Tetradecyl Thioacetic Acid
•Last Updated: September 28 2022
Technically an Omega-3 fatty acid, TTA is a non-metabolizable fatty acid that cannot be used for energy and may be able to burn fat via mechanisms similar to Conjugated Linoleic Acid. Lacking studies in humans at the moment, TTA appears to be a promising future candidate for fat loss and health.
Tetradecyl Thioacetic Acid is most often used for
Last Updated: September 28 2022
Tetradecyl Thioacetic Acid, otherwise known as TTA, is what is known as a PPAR-alpha activator. It is actually an omega-3 fatty acid, but has a sulfur group at the omega-3 position; because of this addition it cannot be burnt for energy and thus has no relevant caloric value to humans.
PPARa activation can be seen as protecting the body from excess fats (similar to PPARy activation). PPARa tends to clear fats from the blood into muscle or liver cells, and encourage them to be burnt for energy in these locations (by comparison, PPARy makes new fat cells for fats to reside in which minimizes their potential toxicity).
The clearing of fat from the blood causes a drop in lipoproteins and a lowering of LDL cholesterol, and the burning of fats causes either fat burning or reduced fat gain. TTA can also decrease blood pressure and exert an anti-oxidant effect, the four mechanisms making it a cardioprotective compound.
It is commonly used with the appetite suppressant oleoylethanolamide as a fat-burning combination.
Note that Tetradecyl Thioacetic Acid is also known as:
- TTA
Not much evidence currently exists in human, but the standard dose appears to be 1g of TTA daily taken in divided dosages with meals.
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18.^Madsen L, Guerre-Millo M, Flindt EN, Berge K, Tronstad KJ, Bergene E, Sebokova E, Rustan AC, Jensen J, Mandrup S, Kristiansen K, Klimes I, Staels B, Berge RKTetradecylthioacetic acid prevents high fat diet induced adiposity and insulin resistanceJ Lipid Res.(2002 May)
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21.^Burri L, Bjørndal B, Wergedahl H, Berge K, Bohov P, Svardal A, Berge RKTetradecylthioacetic acid increases hepatic mitochondrial β-oxidation and alters fatty acid composition in a mouse model of chronic inflammationLipids.(2011 Aug)
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23.^Hagland HR, Nilsson LI, Burri L, Nikolaisen J, Berge RK, Tronstad KJInduction of mitochondrial biogenesis and respiration is associated with mTOR regulation in hepatocytes of rats treated with the pan-PPAR activator tetradecylthioacetic acid (TTA)Biochem Biophys Res Commun.(2013 Jan 11)
24.^Gudbrandsen OA, Hultstrøm M, Leh S, Monica Bivol L, Vågnes Ø, Berge RK, Iversen BMPrevention of hypertension and organ damage in 2-kidney, 1-clip rats by tetradecylthioacetic acidHypertension.(2006 Sep)
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