Whey Protein
•Last Updated: September 28 2022
The protein in cow’s milks is 80% casein and 20% whey protein. Whey protein powder is extremely popular due to its high digestibility and well-researched benefits for both muscle gain and fat loss.
Whey Protein is most often used for
Last Updated: September 28 2022
Whey protein is a collection of proteins found in whey, a byproduct of cheesemaking. When a coagulant (usually renin) is added to milk, the curds (casein) and whey separate; whey protein is the water-soluble part of milk. As a supplement, it’s sold as dry powders with various levels of processing that affect how concentrated a source of protein they are and how fast they’re absorbed.
It’s a high quality, well-absorbed source of protein that’s very useful for hitting targeted daily protein goals. Its benefits extend to the benefits of increased protein intake in general, such as augmenting muscle gain in conjunction with resistance training, limiting muscle loss during low-calorie diets, and modestly limiting fat gain during periods of excessive calorie intake. These effects aren’t exclusive to whey protein but it will likely be more effective than most other protein sources per gram.
Whey does not harm the liver or kidneys, but it can exacerbate pre-existing damage. People with damaged livers or kidneys should exercise caution when increasing protein intake quickly without the guidance of a doctor. See more: can eating too much protein be bad for you?
Note that Whey Protein is also known as:
- whey
- whey concentrate
- whey isolate
- whey hydrolysate
- hydrolyzed whey
- whey protein powder
Whey Protein should not be confused with:
- Milk protein
- Casein protein
To determine your optimal intake, you can use our Protein Intake Calculator, which is based on the evidence presented in our Optimal Protein Intake Guide.
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To lose more fat and retain more muscle on a weight-loss diet, protein quantity matters more than protein quality.
Losing weight is seldom the goal—losing fat is, while preserving muscle. Unfortunately, your body is reluctant to give up its reserves of energy (its fat) and all too quick to metabolize your hard-earned muscle when the caloric deficit gets just a little too high.
Fortunately, what you eat while on a calorie-restricted diet can affect where the weight loss comes from. Diets high in protein, in particular, have benefits with regard to energy metabolism, appetite, overall caloric intake, and muscle retention...
Eating a high-protein diet doesn't appear to harm the kidneys or liver unless there is pre-existing damage and dysfunction. It's possible that dramatically increasing protein intake in a short timespan can lead to adverse effects on the liver and kidneys, but evidence for this is lacking. Bone health also appears to be either largely unaffected or benefited by eating more protein.
Protein and the Kidneys
Don't worry about it if you have healthy kidneys and control your protein intake if you have damaged kidneys. It may be prudent to gradually increase protein intake to higher levels rather than jumping in both feet at a time, but there isn't much on this topic.
It is generally recommended to consume more water during periods when protein intake is being increased...
Glutamine supplementation does not affect body composition, but it may accelerate strength recovery from resistance-training sessions and reduce the occurrence of infections in hard-training endurance athletes.
Glutamine is the most abundant amino acid in your body. Your body can synthesize it, so it is not an essential amino acid (EAA), but your requirements may at time outpace your rate of synthesis, making glutamine conditionally essential. Historically, however, glutamine has been considered conditionally essential only in the critically hurt or sick — burn victims and other people in whom physical stress is exceptionally high and catabolism (body-tissue breakdown) rampant...
Several scales have been developed to rate proteins according to their respective bioavailabilities and, more recently, amino acid profiles. Those scales can help guide your choice of protein, as long as you understand their premises and limitations.
Nutrition sure can seem complicated. You already had to worry about getting enough protein in your diet, should you now make sure you only get quality proteins?
And what makes a “quality protein” anyway?
Different scales have been developed to answer this last question. They rate and rank proteins based on two criteria: bioavailability and amino acid profile.
Bioavailability
Biological Value (BV), Net Protein Utilisation (NPU), and Nitrogen Balance (NB) rate proteins based on nitrogen measurements...
2.^Abd El-Fattah AM, Abd Rabo FH, El-Dieb SM, El-Kashef HAChanges in composition of colostrum of Egyptian buffaloes and Holstein cowsBMC Vet Res.(2012 Mar 5)
3.^Zhang H, Yao J, Zhao D, Liu H, Li J, Guo MChanges in chemical composition of Alxa bactrian camel milk during lactationJ Dairy Sci.(2005 Oct)
4.^Morin DE, Rowan LL, Hurley WL, Braselton WEComposition of milk from llamas in the United StatesJ Dairy Sci.(1995 Aug)
5.^Adkins Y, Zicker SC, Lepine A, Lönnerdal BChanges in nutrient and protein composition of cat milk during lactationAm J Vet Res.(1997 Apr)
7.^Ye X, Yoshida S, Ng TBIsolation of lactoperoxidase, lactoferrin, alpha-lactalbumin, beta-lactoglobulin B and beta-lactoglobulin A from bovine rennet whey using ion exchange chromatographyInt J Biochem Cell Biol.(2000 Nov-Dec)
8.^Conti A, Napolitano L, Cantisani AM, Davoli R, Dall'Olio SBovine beta-lactoglobulin H: isolation by preparative isoelectric focusing in immobilized pH gradients and preliminary characterizationJ Biochem Biophys Methods.(1988 Jun-Jul)
9.^Godovac-Zimmermann J, Krause I, Baranyi M, Fischer-Frühholz S, Juszczak J, Erhardt G, Buchberger J, Klostermeyer HIsolation and rapid sequence characterization of two novel bovine beta-lactoglobulins I and JJ Protein Chem.(1996 Nov)
10.^Godovac-Zimmermann J, Krause I, Buchberger J, Weiss G, Klostermeyer HGenetic variants of bovine beta-lactoglobulin. A novel wild-type beta-lactoglobulin W and its primary sequenceBiol Chem Hoppe Seyler.(1990 Mar)
11.^Sousa GT, Lira FS, Rosa JC, de Oliveira EP, Oyama LM, Santos RV, Pimentel GDDietary whey protein lessens several risk factors for metabolic diseases: a reviewLipids Health Dis.(2012 Jul 10)
12.^Heine WE, Klein PD, Reeds PJThe importance of alpha-lactalbumin in infant nutritionJ Nutr.(1991 Mar)
