Green Tea Extract

Last Updated: February 1 2023

Green tea extract contains phytochemicals, especially catechins like epigallocatechin gallate(EGCG) and caffeine. EGCG and caffeine have been shown to synergistically influence health indices, including body composition, but the contents within green tea extracts vary among brands. Notably, adverse effects have also been reported upon consuming green tea extract.

Green Tea Extract is most often used for

Summary

Green tea extract (GTE) is derived from the Camellia sinensis plant and is added to dietary supplements such as fat burners. Phytochemicals from this plant, especially epigallocatechin gallate (EGCG) and caffeine, can be found in GTE but in higher concentrations. How, when, and where the Camellia sinensis plant is grown, as well as processing practices, influence the constituents of GTE. Therefore, GTE and its contents vary among products. GTE and its benefits have been investigated in diseases such as obesity, cardiovascular disease, cancer, and type 2 diabetes. A meta-analysis of 11 randomized controlled trials (10 that used GTE and one that used whole green tea) found a statistically significant reduction in body weight, BMI, and body fat in participants with type 2 diabetes.[1] Because the participants all had type 2 diabetes, it’s unclear whether this benefit is also found in people with overweight or obesity but without type 2 diabetes. Other studies also suggest that GTE may benefit cardiovascular health[2] and may have anticancer properties.[3] On the other hand, studies of the effects of GTE on glucose metabolism have reported inconsistent results.[4] Caution should be exercised when taking GTE, as adverse effects have been reported.[5] Such adverse effects include gastrointestinal and liver distress but are considered extremely rare.

What else is Green Tea Extract known as?
Note that Green Tea Extract is also known as:
  • Camellia Sinensis
  • Green Tea Extract
  • GTE
  • Green Tea Catechins
Green Tea Extract should not be confused with:
Dosage information

Most doses are standardized against EGCG. Although the amount of EGCG-equivalent varies from one cup of tea to another, depending on many factors (species of tea, length of steeping, time spent oxidizing), one cup of camellia sinensis green tea contains approximately 50mg of EGCG-equivalent.

The benefits of green tea catechins on lipid oxidation and related fat-burning pathways are achieved in a dose dependent manner. Significant effects in humans are noted only at high doses, such as 400-500mg EGCG equivalent per day (most Green Tea Extract supplements are roughly 50% EGCG). Fat burning effects are highly synergistic, almost dependent, on not consuming caffeine habitually.

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References
1.^Asbaghi O, Fouladvand F, Gonzalez MJ, Aghamohammadi V, Choghakhori R, Abbasnezhad AEffect of Green Tea on Anthropometric Indices and Body Composition in Patients with Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis.Complement Med Res.(2021)
2.^Raman G, Avendano EE, Chen S, Wang J, Matson J, Gayer B, Novotny JA, Cassidy ADietary intakes of flavan-3-ols and cardiometabolic health: systematic review and meta-analysis of randomized trials and prospective cohort studies.Am J Clin Nutr.(2019-11-01)
3.^Tommaso Filippini, Marcella Malavolti, Francesca Borrelli, Angelo A Izzo, Susan J Fairweather-Tait, Markus Horneber, Marco VincetiGreen Tea (Camellia Sinensis) for the Prevention of CancerCochrane Database Syst Rev.(2020 Mar 2)
