Colostrum
•Last Updated: September 28 2022
Colostrum, also known as first milk, is a mammary secretion produced by cows and related animals. The results of supplementation are similar to supplementing whey protein, though colostrum may offer some unique benefits for the immune and digestive systems.
Colostrum is most often used for
Last Updated: September 28 2022
Colostrum is a pre-milk fluid produced in the mammary glands of mammals that have recently given birth. Newborns have immature digestive and immune systems, so the enzymes, antibodies, and growth factors colostrum provides promote growth and fight disease. Though colostrum is produced by all mammals, colostrum supplements are usually derived from bovine or (less frequently) goat sources. Colostrum has become a popular nutritional supplement because it is a rich source of enzymes, antibodies, and growth factors not found in other dairy products.
The undeveloped intestinal tract of a newborn allows the growth factors present in colostrum to pass freely through the intestinal wall for absorption. However, fully-developed adult mammal intestines will break down the beneficial compounds before they can be absorbed into the blood stream. Though digestive enzymes prevent colostrum growth factors from affecting muscles, they will still exert a local effect, which increase intestinal integrity. This prevents inflammation, like the kind that can be caused by prolonged, intense exercise, like competitive cycling. Outside of intense exercise, supplementing colostrum will have an effect similar to supplementing whey protein or casein protein.
Athletes often supplement colostrum in an effort to increase fat burning, add lean mass, or increase strength. Since their digestive systems are fully developed, these effects do not occur, and the body breaks down the growth factors and enzymes that colostrum provides before they can be transported to muscle cells.
The antibodies present in colostrum are also effective at reducing diarrhea caused by Escherichia coli and reducing the risk of HIV infection. To prevent E. coli-induced diarrhea, the colostrum must be obtained from an immunized animal.
Note that Colostrum is also known as:
- First Milk
- Bovine colostrum
The standard colostrum dose intended as a protein supplemented or intestinal health agent is between 20-60g. This dose contains 2-4g (10-20%) of immunoglobulin.
Colostrum is supplemented through a powder form.
A colostrum dose intended to reduce the risk of E. coli-induced diarrhea should contain between 400-3,500mg of immunoglobulins. It should be taken shortly after a meal. Colostrum intended to reduce the risk of diseases related to E. coli must come from a cow (or similar animal) that has been immunized against E. coli.
Research feed
1.^Korhonen H1, Pihlanto ATechnological options for the production of health-promoting proteins and peptides derived from milk and colostrumCurr Pharm Des.(2007)
2.^Lund P1, Sangild PT, Aunsholt L, Hartmann B, Holst JJ, Mortensen J, Mortensen PB, Jeppesen PBRandomised controlled trial of colostrum to improve intestinal function in patients with short bowel syndromeEur J Clin Nutr.(2012 Sep)
3.^Gopal PK1, Gill HSOligosaccharides and glycoconjugates in bovine milk and colostrumBr J Nutr.(2000 Nov)
5.^Saito T, Itoh T, Adachi SPresence of two neutral disaccharides containing N-acetylhexosamine in bovine colostrum as free formsBiochim Biophys Acta.(1984 Sep 7)
