Sea Buckthorn
•Last Updated: September 28 2022
Sea buckthorn (Hippophae rhamnoides) is a plant whose leaves are sometimes supplemented (or the berries consumed as juice) for general antiinflammatory and antioxidative purposes. Though healthy, it does not appear to have any unique literature on it to support supplementation.
Sea Buckthorn is most often used for
Last Updated: September 28 2022
Sea buckthorn refers to the plant hippophae rhamnoides, and its usage as a supplement can refer to either the leaves of the plant or the berries that it bears; additionally, the berries can be supplemented as either a dry powder or as an oil derived from the berries. All parts of the plant appear to be bioactive.
This plant appears to be a good source of flavonoids, mostly those structurally related to quercetin and kaempferol. It also has procyanidin (chains of catechin molecules) content like some other plants, with some epigallocatechin and gallocatechin as well (half of the green tea catechins). While Hippophae rhamnoides doesn't have any well researched unique properties (The hippophin molecules are not very well researched by themselves), it appears to be a good collective source of common flavonoid compounds.
Historical usage of this plant has been for cardiovascular and blood health, and it does appear to protect the heart itself in rats and confers anti-platelet effects following higher recommended doses of the supplement in otherwise healthy persons. Some other benefits of this plant, while not completely unique to the plant, include accelerated wound healing and improved skin quality following oral ingestion and some basic neuroprotective properties.
Hippophae rhamnoides is effective at helping with many common health goals that other flavonoids are effective at, and while it seems to have a large base in traditional medicine no highly unique properties or molecules have been detected with this plant yet. Currently, sea buckthorn can be said to be healthy but there is no one reason to supplement with this plant over others that are more effective.
Note that Sea Buckthorn is also known as:
- Hippophae rhamnoides
Sea buckthorn is supplemented as either a dry plant extract (of which both the berries and the leaves are viable options) or as an oil made from the berries.
When supplementing dry extracts, the range of 500-2,000mg is used for both the berry extracts and the leaf extracts. For the oil, slightly higher dosage ranges (2,000-5,000mg) are used daily.
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1.^Saggu S, Divekar HM, Gupta V, Sawhney RC, Banerjee PK, Kumar RAdaptogenic and safety evaluation of seabuckthorn (Hippophae rhamnoides) leaf extract: a dose dependent studyFood Chem Toxicol.(2007 Apr)
2.^Negi B, Kaur R, Dey GProtective effects of a novel sea buckthorn wine on oxidative stress and hypercholesterolemiaFood Funct.(2013 Feb)
3.^Patel CA, Divakar K, Santani D, Solanki HK, Thakkar JHRemedial Prospective of Hippophae rhamnoides Linn. (Sea Buckthorn)ISRN Pharmacol.(2012)
4.^Pichiah PB, Moon HJ, Park JE, Moon YJ, Cha YSEthanolic extract of seabuckthorn (Hippophae rhamnoides L) prevents high-fat diet-induced obesity in mice through down-regulation of adipogenic and lipogenic gene expressionNutr Res.(2012 Nov)
5.^Yang ZG, Wen XF, Li YH, Matsuzaki K, Kitanaka SInhibitory effects of the constituents of Hippophae rhamnoides on 3T3-L1 cell differentiation and nitric oxide production in RAW264.7 cellsChem Pharm Bull (Tokyo).(2013)
6.^Gao W, Chen C, Kong DYHippophins C-F, four new flavonoids, acylated with one monoterpenic acid from the seed residue of Hippophae rhamnoides subsp. sinensisJ Asian Nat Prod Res.(2013 May)
