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Guggul

Guggul is a product of the Guggul tree, Commiphora Mukul. Guggul and its active guggulsterones have been investigated for their usage in elevating thyroid function, but with lacklustre results.

Our evidence-based analysis on guggul features 31 unique references to scientific papers.

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Summary of Guggul

Primary information, health benefits, side effects, usage, and other important details

Guggul is a plant which is known for its active ingredients, the guggulsterones. It has been traditionally used for combatting ailments such as high blood lipids, liver dysfunction and obesity.

Its most well marketed effect, that of being able to increase thyroid activity, does not occur with doses commonly found in supplements. It does, however, exert an anti-cholesterolemic effect (lowers blood cholesterol levels) and is also an anti-inflammatory and anti-oxidant compound.

It is a healthy compound, but not effective for the main means it is marketed for (fat loss).

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How to Take

Recommended dosage, active amounts, other details

A standard dose of guggul (plant extract) is 400-500mg taken thrice daily with meals, totaling 1,200-1,500mg daily (although doses up to 2,000mg have been used before) If using the guggulsterones in isolation, a dose of 25mg taken thrice a day with meals is used.

Sometimes 'gum guggul' is used in doses of 2-4.5g a day (total), and while it is not sure if guggul needs to be consumed with meals it still tends to be recommended out of prudency.

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Human Effect Matrix

Unlocked for Examine members

The Human Effect Matrix summarizes human studies to tell you what effects Guggul has on your body, how much evidence there is, and how strong these effects are.

Full details are available to Examine members.
Grade Level of Evidence
Robust research conducted with repeated double-blind clinical trials
Multiple studies where at least two are double-blind and placebo controlled
Single double-blind study or multiple cohort studies
Uncontrolled or observational studies only
Level of Evidence
? The amount of high quality evidence. The more evidence, the more we can trust the results.
Outcome Magnitude of effect
? The direction and size of the supplement's impact on each outcome. Some supplements can have an increasing effect, others have a decreasing effect, and others have no effect.
Consistency of research results
? Scientific research does not always agree. HIGH or VERY HIGH means that most of the scientific research agrees.
Notes
grade-c Minor Moderate See 2 studies
Either no significant change associated with Guggul supplementation or a small decrease is observed
grade-c Minor Moderate See 2 studies
Although unreliable, there is a possible increase in LDL cholesterol from Guggul supplementation
grade-c Minor Moderate See 2 studies
Possible decrease in total cholesterol, but this is unreliable (and paired with a possible increase in LDL-C, this is likely to be not desirable)
grade-c - Very High See 2 studies
No significant influence of Guggul on triglycerides is detectable
grade-c - - See study
No significant influence on vLDL cholesterol levels
grade-d Minor - See study
Possible reductions in the symptoms associated with osteoarthritis

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Things to Note

Is a Form Of

Other Functions:

Primary Function:

Also Known As

Commiphora mukul, Commiphora Wightii, Guggulsterones, pregna-4, 17-diene-3, 16-dione

Caution Notice

'Dermatological Hypersensitivity' (adverse skin reactions) have been associated with Guggul and Guggulipid consumption

  • The plant guggul had both water soluble and fat soluble fragments; the active guggulsterones are fat soluble.

  • 'Dermatological Hypersensitivity' (adverse skin reactions) have been associated with Guggul and Guggulipid consumption

Click here to see all 31 references.