6.^Urashima T1, Saito T, Ohmisya K, Shimazaki KStructural determination of three neutral oligosaccharides in bovine (Holstein-Friesian) colostrum, including the novel trisaccharide; GalNAc alpha 1-3Gal beta 1-4GlcBiochim Biophys Acta.(1991 Jan 23)
7.^Saito T1, Itoh T, Adachi SChemical structure of three neutral trisaccharides isolated in free form from bovine colostrumCarbohydr Res.(1987 Jul 15)
8.^Veh RW, Michalski JC, Corfield AP, Sander-Wewer M, Gies D, Schauer RNew chromatographic system for the rapid analysis and preparation of colostrum sialyloligosaccharidesJ Chromatogr.(1981 Aug 7)
9.^Parkkinen J, Finne JIsolation of sialyl oligosaccharides and sialyl oligosaccharide phosphates from bovine colostrum and human urineMethods Enzymol.(1987)
10.^Buckley JD1, Butler RN, Southcott E, Brinkworth GDBovine colostrum supplementation during running training increases intestinal permeabilityNutrients.(2009 Feb)
11.^Kunz C1, Rodriguez-Palmero M, Koletzko B, Jensen RNutritional and biochemical properties of human milk, Part I: General aspects, proteins, and carbohydratesClin Perinatol.(1999 Jun)
13.^Mero A1, Kähkönen J, Nykänen T, Parviainen T, Jokinen I, Takala T, Nikula T, Rasi S, Leppäluoto JIGF-I, IgA, and IgG responses to bovine colostrum supplementation during trainingJ Appl Physiol (1985).(2002 Aug)
14.^Mero A1, Miikkulainen H, Riski J, Pakkanen R, Aalto J, Takala TEffects of bovine colostrum supplementation on serum IGF-I, IgG, hormone, and saliva IgA during trainingJ Appl Physiol (1985).(1997 Oct)
15.^Collier RJ1, Miller MA, Hildebrandt JR, Torkelson AR, White TC, Madsen KS, Vicini JL, Eppard PJ, Lanza GMFactors affecting insulin-like growth factor-I concentration in bovine milkJ Dairy Sci.(1991 Sep)
16.^Sparks AL1, Kirkpatrick JG, Chamberlain CS, Waldner D, Spicer LJInsulin-like growth factor-I and its binding proteins in colostrum compared to measures in serum of Holstein neonatesJ Dairy Sci.(2003 Jun)
17.^Khan Z1, Macdonald C, Wicks AC, Holt MP, Floyd D, Ghosh S, Wright NA, Playford RJUse of the 'nutriceutical', bovine colostrum, for the treatment of distal colitis: results from an initial studyAliment Pharmacol Ther.(2002 Nov)
18.^Pakkanen R, Aalto JGrowth factors and antimicrobial factors of bovine colostrumInt Dairy J.(1997 May)
19.^Shing CM1, Hunter DC, Stevenson LMBovine colostrum supplementation and exercise performance: potential mechanismsSports Med.(2009)
20.^Buescher ES1, McWilliams-Koeppen PSoluble tumor necrosis factor-alpha (TNF-alpha) receptors in human colostrum and milk bind to TNF-alpha and neutralize TNF-alpha bioactivityPediatr Res.(1998 Jul)
21.^Yamauchi K1, Tomita M, Giehl TJ, Ellison RT 3rdAntibacterial activity of lactoferrin and a pepsin-derived lactoferrin peptide fragmentInfect Immun.(1993 Feb)
22.^Francis GL1, Upton FM, Ballard FJ, McNeil KA, Wallace JCInsulin-like growth factors 1 and 2 in bovine colostrum. Sequences and biological activities compared with those of a potent truncated formBiochem J.(1988 Apr 1)
23.^Xian CJ1, Shoubridge CA, Read LCDegradation of IGF-I in the adult rat gastrointestinal tract is limited by a specific antiserum or the dietary protein caseinJ Endocrinol.(1995 Aug)
24.^Baumrucker CR1, Blum JWEffects of dietary recombinant human insulin-like growth factor-I on concentrations of hormones and growth factors in the blood of newborn calvesJ Endocrinol.(1994 Jan)
25.^Blum JW1, Baumrucker CRInsulin-like growth factors (IGFs), IGF binding proteins, and other endocrine factors in milk: role in the newbornAdv Exp Med Biol.(2008)