13.^Rapid confirmation and revision of the primary structure of bovineserumalbumin by ESIMS and frit-FAB LC/MS.()
15.^Keogh JB, Woonton BW, Taylor CM, Janakievski F, Desilva K, Clifton PMEffect of glycomacropeptide fractions on cholecystokinin and food intakeBr J Nutr.(2010 Jul)
16.^Kissileff HR, Pi-Sunyer FX, Thornton J, Smith GPC-terminal octapeptide of cholecystokinin decreases food intake in manAm J Clin Nutr.(1981 Feb)
17.^Pi-Sunyer X, Kissileff HR, Thornton J, Smith GPC-terminal octapeptide of cholecystokinin decreases food intake in obese menPhysiol Behav.(1982 Oct)
18.^Burton-Freeman BMGlycomacropeptide (GMP) is not critical to whey-induced satiety, but may have a unique role in energy intake regulation through cholecystokinin (CCK)Physiol Behav.(2008 Jan 28)
19.^Legrand D, Pierce A, Elass E, Carpentier M, Mariller C, Mazurier JLactoferrin structure and functionsAdv Exp Med Biol.(2008)
20.^Duarte DC, Nicolau A, Teixeira JA, Rodrigues LRThe effect of bovine milk lactoferrin on human breast cancer cell linesJ Dairy Sci.(2011 Jan)
21.^Riechel P, Weiss T, Ulber R, Buchholz H, Scheper TAnalysis of bovine lactoferrin in whey using capillary electrophoresis (CE) and micellar electrokinetic chromatography (MEKC)Adv Exp Med Biol.(1998)
22.^Ballard KD, Bruno RS, Seip RL, Quann EE, Volk BM, Freidenreich DJ, Kawiecki DM, Kupchak BR, Chung MY, Kraemer WJ, Volek JSAcute ingestion of a novel whey-derived peptide improves vascular endothelial responses in healthy individuals: a randomized, placebo controlled trialNutr J.(2009 Jul 22)
23.^Ballard KD, Kupchak BR, Volk BM, Mah E, Shkreta A, Liptak C, Ptolemy AS, Kellogg MS, Bruno RS, Seip RL, Maresh CM, Kraemer WJ, Volek JSAcute effects of ingestion of a novel whey-derived extract on vascular endothelial function in overweight, middle-aged men and womenBr J Nutr.(2012 Jun 13:1-12)
24.^Cabanos C, Ekyo A, Amari Y, Kato N, Kuroda M, Nagaoka S, Takaiwa F, Utsumi S, Maruyama NHigh-level production of lactostatin, a hypocholesterolemic peptide, in transgenic rice using soybean A1aB1b as carrierTransgenic Res.(2012 Nov 6)
25.^Sindayikengera S, Xia WSNutritional evaluation of caseins and whey proteins and their hydrolysates from ProtamexJ Zhejiang Univ Sci B.(2006 Feb)
26.^Nilsson M, Holst JJ, Björck IMMetabolic effects of amino acid mixtures and whey protein in healthy subjects: studies using glucose-equivalent drinksAm J Clin Nutr.(2007 Apr)
27.^Tienstra PA, van Riel JA, Mingorance MD, Olieman CAssessment of the capabilities of capillary zone electrophoresis for the determination of hippuric and orotic acid in wheyJ Chromatogr.(1992 Sep 11)
28.^Izumi H, Kosaka N, Shimizu T, Sekine K, Ochiya T, Takase MBovine milk contains microRNA and messenger RNA that are stable under degradative conditionsJ Dairy Sci.(2012 Sep)
29.^Oddy WH, Halonen M, Martinez FD, Lohman IC, Stern DA, Kurzius-Spencer M, Guerra S, Wright ALTGF-beta in human milk is associated with wheeze in infancyJ Allergy Clin Immunol.(2003 Oct)
30.^Hering NA, Andres S, Fromm A, van Tol EA, Amasheh M, Mankertz J, Fromm M, Schulzke JDTransforming growth factor-ß, a whey protein component, strengthens the intestinal barrier by upregulating claudin-4 in HT-29/B6 cellsJ Nutr.(2011 May)
31.^Bounous GWhey protein concentrate (WPC) and glutathione modulation in cancer treatmentAnticancer Res.(2000 Nov-Dec)
32.^Micke P, Beeh KM, Schlaak JF, Buhl ROral supplementation with whey proteins increases plasma glutathione levels of HIV-infected patientsEur J Clin Invest.(2001 Feb)
33.^Micke P, Beeh KM, Buhl REffects of long-term supplementation with whey proteins on plasma glutathione levels of HIV-infected patientsEur J Nutr.(2002 Feb)
34.^Sekhar RV, Patel SG, Guthikonda AP, Reid M, Balasubramanyam A, Taffet GE, Jahoor FDeficient synthesis of glutathione underlies oxidative stress in aging and can be corrected by dietary cysteine and glycine supplementationAm J Clin Nutr.(2011 Sep)
35.^Bounous G, Gervais F, Amer V, Batist G, Gold PThe influence of dietary whey protein on tissue glutathione and the diseases of agingClin Invest Med.(1989 Dec)
36.^Lands LC, Iskandar M, Beaudoin N, Meehan B, Dauletbaev N, Berthiuame YDietary supplementation with pressurized whey in patients with cystic fibrosisJ Med Food.(2010 Feb)
37.^Lands LC, Grey V, Smountas AA, Kramer VG, McKenna DLymphocyte glutathione levels in children with cystic fibrosisChest.(1999 Jul)
38.^Grey V, Mohammed SR, Smountas AA, Bahlool R, Lands LCImproved glutathione status in young adult patients with cystic fibrosis supplemented with whey proteinJ Cyst Fibros.(2003 Dec)
39.^Zavorsky GS, Kubow S, Grey V, Riverin V, Lands LCAn open-label dose-response study of lymphocyte glutathione levels in healthy men and women receiving pressurized whey protein isolate supplementsInt J Food Sci Nutr.(2007 Sep)
40.^Sheikholeslami Vatani D, Ahmadi Kani Golzar FChanges in antioxidant status and cardiovascular risk factors of overweight young men after six weeks supplementation of whey protein isolate and resistance trainingAppetite.(2012 Aug 10)
42.^Jain SKL-Cysteine supplementation as an adjuvant therapy for type-2 diabetesCan J Physiol Pharmacol.(2012 Aug)
43.^Jha S, Calvert JW, Duranski MR, Ramachandran A, Lefer DJHydrogen sulfide attenuates hepatic ischemia-reperfusion injury: role of antioxidant and antiapoptotic signalingAm J Physiol Heart Circ Physiol.(2008 Aug)
44.^Beard RS Jr, Bearden SEVascular complications of cystathionine ß-synthase deficiency: future directions for homocysteine-to-hydrogen sulfide researchAm J Physiol Heart Circ Physiol.(2011 Jan)
45.^Yang G, Wu L, Jiang B, Yang W, Qi J, Cao K, Meng Q, Mustafa AK, Mu W, Zhang S, Snyder SH, Wang RH2S as a physiologic vasorelaxant: hypertension in mice with deletion of cystathionine gamma-lyaseScience.(2008 Oct 24)
46.^Jain SK, Bull R, Rains JL, Bass PF, Levine SN, Reddy S, McVie R, Bocchini JALow levels of hydrogen sulfide in the blood of diabetes patients and streptozotocin-treated rats causes vascular inflammationAntioxid Redox Signal.(2010 Jun 1)
47.^Ishigami M, Hiraki K, Umemura K, Ogasawara Y, Ishii K, Kimura HA source of hydrogen sulfide and a mechanism of its release in the brainAntioxid Redox Signal.(2009 Feb)
48.^Shibuya N, Tanaka M, Yoshida M, Ogasawara Y, Togawa T, Ishii K, Kimura H3-Mercaptopyruvate sulfurtransferase produces hydrogen sulfide and bound sulfane sulfur in the brainAntioxid Redox Signal.(2009 Apr)
49.^Vascular Endothelium Expresses 3-Mercaptopyruvate Sulfurtransferase and Produces Hydrogen Sulfide.()
