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Tetradecyl Thioacetic Acid

Technically an Omega-3 fatty acid, TTA is a non-metabolizable fatty acid that cannot be used for energy and may be able to burn fat via mechanisms similar to Conjugated Linoleic Acid. Lacking studies in humans at the moment, TTA appears to be a promising future candidate for fat loss and health.

Our evidence-based analysis on tetradecyl thioacetic acid features 30 unique references to scientific papers.

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Summary of Tetradecyl Thioacetic Acid

Primary information, health benefits, side effects, usage, and other important details

Tetradecyl Thioacetic Acid, otherwise known as TTA, is what is known as a PPAR-alpha activator. It is actually an omega-3 fatty acid, but has a sulfur group at the omega-3 position; because of this addition it cannot be burnt for energy and thus has no relevant caloric value to humans.

PPARa activation can be seen as protecting the body from excess fats (similar to PPARy activation). PPARa tends to clear fats from the blood into muscle or liver cells, and encourage them to be burnt for energy in these locations (by comparison, PPARy makes new fat cells for fats to reside in which minimizes their potential toxicity).

The clearing of fat from the blood causes a drop in lipoproteins and a lowering of LDL cholesterol, and the burning of fats causes either fat burning or reduced fat gain. TTA can also decrease blood pressure and exert an anti-oxidant effect, the four mechanisms making it a cardioprotective compound.

It is commonly used with the appetite suppressant oleoylethanolamide as a fat-burning combination.

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How to Take

Medical Disclaimer

Recommended dosage, active amounts, other details

Not much evidence currently exists in human, but the standard dose appears to be 1g of TTA daily taken in divided dosages with meals.

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Human Effect Matrix

Unlocked for Examine Plus members

The Human Effect Matrix summarizes human studies to tell you what effects Tetradecyl Thioacetic Acid has on your body, how much evidence there is, and how strong these effects are.

Full details are available to Examine Plus members.
Grade Level of Evidence
Robust research conducted with repeated double-blind clinical trials
Multiple studies where at least two are double-blind and placebo controlled
Single double-blind study or multiple cohort studies
Uncontrolled or observational studies only
Level of Evidence
? The amount of high quality evidence. The more evidence, the more we can trust the results.
Outcome Magnitude of effect
? The direction and size of the supplement's impact on each outcome. Some supplements can have an increasing effect, others have a decreasing effect, and others have no effect.
Consistency of research results
? Scientific research does not always agree. HIGH or VERY HIGH means that most of the scientific research agrees.
grade-c Notable Very High See all 3 studies
The one trial using TTA to reduce triglycerides noted a reduction of around 15%, which is notable and requires replication
grade-c Minor - See study
Expression of VCAM-1 has been noted to be decreased
grade-c Minor Very High See 2 studies
A decrease in serum levels of TNF-a has been noted with supplemental TTA
grade-c Minor Very High See all 3 studies
Possible reductions in total cholesterol with supplementation of TTA
grade-d Minor Moderate See 2 studies
A slight reduction in blood pressure has been noted in dyslipidemic obese men with TTA supplementation
grade-d Minor Low See all 3 studies
An increase in HDL cholesterol has been noted with TTA consumption
grade-d Minor Very High See all 3 studies
Possible reductions in LDL cholesterol seen with TTA consumption
grade-d - - See study
grade-d - - See study
grade-d - Very High See 2 studies
No significant influence on C-Reactive Protein levels
grade-d - Very High See 2 studies
No significant alterations in HbA1c concentrations
grade-d - - See study
grade-d - - See study
grade-d - - See 2 studies
grade-d - Very High See all 3 studies
No significant influence on liver enzymes in preliminary testing for possible toxicity
grade-d - - See study
grade-d - - See study
grade-d - - See study
grade-d - Very High See 2 studies
No significant alterations in serum uric acid seen with supplemental TTA
grade-d - - See study
grade-d - Very High See 2 studies
Although increased mitochondrial fat oxidation was created for underlying the reductions in lipids and blood pressure, no significant influence on body weight was noted in obese men
grade-d - - See study

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Things to Note

Is a Form Of

Primary Function:

Also Known As


Goes Well With

  • Tetradecyl Thioacetic Acid (TTA) is non-stimulatory

  • The taste and texture of TTA powder has been described as similar to styrofoam

  • TTA is fat soluble and should be taken with meals

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Click here to see all 30 references.