acid, a sour flavorant) and one of the isomers, known as (-)-Hydroxycitric acid, is thought to help in weight control.

The mechanism of action is inhibiting an enzyme called Citric acid lysase which is required in the synthesis of fatty acids, known as de novo lipogenesis. At least in rats, evidence of suppressed de novo lipogenesis has been noted and oral consumption of (-)-Hydroxycitric acid appears to reliably reduce food intake and body weight (the latter to a degree where food intake cannot explain all the observed effects)

Studies in humans, for the most part, fail to replicate this; this may be related to less actual activity of de novo lipogenesis in humans and a much higher level in rats. Some isolated studies do note weight loss, but it appears to be quite variable and unreliable. Many studies also do report subjective appetite decrease, but tend to record dropout rates (how often people leave the study due to being unable to maintain the diet protocol) rather than food intake; even then the benefits are still unreliable and sometimes not present.

Although there is some limited potential for (-)-Hydroxycitric acid as a weight loss aid, the magnitude of effect is quite low (up to 2kg over 3 months) and the benefit is unreliable; making it hard to recommend this compound as a fat burner or anti-obesity agent.

What else is Garcinia known as?
Note that Garcinia is also known as:
  • Gambooge
  • Pazham Puzhi
  • Bitter Kola
  • Malabar Tamarind
  • (-)-Hydroxycitric Acid
  • HCA
  • Hydroxycitric Acid
  • Garcinia Cambogia
Garcinia should not be confused with:
Dosage information

Standard dosing of Garcinia Cambogia and its bioactive, (-)-Hydroxycitric acid, is 500mg of (-)-Hydroxycitric acid taken 30-60 minutes prior to a meal and usually taken at up to three different meals daily.

It is unsure if this is the ideal dose since human studies usually fail to find a benefit with any dosage.

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1.^Vasudeva N, Yadav N, Sharma SKNatural products: a safest approach for obesityChin J Integr Med.(2012 Jun)
2.^Márquez F, Babio N, Bulló M, Salas-Salvadó JEvaluation of the safety and efficacy of hydroxycitric acid or Garcinia cambogia extracts in humansCrit Rev Food Sci Nutr.(2012)
3.^Oluyemi KA, Omotuyi IO, Jimoh OR, Adesanya OA, Saalu CL, Josiah SJErythropoietic and anti-obesity effects of Garcinia cambogia (bitter kola) in Wistar ratsBiotechnol Appl Biochem.(2007 Jan)
5.^Masullo M, Bassarello C, Suzuki H, Pizza C, Piacente SPolyisoprenylated benzophenones and an unusual polyisoprenylated tetracyclic xanthone from the fruits of Garcinia cambogiaJ Agric Food Chem.(2008 Jul 9)
11.^Loe YC, Bergeron N, Rodriguez N, Schwarz JMGas chromatography/mass spectrometry method to quantify blood hydroxycitrate concentrationAnal Biochem.(2001 May 1)
12.^Ohia SE, Opere CA, LeDay AM, Bagchi M, Bagchi D, Stohs SJSafety and mechanism of appetite suppression by a novel hydroxycitric acid extract (HCA-SX)Mol Cell Biochem.(2002 Sep)
13.^Hayamizu K, Hirakawa H, Oikawa D, Nakanishi T, Takagi T, Tachibana T, Furuse MEffect of Garcinia cambogia extract on serum leptin and insulin in miceFitoterapia.(2003 Apr)
19.^Hellerstein MKDe novo lipogenesis in humans: metabolic and regulatory aspectsEur J Clin Nutr.(1999 Apr)
23.^Mattes RD, Bormann LEffects of (-)-hydroxycitric acid on appetitive variablesPhysiol Behav.(2000 Oct 1-15)
24.^Heymsfield SB, Allison DB, Vasselli JR, Pietrobelli A, Greenfield D, Nunez CGarcinia cambogia (hydroxycitric acid) as a potential antiobesity agent: a randomized controlled trialJAMA.(1998 Nov 11)
27.^Egras AM, Hamilton WR, Lenz TL, Monaghan MSAn evidence-based review of fat modifying supplemental weight loss productsJ Obes.(2011)
29.^Lenz TL, Hamilton WRSupplemental products used for weight lossJ Am Pharm Assoc (2003).(2004 Jan-Feb)
30.^Pittler MH, Ernst EDietary supplements for body-weight reduction: a systematic reviewAm J Clin Nutr.(2004 Apr)
32.^Cheng IS, Huang SW, Lu HC, Wu CL, Chu YC, Lee SD, Huang CY, Kuo CHOral hydroxycitrate supplementation enhances glycogen synthesis in exercised human skeletal muscleBr J Nutr.(2012 Apr)
33.^Hayamizu K, Tomi H, Kaneko I, Shen M, Soni MG, Yoshino GEffects of Garcinia cambogia extract on serum sex hormones in overweight subjectsFitoterapia.(2008 Jun)
35.^Mathew GE, Mathew B, Shaneeb MM, Nyanthara BDiuretic activity of leaves of garcinia cambogia in ratsIndian J Pharm Sci.(2011 Mar)
37.^Burdock G, Soni M, Bagchi M, Bagchi DGarcinia cambogia toxicity is misleadingFood Chem Toxicol.(2005 Nov)
39.^Soni MG, Burdock GA, Preuss HG, Stohs SJ, Ohia SE, Bagchi DSafety assessment of (-)-hydroxycitric acid and Super CitriMax, a novel calcium/potassium saltFood Chem Toxicol.(2004 Sep)
41.^Hayashi M, Tice RR, MacGregor JT, Anderson D, Blakey DH, Kirsh-Volders M, Oleson FB Jr, Pacchierotti F, Romagna F, Shimada H, et alIn vivo rodent erythrocyte micronucleus assayMutat Res.(1994 Jun)
45.^Stohs SJ, Preuss HG, Ohia SE, Kaats GR, Keen CL, Williams LD, Burdock GANo evidence demonstrating hepatotoxicity associated with hydroxycitric acidWorld J Gastroenterol.(2009 Aug 28)
46.^Actis GC, Bugianesi E, Ottobrelli A, Rizzetto MFatal liver failure following food supplements during chronic treatment with montelukastDig Liver Dis.(2007 Oct)
47.^Mansi IA, Huang JRhabdomyolysis in response to weight-loss herbal medicineAm J Med Sci.(2004 Jun)