Sulbutiamine
•Last Updated: September 28 2022
Sulbutiamine is a synthetic molecule which consists of two Thiamine (Vitamin B1) molecules bound together by a sulfur group, and appears to be somewhat useful in alleviating fatigue; especially that associated with infection.
Sulbutiamine is most often used for
Last Updated: September 28 2022
Note that Sulbutiamine is also known as:
- Arcalion
- Enerion
- Bisibuthiamine
- Youvitan
Sulbutiamine should not be confused with:
- Sibutramine (a pharmaceutical appetite suppressant)
Human studies using sulbutiamine supplementation have used 400mg daily. It is not clear if this is near the optimal dosage, and an ideal dosing regimen (with or without meals and how many divided doses a day) is not currently known.
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2.^Determination of sulbutiamine and its disulfide derivatives in human plasma by HPLC using on-line post-column reactors and fluorimetric detection.()
3.^Bettendorff L, Weekers L, Wins P, Schoffeniels EInjection of sulbutiamine induces an increase in thiamine triphosphate in rat tissuesBiochem Pharmacol.(1990 Dec 1)
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8.^Bizot JC, Herpin A, Pothion S, Pirot S, Trovero F, Ollat HChronic treatment with sulbutiamine improves memory in an object recognition task and reduces some amnesic effects of dizocilpine in a spatial delayed-non-match-to-sample taskProg Neuropsychopharmacol Biol Psychiatry.(2005 Jul)
9.^Tiev KP, Cabane J, Imbert JCTreatment of chronic postinfectious fatigue: randomized double-blind study of two doses of sulbutiamine (400-600 mg/day) versus placeboRev Med Interne.(1999 Oct)
10.^Shah SN; Sulbutiamine Study GroupAdjuvant role of vitamin B analogue (sulbutiamine) with anti-infective treatment in infection associated astheniaJ Assoc Physicians India.(2003 Sep)
12.^Douzenis A, Michopoulos I, Lykouras LSulbutiamine, an 'innocent' over the counter drug, interferes with therapeutic outcome of bipolar disorderWorld J Biol Psychiatry.(2006)
13.^Balzamo E, Vuillon-Cacciuttolo GFacilitation of a state of wakefulness by semi-chronic treatment with sulbutiamin (Arcalion) in Macaca mulattaRev Electroencephalogr Neurophysiol Clin.(1982 Dec)
14.^Asregadoo ERBlood levels of thiamine and ascorbic acid in chronic open-angle glaucomaAnn Ophthalmol.(1979 Jul)
15.^Sedel F, Challe G, Mayer JM, Boutron A, Fontaine B, Saudubray JM, Brivet MThiamine responsive pyruvate dehydrogenase deficiency in an adult with peripheral neuropathy and optic neuropathyJ Neurol Neurosurg Psychiatry.(2008 Jul)
16.^Kang KD, Majid AS, Kim KA, Kang K, Ahn HR, Nho CW, Jung SHSulbutiamine counteracts trophic factor deprivation induced apoptotic cell death in transformed retinal ganglion cellsNeurochem Res.(2010 Nov)
17.^Dmitriev DG, Gamidov SI, Permiakova OVClinical efficacy of the drug enerion in the treatment of patients with psychogenic (functional) erectile dysfunctionUrologiia.(2005 Jan-Feb)
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