Benfotiamine is commonly taken at the oral dose of 300-600mg over the course of the day, usually in two divided doses with meals (150mg or 300mg twice daily).
Benfotiamine
How to Take
Recommended dosage, active amounts, other details
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Human Effect Matrix
Unlocked for Examine members
The Human Effect Matrix summarizes human studies to tell you what effects Benfotiamine has on your body, how much evidence there is, and how strong these effects are.
Full details are available to Examine members.
| Grade | Level of Evidence [show legend] |
|---|---|
|
Robust research conducted with repeated double-blind clinical trials |
|
Multiple studies where at least two are double-blind and placebo controlled |
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Single double-blind study or multiple cohort studies |
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Uncontrolled or observational studies only |
|
Level of Evidence
?
The amount of high quality evidence. The more
evidence, the more we can trust the results.
|
Outcome |
Magnitude of effect
?
The direction and size of the supplement's impact on
each outcome. Some supplements can have an increasing effect, others have a decreasing effect, and others have no effect.
|
Consistency of research results
?
Scientific research does not always agree. HIGH or
VERY HIGH means that most of the scientific research agrees.
|
Notes |
|---|---|---|---|---|
|
|
Minor
|
- See study |
There appears to be an attenuation in how much a cigarette constricts peripheral blood flow by about half, with other biomarkers not changed overly to an overly potent degree.
|
|
|
|
- | - See study |
No significant changes in urinary or serum AGEs observed at the moment
|
|
|
|
- | - See study |
No significant evidence to support alterations in blood pressure.
|
|
|
|
- | Very High See 2 studies |
No significant influences on HDL-C observed.
|
|
|
|
- | Very High See 2 studies |
Two studies in diabetics have failed to find an influence of benfotiamine on HbA1c
|
|
|
|
- | - See study |
Insufficient evidence with the preliminary evidence failing to any influence on circulating cytokines.
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|
- | - See study |
Insufficient evidence to support enhanced kidney function.
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|
|
|
- | - See study |
Although not a primary research end-point, no significant influence on LDL-C is seen.
|
|
|
|
- | - See study |
Preliminary evidence has come back negative over 2 years in type 1 diabetics with diabetic neuropathy.
|
|
|
|
- | Very High See 2 studies |
No evidence to support a reduction in the amount of protein lost in the urine of persons with diabetic nephropathy (UAE between 15-300mg/24 hours). Whether there is a preventative effect or not, there does not appear to be a rehabilitative effect.
|
|
|
|
- | - See study |
No significant changes in total cholesterol
|
|
|
|
- | - See study |
No significant influence on triglycerides.
|
Studies Excluded from Consideration
Confounded with two other B-vitamins[1]
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Things to Note
Primary Function:
Also Known As
S-{(Z)-2-{(4-amino-2-methylpyrimidin-5-yl) methyl-formylamino}-5-phosphonooxypent-2-en-3-yl} benzenecarbothioate
Do Not Confuse With
Sulbutiamine (a molecule made from two Thiamin molecules; very different actions though)
Goes Well With
Aldose Reductase Inhibitors (theoretically additive, since Benfotiamine protects against diabetic complications by many pathways but not by inhibition of this enzyme)
Resveratrol in reducing pain
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