26.^Weström BR, Svendsen J, Ohlsson BG, Tagesson C, Karlsson BWIntestinal transmission of macromolecules (BSA and FITC-labelled dextrans) in the neonatal pig. Influence of age of piglet and molecular weight of markersBiol Neonate.(1984)
27.^Kruse PEThe importance of colostral immunoglobulins and their absorption from the intestine of the newborn animalsAnn Rech Vet.(1983)
28.^Hofman Z1, Smeets R, Verlaan G, Lugt Rv, Verstappen PAThe effect of bovine colostrum supplementation on exercise performance in elite field hockey playersInt J Sport Nutr Exerc Metab.(2002 Dec)
29.^Buckley JD1, Brinkworth GD, Abbott MJEffect of bovine colostrum on anaerobic exercise performance and plasma insulin-like growth factor IJ Sports Sci.(2003 Jul)
30.^Gapper LW1, Copestake DE, Otter DE, Indyk HEAnalysis of bovine immunoglobulin G in milk, colostrum and dietary supplements: a reviewAnal Bioanal Chem.(2007 Sep)
31.^Christiansen S, Guo M, Kjelden DChemical composition and nutrient profile of low molecular weight fraction of bovine colostrumInternational Dairy Journal.(2010 Sep)
32.^Christiansen S, Guo M, Kjelden DChemical composition and nutrient profile of low molecular weight fraction of bovine colostrumInternational Dairy Journal.(2010 Sep)
33.^Jensen GS1, Patel D, Benson KFA novel extract from bovine colostrum whey supports innate immune functions. II. Rapid changes in cellular immune function in humansPrev Med.(2012 May)
34.^Freedman DJ1, Tacket CO, Delehanty A, Maneval DR, Nataro J, Crabb JHMilk immunoglobulin with specific activity against purified colonization factor antigens can protect against oral challenge with enterotoxigenic Escherichia coliJ Infect Dis.(1998 Mar)
35.^Tacket CO1, Losonsky G, Livio S, Edelman R, Crabb J, Freedman DLack of prophylactic efficacy of an enteric-coated bovine hyperimmune milk product against enterotoxigenic Escherichia coli challenge administered during a standard mealJ Infect Dis.(1999 Dec)
36.^Roos N1, Mahé S, Benamouzig R, Sick H, Rautureau J, Tomé D15N-labeled immunoglobulins from bovine colostrum are partially resistant to digestion in human intestineJ Nutr.(1995 May)
38.^Hilpert H, Brüssow H, Mietens C, Sidoti J, Lerner L, Werchau HUse of bovine milk concentrate containing antibody to rotavirus to treat rotavirus gastroenteritis in infantsJ Infect Dis.(1987 Jul)
39.^Brinkworth GD, Buckley JDBovine colostrum supplementation does not affect nutrient absorptive capacity in healthy young menNutr Res.(2003 Dec)
40.^Brinkworth GD1, Buckley JD, Bourdon PC, Gulbin JP, David AOral bovine colostrum supplementation enhances buffer capacity but not rowing performance in elite female rowersInt J Sport Nutr Exerc Metab.(2002 Sep)
41.^Brinkworth GD1, Buckley JDBovine colostrum supplementation does not affect plasma buffer capacity or haemoglobin content in elite female rowersEur J Appl Physiol.(2004 Mar)
42.^Mero A1, Nykänen T, Keinänen O, Knuutinen J, Lahti K, Alen M, Rasi S, Leppäluoto JProtein metabolism and strength performance after bovine colostrum supplementationAmino Acids.(2005 May)
43.^Antonio J1, Sanders MS, Van Gammeren DThe effects of bovine colostrum supplementation on body composition and exercise performance in active men and womenNutrition.(2001 Mar)
44.^Brinkworth GD1, Buckley JD, Slavotinek JP, Kurmis APEffect of bovine colostrum supplementation on the composition of resistance trained and untrained limbs in healthy young menEur J Appl Physiol.(2004 Jan)
45.^Buckley JD1, Abbott MJ, Brinkworth GD, Whyte PBBovine colostrum supplementation during endurance running training improves recovery, but not performanceJ Sci Med Sport.(2002 Jun)
