Last Updated: September 28 2022

Sulbutiamine is a synthetic molecule which consists of two Thiamine (Vitamin B1) molecules bound together by a sulfur group, and appears to be somewhat useful in alleviating fatigue; especially that associated with infection.

Sulbutiamine is most often used for

What else is Sulbutiamine known as?
Note that Sulbutiamine is also known as:
  • Arcalion
  • Enerion
  • Bisibuthiamine
  • Youvitan
Sulbutiamine should not be confused with:
  • Sibutramine (a pharmaceutical appetite suppressant)
Dosage information

Human studies using sulbutiamine supplementation have used 400mg daily. It is not clear if this is near the optimal dosage, and an ideal dosing regimen (with or without meals and how many divided doses a day) is not currently known.

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1.^Trovero F, Gobbi M, Weil-Fuggaza J, Besson MJ, Brochet D, Pirot SEvidence for a modulatory effect of sulbutiamine on glutamatergic and dopaminergic cortical transmissions in the rat brainNeurosci Lett.(2000 Sep 29)
3.^Bettendorff L, Weekers L, Wins P, Schoffeniels EInjection of sulbutiamine induces an increase in thiamine triphosphate in rat tissuesBiochem Pharmacol.(1990 Dec 1)
6.^Kiew KK, Wan Mohamad WB, Ridzuan A, Mafauzy MEffects of sulbutiamine on diabetic polyneuropathy: an open randomised controlled study in type 2 diabeticsMalays J Med Sci.(2002 Jan)
7.^Micheau J, Durkin TP, Destrade C, Rolland Y, Jaffard RChronic administration of sulbutiamine improves long term memory formation in mice: possible cholinergic mediationPharmacol Biochem Behav.(1985 Aug)
13.^Balzamo E, Vuillon-Cacciuttolo GFacilitation of a state of wakefulness by semi-chronic treatment with sulbutiamin (Arcalion) in Macaca mulattaRev Electroencephalogr Neurophysiol Clin.(1982 Dec)
15.^Sedel F, Challe G, Mayer JM, Boutron A, Fontaine B, Saudubray JM, Brivet MThiamine responsive pyruvate dehydrogenase deficiency in an adult with peripheral neuropathy and optic neuropathyJ Neurol Neurosurg Psychiatry.(2008 Jul)
16.^Kang KD, Majid AS, Kim KA, Kang K, Ahn HR, Nho CW, Jung SHSulbutiamine counteracts trophic factor deprivation induced apoptotic cell death in transformed retinal ganglion cellsNeurochem Res.(2010 Nov)