7.^Xu X, Xie B, Pan S, Liu L, Wang Y, Chen CEffects of sea buckthorn procyanidins on healing of acetic acid-induced lesions in the rat stomachAsia Pac J Clin Nutr.(2007)
8.^Arimboor R, Arumughan CEffect of polymerization on antioxidant and xanthine oxidase inhibitory potential of sea buckthorn (H. rhamnoides) proanthocyanidinsJ Food Sci.(2012 Oct)
9.^Isolation of five types of flavonol from seabuckthorn (Hippophae rhamnoides) and induction of apoptosis by some of the flavonols in human promyelotic leukemia HL-60 cells.()
10.^Sharma UK, Sharma K, Sharma N, Sharma A, Singh HP, Sinha AKMicrowave-assisted efficient extraction of different parts of Hippophae rhamnoides for the comparative evaluation of antioxidant activity and quantification of its phenolic constituents by reverse-phase high-performance liquid chromatography (RP-HPLC)J Agric Food Chem.(2008 Jan 23)
11.^Subcritical water extraction of antioxidant compounds from Seabuckthorn (Hippophae rhamnoides) leaves for the comparative evaluation of antioxidant activity.()
12.^Fang R, Veitch NC, Kite GC, Porter EA, Simmonds MSEnhanced Profiling of Flavonol Glycosides in the Fruits of Sea Buckthorn (Hippophae rhamnoides)J Agric Food Chem.(2013 Apr 16)
13.^Arimboor R, Arumughan CHPLC-DAD-MS/MS profiling of antioxidant flavonoid glycosides in sea buckthorn (Hippophae rhamnoides L.) seedsInt J Food Sci Nutr.(2012 Sep)
14.^Tulsawani R, Gupta R, Misra KEfficacy of aqueous extract of Hippophae rhamnoides and its bio-active flavonoids against hypoxia-induced cell deathIndian J Pharmacol.(2013 May)
15.^Zhang J, Gao W, Cao MS, Kong DYThree new flavonoids from the seeds of Hippophae rhamnoides subsp. sinensisJ Asian Nat Prod Res.(2012)
16.^Giuffrida D, Pintea A, Dugo P, Torre G, Pop RM, Mondello LDetermination of carotenoids and their esters in fruits of sea buckthorn (Hippophae rhamnoides L.) by HPLC-DAD-APCI-MSPhytochem Anal.(2012 May-Jun)
17.^Weller P, Breithaupt DEIdentification and quantification of zeaxanthin esters in plants using liquid chromatography-mass spectrometryJ Agric Food Chem.(2003 Nov 19)
18.^Kruczek M, Swiderski A, Mech-Nowak A, Król KAntioxidant capacity of crude extracts containing carotenoids from the berries of various cultivars of Sea buckthorn (Hippophae rhamnoides L.)Acta Biochim Pol.(2012)
19.^Influence of origin, harvesting time and weather conditions on content of inositols and methylinositols in sea buckthorn (Hippophaë rhamnoides) berries.()
20.^Kwon DJ, Bae YS, Ju SM, Goh AR, Youn GS, Choi SY, Park JCasuarinin suppresses TARC/CCL17 and MDC/CCL22 production via blockade of NF-κB and STAT1 activation in HaCaT cellsBiochem Biophys Res Commun.(2012 Jan 27)
21.^Gutzeit D, Klaubert B, Rychlik M, Winterhalter P, Jerz GEffects of processing and of storage on the stability of pantothenic acid in sea buckthorn products (Hippophaë rhamnoides L. ssp. rhamnoides) assessed by stable isotope dilution assayJ Agric Food Chem.(2007 May 16)
22.^Gutzeit D, Mönch S, Jerz G, Winterhalter P, Rychlik MFolate content in sea buckthorn berries and related products (Hippophaë rhamnoides L. ssp. rhamnoides): LC-MS/MS determination of folate vitamer stability influenced by processing and storage assessed by stable isotope dilution assayAnal Bioanal Chem.(2008 May)
23.^Gutzeit D, Baleanu G, Winterhalter P, Jerz GVitamin C content in sea buckthorn berries (Hippophaë rhamnoides L. ssp. rhamnoides) and related products: a kinetic study on storage stability and the determination of processing effectsJ Food Sci.(2008 Nov)
24.^Johansson AK, Korte H, Yang B, Stanley JC, Kallio HPSea buckthorn berry oil inhibits platelet aggregationJ Nutr Biochem.(2000 Oct)
25.^Dulf FVFatty acids in berry lipids of six sea buckthorn (Hippophae rhamnoides L., subspecies carpatica) cultivars grown in RomaniaChem Cent J.(2012 Sep 20)