5.^Oketch-Rabah HA, Roe AL, Rider CV, Bonkovsky HL, Giancaspro GI, Navarro V, Paine MF, Betz JM, Marles RJ, Casper S, Gurley B, Jordan SA, He K, Kapoor MP, Rao TP, Sherker AH, Fontana RJ, Rossi S, Vuppalanchi R, Seeff LB, Stolz A, Ahmad J, Koh C, Serrano J, Low Dog T, Ko RUnited States Pharmacopeia (USP) comprehensive review of the hepatotoxicity of green tea extracts.Toxicol Rep.(2020)
6.^Park YS, Lee MK, Heo BG, Ham KS, Kang SG, Cho JY, Gorinstein SComparison of the nutrient and chemical contents of traditional Korean Chungtaejeon and green teasPlant Foods Hum Nutr.(2010 Jun)
7.^Park SK, Jung IC, Lee WK, Lee YS, Park HK, Go HJ, Kim K, Lim NK, Hong JT, Ly SY, Rho SSA combination of green tea extract and l-theanine improves memory and attention in subjects with mild cognitive impairment: a double-blind placebo-controlled studyJ Med Food.(2011 Apr)
9.^Mantione KJ, Kream RM, Stefano GBCatechol-O-methyltransferase: potential relationship to idiopathic hypertensionArch Med Sci.(2010 Jun 30)
11.^Keränen T, Gordin A, Karlsson M, Korpela K, Pentikäinen PJ, Rita H, Schultz E, Seppälä L, Wikberg TInhibition of soluble catechol-O-methyltransferase and single-dose pharmacokinetics after oral and intravenous administration of entacaponeEur J Clin Pharmacol.(1994)
12.^Nissinen E, Lindén IB, Schultz E, Pohto PBiochemical and pharmacological properties of a peripherally acting catechol-O-methyltransferase inhibitor entacaponeNaunyn Schmiedebergs Arch Pharmacol.(1992 Sep)
13.^Okushio K, Suzuki M, Matsumoto N, Nanjo F, Hara YMethylation of tea catechins by rat liver homogenatesBiosci Biotechnol Biochem.(1999 Feb)
16.^Gugler R, Dengler HJInhibition of human liver catechol-O-methyltransferase by flavonoidsNaunyn Schmiedebergs Arch Pharmacol.(1973)
18.^Steffen Y, Gruber C, Schewe T, Sies HMono-O-methylated flavanols and other flavonoids as inhibitors of endothelial NADPH oxidaseArch Biochem Biophys.(2008 Jan 15)
19.^Werner P, Di Rocco A, Prikhojan A, Rempel N, Bottiglieri T, Bressman S, Yahr MDCOMT-dependent protection of dopaminergic neurons by methionine, dimethionine and S-adenosylmethionine (SAM) against L-dopa toxicity in vitroBrain Res.(2001 Mar 2)
20.^Ghimire LV, Kohli U, Li C, Sofowora GG, Muszkat M, Friedman EA, Solus JF, Wood AJ, Stein CM, Kurnik DCatecholamine pathway gene variation is associated with norepinephrine and epinephrine concentrations at rest and after exercisePharmacogenet Genomics.(2012 Apr)
21.^Miller RJ, Jackson KG, Dadd T, Mayes AE, Brown AL, Lovegrove JA, Minihane AMThe impact of the catechol-O-methyltransferase genotype on vascular function and blood pressure after acute green tea ingestionMol Nutr Food Res.(2012 Jun)
22.^Inoue-Choi M, Yuan JM, Yang CS, Van Den Berg DJ, Lee MJ, Gao YT, Yu MCGenetic Association Between the COMT Genotype and Urinary Levels of Tea Polyphenols and Their Metabolites among Daily Green Tea DrinkersInt J Mol Epidemiol Genet.(2010)
23.^Hodgson AB, Randell RK, Boon N, Garczarek U, Mela DJ, Jeukendrup AE, Jacobs DMMetabolic response to green tea extract during rest and moderate-intensity exerciseJ Nutr Biochem.(2012 Sep 10)
25.^Pellegrini R et al.Laminin receptor expression and function in small-cell lung carcinomaInt J Cancer Suppl.(1994)
26.^Tachibana H et al.A receptor for green tea polyphenol EGCGNat Struct Mol Biol.(2004)
27.^Warden BA, Smith LS, Beecher GR, Balentine DA, Clevidence BACatechins are bioavailable in men and women drinking black tea throughout the dayJ Nutr.(2001 Jun)
