Summary of Sea Buckthorn
Primary Information, Benefits, Effects, and Important Facts
Sea buckthorn refers to the plant hippophae rhamnoides, and its usage as a supplement can refer to either the leaves of the plant or the berries that it bears; additionally, the berries can be supplemented as either a dry powder or as an oil derived from the berries. All parts of the plant appear to be bioactive.
This plant appears to be a good source of flavonoids, mostly those structurally related to quercetin and kaempferol. It also has procyanidin (chains of catechin molecules) content like some other plants, with some epigallocatechin and gallocatechin as well (half of the green tea catechins). While Hippophae rhamnoides doesn't have any well researched unique properties (The hippophin molecules are not very well researched by themselves), it appears to be a good collective source of common flavonoid compounds.
Historical usage of this plant has been for cardiovascular and blood health, and it does appear to protect the heart itself in rats and confers anti-platelet effects following higher recommended doses of the supplement in otherwise healthy persons. Some other benefits of this plant, while not completely unique to the plant, include accelerated wound healing and improved skin quality following oral ingestion and some basic neuroprotective properties.
Hippophae rhamnoides is effective at helping with many common health goals that other flavonoids are effective at, and while it seems to have a large base in traditional medicine no highly unique properties or molecules have been detected with this plant yet. Currently, sea buckthorn can be said to be healthy but there is no one reason to supplement with this plant over others that are more effective.
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Things To Know & Note
The leaves and berries of the plant can both be encapsulated in powder form for supplementation, as can an oil derived from the berries; all parts are active in the body following oral ingestion
How to Take Sea Buckthorn
Recommended dosage, active amounts, other details
Sea buckthorn is supplemented as either a dry plant extract (of which both the berries and the leaves are viable options) or as an oil made from the berries.
When supplementing dry extracts, the range of 500-2,000mg is used for both the berry extracts and the leaf extracts. For the oil, slightly higher dosage ranges (2,000-5,000mg) are used daily.
Human Effect Matrix
The Human Effect Matrix looks at human studies (it excludes animal and in vitro studies) to tell you what effects sea buckthorn has on your body, and how strong these effects are.
|Grade||Level of Evidence [show legend]|
|Robust research conducted with repeated double-blind clinical trials|
|Multiple studies where at least two are double-blind and placebo controlled|
|Single double-blind study or multiple cohort studies|
|Uncontrolled or observational studies only|
Level of Evidence
? The amount of high quality evidence. The more evidence, the more we can trust the results.
Magnitude of effect
? The direction and size of the supplement's impact on each outcome. Some supplements can have an increasing effect, others have a decreasing effect, and others have no effect.
Consistency of research results
? Scientific research does not always agree. HIGH or VERY HIGH means that most of the scientific research agrees.
|Minor||- See study|
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Scientific Research on Sea Buckthorn
Click on any below to expand the corresponding section. Click on to collapse it.
Sea Buckthorn (Hippophae rhamnoides of the family Elaeagnaceae) is a small shrub (3-15 feet in height) that is known to grow in high altitudes of 7,000-15,000m above sea level in the north west Himalaya region. Its berries are sometimes drunk as either a juice or wine and can also be used for producing oils. Both the berries and the leaves can be used as dietary supplements.