50.^Cai WJ, Wang MJ, Moore PK, Jin HM, Yao T, Zhu YCThe novel proangiogenic effect of hydrogen sulfide is dependent on Akt phosphorylationCardiovasc Res.(2007 Oct 1)
51.^Wang Y, Zhao X, Jin H, Wei H, Li W, Bu D, Tang X, Ren Y, Tang C, Du JRole of hydrogen sulfide in the development of atherosclerotic lesions in apolipoprotein E knockout miceArterioscler Thromb Vasc Biol.(2009 Feb)
52.^Whiteman M, Gooding KM, Whatmore JL, Ball CI, Mawson D, Skinner K, Tooke JE, Shore ACAdiposity is a major determinant of plasma levels of the novel vasodilator hydrogen sulphideDiabetologia.(2010 Aug)
53.^Carunchia Whetstine ME, Croissant AE, Drake MACharacterization of dried whey protein concentrate and isolate flavorJ Dairy Sci.(2005 Nov)
54.^Potier M, Tomé DComparison of digestibility and quality of intact proteins with their respective hydrolysatesJ AOAC Int.(2008 Jul-Aug)
55.^Alexander DD, Cabana MDPartially hydrolyzed 100% whey protein infant formula and reduced risk of atopic dermatitis: a meta-analysisJ Pediatr Gastroenterol Nutr.(2010 Apr)
56.^Alexander DD, Schmitt DF, Tran NL, Barraj LM, Cushing CAPartially hydrolyzed 100% whey protein infant formula and atopic dermatitis risk reduction: a systematic review of the literatureNutr Rev.(2010 Apr)
57.^von Berg A, Koletzko S, Filipiak-Pittroff B, Laubereau B, Grübl A, Wichmann HE, Bauer CP, Reinhardt D, Berdel D; German Infant Nutritional Intervention Study GroupCertain hydrolyzed formulas reduce the incidence of atopic dermatitis but not that of asthma: three-year results of the German Infant Nutritional Intervention StudyJ Allergy Clin Immunol.(2007 Mar)
58.^Pennings B, Boirie Y, Senden JM, Gijsen AP, Kuipers H, van Loon LJWhey protein stimulates postprandial muscle protein accretion more effectively than do casein and casein hydrolysate in older menAm J Clin Nutr.(2011 May)
59.^Buckley JD, Thomson RL, Coates AM, Howe PR, DeNichilo MO, Rowney MKSupplementation with a whey protein hydrolysate enhances recovery of muscle force-generating capacity following eccentric exerciseJ Sci Med Sport.(2010 Jan)
60.^Characterization of ultrafiltration membranes. Part II — Mass transport measurements for low and high molecular weight synthetic polymers in water solutions.()
61.^Marella C, Muthukumarappan K, Metzger LEEvaluation of commercially available, wide-pore ultrafiltration membranes for production of a-lactalbumin-enriched whey protein concentrateJ Dairy Sci.(2011 Mar)
62.^Cheang B, Zydney ALSeparation of alpha-lactalbumin and beta-lactoglobulin using membrane ultrafiltrationBiotechnol Bioeng.(2003 Jul 20)
63.^McDonough FE, Hargrove RE, Mattingly WA, Posati LP, Alford JAComposition and properties of whey protein concentrates from ultrafiltrationJ Dairy Sci.(1974 Dec)
65.^Hall WL, Millward DJ, Long SJ, Morgan LMCasein and whey exert different effects on plasma amino acid profiles, gastrointestinal hormone secretion and appetiteBr J Nutr.(2003 Feb)
66.^Mishima Y, Amano Y, Takahashi Y, Mishima Y, Moriyama N, Miyake T, Ishimura N, Ishihara S, Kinoshita YGastric emptying of liquid and solid meals at various temperatures: effect of meal temperature for gastric emptyingJ Gastroenterol.(2009)
67.^Lorient D, Linden GDephosphorylation of bovine casein by milk alkaline phosphataseJ Dairy Res.(1976 Feb)
68.^Li-Chan E, Nakai SEnzymic dephosphorylation of bovine casein to improve acid clotting properties and digestibility for infant formulaJ Dairy Res.(1989)
69.^Mahé S, Roos N, Benamouzig R, Davin L, Luengo C, Gagnon L, Gaussergès N, Rautureau J, Tomé DGastrojejunal kinetics and the digestion of {15N}beta-lactoglobulin and casein in humans: the influence of the nature and quantity of the proteinAm J Clin Nutr.(1996 Apr)
70.^Power O, Hallihan A, Jakeman PHuman insulinotropic response to oral ingestion of native and hydrolysed whey proteinAmino Acids.(2009 Jul)
71.^Calbet JA, Holst JJGastric emptying, gastric secretion and enterogastrone response after administration of milk proteins or their peptide hydrolysates in humansEur J Nutr.(2004 Jun)
72.^Boirie Y, Dangin M, Gachon P, Vasson MP, Maubois JL, Beaufrère BSlow and fast dietary proteins differently modulate postprandial protein accretionProc Natl Acad Sci U S A.(1997 Dec 23)
73.^Tipton KD, Elliott TA, Cree MG, Wolf SE, Sanford AP, Wolfe RRIngestion of casein and whey proteins result in muscle anabolism after resistance exerciseMed Sci Sports Exerc.(2004 Dec)
74.^Reitelseder S, Agergaard J, Doessing S, Helmark IC, Lund P, Kristensen NB, Frystyk J, Flyvbjerg A, Schjerling P, van Hall G, Kjaer M, Holm LWhey and casein labeled with L-{1-13C}leucine and muscle protein synthesis: effect of resistance exercise and protein ingestionAm J Physiol Endocrinol Metab.(2011 Jan)
75.^Pal S, Ellis VThe acute effects of four protein meals on insulin, glucose, appetite and energy intake in lean menBr J Nutr.(2010 Oct)
76.^The digestion rate of protein is an independent regulating factor of postprandial protein retention.()
77.^Murakami M, Tonouchi H, Takahashi R, Kitazawa H, Kawai Y, Negishi H, Saito TStructural analysis of a new anti-hypertensive peptide (beta-lactosin B) isolated from a commercial whey productJ Dairy Sci.(2004 Jul)
78.^Tavares T, Contreras Mdel M, Amorim M, Pintado M, Recio I, Malcata FXNovel whey-derived peptides with inhibitory effect against angiotensin-converting enzyme: in vitro effect and stability to gastrointestinal enzymesPeptides.(2011 May)
79.^Tavares T, Sevilla MÁ, Montero MJ, Carrón R, Malcata FXAcute effect of whey peptides upon blood pressure of hypertensive rats, and relationship with their angiotensin-converting enzyme inhibitory activityMol Nutr Food Res.(2012 Feb)
80.^Weimann C, Meisel H, Erhardt GShort communication: bovine kappa-casein variants result in different angiotensin I converting enzyme (ACE) inhibitory peptidesJ Dairy Sci.(2009 May)
81.^Welderufael FT, Gibson T, Jauregi PProduction of angiotensin-I-converting enzyme inhibitory peptides from ß-lactoglobulin- and casein-derived peptides: an integrative approachBiotechnol Prog.(2012 May)
82.^Nakamura Y, Yamamoto N, Sakai K, Takano TAntihypertensive effect of sour milk and peptides isolated from it that are inhibitors to angiotensin I-converting enzymeJ Dairy Sci.(1995 Jun)
83.^Sipola M, Finckenberg P, Santisteban J, Korpela R, Vapaatalo H, Nurminen MLLong-term intake of milk peptides attenuates development of hypertension in spontaneously hypertensive ratsJ Physiol Pharmacol.(2001 Dec)