28.^Lambert JD1, Hong J, Kim DH, Mishin VM, Yang CSPiperine enhances the bioavailability of the tea polyphenol (-)-epigallocatechin-3-gallate in miceJ Nutr.(2004 Aug)
29.^Chen L1, Lee MJ, Li H, Yang CSAbsorption, distribution, elimination of tea polyphenols in ratsDrug Metab Dispos.(1997 Sep)
33.^Chow HH, Hakim IA, Vining DR, Crowell JA, Ranger-Moore J, Chew WM, Celaya CA, Rodney SR, Hara Y, Alberts DSEffects of dosing condition on the oral bioavailability of green tea catechins after single-dose administration of Polyphenon E in healthy individualsClin Cancer Res.(2005 Jun 15)
34.^Lambert JD1, Lee MJ, Lu H, Meng X, Hong JJ, Seril DN, Sturgill MG, Yang CSEpigallocatechin-3-gallate is absorbed but extensively glucuronidated following oral administration to miceJ Nutr.(2003 Dec)
37.^Chow HH, Cai Y, Hakim IA, Crowell JA, Shahi F, Brooks CA, Dorr RT, Hara Y, Alberts DSPharmacokinetics and safety of green tea polyphenols after multiple-dose administration of epigallocatechin gallate and polyphenon E in healthy individualsClin Cancer Res.(2003 Aug 15)
41.^Del Rio D, Calani L, Cordero C, Salvatore S, Pellegrini N, Brighenti FBioavailability and catabolism of green tea flavan-3-ols in humansNutrition.(2010 Nov-Dec)
43.^Yang CS, Chen L, Lee MJ, Balentine D, Kuo MC, Schantz SPBlood and urine levels of tea catechins after ingestion of different amounts of green tea by human volunteersCancer Epidemiol Biomarkers Prev.(1998 Apr)
44.^Henning SM, Niu Y, Liu Y, Lee NH, Hara Y, Thames GD, Minutti RR, Carpenter CL, Wang H, Heber DBioavailability and antioxidant effect of epigallocatechin gallate administered in purified form versus as green tea extract in healthy individualsJ Nutr Biochem.(2005 Oct)
47.^Lambert JD, Sang S, Yang CSPossible controversy over dietary polyphenols: benefits vs risksChem Res Toxicol.(2007 Apr)
48.^Miller RJ, Jackson KG, Dadd T, Nicol B, Dick JL, Mayes AE, Brown AL, Minihane AMA preliminary investigation of the impact of catechol-O-methyltransferase genotype on the absorption and metabolism of green tea catechinsEur J Nutr.(2012 Feb)
49.^Hursel R, Viechtbauer W, Westerterp-Plantenga MSThe effects of green tea on weight loss and weight maintenance: a meta-analysisInt J Obes (Lond).(2009 Sep)
50.^Suganuma M, Okabe S, Oniyama M, Tada Y, Ito H, Fujiki HWide distribution of {3H}(-)-epigallocatechin gallate, a cancer preventive tea polyphenol, in mouse tissueCarcinogenesis.(1998 Oct)
51.^Scholey A, Downey LA, Ciorciari J, Pipingas A, Nolidin K, Finn M, Wines M, Catchlove S, Terrens A, Barlow E, Gordon L, Stough CAcute neurocognitive effects of epigallocatechin gallate (EGCG)Appetite.(2012 Apr)
53.^Vignes M, Maurice T, Lanté F, Nedjar M, Thethi K, Guiramand J, Récasens MAnxiolytic properties of green tea polyphenol (-)-epigallocatechin gallate (EGCG)Brain Res.(2006 Sep 19)
56.^Heese T, Jenkinson J, Love C, Milam R, Perkins L, Adams C, McCall S, Ceremuga TEAnxiolytic effects of L-theanine--a component of green tea--when combined with midazolam, in the male Sprague-Dawley ratAANA J.(2009 Dec)
57.^Lu K, Gray MA, Oliver C, Liley DT, Harrison BJ, Bartholomeusz CF, Phan KL, Nathan PJThe acute effects of L-theanine in comparison with alprazolam on anticipatory anxiety in humansHum Psychopharmacol.(2004 Oct)
58.^Sachdeva AK, Kuhad A, Tiwari V, Arora V, Chopra KProtective effect of epigallocatechin gallate in murine water-immersion stress model of chronic fatigue syndromeBasic Clin Pharmacol Toxicol.(2010 Jun)