Sea Buckthorn contains:
Hippophins C-F (seeds of the sinensis variant) which are kaempferol glycosides
There are some molecules that are (currently known to be) unique to sea buckthorn and are named after it accordingly. They appear to be flavonoid glycosides
Various forms of Quercetin (itself at 29.7µg/g in the seeds only) including Pentamethylquercetin, Isorhamnetin (3.74-147µg/g and highest in leaves or 27.91-112.65µg/g in water extracts) and related glycosides, Quercetin-3,O-galactoside (34.98-334µg/g and highest in leaves), Quercetin-3-O-glucoside-7-O-rhamnoside, and Rutin (155-365µg/g and highest in leaves)
Other carotenoids including neoxanthin (0.01-0.08% total carotenoids), Lutein (0.23-0.27% total carotenoids), β-carotene (14.68-29.06% total carotenoids), and γ-carotene (2.39-3.99% total carotenoids). Total carotenoids in the fruits range from 8.85-25.51mg/100g with an outlier of 43.06mg/100g
Panthenoic Acid (Vitamin B5) in the berries
Vitamins B1, B2, and B6 in the berries
Beyond the hippophins, sea buckthorn appears to have a large variety of the standard polyphenolics with more relevant concentrations of quercetin and its analogues (isorhamnetin, quercetin glycosides) as well as procyanidins made of catechins. Kaempferol is also a large component, as it is also the backbone for the hippophins
The fatty acid composition (found in seed and berry oils with fat content, but not in supplements derived from leaves) includes:
1.5% of stearic acid
5.5% of vaccenic acid (18:1n7)
11.4% of alpha-linolenic acid
Whereas volatile compounds include:
2-methylbutanoic acid ethyl ester
3-methylbutanoic acid ethyl ester
Hexanoic and octanoic acid ethyl esters
3-methylbutyl 2-methylbutanoate and 3-methylbutyl 3-methylbutanoate
Benzoic acid methyl ester
The aforementioned compounds confer taste and aromatic properties to sea buckthorn, but their contributions to health effects are not known
The total antioxidant capacity of the plant appears to be about 0.2–18.2% (ABTS method) or 0.7–28.2% (TEAC method) as potent as Trolox (water soluble Vitamin E) using a variety of analytical methods, with the higher values thought to be more reflective of the plant as compounds could have been destroyed with other testing methods. Other studies have noted that gallic acid equivalents (GAE) of seabuckthorn are 76.07–93.72mg/g in the leaves (higher at 363mg/g in the water extract) and that seabuckthorn is less potent than Vitamin C in vitro. Total carotenoids can vary from 1.5−18.5mg/100g fresh weight of the berries.
Most antioxidants appear to accumulate in the seeds relative to the pulp, leaves, or stem, despite most flavonoids being in the leaves (and least in seeds). The total phenolic content of the leaves is 47.06–66.03mg/g rutin equivalents (RE).
The antioxidative potency of sea buckthorn is present and somewhat respectable, but when compared to the research standards (Vitamin E, Vitamin C, Gallic Acid) it appears to be significantly weaker
The main flavonoids of sea buckthorn (isorhamnetin, kaempferol and quercetin) appear to be absorbed following oral ingestion and solid dispersions of the flavonoids appear to have greater bioavailability than do the basic flavonoids or self-emulsifying delivery systems.
Isolated procyanidins from sea buckthorn appear to reduce the rate of protein absorption with an EC50 somewhere between 39.8-65.8μg/mL, and the tested extracts were able to inhibit protein digestive enzymes in vitro with a potency of 57.5-67.7% (trypsin) and 44.1-60.3% (pepsin).
May possibly reduce the rate of protein absorption secondary to inhibiting enzymes of protein hydrolysis
Ingestion of sea buckthorn berries and extracts has been noted to delay the spike in triglycerides following a test meal in humans, although the total AUC of triglycerides (indicative of absorption) was unaffected. This was mostly attributed to the fiber component and is similar to previous literature looking at the influence of sea buckthorn berries on postprandial glycemia (carbohydrate absorption).
One rat intervention using 500-1,000mg/kg of the ethanolic extract of sea buckthorn noted reduced food intake in a dose-dependent manner and a decrease in leptin, whereas a study in children (with dyspepsia) has noted an increase in leptin and neuropeptide Y, suggesting an increase in appetite.
Unclear influences on appetite regulation
50-200mg/kg of sea buckthorn (75% ethanolic extract of leaves) for 21 days prior to scopolamine administration was able to dose-dependently reduce lipid peroxidation as assessed by MDA concentrations and acetylcholinesterase activity, both of which were fully normalized at 200mg/kg. Cognition also appeared to be preserved with sea buckthorn ingestion.
Oral sea buckthorn appears to have neuroprotective properties, and they are of moderate to respectable potency according to the preliminary evidence
A single dose of the water extract of sea buckthorn leaves appears to have adaptogenic properties in rats given a cold/hypoxia/restraint test, with the dosage of 100mg/kg taken 30 minutes prior having the most adaptogenic effect (recovery hastened by 42%) and 12.5mg/kg having some efficacy. Five days of dosing failed to outperform a single dose and the mechanisms are thought to be related to attenuating a shift to glycolytic metabolism during stress testing (or at least a preservation of glycogen).
Clotting time appears to be increased with sea buckthorn, with an infusion of 300mcg/kg of the flavones administered to mice prolonging clotting time by 36.7%. In vitro, a concentration of 3mcg/mL appears to be effective in reducing collagen-induced platelet aggregation.
