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Benfotiamine is a relative of the vitamin Thiamine (B1) that appears to have a therapeutic role in pain reduction and diabetic complications (neuropathies and nephropathies); confers bioavailable Vitamin B1 after oral ingestion.

Our evidence-based analysis on benfotiamine features 53 unique references to scientific papers.

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Last Updated:

How to Take

Recommended dosage, active amounts, other details

Benfotiamine is commonly taken at the oral dose of 300-600mg over the course of the day, usually in two divided doses with meals (150mg or 300mg twice daily).

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Human Effect Matrix

Unlocked for Examine members

The Human Effect Matrix summarizes human studies to tell you what effects Benfotiamine has on your body, how much evidence there is, and how strong these effects are.

Full details are available to Examine members.
Grade Level of Evidence
Robust research conducted with repeated double-blind clinical trials
Multiple studies where at least two are double-blind and placebo controlled
Single double-blind study or multiple cohort studies
Uncontrolled or observational studies only
Level of Evidence
? The amount of high quality evidence. The more evidence, the more we can trust the results.
Outcome Magnitude of effect
? The direction and size of the supplement's impact on each outcome. Some supplements can have an increasing effect, others have a decreasing effect, and others have no effect.
Consistency of research results
? Scientific research does not always agree. HIGH or VERY HIGH means that most of the scientific research agrees.
grade-c Minor - See study
There appears to be an attenuation in how much a cigarette constricts peripheral blood flow by about half, with other biomarkers not changed overly to an overly potent degree.
grade-c - - See study
No significant changes in urinary or serum AGEs observed at the moment
grade-c - - See study
No significant evidence to support alterations in blood pressure.
grade-c - Very High See 2 studies
No significant influences on HDL-C observed.
grade-c - Very High See 2 studies
Two studies in diabetics have failed to find an influence of benfotiamine on HbA1c
grade-c - - See study
Insufficient evidence with the preliminary evidence failing to any influence on circulating cytokines.
grade-c - - See study
Insufficient evidence to support enhanced kidney function.
grade-c - - See study
Although not a primary research end-point, no significant influence on LDL-C is seen.
grade-c - - See study
Preliminary evidence has come back negative over 2 years in type 1 diabetics with diabetic neuropathy.
grade-c - Very High See 2 studies
No evidence to support a reduction in the amount of protein lost in the urine of persons with diabetic nephropathy (UAE between 15-300mg/24 hours). Whether there is a preventative effect or not, there does not appear to be a rehabilitative effect.
grade-c - - See study
No significant changes in total cholesterol
grade-c - - See study
No significant influence on triglycerides.

Studies Excluded from Consideration

  • Confounded with two other B-vitamins[1]

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Things to Note

Also Known As

S-{(Z)-2-{(4-amino-2-methylpyrimidin-5-yl) methyl-formylamino}-5-phosphonooxypent-2-en-3-yl} benzenecarbothioate

Do Not Confuse With

Sulbutiamine (a molecule made from two Thiamin molecules; very different actions though)

Goes Well With

  • Aldose Reductase Inhibitors (theoretically additive, since Benfotiamine protects against diabetic complications by many pathways but not by inhibition of this enzyme)

  • Resveratrol in reducing pain

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Click here to see all 53 references.