84.^Murakami I, Hosono H, Suzuki S, Kurihara J, Itagaki F, Watanabe MEnhancement or Suppression of ACE Inhibitory Activity by a Mixture of Tea and Foods for Specified Health Uses (FOSHU) That Are Marketed as "Support for Normal Blood Pressure"ISRN Pharm.(2011)
85.^Hodgson JM, Zhu K, Lewis JR, Kerr D, Meng X, Solah V, Devine A, Binns CW, Woodman RJ, Prince RLLong-term effects of a protein-enriched diet on blood pressure in older womenBr J Nutr.(2012 Jun)
86.^Lee YM, Skurk T, Hennig M, Hauner HEffect of a milk drink supplemented with whey peptides on blood pressure in patients with mild hypertensionEur J Nutr.(2007 Feb)
87.^Seppo L, Jauhiainen T, Poussa T, Korpela RA fermented milk high in bioactive peptides has a blood pressure-lowering effect in hypertensive subjectsAm J Clin Nutr.(2003 Feb)
88.^Pal S, Ellis VThe chronic effects of whey proteins on blood pressure, vascular function, and inflammatory markers in overweight individualsObesity (Silver Spring).(2010 Jul)
89.^Pal S, Ellis VAcute effects of whey protein isolate on blood pressure, vascular function and inflammatory markers in overweight postmenopausal womenBr J Nutr.(2011 May)
90.^Gentilcore D, Hausken T, Meyer JH, Chapman IM, Horowitz M, Jones KLEffects of intraduodenal glucose, fat, and protein on blood pressure, heart rate, and splanchnic blood flow in healthy older subjectsAm J Clin Nutr.(2008 Jan)
91.^Pal S, Ellis V, Ho SAcute effects of whey protein isolate on cardiovascular risk factors in overweight, post-menopausal womenAtherosclerosis.(2010 Sep)
92.^Holmer-Jensen J, Karhu T, Mortensen LS, Pedersen SB, Herzig KH, Hermansen KDifferential effects of dietary protein sources on postprandial low-grade inflammation after a single high fat meal in obese non-diabetic subjectsNutr J.(2011 Oct 19)
93.^Koenen RR, von Hundelshausen P, Nesmelova IV, Zernecke A, Liehn EA, Sarabi A, Kramp BK, Piccinini AM, Paludan SR, Kowalska MA, Kungl AJ, Hackeng TM, Mayo KH, Weber CDisrupting functional interactions between platelet chemokines inhibits atherosclerosis in hyperlipidemic miceNat Med.(2009 Jan)
94.^Mortensen LS, Hartvigsen ML, Brader LJ, Astrup A, Schrezenmeir J, Holst JJ, Thomsen C, Hermansen KDifferential effects of protein quality on postprandial lipemia in response to a fat-rich meal in type 2 diabetes: comparison of whey, casein, gluten, and cod proteinAm J Clin Nutr.(2009 Jul)
95.^Morifuji M, Kanda A, Koga J, Kawanaka K, Higuchi MPost-exercise carbohydrate plus whey protein hydrolysates supplementation increases skeletal muscle glycogen level in ratsAmino Acids.(2010 Apr)
96.^Kanda A, Morifuji M, Fukasawa T, Koga J, Kanegae M, Kawanaka K, Higuchi MDietary Whey Protein Hydrolysates Increase Skeletal Muscle Glycogen Levels via Activation of Glycogen Synthase in MiceJ Agric Food Chem.(2012 Oct 31)
97.^Morifuji M, Koga J, Kawanaka K, Higuchi MBranched-chain amino acid-containing dipeptides, identified from whey protein hydrolysates, stimulate glucose uptake rate in L6 myotubes and isolated skeletal musclesJ Nutr Sci Vitaminol (Tokyo).(2009 Feb)
98.^Fei YJ, Sugawara M, Liu JC, Li HW, Ganapathy V, Ganapathy ME, Leibach FHcDNA structure, genomic organization, and promoter analysis of the mouse intestinal peptide transporter PEPT1Biochim Biophys Acta.(2000 Jun 21)
99.^Chitapanarux T, Tienboon P, Pojchamarnwiputh S, Leelarungrayub DOpen-labeled pilot study of cysteine-rich whey protein isolate supplementation for nonalcoholic steatohepatitis patientsJ Gastroenterol Hepatol.(2009 Jun)
100.^Rains JL, Jain SKOxidative stress, insulin signaling, and diabetesFree Radic Biol Med.(2011 Mar 1)
101.^Dröge WOxidative stress and ageing: is ageing a cysteine deficiency syndromePhilos Trans R Soc Lond B Biol Sci.(2005 Dec 29)
102.^Haber CA, Lam TK, Yu Z, Gupta N, Goh T, Bogdanovic E, Giacca A, Fantus IGN-acetylcysteine and taurine prevent hyperglycemia-induced insulin resistance in vivo: possible role of oxidative stressAm J Physiol Endocrinol Metab.(2003 Oct)
103.^Blouet C, Mariotti F, Mikogami T, Tome D, Huneau JFMeal cysteine improves postprandial glucose control in rats fed a high-sucrose mealJ Nutr Biochem.(2007 Aug)
104.^Blouet C, Mariotti F, Azzout-Marniche D, Mathé V, Mikogami T, Tomé D, Huneau JFDietary cysteine alleviates sucrose-induced oxidative stress and insulin resistanceFree Radic Biol Med.(2007 Apr 1)
105.^Song D, Hutchings S, Pang CCChronic N-acetylcysteine prevents fructose-induced insulin resistance and hypertension in ratsEur J Pharmacol.(2005 Jan 31)
106.^Diniz YS, Rocha KK, Souza GA, Galhardi CM, Ebaid GM, Rodrigues HG, Novelli Filho JL, Cicogna AC, Novelli ELEffects of N-acetylcysteine on sucrose-rich diet-induced hyperglycaemia, dyslipidemia and oxidative stress in ratsEur J Pharmacol.(2006 Aug 14)
107.^Jain SK, Velusamy T, Croad JL, Rains JL, Bull RL-cysteine supplementation lowers blood glucose, glycated hemoglobin, CRP, MCP-1, and oxidative stress and inhibits NF-kappaB activation in the livers of Zucker diabetic ratsFree Radic Biol Med.(2009 Jun 15)
108.^Supplementation of N-acetylcysteine inhibits NF?B activation and protects against alloxan-induced diabetes in CD-1 mice.()
109.^Pieper GM, Siebeneich WOral administration of the antioxidant, N-acetylcysteine, abrogates diabetes-induced endothelial dysfunctionJ Cardiovasc Pharmacol.(1998 Jul)
110.^Prevention of glucose toxicity in HIT-T15 cells and Zucker diabetic fatty rats by antioxidants.()
111.^Kaneto H, Kajimoto Y, Miyagawa J, Matsuoka T, Fujitani Y, Umayahara Y, Hanafusa T, Matsuzawa Y, Yamasaki Y, Hori MBeneficial effects of antioxidants in diabetes: possible protection of pancreatic beta-cells against glucose toxicityDiabetes.(1999 Dec)
112.^Frid AH, Nilsson M, Holst JJ, Björck IMEffect of whey on blood glucose and insulin responses to composite breakfast and lunch meals in type 2 diabetic subjectsAm J Clin Nutr.(2005 Jul)
113.^Abrahão VNourishing the dysfunctional gut and whey proteinCurr Opin Clin Nutr Metab Care.(2012 Sep)
114.^Liu X, Murali SG, Holst JJ, Ney DMWhey protein potentiates the intestinotrophic action of glucagon-like peptide-2 in parenterally fed ratsAm J Physiol Regul Integr Comp Physiol.(2009 Nov)
115.^Ten Have GA, Engelen MP, Soeters PB, Deutz NEAbsence of post-prandial gut anabolism after intake of a low quality protein mealClin Nutr.(2012 Apr)
116.^Benjamin J, Makharia G, Ahuja V, Anand Rajan KD, Kalaivani M, Gupta SD, Joshi YKGlutamine and whey protein improve intestinal permeability and morphology in patients with Crohn's disease: a randomized controlled trialDig Dis Sci.(2012 Apr)