63.^Fitzpatrick DF, Hirschfield SL, Ricci T, Jantzen P, Coffey RGEndothelium-dependent vasorelaxation caused by various plant extractsJ Cardiovasc Pharmacol.(1995 Jul)
64.^Loke WM, Hodgson JM, Proudfoot JM, McKinley AJ, Puddey IB, Croft KDPure dietary flavonoids quercetin and (-)-epicatechin augment nitric oxide products and reduce endothelin-1 acutely in healthy menAm J Clin Nutr.(2008 Oct)
67.^Lorenz M, Jochmann N, von Krosigk A, Martus P, Baumann G, Stangl K, Stangl VAddition of milk prevents vascular protective effects of teaEur Heart J.(2007 Jan)
68.^van der Burg-Koorevaar MC, Miret S, Duchateau GSEffect of milk and brewing method on black tea catechin bioaccessibilityJ Agric Food Chem.(2011 Jul 27)
69.^Pfeuffer M, Schrezenmeir JAddition of milk prevents vascular protective effects of teaEur Heart J.(2007 May)
70.^Prabhakar VR, Venkatesan NMilk casein and its benefits on cardiovascular riskEur Heart J.(2007 Jun)
72.^Abe I, Seki T, Noguchi HPotent and selective inhibition of squalene epoxidase by synthetic galloyl estersBiochem Biophys Res Commun.(2000 Apr 2)
84.^Karhunen T et al.Distribution of catechol-O-methyltransferase enzyme in rat tissuesJ Histochem Cytochem.(1994)
89.^Thielecke F, Rahn G, Böhnke J, Adams F, Birkenfeld AL, Jordan J, Boschmann MEpigallocatechin-3-gallate and postprandial fat oxidation in overweight/obese male volunteers: a pilot studyEur J Clin Nutr.(2010 Jul)
91.^Brown AL, Lane J, Holyoak C, Nicol B, Mayes AE, Dadd THealth effects of green tea catechins in overweight and obese men: a randomised controlled cross-over trialBr J Nutr.(2011 Dec)
93.^Derdemezis CS, Kiortsis DN, Tsimihodimos V, Petraki MP, Vezyraki P, Elisaf MS, Tselepis ADEffect of Plant Polyphenols on Adipokine Secretion from Human SGBS AdipocytesBiochem Res Int.(2011)
94.^Wolfram S, Raederstorff D, Wang Y, Teixeira SR, Elste V, Weber PTEAVIGO (epigallocatechin gallate) supplementation prevents obesity in rodents by reducing adipose tissue massAnn Nutr Metab.(2005 Jan-Feb)
96.^Furuyashiki T, Nagayasu H, Aoki Y, Bessho H, Hashimoto T, Kanazawa K, Ashida HTea catechin suppresses adipocyte differentiation accompanied by down-regulation of PPARgamma2 and C/EBPalpha in 3T3-L1 cellsBiosci Biotechnol Biochem.(2004 Nov)
100.^Chen N, Bezzina R, Hinch E, Lewandowski PA, Cameron-Smith D, Mathai ML, Jois M, Sinclair AJ, Begg DP, Wark JD, Weisinger HS, Weisinger RSGreen tea, black tea, and epigallocatechin modify body composition, improve glucose tolerance, and differentially alter metabolic gene expression in rats fed a high-fat dietNutr Res.(2009 Nov)
102.^Wang Y, Jones Voy B, Urs S, Kim S, Soltani-Bejnood M, Quigley N, Heo YR, Standridge M, Andersen B, Dhar M, Joshi R, Wortman P, Taylor JW, Chun J, Leuze M, Claycombe K, Saxton AM, Moustaid-Moussa NThe human fatty acid synthase gene and de novo lipogenesis are coordinately regulated in human adipose tissueJ Nutr.(2004 May)
105.^Nagao T, Komine Y, Soga S, Meguro S, Hase T, Tanaka Y, Tokimitsu IIngestion of a tea rich in catechins leads to a reduction in body fat and malondialdehyde-modified LDL in menAm J Clin Nutr.(2005 Jan)
106.^Gregersen NT, Bitz C, Krog-Mikkelsen I, Hels O, Kovacs EM, Rycroft JA, Frandsen E, Mela DJ, Astrup AEffect of moderate intakes of different tea catechins and caffeine on acute measures of energy metabolism under sedentary conditionsBr J Nutr.(2009 Oct)
108.^Seifert JG, Nelson A, Devonish J, Burke ER, Stohs SJEffect of acute administration of an herbal preparation on blood pressure and heart rate in humansInt J Med Sci.(2011 Mar 2)
