Things To Know & Note
Is a Form Of
Other Functions:
Also Known As
Thiamine
Caution Notice
Examine.com Medical DisclaimerHow to Take Vitamin B1
Recommended dosage, active amounts, other details
Thiamine supplements are usually taken at doses well above the RDA, such as 100-300mg, in instances where thiamine is considered to be deficient such as high blood sugar or high alcohol intake. When using thiamine at this dose timing does not matter much and either one dose can be taken in the morning or multiple doses throughout; thiamine does not need to be ingested with food to be absorbed.
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Human Effect Matrix
The Human Effect Matrix looks at human studies (it excludes animal and in vitro studies) to tell you what effects vitamin b1 has on your body, and how strong these effects are.
Grade | Level of Evidence [show legend] |
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Robust research conducted with repeated double-blind clinical trials |
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Multiple studies where at least two are double-blind and placebo controlled |
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Single double-blind study or multiple cohort studies |
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Uncontrolled or observational studies only |
Level of Evidence
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The amount of high quality evidence. The more
evidence, the more we can trust the results.
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Outcome |
Magnitude of effect
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The direction and size of the supplement's impact on
each outcome. Some supplements can have an increasing effect, others have a decreasing effect, and others have no effect.
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Consistency of research results
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Scientific research does not always agree. HIGH or
VERY HIGH means that most of the scientific research agrees.
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Notes |
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Very High See 2 studies |
One study found a staggering reduction in symptoms with 100 mg of vitamin B1 daily. It wasn't clear what the baseline vitamin B1 status of the participants was. Another study found a notable benefit of 100 mg daily over 2 months, and also that the improvement was additive with calcium, with the combination being notably more potent than either separately. Much more research is needed.
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- See study |
In instances where thiamine is deficient, replenishment of thiamine appears to cause a modest decrease in blood pressure.
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- | - See study |
No changes of note in people with high blood sugar
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- | - See study |
No significant changes in people with hyperglycemia
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- | - See study |
No change noted in those with high blood sugar
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- | - See study |
No change noted in people with high blood sugar
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- | - See study |
No observed changes in a population with hyperglycemia
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Frequently Asked Questions about Vitamin B1
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Research Breakdown on Vitamin B1
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References
- ^ a b c Thornalley PJ et al.. High prevalence of low plasma thiamine concentration in diabetes linked to a marker of vascular disease. Diabetologia. (2007)
- ^ a b c Hoyumpa AM Jr. Mechanisms of thiamin deficiency in chronic alcoholism. Am J Clin Nutr. (1980)
- ^ a b c Kerns JC1, Arundel C2, Chawla LS. Thiamin deficiency in people with obesity. Adv Nutr. (2015)
- ^ Flancbaum L et al.. Preoperative nutritional status of patients undergoing Roux-en-Y gastric bypass for morbid obesity. J Gastrointest Surg. (2006)
- ^ Carrodeguas L et al.. Preoperative thiamine deficiency in obese population undergoing laparoscopic bariatric surgery. Surg Obes Relat Dis. (2005)
- ^ Lonsdale D. A review of the biochemistry, metabolism and clinical benefits of thiamin(e) and its derivatives. Evid Based Complement Alternat Med. (2006)
- ^ Wada T et al.. A new thiamine derivative, S-benzoylthiamine O-monophosphate. Science. (1961)
- ^ Balakumar P et al.. The multifaceted therapeutic potential of benfotiamine. Pharmacol Res. (2010)
- ^ Hassan R, Qureshi H, Zuberi SJ. Effect of thiamine on glucose utilization in hepatic cirrhosis. J Gastroenterol Hepatol. (1991)
- Abdollahifard S, Rahmanian Koshkaki A, Moazamiyanfar R. The effects of vitamin B1 on ameliorating the premenstrual syndrome symptoms. Glob J Health Sci. (2014)
- Depeint F, et al. Mitochondrial function and toxicity: role of the B vitamin family on mitochondrial energy metabolism. Chem Biol Interact. (2006)
- Selhub J. Folate, vitamin B12 and vitamin B6 and one carbon metabolism. J Nutr Health Aging. (2002)
- Chen AC, et al. A Phase 3 Randomized Trial of Nicotinamide for Skin-Cancer Chemoprevention. N Engl J Med. (2015)
- Brasky TM, White E, Chen CL. Long-Term, Supplemental, One-Carbon Metabolism-Related Vitamin B Use in Relation to Lung Cancer Risk in the Vitamins and Lifestyle (VITAL) Cohort. J Clin Oncol. (2017)
- White E, et al. VITamins And Lifestyle cohort study: study design and characteristics of supplement users. Am J Epidemiol. (2004)
- Kim YI. Folate and colorectal cancer: an evidence-based critical review. Mol Nutr Food Res. (2007)
- Kok DE, et al. The effects of long-term daily folic acid and vitamin B12 supplementation on genome-wide DNA methylation in elderly subjects. Clin Epigenetics. (2015)
- Corbin JM, Ruiz-Echevarría MJ. One-Carbon Metabolism in Prostate Cancer: The Role of Androgen Signaling. Int J Mol Sci. (2016)