117.^Bortolotti M, Maiolo E, Corazza M, Van Dijke E, Schneiter P, Boss A, Carrel G, Giusti V, Lê KA, Quo Chong DG, Buehler T, Kreis R, Boesch C, Tappy LEffects of a whey protein supplementation on intrahepatocellular lipids in obese female patientsClin Nutr.(2011 Aug)
118.^Elattar G, Saleh Z, El-Shebini S, Farrag A, Zoheiry M, Hassanein A, El-Ghannam M, Shendy S, El-Dabaa E, Zahran NThe use of whey protein concentrate in management of chronic hepatitis C virus - a pilot studyArch Med Sci.(2010 Oct)
119.^Hamad EM, Taha SH, Abou Dawood AG, Sitohy MZ, Abdel-Hamid MProtective effect of whey proteins against nonalcoholic fatty liver in ratsLipids Health Dis.(2011 Apr 13)
120.^Haraguchi FK, Silva ME, Neves LX, dos Santos RC, Pedrosa MLWhey protein precludes lipid and protein oxidation and improves body weight gain in resistance-exercised ratsEur J Nutr.(2011 Aug)
121.^Poortmans JR, Dellalieux ODo regular high protein diets have potential health risks on kidney function in athletesInt J Sport Nutr Exerc Metab.(2000 Mar)
122.^Friedman AN, Ogden LG, Foster GD, Klein S, Stein R, Miller B, Hill JO, Brill C, Bailer B, Rosenbaum DR, Wyatt HRComparative effects of low-carbohydrate high-protein versus low-fat diets on the kidneyClin J Am Soc Nephrol.(2012 Jul)
123.^Brinkworth GD, Buckley JD, Noakes M, Clifton PMRenal function following long-term weight loss in individuals with abdominal obesity on a very-low-carbohydrate diet vs high-carbohydrate dietJ Am Diet Assoc.(2010 Apr)
124.^Cornish SM, Candow DG, Jantz NT, Chilibeck PD, Little JP, Forbes S, Abeysekara S, Zello GAConjugated linoleic acid combined with creatine monohydrate and whey protein supplementation during strength trainingInt J Sport Nutr Exerc Metab.(2009 Feb)
125.^Kasiske BL, Cleary MP, O'Donnell MP, Keane WFEffects of carbohydrate restriction on renal injury in the obese Zucker ratAm J Clin Nutr.(1986 Jul)
126.^Effect on renal haemodynamics, glomerular filtration rate and albumin excretion of high oral protein load.()
127.^Kontessis P, Jones S, Dodds R, Trevisan R, Nosadini R, Fioretto P, Borsato M, Sacerdoti D, Viberti GRenal, metabolic and hormonal responses to ingestion of animal and vegetable proteinsKidney Int.(1990 Jul)
128.^Kontessis PA, Bossinakou I, Sarika L, Iliopoulou E, Papantoniou A, Trevisan R, Roussi D, Stipsanelli K, Grigorakis S, Souvatzoglou ARenal, metabolic, and hormonal responses to proteins of different origin in normotensive, nonproteinuric type I diabetic patientsDiabetes Care.(1995 Sep)
129.^Wiseman MJ, Hunt R, Goodwin A, Gross JL, Keen H, Viberti GCDietary composition and renal function in healthy subjectsNephron.(1987)
130.^PULLMAN TN, ALVING AS, DERN RJ, LANDOWNE MThe influence of dietary protein intake on specific renal functions in normal manJ Lab Clin Med.(1954 Aug)
131.^Brändle E, Sieberth HG, Hautmann REEffect of chronic dietary protein intake on the renal function in healthy subjectsEur J Clin Nutr.(1996 Nov)
133.^Skov AR, Toubro S, Bülow J, Krabbe K, Parving HH, Astrup AChanges in renal function during weight loss induced by high vs low-protein low-fat diets in overweight subjectsInt J Obes Relat Metab Disord.(1999 Nov)
134.^Friedman ANHigh-protein diets: potential effects on the kidney in renal health and diseaseAm J Kidney Dis.(2004 Dec)
135.^Brenner BM, Meyer TW, Hostetter THDietary protein intake and the progressive nature of kidney disease: the role of hemodynamically mediated glomerular injury in the pathogenesis of progressive glomerular sclerosis in aging, renal ablation, and intrinsic renal diseaseN Engl J Med.(1982 Sep 9)
137.^Markus CR, Olivier B, Panhuysen GE, Van Der Gugten J, Alles MS, Tuiten A, Westenberg HG, Fekkes D, Koppeschaar HF, de Haan EEThe bovine protein alpha-lactalbumin increases the plasma ratio of tryptophan to the other large neutral amino acids, and in vulnerable subjects raises brain serotonin activity, reduces cortisol concentration, and improves mood under stressAm J Clin Nutr.(2000 Jun)
138.^Citraro R, Scicchitano F, De Fazio S, Raggio R, Mainardi P, Perucca E, De Sarro G, Russo EPreclinical activity profile of a-lactoalbumin, a whey protein rich in tryptophan, in rodent models of seizures and epilepsyEpilepsy Res.(2011 Jun)
139.^Mainardi P, Leonardi A, Albano CPotentiation of brain serotonin activity may inhibit seizures, especially in drug-resistant epilepsyMed Hypotheses.(2008)
140.^Errichiello L, Pezzella M, Santulli L, Striano S, Zara F, Minetti C, Mainardi P, Striano PA proof-of-concept trial of the whey protein alfa-lactalbumin in chronic cortical myoclonusMov Disord.(2011 Dec)
141.^Rusu D, Drouin R, Pouliot Y, Gauthier S, Poubelle PEA bovine whey protein extract can enhance innate immunity by priming normal human blood neutrophilsJ Nutr.(2009 Feb)
142.^Migliore-Samour D, Roch-Arveiller M, Tissot M, Jazziri M, Keddad K, Giroud JP, Jollès PEffects of tripeptides derived from milk proteins on polymorphonuclear oxidative and phosphoinositide metabolismsBiochem Pharmacol.(1992 Aug 18)
143.^Li EW, Mine YImmunoenhancing effects of bovine glycomacropeptide and its derivatives on the proliferative response and phagocytic activities of human macrophagelike cells, U937J Agric Food Chem.(2004 May 5)
144.^Wong KF, Middleton N, Montgomery M, Dey M, Carr RIImmunostimulation of murine spleen cells by materials associated with bovine milk protein fractionsJ Dairy Sci.(1998 Jul)
145.^Ebert EC, Roberts AILamina propria lymphocytes produce interferon-gamma and develop suppressor activity in response to lactoglobulinDig Dis Sci.(2001 Mar)
146.^Wong CW, Seow HF, Husband AJ, Regester GO, Watson DLEffects of purified bovine whey factors on cellular immune functions in ruminantsVet Immunol Immunopathol.(1997 May)
148.^Zemel MB, Sun X, Sobhani T, Wilson BEffects of dairy compared with soy on oxidative and inflammatory stress in overweight and obese subjectsAm J Clin Nutr.(2010 Jan)
149.^Panagiotakos DB, Pitsavos CH, Zampelas AD, Chrysohoou CA, Stefanadis CIDairy products consumption is associated with decreased levels of inflammatory markers related to cardiovascular disease in apparently healthy adults: the ATTICA studyJ Am Coll Nutr.(2010 Aug)
150.^Kennedy RS, Konok GP, Bounous G, Baruchel S, Lee TDThe use of a whey protein concentrate in the treatment of patients with metastatic carcinoma: a phase I-II clinical studyAnticancer Res.(1995 Nov-Dec)
151.^Kanwar JR, Palmano KP, Sun X, Kanwar RK, Gupta R, Haggarty N, Rowan A, Ram S, Krissansen GW'Iron-saturated' lactoferrin is a potent natural adjuvant for augmenting cancer chemotherapyImmunol Cell Biol.(2008 Mar-Apr)