46.^Playford RJ1, MacDonald CE, Calnan DP, Floyd DN, Podas T, Johnson W, Wicks AC, Bashir O, Marchbank TCo-administration of the health food supplement, bovine colostrum, reduces the acute non-steroidal anti-inflammatory drug-induced increase in intestinal permeabilityClin Sci (Lond).(2001 Jun)
47.^Pals KL1, Chang RT, Ryan AJ, Gisolfi CVEffect of running intensity on intestinal permeabilityJ Appl Physiol (1985).(1997 Feb)
48.^Lambert GPStress-induced gastrointestinal barrier dysfunction and its inflammatory effectsJ Anim Sci.(2009 Apr)
49.^Lambert GPIntestinal barrier dysfunction, endotoxemia, and gastrointestinal symptoms: the 'canary in the coal mine' during exercise-heat stressMed Sport Sci.(2008)
50.^Marchbank T1, Davison G, Oakes JR, Ghatei MA, Patterson M, Moyer MP, Playford RJThe nutriceutical bovine colostrum truncates the increase in gut permeability caused by heavy exercise in athletesAm J Physiol Gastrointest Liver Physiol.(2011 Mar)
51.^Rokutan KRole of heat shock proteins in gastric mucosal protectionJ Gastroenterol Hepatol.(2000 Mar)
52.^Shing CM1, Peake J, Suzuki K, Okutsu M, Pereira R, Stevenson L, Jenkins DG, Coombes JSEffects of bovine colostrum supplementation on immune variables in highly trained cyclistsJ Appl Physiol (1985).(2007 Mar)
53.^Shing CM1, Jenkins DG, Stevenson L, Coombes JSThe influence of bovine colostrum supplementation on exercise performance in highly trained cyclistsBr J Sports Med.(2006 Sep)
54.^Wolvers DA1, van Herpen-Broekmans WM, Logman MH, van der Wielen RP, Albers REffect of a mixture of micronutrients, but not of bovine colostrum concentrate, on immune function parameters in healthy volunteers: a randomized placebo-controlled studyNutr J.(2006 Nov 21)
55.^He F1, Tuomola E, Arvilommi H, Salminen SModulation of human humoral immune response through orally administered bovine colostrumFEMS Immunol Med Microbiol.(2001 Aug)
56.^Crooks CV1, Wall CR, Cross ML, Rutherfurd-Markwick KJThe effect of bovine colostrum supplementation on salivary IgA in distance runnersInt J Sport Nutr Exerc Metab.(2006 Feb)
57.^Carol A1, Witkamp RF, Wichers HJ, Mensink MBovine colostrum supplementation's lack of effect on immune variables during short-term intense exercise in well-trained athletesInt J Sport Nutr Exerc Metab.(2011 Apr)
58.^Crooks C1, Cross ML, Wall C, Ali AEffect of bovine colostrum supplementation on respiratory tract mucosal defenses in swimmersInt J Sport Nutr Exerc Metab.(2010 Jun)
59.^Patıroğlu T1, Kondolot MThe effect of bovine colostrum on viral upper respiratory tract infections in children with immunoglobulin A deficiencyClin Respir J.(2013 Jan)
60.^Siber GR, Schur PH, Aisenberg AC, Weitzman SA, Schiffman GCorrelation between serum IgG-2 concentrations and the antibody response to bacterial polysaccharide antigensN Engl J Med.(1980 Jul 24)
61.^McKune AJ1, Smith LL, Semple SJ, Mokethwa B, Wadee AAImmunoglobulin responses to a repeated bout of downhill runningBr J Sports Med.(2006 Oct)
62.^Sacerdote P1, Mussano F, Franchi S, Panerai AE, Bussolati G, Carossa S, Bartorelli A, Bussolati BBiological components in a standardized derivative of bovine colostrumJ Dairy Sci.(2013 Mar)
63.^Uchida K1, Hiruta N, Yamaguchi H, Yamashita K, Fujimura K, Yasui HAugmentation of cellular immunity and protection against influenza virus infection by bovine late colostrum in miceNutrition.(2012 Apr)
64.^Shing CM1, Peake JM, Suzuki K, Jenkins DG, Coombes JSBovine colostrum modulates cytokine production in human peripheral blood mononuclear cells stimulated with lipopolysaccharide and phytohemagglutininJ Interferon Cytokine Res.(2009 Jan)
