Benfotiamine is commonly taken at the oral dose of 300-600mg over the course of the day, usually in two divided doses with meals (150mg or 300mg twice daily).
Benfotiamine
Get the latest information on 400+ supplements and their effects on 600+ health conditions & outcomes.
By becoming an Examine Plus member, you'll have access to all of the latest nutrition research. Quickly and easily look up scientific research on over 400 supplements across over 600 different health goals, outcomes, conditions, and more.
Already a subscriber to any of our membership plans? Click here to login.
Human Effect Matrix
Unlocked for Examine Plus membersThe Human Effect Matrix summarizes human studies to tell you what effects Benfotiamine has on your body, how much evidence there is, and how strong these effects are.
Full details are available to Examine Plus members.
| Grade | Level of Evidence [show legend] |
|---|---|
|
Robust research conducted with repeated double-blind clinical trials |
|
Multiple studies where at least two are double-blind and placebo controlled |
|
Single double-blind study or multiple cohort studies |
|
Uncontrolled or observational studies only |
|
Level of Evidence
?
The amount of high quality evidence. The more
evidence, the more we can trust the results.
|
Outcome |
Magnitude of effect
?
The direction and size of the supplement's impact on
each outcome. Some supplements can have an increasing effect, others have a decreasing effect, and others have no effect.
|
Consistency of research results
?
Scientific research does not always agree. HIGH or
VERY HIGH means that most of the scientific research agrees.
|
Notes |
|---|---|---|---|---|
|
|
Minor
|
- See study |
There appears to be an attenuation in how much a cigarette constricts peripheral blood flow by about half, with other biomarkers not changed overly to an overly potent degree.
|
|
|
|
- | - See study |
No significant changes in urinary or serum AGEs observed at the moment
|
|
|
|
- | - See study |
No significant evidence to support alterations in blood pressure.
|
|
|
|
- | Very High See 2 studies |
No significant influences on HDL-C observed.
|
|
|
|
- | Very High See 2 studies |
Two studies in diabetics have failed to find an influence of benfotiamine on HbA1c
|
|
|
|
- | - See study |
Insufficient evidence with the preliminary evidence failing to any influence on circulating cytokines.
|
|
|
|
- | - See study |
Insufficient evidence to support enhanced kidney function.
|
|
|
|
- | - See study |
Although not a primary research end-point, no significant influence on LDL-C is seen.
|
|
|
|
- | - See study |
Preliminary evidence has come back negative over 2 years in type 1 diabetics with diabetic neuropathy.
|
|
|
|
- | Very High See 2 studies |
No evidence to support a reduction in the amount of protein lost in the urine of persons with diabetic nephropathy (UAE between 15-300mg/24 hours). Whether there is a preventative effect or not, there does not appear to be a rehabilitative effect.
|
|
|
|
- | - See study |
No significant changes in total cholesterol
|
|
|
|
- | - See study |
No significant influence on triglycerides.
|
Studies Excluded from Consideration
Confounded with two other B-vitamins[1]
Become an Examine Plus member to access the latest nutrition research on over 400 supplements across over 600 different health goals, outcomes, conditions, and more.
Becoming an Examine Plus member not only unlocks the Human Effect Matrix for supplements, but also all health topics on Examine.com. We neatly summarize all the latest research so you can make the best decisions for your health based on what's accurate and not out-dated information.
Things to Note
Primary Function:
Also Known As
S-{(Z)-2-{(4-amino-2-methylpyrimidin-5-yl) methyl-formylamino}-5-phosphonooxypent-2-en-3-yl} benzenecarbothioate
Do Not Confuse With
Sulbutiamine (a molecule made from two Thiamin molecules; very different actions though)
Goes Well With
Aldose Reductase Inhibitors (theoretically additive, since Benfotiamine protects against diabetic complications by many pathways but not by inhibition of this enzyme)
Resveratrol in reducing pain
Tired of misinformation? Get unbiased info on supplements.
At Examine.com, our incentives line up with yours — getting unbiased information. It’s why we don’t sell any advertising or supplements.
Join over 250,000 people who’ve learned about effective versus overrated supplements, supplement buying tips, and how to combine supplements for safety and efficacy.
Click here to see all 53 references.