152.^Burrow H, Kanwar RK, Kanwar JRAntioxidant enzyme activities of iron-saturated bovine lactoferrin (Fe-bLf) in human gut epithelial cells under oxidative stressMed Chem.(2011 May)
153.^Roseanu A, Florian PE, Moisei M, Sima LE, Evans RW, Trif MLiposomalization of lactoferrin enhanced its anti-tumoral effects on melanoma cellsBiometals.(2010 Jun)
154.^Castro GA, Maria DA, Bouhallab S, Sgarbieri VCIn vitro impact of a whey protein isolate (WPI) and collagen hydrolysates (CHs) on B16F10 melanoma cells proliferationJ Dermatol Sci.(2009 Oct)
155.^Xu XX, Jiang HR, Li HB, Zhang TN, Zhou Q, Liu NApoptosis of stomach cancer cell SGC-7901 and regulation of Akt signaling way induced by bovine lactoferrinJ Dairy Sci.(2010 Jun)
156.^Li D, Sakashita S, Morishita Y, Kano J, Shiba A, Sato T, Noguchi MBinding of lactoferrin to IGBP1 triggers apoptosis in a lung adenocarcinoma cell lineAnticancer Res.(2011 Feb)
157.^Furlong SJ, Mader JS, Hoskin DWBovine lactoferricin induces caspase-independent apoptosis in human B-lymphoma cells and extends the survival of immune-deficient mice bearing B-lymphoma xenograftsExp Mol Pathol.(2010 Jun)
158.^Kozu T, Iinuma G, Ohashi Y, Saito Y, Akasu T, Saito D, Alexander DB, Iigo M, Kakizoe T, Tsuda HEffect of orally administered bovine lactoferrin on the growth of adenomatous colorectal polyps in a randomized, placebo-controlled clinical trialCancer Prev Res (Phila).(2009 Nov)
159.^Tsuda H, Kozu T, Iinuma G, Ohashi Y, Saito Y, Saito D, Akasu T, Alexander DB, Futakuchi M, Fukamachi K, Xu J, Kakizoe T, Iigo MCancer prevention by bovine lactoferrin: from animal studies to human trialBiometals.(2010 Jun)
160.^Gibbons JA, Kanwar RK, Kanwar JRLactoferrin and cancer in different cancer modelsFront Biosci (Schol Ed).(2011 Jun 1)
161.^Dillon EL, Basra G, Horstman AM, Casperson SL, Randolph KM, Durham WJ, Urban RJ, Diaz-Arrastia C, Levine L, Hatch SS, Willis M, Richardson G, Sheffield-Moore MCancer cachexia and anabolic interventions: a case reportJ Cachexia Sarcopenia Muscle.(2012 May 15)
162.^Deutz NE, Safar A, Schutzler S, Memelink R, Ferrando A, Spencer H, van Helvoort A, Wolfe RRMuscle protein synthesis in cancer patients can be stimulated with a specially formulated medical foodClin Nutr.(2011 Dec)
163.^Hulmi JJ, Kovanen V, Lisko I, Selänne H, Mero AAThe effects of whey protein on myostatin and cell cycle-related gene expression responses to a single heavy resistance exercise bout in trained older menEur J Appl Physiol.(2008 Jan)
164.^Hulmi JJ, Tannerstedt J, Selänne H, Kainulainen H, Kovanen V, Mero AAResistance exercise with whey protein ingestion affects mTOR signaling pathway and myostatin in menJ Appl Physiol.(2009 May)
165.^Hulmi JJ, Kovanen V, Selänne H, Kraemer WJ, Häkkinen K, Mero AAAcute and long-term effects of resistance exercise with or without protein ingestion on muscle hypertrophy and gene expressionAmino Acids.(2009 Jul)
166.^Bunn JA, Buford TW, Serra MC, Kreider RB, Willoughby DSProtein and Amino Acid Supplementation Does Not Alter Proteolytic Gene Expression following ImmobilizationJ Nutr Metab.(2011)
167.^Moore DR, Atherton PJ, Rennie MJ, Tarnopolsky MA, Phillips SMResistance exercise enhances mTOR and MAPK signalling in human muscle over that seen at rest after bolus protein ingestionActa Physiol (Oxf).(2011 Mar)
168.^Biolo G, Tipton KD, Klein S, Wolfe RRAn abundant supply of amino acids enhances the metabolic effect of exercise on muscle proteinAm J Physiol.(1997 Jul)
170.^Burd NA, West DW, Moore DR, Atherton PJ, Staples AW, Prior T, Tang JE, Rennie MJ, Baker SK, Phillips SMEnhanced amino acid sensitivity of myofibrillar protein synthesis persists for up to 24 h after resistance exercise in young menJ Nutr.(2011 Apr 1)
171.^Yang Y, Breen L, Burd NA, Hector AJ, Churchward-Venne TA, Josse AR, Tarnopolsky MA, Phillips SMResistance exercise enhances myofibrillar protein synthesis with graded intakes of whey protein in older menBr J Nutr.(2012 Feb 7:1-9)
172.^Moore DR, Robinson MJ, Fry JL, Tang JE, Glover EI, Wilkinson SB, Prior T, Tarnopolsky MA, Phillips SMIngested protein dose response of muscle and albumin protein synthesis after resistance exercise in young menAm J Clin Nutr.(2009 Jan)
173.^Levenhagen DK, Carr C, Carlson MG, Maron DJ, Borel MJ, Flakoll PJPostexercise protein intake enhances whole-body and leg protein accretion in humansMed Sci Sports Exerc.(2002 May)
174.^Hoffman JR, Ratamess NA, Tranchina CP, Rashti SL, Kang J, Faigenbaum ADEffect of protein-supplement timing on strength, power, and body-composition changes in resistance-trained menInt J Sport Nutr Exerc Metab.(2009 Apr)
175.^Kerksick CM, Rasmussen CJ, Lancaster SL, Magu B, Smith P, Melton C, Greenwood M, Almada AL, Earnest CP, Kreider RBThe effects of protein and amino acid supplementation on performance and training adaptations during ten weeks of resistance trainingJ Strength Cond Res.(2006 Aug)
176.^Andersen LL, Tufekovic G, Zebis MK, Crameri RM, Verlaan G, Kjaer M, Suetta C, Magnusson P, Aagaard PThe effect of resistance training combined with timed ingestion of protein on muscle fiber size and muscle strengthMetabolism.(2005 Feb)
177.^Hartman JW, Tang JE, Wilkinson SB, Tarnopolsky MA, Lawrence RL, Fullerton AV, Phillips SMConsumption of fat-free fluid milk after resistance exercise promotes greater lean mass accretion than does consumption of soy or carbohydrate in young, novice, male weightliftersAm J Clin Nutr.(2007 Aug)
178.^Weisgarber KD, Candow DG, Vogt E SMWhey Protein Before and During Resistance Exercise Has No Effect on Muscle Mass and Strength in Untrained Young AdultsInt J Sport Nutr Exerc Metab.(2012 Jul 4)
179.^Kukuljan S, Nowson CA, Sanders K, Daly RMEffects of resistance exercise and fortified milk on skeletal muscle mass, muscle size, and functional performance in middle-aged and older men: an 18-mo randomized controlled trialJ Appl Physiol.(2009 Dec)
180.^Candow DG, Chilibeck PD, Facci M, Abeysekara S, Zello GAProtein supplementation before and after resistance training in older menEur J Appl Physiol.(2006 Jul)
181.^Weinheimer EM, Conley TB, Kobza VM, Sands LP, Lim E, Janle EM, Campbell WWWhey protein supplementation does not affect exercise training-induced changes in body composition and indices of metabolic syndrome in middle-aged overweight and obese adultsJ Nutr.(2012 Aug)
182.^Dangin M, Guillet C, Garcia-Rodenas C, Gachon P, Bouteloup-Demange C, Reiffers-Magnani K, Fauquant J, Ballèvre O, Beaufrère BThe rate of protein digestion affects protein gain differently during aging in humansJ Physiol.(2003 Jun 1)