The berry oil (made from seeds and berries) has been noted to reduce ADP-induced aggregation rate (3%) and maximal platelet aggregation (5-15% depending on concentration of ADP) when taken at the dosage of 5,000mg daily over the course of 4-8 weeks, relative to the active control of coconut oil.
Sea buckthorn has been shown to exert protection against hypoxia-induced vascular leakage. In rats subject to experimental polycythemia (an increase in blood volume and erythrocytosis associated with higher altitudes,) 35-140mg/kg of the flavonoids from sea buckthorn daily for five weeks is able to attenuate adverse changes with 70-140mg/kg being equally effective (and 35mg/kg being barely effective). This has been noted previously with isolated quercetin as two of its sources, buckthorn and ginkgo biloba, are sources of it and are used for high altitude sickness.
It has been noted that pentamethylquercetin is able to induce adiponectin expression (1-10μM but not 0.1-0.3μM) in differentiated adipocytes (without inherently affecting lipid accumulation) which appeared to be in part due to the observed upregulation of PPARγ mRNA and also thought to be partly due to reducing the effects of TNF-α and IL-6 (negative regulators of adiponectin) via reducing their secretion. That being said, elsewhere PPARγ is reduced by isorhamnetin which contributes to a suppression of adipogenesis and suppression of adiponectin secretion.
The overall methanolic extract has been noted to inhibit adipocyte triglyceride accumulation (35% at 30µg/mL), although the chloroform extract was more effective at 82%. The bioactive molecules underlying these effects were thought to be the triterpenoids (including ursolic acid) and flavonoid aglycones.
When an ethanolic extract of sea buckthorn (1,000mg/kg) is given to rats, hepatic expression of PPARγ appears to be increased.
Different isolated components in sea buckthorn seem to differentially modulate adipocyte function and growth. Overall, there is perhaps an increase in PPARγ
Supplementing mice with a 70% ethanolic extract of sea buckthorn at 500-1,000mg/kg bodyweight over 13 weeks was associated with reduced weight and fat gain when participants were subjected to an obesogenic diet. The sea buckthorn intervention was associated with a reduction in food intake, leptin concentrations in serum, and hepatic triglycerides.
This study noted that the 1,000mg/kg group had 47% lower liver fat than did normal diet control, despite being subject to a high fat diet (with the high fat diet control experiencing a 46% increase in dietary fat relative to control).
The 80% methanolic extract of sea buckthorn has been found to inhibit nitric oxide production in macrophages with 63% potency at a concentration of 30µg/mL. When testing isolated compounds with potency, it was found that possible explanatory molecules may be kaempferol (IC50 of 18.2µM), quercetin (20.6µM), ursolic acid (17.8µM), 23-hydroxy ursolic acid (12.5µM), and pomolic acid (16µM).
In another study, TNF-α and IL-6 secretion from adipocytes has been noted to be reduced in vitro at 3-10μM (isolated pentamethylquercetin).
Sea buckthorn appears to have antiulcer properties, secondary to both its antioxidant properties and an ability to increase the hydrophobicity of the stomach and slow gastric emptying which occurs in a dose-depedent manner at 3.5-7mL/kg of the seed oil or extracts of the oil.
The seed oil, composed of mostly procyanidins and the polyphenols, appears to have biologically relevant anti-ulcer properties in research animals. This has not been tested in humans.
Sea buckthorn water extract is able to prevent hepatocytes from oxidative cell death induced by hypoxia (causes increased reactive oxygen species and enzyme leakage indicative of membrane damage) with efficacy at 10µg/mL and near complete efficacy at 50µg/mL.
In the liver, oral ingestion of sea buckthorn (as wine) in mice subject to a high cholesterol diet and oxidative stress resulted decreased lipid peroxidation in the liver and a better lipid profile in serum.
Sea buckthorn oil at 2g daily appears to reduce symptoms of dry eye in humans. This appears to be associated with reducing the tear film hyperosmolarity (involved in the pathology of dry eyes as it activates inflammatory signalling) but not associated with altering the fatty acid composition of eye tissue.
Oral supplementation of a sea buckthorn extract (50mg/kg) daily for six weeks in irradiated nude mice is able to effectively prevent UV-induced changes in skin quality and wrinkling.
