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Sulbutiamine

Sulbutiamine is a synthetic molecule which consists of two Thiamine (Vitamin B1) molecules bound together by a sulfur group, and appears to be somewhat useful in alleviating fatigue; especially that associated with infection.

Our evidence-based analysis on sulbutiamine features 17 unique references to scientific papers.

Research analysis led by .
Reviewed by
Examine.com Team
Last Updated:

How to Take

Medical Disclaimer

Recommended dosage, active amounts, other details

Human studies using sulbutiamine supplementation have used 400mg daily. It is not clear if this is near the optimal dosage, and an ideal dosing regimen (with or without meals and how many divided doses a day) is not currently known.

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Human Effect Matrix

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The Human Effect Matrix summarizes human studies to tell you what effects Sulbutiamine has on your body, how much evidence there is, and how strong these effects are.

Full details are available to Examine Plus members.
Grade Level of Evidence
Robust research conducted with repeated double-blind clinical trials
Multiple studies where at least two are double-blind and placebo controlled
Single double-blind study or multiple cohort studies
Uncontrolled or observational studies only
Level of Evidence
? The amount of high quality evidence. The more evidence, the more we can trust the results.
Outcome Magnitude of effect
? The direction and size of the supplement's impact on each outcome. Some supplements can have an increasing effect, others have a decreasing effect, and others have no effect.
Consistency of research results
? Scientific research does not always agree. HIGH or VERY HIGH means that most of the scientific research agrees.
Notes
grade-d - - See study
No significant influence on blood glucose in diabetics detected
grade-d - - See study
No significant influence of sulbutiamine on HbA1c
grade-d - - See study
Insufficient evidence to support a role in diabetic neuropathy associated with sulbutiamine supplementation
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Things to Note

Is a Form Of

Primary Function:

Also Known As

Arcalion, Enerion, Bisibuthiamine, Youvitan

Do Not Confuse With

Sibutramine (a pharmaceutical appetite suppressant)

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Click here to see all 17 references.