183.^Dideriksen KJ, Reitelseder S, Petersen SG, Hjort M, Helmark IC, Kjaer M, Holm LStimulation of muscle protein synthesis by whey and caseinate ingestion after resistance exercise in elderly individualsScand J Med Sci Sports.(2011 Dec)
184.^Wycherley TP, Noakes M, Clifton PM, Cleanthous X, Keogh JB, Brinkworth GDTiming of protein ingestion relative to resistance exercise training does not influence body composition, energy expenditure, glycaemic control or cardiometabolic risk factors in a hypocaloric, high protein diet in patients with type 2 diabetesDiabetes Obes Metab.(2010 Dec)
185.^Esmarck B, Andersen JL, Olsen S, Richter EA, Mizuno M, Kjaer MTiming of postexercise protein intake is important for muscle hypertrophy with resistance training in elderly humansJ Physiol.(2001 Aug 15)
186.^Jordan LY, Melanson EL, Melby CL, Hickey MS, Miller BFNitrogen balance in older individuals in energy balance depends on timing of protein intakeJ Gerontol A Biol Sci Med Sci.(2010 Oct)
187.^Tipton KD, Rasmussen BB, Miller SL, Wolf SE, Owens-Stovall SK, Petrini BE, Wolfe RRTiming of amino acid-carbohydrate ingestion alters anabolic response of muscle to resistance exerciseAm J Physiol Endocrinol Metab.(2001 Aug)
188.^An oral essential amino acid-carbohydrate supplement enhances muscle protein anabolism after resistance exercise.()
189.^Levenhagen DK, Gresham JD, Carlson MG, Maron DJ, Borel MJ, Flakoll PJPostexercise nutrient intake timing in humans is critical to recovery of leg glucose and protein homeostasisAm J Physiol Endocrinol Metab.(2001 Jun)
190.^Hoffman JR, Ratamess NA, Tranchina CP, Rashti SL, Kang J, Faigenbaum ADEffect of a proprietary protein supplement on recovery indices following resistance exercise in strength/power athletesAmino Acids.(2010 Mar)
191.^Etheridge T, Philp A, Watt PWA single protein meal increases recovery of muscle function following an acute eccentric exercise boutAppl Physiol Nutr Metab.(2008 Jun)
192.^Ratamess NA, Kraemer WJ, Volek JS, Rubin MR, Gómez AL, French DN, Sharman MJ, McGuigan MM, Scheett T, Häkkinen K, Newton RU, Dioguardi FThe effects of amino acid supplementation on muscular performance during resistance training overreachingJ Strength Cond Res.(2003 May)
193.^Nosaka K, Sacco P, Mawatari KEffects of amino acid supplementation on muscle soreness and damageInt J Sport Nutr Exerc Metab.(2006 Dec)
194.^Shimomura Y, Yamamoto Y, Bajotto G, Sato J, Murakami T, Shimomura N, Kobayashi H, Mawatari KNutraceutical effects of branched-chain amino acids on skeletal muscleJ Nutr.(2006 Feb)
195.^Bouthegourd JC, Roseau SM, Makarios-Lahham L, Leruyet PM, Tomé DG, Even PCA preexercise alpha-lactalbumin-enriched whey protein meal preserves lipid oxidation and decreases adiposity in ratsAm J Physiol Endocrinol Metab.(2002 Sep)
196.^Lorenzen J, Frederiksen R, Hoppe C, Hvid R, Astrup AThe effect of milk proteins on appetite regulation and diet-induced thermogenesisEur J Clin Nutr.(2012 May)
197.^Hackney KJ, Bruenger AJ, Lemmer JTTiming protein intake increases energy expenditure 24 h after resistance trainingMed Sci Sports Exerc.(2010 May)
198.^Baer DJ, Stote KS, Paul DR, Harris GK, Rumpler WV, Clevidence BAWhey protein but not soy protein supplementation alters body weight and composition in free-living overweight and obese adultsJ Nutr.(2011 Aug)
199.^Khalil DA, Lucas EA, Juma S, Smith BJ, Payton ME, Arjmandi BHSoy protein supplementation increases serum insulin-like growth factor-I in young and old men but does not affect markers of bone metabolismJ Nutr.(2002 Sep)
200.^Zhou J, Keenan MJ, Losso JN, Raggio AM, Shen L, McCutcheon KL, Tulley RT, Blackman MR, Martin RJDietary whey protein decreases food intake and body fat in ratsObesity (Silver Spring).(2011 Aug)
201.^Lam SM, Moughan PJ, Awati A, Morton HRThe influence of whey protein and glycomacropeptide on satiety in adult humansPhysiol Behav.(2009 Jan 8)
202.^Luhovyy BL, Akhavan T, Anderson GHWhey proteins in the regulation of food intake and satietyJ Am Coll Nutr.(2007 Dec)
203.^Abou Samra R, Keersmaekers L, Brienza D, Mukherjee R, Mace KEffect of different protein sources on satiation and short-term satiety when consumed as a starterNutr J.(2011 Dec 23)
204.^Effect of premeal consumption of whey protein and its hydrolysate on food intake and postmeal glycemia and insulin responses in young adults.()
205.^Poppitt SD, Proctor J, McGill AT, Wiessing KR, Falk S, Xin L, Budgett SC, Darragh A, Hall RSLow-dose whey protein-enriched water beverages alter satiety in a study of overweight womenAppetite.(2011 Apr)
206.^Astbury NM, Stevenson EJ, Morris P, Taylor MA, Macdonald IADose-response effect of a whey protein preload on within-day energy intake in lean subjectsBr J Nutr.(2010 Dec)
207.^Frestedt JL, Zenk JL, Kuskowski MA, Ward LS, Bastian EDA whey-protein supplement increases fat loss and spares lean muscle in obese subjects: a randomized human clinical studyNutr Metab (Lond).(2008 Mar 27)
208.^Zhu K, Meng X, Kerr DA, Devine A, Solah V, Binns CW, Prince RLThe effects of a two-year randomized, controlled trial of whey protein supplementation on bone structure, IGF-1, and urinary calcium excretion in older postmenopausal womenJ Bone Miner Res.(2011 Sep)
209.^Rennie MJ, Wackerhage H, Spangenburg EE, Booth FWControl of the size of the human muscle massAnnu Rev Physiol.(2004)
210.^Cuthbertson D, Smith K, Babraj J, Leese G, Waddell T, Atherton P, Wackerhage H, Taylor PM, Rennie MJAnabolic signaling deficits underlie amino acid resistance of wasting, aging muscleFASEB J.(2005 Mar)
212.^Leucine supplementation improves muscle protein synthesis in elderly men independently of hyperaminoacidaemia.()
213.^Tang JE, Moore DR, Kujbida GW, Tarnopolsky MA, Phillips SMIngestion of whey hydrolysate, casein, or soy protein isolate: effects on mixed muscle protein synthesis at rest and following resistance exercise in young menJ Appl Physiol.(2009 Sep)
214.^Whey protein stimulates postprandial muscle protein accretion more effectively than do casein and casein hydrolysate in older men.()
215.^Dangin M, Boirie Y, Garcia-Rodenas C, Gachon P, Fauquant J, Callier P, Ballèvre O, Beaufrère BThe digestion rate of protein is an independent regulating factor of postprandial protein retentionAm J Physiol Endocrinol Metab.(2001 Feb)
216.^Engelen MP, Rutten EP, De Castro CL, Wouters EF, Schols AM, Deutz NECasein protein results in higher prandial and exercise induced whole body protein anabolism than whey protein in Chronic Obstructive Pulmonary DiseaseMetabolism.(2012 Sep)
