Quick Navigation

Oleoylethanolamide

Oleoylethanolamide (OEA) is a molecule produced in the body, usually found in the intestines. It is responsible for the feeling of satiety after meals. Further research is needed to determine if oral supplementation of OEA provides benefits for weight loss.

Our evidence-based analysis on oleoylethanolamide features 47 unique references to scientific papers.

Kamal Patel
Research analysis led by and reviewed by the Examine team.
Last Updated:

Summary of Oleoylethanolamide

Primary information, health benefits, side effects, usage, and other important details

Oleoylethanolamide (OEA) is a molecule produced in the body, usually found in the intestines. It is responsible for the feeling of satiety following meals.

OEA is sometimes included in fat burning supplement stacks. There is currently no human evidence that suggests oral supplementation of OEA is able to burn fat.

OEA acts on a receptor called Peroxisome Proliferator-Activated Receptor Alpha (PPARα). When this receptor is activated in the intestines of rats, the animals consume less food. Research on rats shows that both injections and oral intake of OEA causes a reliable reduction in the amount of food eaten.

Limited human evidence suggests that OEA may be able to aid fat loss by acting on PPARα. When this receptor is activated in fat tissue, energy expenditure increases. Further evidence is needed before oral supplementation of OEA can be recommended for weight loss.

Guidance from the experts

Learn what supplements to take for your specific health goals with the Examine Supplement Guides.

Want a deeper look at the research? Examine Members get full access to the comprehensive research database, monthly study summaries, and the latest in-depth analysis.

Your support allows us to be 100% independent and unbiased.


How to Take

Recommended dosage, active amounts, other details

Research on rats has observed effects at a daily dose of 10mg/kg of bodyweight. This is roughly equivalent to the following human dosages:

  • 128.5 mg for a 150 lb person

  • 171.4 mg for a 200 lb person

  • 214.3 mg for a 250 lb person

Things to Note

Is a Form Of

Primary Function:

Also Known As

OEA, NOPE (a precursor)

Goes Well With

  • OEA is not known to be stimulatory

Get our free 5-day course on the essentials of supplementation.

At Examine, our incentives line up with yours — getting unbiased information. That's why we don’t sell any advertising or supplements.

Join over 250,000 people who have learned about effective versus overrated supplements, tips for buying supplements, and how to combine supplements for safety and efficacy.

Click here to see all 47 references.

  • Get the latest research

    Examine is your partner to better health.

    Get access to the most up-to-date, in-depth research reviews. No industry ties, no sponsors, no bias.

    Try free for 14 days

This page is regularly updated, to include the most recently available clinical trial evidence.

Each member of our research team is required to have no conflicts of interest, including with supplement manufacturers, food companies, and industry funders. The team includes nutrition researchers, registered dietitians, physicians, and pharmacists. We have a strict editorial process.

This page features 47 references. All factual claims are followed by specifically-applicable references. Click here to see the full set of research information and references for Oleoylethanolamide.

Examine.com is intended to be used for educational and information purposes only. Examine.com and its Editors do not advocate nutritional supplementation over proper medical advice or treatment and this sentiment will never be expressed through pages hosted under Examine.com. If using any pharmaceuticals or drugs given to you by a doctor or received with a prescription, you must consult with the doctor in question or an equally qualified Health Care Professional prior to using any nutritional supplementation. If undergoing medical therapies, then consult with your respective Therapist or Health Care Professional about possible interactions between your Treatment, any Pharmaceuticals or Drugs being given, and possible nutritional supplements or practices hosted on Examine.com.

Examine.com does not assume liability for any actions undertaken after visiting these pages, and does not assume liability if one misuses supplements. Examine.com and its Editors do not ensure that unforeseen side effects will not occur even at the proper dosages, and thereby does not assume liability for any side effects from supplements or practices hosted under the domain of Examine.com.

Supplements

Articles

Health Topics

Membership Free Trial

Protein Intake Guide + Calculator

How to read a study

Company

Resources

Never miss an update!

Your email is safe with us. We don’t share personal data.

This website is certified by Health On the Net Foundation. Click to verify.