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Vitamin B1

Thiamine (Vitamin B1) is an essential vitamin involved heavily in glucose production. While not a common deficiency in an otherwise healthy diet and limited benefits when taken by a healthy subject, instances of high blood glucose and/or alcoholism can increase the need for this vitamin drastically.

Our evidence-based analysis on vitamin b1 features 18 unique references to scientific papers.

Research analysis led by .
Reviewed by
Examine.com Team
Last Updated:

How to Take

Medical Disclaimer

Recommended dosage, active amounts, other details

Thiamine supplements are usually taken at doses well above the RDA, such as 100-300mg, in instances where thiamine is considered to be deficient such as high blood sugar or high alcohol intake. When using thiamine at this dose timing does not matter much and either one dose can be taken in the morning or multiple doses throughout; thiamine does not need to be ingested with food to be absorbed.

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Human Effect Matrix

Unlocked for Examine members

The Human Effect Matrix summarizes human studies to tell you what effects Vitamin B1 has on your body, how much evidence there is, and how strong these effects are.

Full details are available to Examine members.
Grade Level of Evidence
Robust research conducted with repeated double-blind clinical trials
Multiple studies where at least two are double-blind and placebo controlled
Single double-blind study or multiple cohort studies
Uncontrolled or observational studies only
Level of Evidence
? The amount of high quality evidence. The more evidence, the more we can trust the results.
Outcome Magnitude of effect
? The direction and size of the supplement's impact on each outcome. Some supplements can have an increasing effect, others have a decreasing effect, and others have no effect.
Consistency of research results
? Scientific research does not always agree. HIGH or VERY HIGH means that most of the scientific research agrees.
Notes
grade-d Strong Very High See 2 studies
One study found a staggering reduction in symptoms with 100 mg of vitamin B1 daily. It wasn't clear what the baseline vitamin B1 status of the participants was. Another study found a notable benefit of 100 mg daily over 2 months, and also that the improvement was additive with calcium, with the combination being notably more potent than either separately. Much more research is needed.
grade-d Minor - See study
In instances where thiamine is deficient, replenishment of thiamine appears to cause a modest decrease in blood pressure.
grade-d - - See study
No changes of note in people with high blood sugar
grade-d - - See study
No significant changes in people with hyperglycemia
grade-d - - See study
No change noted in those with high blood sugar
grade-d - - See study
No change noted in people with high blood sugar
grade-d - - See study
No observed changes in a population with hyperglycemia

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Frequently Asked Questions and Articles on Vitamin B1

Do B vitamins increase the risk of getting cancer?
Recent evidence has linked B vitamins (specifically B6 and B12) to an increased risk of lung cancer in men, especially in smokers. Here, we analyze the study and interview the lead author, Dr. Theodore Brasky.

Things to Note

Is a Form Of

Also Known As

Thiamine

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Click here to see all 18 references.