Appears to be protective of the skin following oral ingestion
Sea buckthorn appears to be a traditional remedy for increasing wound healing rates.
Oral ingestion of the oil from sea buckthorn (2.5mL/kg to rats) as well as topical application (200µL) are both effective in increasing the rate of healing in a burn model, and topical application of the isolated flavonoids (1% of solution) has been found to accelerate the healing of incision wounds. The healing properties appear to be associated with increased angiogenesis (as assessed by increased metalloproteinases 2 and 9 as well as VEGF expression).
Oral ingestion, as well as topical administration, show some efficacy in accelerating wound healing rates. There is currently no human evidence nor are there comparisons to reference drugs in order to assess potency
Acute toxicity studies suggest that the LD50 value for the leaf water extract is greater than 10,000mg/kg bodyweight in rats when taken daily for 14 days and subchronic intake suggested that intakes of 1,000-2,000mg/kg for 14 days were associated with nontoxic changes in hepatic and renal weight.
- Saggu S, et al. Adaptogenic and safety evaluation of seabuckthorn (Hippophae rhamnoides) leaf extract: a dose dependent study. Food Chem Toxicol. (2007)
- Negi B, Kaur R, Dey G. Protective effects of a novel sea buckthorn wine on oxidative stress and hypercholesterolemia. Food Funct. (2013)
- Patel CA, et al. Remedial Prospective of Hippophae rhamnoides Linn. (Sea Buckthorn). ISRN Pharmacol. (2012)
- Pichiah PB, et al. Ethanolic extract of seabuckthorn (Hippophae rhamnoides L) prevents high-fat diet-induced obesity in mice through down-regulation of adipogenic and lipogenic gene expression. Nutr Res. (2012)
- Yang ZG, et al. Inhibitory effects of the constituents of Hippophae rhamnoides on 3T3-L1 cell differentiation and nitric oxide production in RAW264.7 cells. Chem Pharm Bull (Tokyo). (2013)
- Gao W, Chen C, Kong DY. Hippophins C-F, four new flavonoids, acylated with one monoterpenic acid from the seed residue of Hippophae rhamnoides subsp. sinensis. J Asian Nat Prod Res. (2013)
- Xu X, et al. Effects of sea buckthorn procyanidins on healing of acetic acid-induced lesions in the rat stomach. Asia Pac J Clin Nutr. (2007)
- Arimboor R, Arumughan C. Effect of polymerization on antioxidant and xanthine oxidase inhibitory potential of sea buckthorn (H. rhamnoides) proanthocyanidins. J Food Sci. (2012)
- Isolation of five types of flavonol from seabuckthorn (Hippophae rhamnoides) and induction of apoptosis by some of the flavonols in human promyelotic leukemia HL-60 cells.
- Sharma UK, et al. Microwave-assisted efficient extraction of different parts of Hippophae rhamnoides for the comparative evaluation of antioxidant activity and quantification of its phenolic constituents by reverse-phase high-performance liquid chromatography (RP-HPLC). J Agric Food Chem. (2008)
- Subcritical water extraction of antioxidant compounds from Seabuckthorn (Hippophae rhamnoides) leaves for the comparative evaluation of antioxidant activity.
- Fang R, et al. Enhanced Profiling of Flavonol Glycosides in the Fruits of Sea Buckthorn (Hippophae rhamnoides). J Agric Food Chem. (2013)
- Arimboor R, Arumughan C. HPLC-DAD-MS/MS profiling of antioxidant flavonoid glycosides in sea buckthorn (Hippophae rhamnoides L.) seeds. Int J Food Sci Nutr. (2012)
- Tulsawani R, Gupta R, Misra K. Efficacy of aqueous extract of Hippophae rhamnoides and its bio-active flavonoids against hypoxia-induced cell death. Indian J Pharmacol. (2013)
- Zhang J, et al. Three new flavonoids from the seeds of Hippophae rhamnoides subsp. sinensis. J Asian Nat Prod Res. (2012)
- Giuffrida D, et al. Determination of carotenoids and their esters in fruits of sea buckthorn (Hippophae rhamnoides L.) by HPLC-DAD-APCI-MS. Phytochem Anal. (2012)
- Weller P, Breithaupt DE. Identification and quantification of zeaxanthin esters in plants using liquid chromatography-mass spectrometry. J Agric Food Chem. (2003)
- Kruczek M, et al. Antioxidant capacity of crude extracts containing carotenoids from the berries of various cultivars of Sea buckthorn (Hippophae rhamnoides L.). Acta Biochim Pol. (2012)
- Influence of origin, harvesting time and weather conditions on content of inositols and methylinositols in sea buckthorn (Hippophaë rhamnoides) berries.