217.^Pal S, Ellis V, Dhaliwal SEffects of whey protein isolate on body composition, lipids, insulin and glucose in overweight and obese individualsBr J Nutr.(2010 Sep)
218.^Haraguchi FK, Pedrosa ML, Paula H, Santos RC, Silva MEEvaluation of biological and biochemical quality of whey proteinJ Med Food.(2010 Dec)
219.^de Aguilar-Nascimento JE, Prado Silveira BR, Dock-Nascimento DBEarly enteral nutrition with whey protein or casein in elderly patients with acute ischemic stroke: a double-blind randomized trialNutrition.(2011 Apr)
220.^Baer DJ, Stote KS, Paul DR, Harris GK, Rumpler WV, Clevidence BAWhey protein but not soy protein supplementation alters body weight and composition in free-living overweight and obese adultsJ Nutr.(2011 Aug)
221.^Candow DG, Burke NC, Smith-Palmer T, Burke DGEffect of whey and soy protein supplementation combined with resistance training in young adultsInt J Sport Nutr Exerc Metab.(2006 Jun)
222.^Hays NP, Kim H, Wells AM, Kajkenova O, Evans WJEffects of whey and fortified collagen hydrolysate protein supplements on nitrogen balance and body composition in older womenJ Am Diet Assoc.(2009 Jun)
223.^Howarth KR, Moreau NA, Phillips SM, Gibala MJCoingestion of protein with carbohydrate during recovery from endurance exercise stimulates skeletal muscle protein synthesis in humansJ Appl Physiol.(2009 Apr)
224.^Breen L, Philp A, Witard OC, Jackman SR, Selby A, Smith K, Baar K, Tipton KDThe influence of carbohydrate-protein co-ingestion following endurance exercise on myofibrillar and mitochondrial protein synthesisJ Physiol.(2011 Aug 15)
225.^Koopman R, Wagenmakers AJ, Manders RJ, Zorenc AH, Senden JM, Gorselink M, Keizer HA, van Loon LJCombined ingestion of protein and free leucine with carbohydrate increases postexercise muscle protein synthesis in vivo in male subjectsAm J Physiol Endocrinol Metab.(2005 Apr)
226.^Koopman R, Verdijk LB, Beelen M, Gorselink M, Kruseman AN, Wagenmakers AJ, Kuipers H, van Loon LJCo-ingestion of leucine with protein does not further augment post-exercise muscle protein synthesis rates in elderly menBr J Nutr.(2008 Mar)
227.^Koopman R, Verdijk L, Manders RJ, Gijsen AP, Gorselink M, Pijpers E, Wagenmakers AJ, van Loon LJCo-ingestion of protein and leucine stimulates muscle protein synthesis rates to the same extent in young and elderly lean menAm J Clin Nutr.(2006 Sep)
228.^Churchward-Venne TA, Burd NA, Mitchell CJ, West DW, Philp A, Marcotte GR, Baker SK, Baar K, Phillips SMSupplementation of a suboptimal protein dose with leucine or essential amino acids: effects on myofibrillar protein synthesis at rest and following resistance exercise in menJ Physiol.(2012 Jun 1)
229.^Rodondi A, Ammann P, Ghilardi-Beuret S, Rizzoli RZinc increases the effects of essential amino acids-whey protein supplements in frail elderlyJ Nutr Health Aging.(2009 Jun)
230.^Chevalley T, Hoffmeyer P, Bonjour JP, Rizzoli REarly serum IGF-I response to oral protein supplements in elderly women with a recent hip fractureClin Nutr.(2010 Feb)
231.^Schürch MA, Rizzoli R, Slosman D, Vadas L, Vergnaud P, Bonjour JPProtein supplements increase serum insulin-like growth factor-I levels and attenuate proximal femur bone loss in patients with recent hip fracture. A randomized, double-blind, placebo-controlled trialAnn Intern Med.(1998 May 15)
232.^Oben J, Kothari SC, Anderson MLAn open label study to determine the effects of an oral proteolytic enzyme system on whey protein concentrate metabolism in healthy malesJ Int Soc Sports Nutr.(2008 Jul 24)
233.^Pettersson-Kastberg J, Mossberg AK, Trulsson M, Yong YJ, Min S, Lim Y, O'Brien JE, Svanborg C, Mok KHalpha-Lactalbumin, engineered to be nonnative and inactive, kills tumor cells when in complex with oleic acid: a new biological function resulting from partial unfoldingJ Mol Biol.(2009 Dec 18)
235.^Svensson M, Håkansson A, Mossberg AK, Linse S, Svanborg CConversion of alpha-lactalbumin to a protein inducing apoptosisProc Natl Acad Sci U S A.(2000 Apr 11)
236.^Permyakov SE, Knyazeva EL, Leonteva MV, Fadeev RS, Chekanov AV, Zhadan AP, Håkansson AP, Akatov VS, Permyakov EAA novel method for preparation of HAMLET-like protein complexesBiochimie.(2011 Sep)
237.^Hakansson AP, Roche-Hakansson H, Mossberg AK, Svanborg CApoptosis-like death in bacteria induced by HAMLET, a human milk lipid-protein complexPLoS One.(2011 Mar 10)
238.^Svensson M, Düringer C, Hallgren O, Mossberg AK, Håkansson A, Linse S, Svanborg CHamlet--a complex from human milk that induces apoptosis in tumor cells but spares healthy cellsAdv Exp Med Biol.(2002)
239.^Permyakov SE, Knyazeva EL, Khasanova LM, Fadeev RS, Zhadan AP, Roche-Hakansson H, Håkansson AP, Akatov VS, Permyakov EAOleic acid is a key cytotoxic component of HAMLET-like complexesBiol Chem.(2012 Jan 1)
240.^Lisková K, Kelly AL, O'Brien N, Brodkorb AEffect of denaturation of alpha-lactalbumin on the formation of BAMLET (bovine alpha-lactalbumin made lethal to tumor cells)J Agric Food Chem.(2010 Apr 14)
241.^Pettersson J, Mossberg AK, Svanborg Calpha-Lactalbumin species variation, HAMLET formation, and tumor cell deathBiochem Biophys Res Commun.(2006 Jun 23)
242.^Brinkmann CR, Thiel S, Larsen MK, Petersen TE, Jensenius JC, Heegaard CWPreparation and comparison of cytotoxic complexes formed between oleic acid and either bovine or human a-lactalbuminJ Dairy Sci.(2011 May)
243.^Optimization of thermal pretreatment conditions for the separation of native alpha-lactalbumin from whey protein concentrates by means of selective denaturation of beta-lactoglobulin.()
244.^Fast J, Mossberg AK, Svanborg C, Linse SStability of HAMLET--a kinetically trapped alpha-lactalbumin oleic acid complexProtein Sci.(2005 Feb)
245.^Khan S, Casadio YS, Lai CT, Prime DK, Hepworth AR, Trengove NJ, Hartmann PEInvestigation of Short-term Variations in Casein and Whey Proteins in Breast Milk of Term MothersJ Pediatr Gastroenterol Nutr.(2012 Aug)
246.^Liao Y, Alvarado R, Phinney B, Lönnerdal BProteomic characterization of human milk whey proteins during a twelve-month lactation periodJ Proteome Res.(2011 Apr 1)
247.^Osborn DA, Sinn JFormulas containing hydrolysed protein for prevention of allergy and food intolerance in infantsCochrane Database Syst Rev.(2006 Oct 18)
248.^Kucia M, Langhammer M, Görs S, Albrecht E, Hammon HM, Nürnberg G, Metges CCHigh-protein diet during gestation and lactation affects mammary gland mRNA abundance, milk composition and pre-weaning litter growth in miceAnimal.(2011 Feb)
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