26.^Socaci SA, Socaciu C, Tofană M, Raţi IV, Pintea AIn-tube Extraction and GC-MS Analysis of Volatile Components from Wild and Cultivated sea buckthorn (Hippophae rhamnoides L. ssp. Carpatica) Berry Varieties and JuicePhytochem Anal.(2013 Jan 15)
27.^Carotenoids in Sea Buckthorn (Hippophae rhamnoides L.) Berries during Ripening and Use of Pheophytin a as a Maturity Marker.()
28.^Li G, Zeng X, Xie Y, Cai Z, Moore JC, Yuan X, Cheng Z, Ji GPharmacokinetic properties of isorhamnetin, kaempferol and quercetin after oral gavage of total flavones of Hippophae rhamnoides L. in rats using a UPLC-MS methodFitoterapia.(2012 Jan)
29.^Zhao G, Duan J, Xie Y, Lin G, Luo H, Li G, Yuan XEffects of solid dispersion and self-emulsifying formulations on the solubility, dissolution, permeability and pharmacokinetics of isorhamnetin, quercetin and kaempferol in total flavones of Hippophae rhamnoides LDrug Dev Ind Pharm.(2013 Jul)
30.^Arimboor R, Arumughan CSea buckthorn (Hippophae rhamnoides) proanthocyanidins inhibit in vitro enzymatic hydrolysis of proteinJ Food Sci.(2011 Aug)
31.^Linderborg KM, Lehtonen HM, Järvinen R, Viitanen M, Kallio HThe fibres and polyphenols in sea buckthorn (Hippophaë rhamnoides) extraction residues delay postprandial lipemiaInt J Food Sci Nutr.(2012 Jun)
32.^Lehtonen HM, Järvinen R, Linderborg K, Viitanen M, Venojärvi M, Alanko H, Kallio HPostprandial hyperglycemia and insulin response are affected by sea buckthorn (Hippophaë rhamnoides ssp. turkestanica) berry and its ethanol-soluble metabolitesEur J Clin Nutr.(2010 Dec)
33.^Xiao M, Qiu X, Yue D, Cai Y, Mo QInfluence of hippophae rhamnoides on two appetite factors, gastric emptying and metabolic parameters, in children with functional dyspepsiaHell J Nucl Med.(2013 Jan-Apr)
34.^Attrey DP, Singh AK, Naved T, Roy BEffect of seabuckthorn extract on scopolamine induced cognitive impairmentIndian J Exp Biol.(2012 Oct)
35.^Saggu S, Kumar RPossible mechanism of adaptogenic activity of seabuckthorn (Hippophae rhamnoides) during exposure to cold, hypoxia and restraint (C-H-R) stress induced hypothermia and post stress recovery in ratsFood Chem Toxicol.(2007 Dec)
36.^Saggu S, Kumar REffect of seabuckthorn leaf extracts on circulating energy fuels, lipid peroxidation and antioxidant parameters in rats during exposure to cold, hypoxia and restraint (C-H-R) stress and post stress recoveryPhytomedicine.(2008 Jun)
37.^Sun B, Sun GB, Xiao J, Chen RC, Wang X, Wu Y, Cao L, Yang ZH, Sun XBIsorhamnetin inhibits H₂O₂-induced activation of the intrinsic apoptotic pathway in H9c2 cardiomyocytes through scavenging reactive oxygen species and ERK inactivationJ Cell Biochem.(2012 Feb)
38.^Malik S, Goyal S, Ojha SK, Bharti S, Nepali S, Kumari S, Singh V, Arya DSSeabuckthorn attenuates cardiac dysfunction and oxidative stress in isoproterenol-induced cardiotoxicity in ratsInt J Toxicol.(2011 Dec)
39.^Cheng J, Kondo K, Suzuki Y, Ikeda Y, Meng X, Umemura KInhibitory effects of total flavones of Hippophae Rhamnoides L on thrombosis in mouse femoral artery and in vitro platelet aggregationLife Sci.(2003 Apr 4)
40.^Modulation of Hypoxia-Induced Pulmonary Vascular Leakage in Rats by Seabuckthorn (Hippophae rhamnoides L.).()
41.^Windsor JS, Rodway GWHeights and haematology: the story of haemoglobin at altitudePostgrad Med J.(2007 Mar)
42.^Jefferson JA, Escudero E, Hurtado ME, Kelly JP, Swenson ER, Wener MH, Burnier M, Maillard M, Schreiner GF, Schoene RB, Hurtado A, Johnson RJHyperuricemia, hypertension, and proteinuria associated with high-altitude polycythemiaAm J Kidney Dis.(2002 Jun)
43.^Zhou JY, Zhou SW, Du XH, Zeng SYProtective effect of total flavonoids of seabuckthorn (Hippophae rhamnoides) in simulated high-altitude polycythemia in ratsMolecules.(2012 Sep 28)