- Kwon DJ, et al. Casuarinin suppresses TARC/CCL17 and MDC/CCL22 production via blockade of NF-κB and STAT1 activation in HaCaT cells. Biochem Biophys Res Commun. (2012)
- Gutzeit D, et al. Effects of processing and of storage on the stability of pantothenic acid in sea buckthorn products (Hippophaë rhamnoides L. ssp. rhamnoides) assessed by stable isotope dilution assay. J Agric Food Chem. (2007)
- Gutzeit D, et al. Folate content in sea buckthorn berries and related products (Hippophaë rhamnoides L. ssp. rhamnoides): LC-MS/MS determination of folate vitamer stability influenced by processing and storage assessed by stable isotope dilution assay. Anal Bioanal Chem. (2008)
- Gutzeit D, et al. Vitamin C content in sea buckthorn berries (Hippophaë rhamnoides L. ssp. rhamnoides) and related products: a kinetic study on storage stability and the determination of processing effects. J Food Sci. (2008)
- Johansson AK, et al. Sea buckthorn berry oil inhibits platelet aggregation. J Nutr Biochem. (2000)
- Dulf FV. Fatty acids in berry lipids of six sea buckthorn (Hippophae rhamnoides L., subspecies carpatica) cultivars grown in Romania. Chem Cent J. (2012)
- Socaci SA, et al. In-tube Extraction and GC-MS Analysis of Volatile Components from Wild and Cultivated sea buckthorn (Hippophae rhamnoides L. ssp. Carpatica) Berry Varieties and Juice. Phytochem Anal. (2013)
- Carotenoids in Sea Buckthorn (Hippophae rhamnoides L.) Berries during Ripening and Use of Pheophytin a as a Maturity Marker.
- Li G, et al. Pharmacokinetic properties of isorhamnetin, kaempferol and quercetin after oral gavage of total flavones of Hippophae rhamnoides L. in rats using a UPLC-MS method. Fitoterapia. (2012)
- Zhao G, et al. Effects of solid dispersion and self-emulsifying formulations on the solubility, dissolution, permeability and pharmacokinetics of isorhamnetin, quercetin and kaempferol in total flavones of Hippophae rhamnoides L. Drug Dev Ind Pharm. (2013)
- Arimboor R, Arumughan C. Sea buckthorn (Hippophae rhamnoides) proanthocyanidins inhibit in vitro enzymatic hydrolysis of protein. J Food Sci. (2011)
- Linderborg KM, et al. The fibres and polyphenols in sea buckthorn (Hippophaë rhamnoides) extraction residues delay postprandial lipemia. Int J Food Sci Nutr. (2012)
- Lehtonen HM, et al. Postprandial hyperglycemia and insulin response are affected by sea buckthorn (Hippophaë rhamnoides ssp. turkestanica) berry and its ethanol-soluble metabolites. Eur J Clin Nutr. (2010)
- Xiao M, et al. Influence of hippophae rhamnoides on two appetite factors, gastric emptying and metabolic parameters, in children with functional dyspepsia. Hell J Nucl Med. (2013)
- Attrey DP, et al. Effect of seabuckthorn extract on scopolamine induced cognitive impairment. Indian J Exp Biol. (2012)
- Saggu S, Kumar R. Possible mechanism of adaptogenic activity of seabuckthorn (Hippophae rhamnoides) during exposure to cold, hypoxia and restraint (C-H-R) stress induced hypothermia and post stress recovery in rats. Food Chem Toxicol. (2007)
- Saggu S, Kumar R. Effect of seabuckthorn leaf extracts on circulating energy fuels, lipid peroxidation and antioxidant parameters in rats during exposure to cold, hypoxia and restraint (C-H-R) stress and post stress recovery. Phytomedicine. (2008)
- Sun B, et al. Isorhamnetin inhibits H₂O₂-induced activation of the intrinsic apoptotic pathway in H9c2 cardiomyocytes through scavenging reactive oxygen species and ERK inactivation. J Cell Biochem. (2012)
- Malik S, et al. Seabuckthorn attenuates cardiac dysfunction and oxidative stress in isoproterenol-induced cardiotoxicity in rats. Int J Toxicol. (2011)
- Cheng J, et al. Inhibitory effects of total flavones of Hippophae Rhamnoides L on thrombosis in mouse femoral artery and in vitro platelet aggregation. Life Sci. (2003)
- Modulation of Hypoxia-Induced Pulmonary Vascular Leakage in Rats by Seabuckthorn (Hippophae rhamnoides L.).