109.^Wang H, Wen Y, Du Y, Yan X, Guo H, Rycroft JA, Boon N, Kovacs EM, Mela DJEffects of catechin enriched green tea on body compositionObesity (Silver Spring).(2010 Apr)
110.^Maki KC, Reeves MS, Farmer M, Yasunaga K, Matsuo N, Katsuragi Y, Komikado M, Tokimitsu I, Wilder D, Jones F, Blumberg JB, Cartwright YGreen tea catechin consumption enhances exercise-induced abdominal fat loss in overweight and obese adultsJ Nutr.(2009 Feb)
111.^Hursel R, Viechtbauer W, Dulloo AG, Tremblay A, Tappy L, Rumpler W, Westerterp-Plantenga MSThe effects of catechin rich teas and caffeine on energy expenditure and fat oxidation: a meta-analysisObes Rev.(2011 Jul)
112.^Dean S, Braakhuis A, Paton CThe effects of EGCG on fat oxidation and endurance performance in male cyclistsInt J Sport Nutr Exerc Metab.(2009 Dec)
114.^Richards JC, Lonac MC, Johnson TK, Schweder MM, Bell CEpigallocatechin-3-gallate increases maximal oxygen uptake in adult humansMed Sci Sports Exerc.(2010 Apr)
115.^Strong R, Miller RA, Astle CM, Baur JA, de Cabo R, Fernandez E, Guo W, Javors M, Kirkland JL, Nelson JF, Sinclair DA, Teter B, Williams D, Zaveri N, Nadon NL, Harrison DEEvaluation of Resveratrol, Green Tea Extract, Curcumin, Oxaloacetic Acid, and Medium-Chain Triglyceride Oil on Life Span of Genetically Heterogeneous MiceJ Gerontol A Biol Sci Med Sci.(2012 Mar 26)
122.^Murase T, Haramizu S, Shimotoyodome A, Nagasawa A, Tokimitsu IGreen tea extract improves endurance capacity and increases muscle lipid oxidation in miceAm J Physiol Regul Integr Comp Physiol.(2005 Mar)
124.^Nobbs AH, Jenkinson HF, Jakubovics NSStick to your gums: mechanisms of oral microbial adherenceJ Dent Res.(2011)
125.^Abdulbaqi HR, Himratul-Aznita WH, Baharuddin NAEvaluation of Salvadora persica L. and green tea anti-plaque effect: a randomized controlled crossover clinical trialBMC Complement Altern Med.(2016)
129.^Zhao LJ et al.Relationship of obesity with osteoporosisJ Clin Endocrinol Metab.(2007)
130.^Watts NB, GLOW investigatorsInsights from the Global Longitudinal Study of Osteoporosis in Women (GLOW)Nat Rev Endocrinol.(2014)
137.^Nishikawa H, Wakano K, Kitani SInhibition of NADPH oxidase subunits translocation by tea catechin EGCG in mast cellBiochem Biophys Res Commun.(2007)
141.^Wu AH, Spicer D, Stanczyk FZ, Tseng CC, Yang CS, Pike MCEffect of 2-month controlled green tea intervention on lipoprotein cholesterol, glucose, and hormone levels in healthy postmenopausal womenCancer Prev Res (Phila).(2012 Mar)
143.^Figueiroa MS, César Vieira JS, Leite DS, Filho RC, Ferreira F, Gouveia PS, Udrisar DP, Wanderley MIGreen tea polyphenols inhibit testosterone production in rat Leydig cellsAsian J Androl.(2009 May)
144.^Satoh K, Sakamoto Y, Ogata A, Nagai F, Mikuriya H, Numazawa M, Yamada K, Aoki NInhibition of aromatase activity by green tea extract catechins and their endocrinological effects of oral administration in ratsFood Chem Toxicol.(2002 Jul)
145.^Hiipakka RA, Zhang HZ, Dai W, Dai Q, Liao SStructure-activity relationships for inhibition of human 5alpha-reductases by polyphenolsBiochem Pharmacol.(2002 Mar 15)
147.^Young JF, Dragstedt LO, Haraldsdóttir J, Daneshvar B, Kall MA, Loft S, Nilsson L, Nielsen SE, Mayer B, Skibsted LH, Huynh-Ba T, Hermetter A, Sandström BGreen tea extract only affects markers of oxidative status postprandially: lasting antioxidant effect of flavonoid-free dietBr J Nutr.(2002 Apr)