65.^Biswas P1, Vecchi A, Mantegani P, Mantelli B, Fortis C, Lazzarin AImmunomodulatory effects of bovine colostrum in human peripheral blood mononuclear cellsNew Microbiol.(2007 Oct)
66.^Davison G1, Diment BCBovine colostrum supplementation attenuates the decrease of salivary lysozyme and enhances the recovery of neutrophil function after prolonged exerciseBr J Nutr.(2010 May)
67.^Ricken KH1, Rieder T, Hauck G, Kindermann WChanges in lymphocyte subpopulations after prolonged exerciseInt J Sports Med.(1990 Apr)
68.^Lambert CP1, Flynn MG, Braun WA, Mylona EInfluence of acute submaximal exercise on T-lymphocyte suppressor cell function in healthy young menEur J Appl Physiol.(2000 May)
69.^Julius MH1, Janusz M, Lisowski JA colostral protein that induces the growth and differentiation of resting B lymphocytesJ Immunol.(1988 Mar 1)
70.^Janusz M1, Zabłocka AColostrinin: a proline-rich polypeptide complex of potential therapeutic interestCell Mol Biol (Noisy-le-grand).(2013 Nov 3)
71.^Brinkworth GD1, Buckley JDConcentrated bovine colostrum protein supplementation reduces the incidence of self-reported symptoms of upper respiratory tract infection in adult malesEur J Nutr.(2003 Aug)
72.^Marcotte H1, Lavoie MCOral microbial ecology and the role of salivary immunoglobulin AMicrobiol Mol Biol Rev.(1998 Mar)
77.^Cloyd MW1, Chen JJ, Adeqboyega P, Wang LHow does HIV cause depletion of CD4 lymphocytes? A mechanism involving virus signaling through its cellular receptorsCurr Mol Med.(2001 Nov)
78.^Smith CJ1, Sabin CA, Lampe FC, Kinloch-de-Loes S, Gumley H, Carroll A, Prinz B, Youle M, Johnson MA, Phillips ANThe potential for CD4 cell increases in HIV-positive individuals who control viraemia with highly active antiretroviral therapyAIDS.(2003 May 2)
79.^Kaufmann GR1, Perrin L, Pantaleo G, Opravil M, Furrer H, Telenti A, Hirschel B, Ledergerber B, Vernazza P, Bernasconi E, Rickenbach M, Egger M, Battegay M; Swiss HIV Cohort Study GroupCD4 T-lymphocyte recovery in individuals with advanced HIV-1 infection receiving potent antiretroviral therapy for 4 years: the Swiss HIV Cohort StudyArch Intern Med.(2003 Oct 13)
80.^Piketty C1, Castiel P, Belec L, Batisse D, Si Mohamed A, Gilquin J, Gonzalez-Canali G, Jayle D, Karmochkine M, Weiss L, Aboulker JP, Kazatchkine MDDiscrepant responses to triple combination antiretroviral therapy in advanced HIV diseaseAIDS.(1998 May 7)
81.^Byakwaga H1, Kelly M, Purcell DF, French MA, Amin J, Lewin SR, Haskelberg H, Kelleher AD, Garsia R, Boyd MA, Cooper DA, Emery S; CORAL Study GroupIntensification of antiretroviral therapy with raltegravir or addition of hyperimmune bovine colostrum in HIV-infected patients with suboptimal CD4+ T-cell response: a randomized controlled trialJ Infect Dis.(2011 Nov 15)
82.^Florén CH1, Chinenye S, Elfstrand L, Hagman C, Ihse IColoPlus, a new product based on bovine colostrum, alleviates HIV-associated diarrhoeaScand J Gastroenterol.(2006 Jun)
83.^Shing CM1, Peake JM, Suzuki K, Jenkins DG, Coombes JSA pilot study: bovine colostrum supplementation and hormonal and autonomic responses to competitive cyclingJ Sports Med Phys Fitness.(2013 Oct)
84.^Coombes JS1, Conacher M, Austen SK, Marshall PADose effects of oral bovine colostrum on physical work capacity in cyclistsMed Sci Sports Exerc.(2002 Jul)
85.^Jones JI1, Clemmons DRInsulin-like growth factors and their binding proteins: biological actionsEndocr Rev.(1995 Feb)