- Windsor JS, Rodway GW. Heights and haematology: the story of haemoglobin at altitude. Postgrad Med J. (2007)
- Jefferson JA, et al. Hyperuricemia, hypertension, and proteinuria associated with high-altitude polycythemia. Am J Kidney Dis. (2002)
- Zhou JY, et al. Protective effect of total flavonoids of seabuckthorn (Hippophae rhamnoides) in simulated high-altitude polycythemia in rats. Molecules. (2012)
- Zhou J, et al. Modulatory effects of quercetin on hypobaric hypoxic rats. Eur J Pharmacol. (2012)
- Chen L, et al. Pentamethylquercetin improves adiponectin expression in differentiated 3T3-L1 cells via a mechanism that implicates PPARγ together with TNF-α and IL-6. Molecules. (2011)
- Kim KY, et al. c-Jun N-terminal kinase is involved in the suppression of adiponectin expression by TNF-alpha in 3T3-L1 adipocytes. Biochem Biophys Res Commun. (2005)
- Fasshauer M, et al. Adiponectin gene expression and secretion is inhibited by interleukin-6 in 3T3-L1 adipocytes. Biochem Biophys Res Commun. (2003)
- Lee J, et al. Isorhamnetin represses adipogenesis in 3T3-L1 cells. Obesity (Silver Spring). (2009)
- Rodhe Y, et al. The effect of sea buckthorn supplement on oral health, inflammation, and DNA damage in hemodialysis patients: a double-blinded, randomized crossover study. J Ren Nutr. (2013)
- Xing J, et al. Effects of sea buckthorn (Hippophaë rhamnoides L.) seed and pulp oils on experimental models of gastric ulcer in rats. Fitoterapia. (2002)
- Huff NK, et al. Effect of sea buckthorn berries and pulp in a liquid emulsion on gastric ulcer scores and gastric juice pH in horses. J Vet Intern Med. (2012)
- Lefebvre VH, et al. Adenine nucleotides and inhibition of protein synthesis in isolated hepatocytes incubated under different pO2 levels. Arch Biochem Biophys. (1993)
- Lluis JM, et al. Critical role of mitochondrial glutathione in the survival of hepatocytes during hypoxia. J Biol Chem. (2005)
- Larmo PS, et al. Oral sea buckthorn oil attenuates tear film osmolarity and symptoms in individuals with dry eye. J Nutr. (2010)
- Järvinen RL, et al. Effects of oral sea buckthorn oil on tear film Fatty acids in individuals with dry eye. Cornea. (2011)
- Luo L, et al. Hyperosmolar saline is a proinflammatory stress on the mouse ocular surface. Eye Contact Lens. (2005)
- [No authors listed. The definition and classification of dry eye disease: report of the Definition and Classification Subcommittee of the International Dry Eye WorkShop (2007). Ocul Surf. (2007)
- Hwang IS, et al. UV radiation-induced skin aging in hairless mice is effectively prevented by oral intake of sea buckthorn (Hippophae rhamnoides L.) fruit blend for 6 weeks through MMP suppression and increase of SOD activity. Int J Mol Med. (2012)
- Majewska I, Gendaszewska-Darmach E. Proangiogenic activity of plant extracts in accelerating wound healing - a new face of old phytomedicines. Acta Biochim Pol. (2011)
- Upadhyay NK, et al. Safety and healing efficacy of Sea buckthorn (Hippophae rhamnoides L.) seed oil on burn wounds in rats. Food Chem Toxicol. (2009)
- Gupta A, et al. Influence of sea buckthorn (Hippophae rhamnoides L.) flavone on dermal wound healing in rats. Mol Cell Biochem. (2006)
- Grad SC, Muresan I, Dumitrascu DL. Generalized yellow skin caused by high intake of sea buckthorn. Forsch Komplementmed. (2012)