151.^Li Y, Chang SC, Goldstein BY, Scheider WL, Cai L, You NC, Tarleton HP, Ding B, Zhao J, Wu M, Jiang Q, Yu S, Rao J, Lu QY, Zhang ZF, Mu LGreen tea consumption, inflammation and the risk of primary hepatocellular carcinoma in a Chinese populationCancer Epidemiol.(2011 Aug)
153.^Yu MC, Yuan JMEnvironmental factors and risk for hepatocellular carcinomaGastroenterology.(2004 Nov)
154.^Wang N, Zheng Y, Jiang Q, Yu X, Chen YTea and reduced liver cancer mortalityEpidemiology.(2008 Sep)
155.^Ui A, Kuriyama S, Kakizaki M, Sone T, Nakaya N, Ohmori-Matsuda K, Hozawa A, Nishino Y, Tsuji IGreen tea consumption and the risk of liver cancer in Japan: the Ohsaki Cohort studyCancer Causes Control.(2009 Dec)
156.^Montella M, Polesel J, La Vecchia C, Dal Maso L, Crispo A, Crovatto M, Casarin P, Izzo F, Tommasi LG, Talamini R, Franceschi SCoffee and tea consumption and risk of hepatocellular carcinoma in ItalyInt J Cancer.(2007 Apr 1)
158.^Chow HH, Hakim IA, Vining DR, Crowell JA, Cordova CA, Chew WM, Xu MJ, Hsu CH, Ranger-Moore J, Alberts DSEffects of repeated green tea catechin administration on human cytochrome P450 activityCancer Epidemiol Biomarkers Prev.(2006 Dec)
160.^Sohn OS, Surace A, Fiala ES, Richie JP Jr, Colosimo S, Zang E, Weisburger JHEffects of green and black tea on hepatic xenobiotic metabolizing systems in the male F344 ratXenobiotica.(1994 Feb)
161.^Bu-Abbas A, Clifford MN, Walker R, Ioannides CSelective induction of rat hepatic CYP1 and CYP4 proteins and of peroxisomal proliferation by green teaCarcinogenesis.(1994 Nov)
162.^Ayalogu EO, Snelling J, Lewis DF, Talwar S, Clifford MN, Ioannides CInduction of hepatic CYP1A2 by the oral administration of caffeine to rats: lack of association with the Ah locusBiochim Biophys Acta.(1995 Oct 17)
163.^Goasduff T, Dréano Y, Guillois B, Ménez JF, Berthou FInduction of liver and kidney CYP1A1/1A2 by caffeine in ratBiochem Pharmacol.(1996 Dec 24)
164.^Janle EM, Morré DM, Morré DJ, Zhou Q, Zhu YPharmacokinetics of Green Tea Catechins in Extract and Sustained-Release PreparationsJ Diet Suppl.(2008 Nov 1)
166.^Morré DJ, Morré DM, Sun H, Cooper R, Chang J, Janle EMTea catechin synergies in inhibition of cancer cell proliferation and of a cancer specific cell surface oxidase (ECTO-NOX)Pharmacol Toxicol.(2003 May)
168.^Berger SJ, Gupta S, Belfi CA, Gosky DM, Mukhtar HGreen tea constituent (--)-epigallocatechin-3-gallate inhibits topoisomerase I activity in human colon carcinoma cellsBiochem Biophys Res Commun.(2001 Oct 19)
170.^Ahmad N, Feyes DK, Nieminen AL, Agarwal R, Mukhtar HGreen tea constituent epigallocatechin-3-gallate and induction of apoptosis and cell cycle arrest in human carcinoma cellsJ Natl Cancer Inst.(1997 Dec 17)
172.^Nishikawa T, Nakajima T, Moriguchi M, Jo M, Sekoguchi S, Ishii M, Takashima H, Katagishi T, Kimura H, Minami M, Itoh Y, Kagawa K, Okanoue TA green tea polyphenol, epigalocatechin-3-gallate, induces apoptosis of human hepatocellular carcinoma, possibly through inhibition of Bcl-2 family proteinsJ Hepatol.(2006 Jun)
174.^Nguyen MM, Ahmann FR, Nagle RB, Hsu CH, Tangrea JA, Parnes HL, Sokoloff MH, Gretzer MB, Chow HHRandomized, double-blind, placebo-controlled trial of polyphenon E in prostate cancer patients before prostatectomy: evaluation of potential chemopreventive activitiesCancer Prev Res (Phila).(2012 Feb)
176.^Yang CS, Wang X, Lu G, Picinich SCCancer prevention by tea: animal studies, molecular mechanisms and human relevanceNat Rev Cancer.(2009 Jun)
