Muscle protein synthesis (MPS)

Last Updated: August 26 2021

MPS is the process by which skeletal muscle makes new proteins. The balance between MPS and MPB over time determines whether muscle is gained or lost.


For a muscle to grow (i.e., to hypertrophy), the rate of MPS must exceed the rate of MPB over time. Note that “protein synthesis” refers to the creation of any protein in your body; if your interest lies in muscle growth, you need to focus on MPS specifically.

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