86.^Kojima M1, Hosoda H, Date Y, Nakazato M, Matsuo H, Kangawa KGhrelin is a growth-hormone-releasing acylated peptide from stomachNature.(1999 Dec 9)
87.^Kotunia A1, Zabielski RGhrelin in the postnatal development of the gastrointestinal tractJ Physiol Pharmacol.(2006 Nov)
89.^Yolken RH, Losonsky GA, Vonderfecht S, Leister F, Wee SBAntibody to human rotavirus in cow's milkN Engl J Med.(1985 Mar 7)
90.^Black REEpidemiology of travelers' diarrhea and relative importance of various pathogensRev Infect Dis.(1990 Jan-Feb)
91.^Tacket CO1, Losonsky G, Link H, Hoang Y, Guesry P, Hilpert H, Levine MMProtection by milk immunoglobulin concentrate against oral challenge with enterotoxigenic Escherichia coliN Engl J Med.(1988 May 12)
92.^Otto W1, Najnigier B, Stelmasiak T, Robins-Browne RMRandomized control trials using a tablet formulation of hyperimmune bovine colostrum to prevent diarrhea caused by enterotoxigenic Escherichia coli in volunteersScand J Gastroenterol.(2011 Jul)
93.^Levine MM, Nalin DR, Hoover DL, Bergquist EJ, Hornick RB, Young CRImmunity to enterotoxigenic Escherichia coliInfect Immun.(1979 Mar)
94.^Kotler DP, Gaetz HP, Lange M, Klein EB, Holt PREnteropathy associated with the acquired immunodeficiency syndromeAnn Intern Med.(1984 Oct)
95.^Ungar BL1, Ward DJ, Fayer R, Quinn CACessation of Cryptosporidium-associated diarrhea in an acquired immunodeficiency syndrome patient after treatment with hyperimmune bovine colostrumGastroenterology.(1990 Feb)
96.^Nord J1, Ma P, DiJohn D, Tzipori S, Tacket COTreatment with bovine hyperimmune colostrum of cryptosporidial diarrhea in AIDS patientsAIDS.(1990 Jun)
97.^Greenberg PD1, Cello JPTreatment of severe diarrhea caused by Cryptosporidium parvum with oral bovine immunoglobulin concentrate in patients with AIDSJ Acquir Immune Defic Syndr Hum Retrovirol.(1996 Dec 1)
98.^Rump JA1, Arndt R, Arnold A, Bendick C, Dichtelmüller H, Franke M, Helm EB, Jäger H, Kampmann B, Kolb P, et alTreatment of diarrhoea in human immunodeficiency virus-infected patients with immunoglobulins from bovine colostrumClin Investig.(1992 Jul)
99.^Kaducu FO1, Okia SA, Upenytho G, Elfstrand L, Florén CHEffect of bovine colostrum-based food supplement in the treatment of HIV-associated diarrhea in Northern Uganda: a randomized controlled trialIndian J Gastroenterol.(2011 Dec)
100.^Playford RJ1, Floyd DN, Macdonald CE, Calnan DP, Adenekan RO, Johnson W, Goodlad RA, Marchbank TBovine colostrum is a health food supplement which prevents NSAID induced gut damageGut.(1999 May)
101.^Dignass AU1, Podolsky DKCytokine modulation of intestinal epithelial cell restitution: central role of transforming growth factor betaGastroenterology.(1993 Nov)
102.^Hagiwara T1, Shinoda I, Fukuwatari Y, Shimamura SEffects of lactoferrin and its peptides on proliferation of rat intestinal epithelial cell line, IEC-18, in the presence of epidermal growth factorBiosci Biotechnol Biochem.(1995 Oct)
103.^Willis WL1, Hariharan S, David JJ, Strauch ARTransglutaminase-2 mediates calcium-regulated crosslinking of the Y-box 1 (YB-1) translation-regulatory protein in TGFβ1-activated myofibroblastsJ Cell Biochem.(2013 Dec)
104.^Finnson KW1, McLean S2, Di Guglielmo GM2, Philip A1Dynamics of Transforming Growth Factor Beta Signaling in Wound Healing and ScarringAdv Wound Care (New Rochelle).(2013 Jun)
105.^Powell-Tuck J, Day DW, Buckell NA, Wadsworth J, Lennard-Jones JECorrelations between defined sigmoidoscopic appearances and other measures of disease activity in ulcerative colitisDig Dis Sci.(1982 Jun)
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