178.^Kitani K, Yokozawa T, Osawa TInterventions in aging and age-associated pathologies by means of nutritional approachesAnn N Y Acad Sci.(2004 Jun)
189.^Chung JH, Kim S, Lee SJ, Chung JO, Oh YJ, Shim SMGreen tea formulations with vitamin C and xylitol on enhanced intestinal transport of green tea catechinsJ Food Sci.(2013 May)
192.^Diepvens K, Westerterp KR, Westerterp-Plantenga MSObesity and thermogenesis related to the consumption of caffeine, ephedrine, capsaicin, and green teaAm J Physiol Regul Integr Comp Physiol.(2007 Jan)
193.^Dulloo AG, Seydoux J, Girardier L, Chantre P, Vandermander JGreen tea and thermogenesis: interactions between catechin-polyphenols, caffeine and sympathetic activityInt J Obes Relat Metab Disord.(2000 Feb)
194.^Dulloo AG, Duret C, Rohrer D, Girardier L, Mensi N, Fathi M, Chantre P, Vandermander JEfficacy of a green tea extract rich in catechin polyphenols and caffeine in increasing 24-h energy expenditure and fat oxidation in humansAm J Clin Nutr.(1999 Dec)
195.^Dulloo AG, Geissler CA, Horton T, Collins A, Miller DSNormal caffeine consumption: influence on thermogenesis and daily energy expenditure in lean and postobese human volunteersAm J Clin Nutr.(1989 Jan)
196.^Westerterp-Plantenga MSGreen tea catechins, caffeine and body-weight regulationPhysiol Behav.(2010 Apr 26)
197.^Kovacs EM, Lejeune MP, Nijs I, Westerterp-Plantenga MSEffects of green tea on weight maintenance after body-weight lossBr J Nutr.(2004 Mar)
198.^Morré DJ, Morré DMSynergistic Capsicum-tea mixtures with anticancer activityJ Pharm Pharmacol.(2003 Jul)
199.^Morré DM, Morré DJCatechin-vanilloid synergies with potential clinical applications in cancerRejuvenation Res.(2006 Spring)
201.^Zhou Q, Zhu Y, Chiang H, Yagiz K, Morre DJ, Morre DM, Janle E, Kissinger PTIdentification of the major vanilloid component in Capsicum extract by HPLC-EC and HPLC-MSPhytochem Anal.(2004 Mar-Apr)
202.^Shimizu M, Kobayashi Y, Suzuki M, Satsu H, Miyamoto YRegulation of intestinal glucose transport by tea catechinsBiofactors.(2000)
203.^Kobayashi Y, Suzuki M, Satsu H, Arai S, Hara Y, Suzuki K, Miyamoto Y, Shimizu MGreen tea polyphenols inhibit the sodium-dependent glucose transporter of intestinal epithelial cells by a competitive mechanismJ Agric Food Chem.(2000 Nov)
206.^Naz S, Siddiqi R, Dew TP, Williamson GEpigallocatechin-3-gallate inhibits lactase but is alleviated by salivary proline-rich proteinsJ Agric Food Chem.(2011 Mar 23)
208.^Lochocka K, Bajerska J, Glapa A, Fidler-Witon E, Nowak JK, Szczapa T, Grebowiec P, Lisowska A, Walkowiak JGreen tea extract decreases starch digestion and absorption from a test meal in humans: a randomized, placebo-controlled crossover studySci Rep.(2015 Jul 30)
209.^Juhel C, Armand M, Pafumi Y, Rosier C, Vandermander J, Lairon DGreen tea extract (AR25) inhibits lipolysis of triglycerides in gastric and duodenal medium in vitroJ Nutr Biochem.(2000 Jan)
210.^Nakai M, Fukui Y, Asami S, Toyoda-Ono Y, Iwashita T, Shibata H, Mitsunaga T, Hashimoto F, Kiso YInhibitory effects of oolong tea polyphenols on pancreatic lipase in vitroJ Agric Food Chem.(2005 Jun 1)
213.^Ikeda I, Imasato Y, Sasaki E, Nakayama M, Nagao H, Takeo T, Yayabe F, Sugano MTea catechins decrease micellar solubility and intestinal absorption of cholesterol in ratsBiochim Biophys Acta.(1992 Jul 29)
214.^Raederstorff DG, Schlachter MF, Elste V, Weber PEffect of EGCG on lipid absorption and plasma lipid levels in ratsJ Nutr Biochem.(2003 Jun)
215.^Afzal M, Safer AM, Al-Bloushi SCoQ9 potentiates green tea antioxidant activities in Wistar ratsBiofactors.(2005)