44.^Zhou J, Zhou S, Gao Y, Zeng SModulatory effects of quercetin on hypobaric hypoxic ratsEur J Pharmacol.(2012 Jan 15)
45.^Chen L, He T, Han Y, Sheng JZ, Jin S, Jin MWPentamethylquercetin improves adiponectin expression in differentiated 3T3-L1 cells via a mechanism that implicates PPARγ together with TNF-α and IL-6Molecules.(2011 Jul 6)
46.^Kim KY, Kim JK, Jeon JH, Yoon SR, Choi I, Yang Yc-Jun N-terminal kinase is involved in the suppression of adiponectin expression by TNF-alpha in 3T3-L1 adipocytesBiochem Biophys Res Commun.(2005 Feb 11)
47.^Fasshauer M, Kralisch S, Klier M, Lossner U, Bluher M, Klein J, Paschke RAdiponectin gene expression and secretion is inhibited by interleukin-6 in 3T3-L1 adipocytesBiochem Biophys Res Commun.(2003 Feb 21)
48.^Lee J, Jung E, Lee J, Kim S, Huh S, Kim Y, Kim Y, Byun SY, Kim YS, Park DIsorhamnetin represses adipogenesis in 3T3-L1 cellsObesity (Silver Spring).(2009 Feb)
49.^Rodhe Y, Woodhill T, Thorman R, Möller L, Hylander BThe effect of sea buckthorn supplement on oral health, inflammation, and DNA damage in hemodialysis patients: a double-blinded, randomized crossover studyJ Ren Nutr.(2013 May)
50.^Xing J, Yang B, Dong Y, Wang B, Wang J, Kallio HPEffects of sea buckthorn (Hippophaë rhamnoides L.) seed and pulp oils on experimental models of gastric ulcer in ratsFitoterapia.(2002 Dec)
51.^Huff NK, Auer AD, Garza F Jr, Keowen ML, Kearney MT, McMullin RB, Andrews FMEffect of sea buckthorn berries and pulp in a liquid emulsion on gastric ulcer scores and gastric juice pH in horsesJ Vet Intern Med.(2012 Sep-Oct)
52.^Lefebvre VH, Van Steenbrugge M, Beckers V, Roberfroid M, Buc-Calderon PAdenine nucleotides and inhibition of protein synthesis in isolated hepatocytes incubated under different pO2 levelsArch Biochem Biophys.(1993 Aug 1)
53.^Lluis JM, Morales A, Blasco C, Colell A, Mari M, Garcia-Ruiz C, Fernandez-Checa JCCritical role of mitochondrial glutathione in the survival of hepatocytes during hypoxiaJ Biol Chem.(2005 Feb 4)
54.^Larmo PS, Järvinen RL, Setälä NL, Yang B, Viitanen MH, Engblom JR, Tahvonen RL, Kallio HPOral sea buckthorn oil attenuates tear film osmolarity and symptoms in individuals with dry eyeJ Nutr.(2010 Aug)
55.^Järvinen RL, Larmo PS, Setälä NL, Yang B, Engblom JR, Viitanen MH, Kallio HPEffects of oral sea buckthorn oil on tear film Fatty acids in individuals with dry eyeCornea.(2011 Sep)
56.^Luo L, Li DQ, Corrales RM, Pflugfelder SCHyperosmolar saline is a proinflammatory stress on the mouse ocular surfaceEye Contact Lens.(2005 Sep)
57.^[No authors listedThe definition and classification of dry eye disease: report of the Definition and Classification Subcommittee of the International Dry Eye WorkShop (2007)Ocul Surf.(2007 Apr)
58.^Hwang IS, Kim JE, Choi SI, Lee HR, Lee YJ, Jang MJ, Son HJ, Lee HS, Oh CH, Kim BH, Lee SH, Hwang DYUV radiation-induced skin aging in hairless mice is effectively prevented by oral intake of sea buckthorn (Hippophae rhamnoides L.) fruit blend for 6 weeks through MMP suppression and increase of SOD activityInt J Mol Med.(2012 Aug)
59.^Majewska I, Gendaszewska-Darmach EProangiogenic activity of plant extracts in accelerating wound healing - a new face of old phytomedicinesActa Biochim Pol.(2011)
60.^Upadhyay NK, Kumar R, Mandotra SK, Meena RN, Siddiqui MS, Sawhney RC, Gupta ASafety and healing efficacy of Sea buckthorn (Hippophae rhamnoides L.) seed oil on burn wounds in ratsFood Chem Toxicol.(2009 Jun)
61.^Gupta A, Kumar R, Pal K, Singh V, Banerjee PK, Sawhney RCInfluence of sea buckthorn (Hippophae rhamnoides L.) flavone on dermal wound healing in ratsMol Cell Biochem.(2006 Oct)
62.^Grad SC, Muresan I, Dumitrascu DLGeneralized yellow skin caused by high intake of sea buckthornForsch Komplementmed.(2012)
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