216.^Manikandan R, Beulaja M, Arulvasu C, Sellamuthu S, Dinesh D, Prabhu D, Babu G, Vaseeharan B, Prabhu NMSynergistic anticancer activity of curcumin and catechin: an in vitro study using human cancer cell linesMicrosc Res Tech.(2012 Feb)
217.^Xu G, Ren G, Xu X, Yuan H, Wang Z, Kang L, Yu W, Tian KCombination of curcumin and green tea catechins prevents dimethylhydrazine-induced colon carcinogenesisFood Chem Toxicol.(2010 Jan)
218.^Xu G, Huang W, Zhang WM, Lai ZS, He MR, Wang YD, Zhang YLEffects of combined use of curcumin and catechin on cyclooxygenase-2 mRNA expression in dimethylhydrazine-induced rat colon carcinogenesisDi Yi Jun Yi Da Xue Xue Bao.(2005 Jan)
219.^Saha A, Kuzuhara T, Echigo N, Suganuma M, Fujiki HNew role of (-)-epicatechin in enhancing the induction of growth inhibition and apoptosis in human lung cancer cells by curcuminCancer Prev Res (Phila).(2010 Aug)
220.^Zijp IM, Korver O, Tijburg LBEffect of tea and other dietary factors on iron absorptionCrit Rev Food Sci Nutr.(2000 Sep)
224.^Ullmann U, Haller J, Bakker GC, Brink EJ, Weber PEpigallocatechin gallate (EGCG) (TEAVIGO) does not impair nonhaem-iron absorption in manPhytomedicine.(2005 Jun)
227.^Giunta B, Hou H, Zhu Y, Salemi J, Ruscin A, Shytle RD, Tan JFish oil enhances anti-amyloidogenic properties of green tea EGCG in Tg2576 miceNeurosci Lett.(2010 Mar 8)
231.^McMillan B, Riggs DR, Jackson BJ, Cunningham C, McFadden DWDietary influence on pancreatic cancer growth by catechin and inositol hexaphosphateJ Surg Res.(2007 Jul)
239.^van Zanden JJ, Wortelboer HM, Bijlsma S, Punt A, Usta M, Bladeren PJ, Rietjens IM, Cnubben NHQuantitative structure activity relationship studies on the flavonoid mediated inhibition of multidrug resistance proteins 1 and 2Biochem Pharmacol.(2005 Feb 15)
240.^Yang CS, Sang S, Lambert JD, Lee MJBioavailability issues in studying the health effects of plant polyphenolic compoundsMol Nutr Food Res.(2008 Jun)
241.^Borst P, Evers R, Kool M, Wijnholds JThe multidrug resistance protein familyBiochim Biophys Acta.(1999 Dec 6)
242.^Jain DP, Pancholi SS, Patel RSynergistic antioxidant activity of green tea with some herbsJ Adv Pharm Technol Res.(2011 Jul)
244.^Hwang JT, Park IJ, Shin JI, Lee YK, Lee SK, Baik HW, Ha J, Park OJGenistein, EGCG, and capsaicin inhibit adipocyte differentiation process via activating AMP-activated protein kinaseBiochem Biophys Res Commun.(2005 Dec 16)
245.^Huang X, Kojima-Yuasa A, Xu S, Norikura T, Kennedy DO, Hasuma T, Matsui-Yuasa IGreen tea extract enhances the selective cytotoxic activity of Zizyphus jujuba extracts in HepG2 cellsAm J Chin Med.(2008)
247.^Ullmann U, Haller J, Decourt JP, Girault N, Girault J, Richard-Caudron AS, Pineau B, Weber PA single ascending dose study of epigallocatechin gallate in healthy volunteersJ Int Med Res.(2003 Mar-Apr)
249.^[No authors listedBody surface area for adjustment of drug doseDrug Ther Bull.(2010 Mar)
250.^Kouno T, Katsumata N, Mukai H, Ando M, Watanabe TStandardization of the body surface area (BSA) formula to calculate the dose of anticancer agents in JapanJpn J Clin Oncol.(2003 Jun)
251.^Isbrucker RA, Edwards JA, Wolz E, Davidovich A, Bausch JSafety studies on epigallocatechin gallate (EGCG) preparations. Part 2: dermal, acute and short-term toxicity studiesFood Chem Toxicol.(2006 May)
252.^Galati G, Lin A, Sultan AM, O'Brien PJCellular and in vivo hepatotoxicity caused by green tea phenolic acids and catechinsFree Radic Biol Med.(2006 Feb 15)