Boron
•Last Updated: September 28 2022
Boron is a dietary mineral which is claimed to increase testosterone when supplemented at doses higher than from food, but research is lacking. It might as a byproduct of its anti-inflammatory effects.
Boron is most often used for
Last Updated: September 28 2022
Boron is a trace mineral with biological effects, though its essentiality is debated.
It seems to be able to reduce levels of inflammatory markers, and may reduce rheumatoid arthritis, osteoarthritis, and menstural cramps, though much more research is needed before we can be confident in these benefits. It also might have a small positive effect on LDL-cholesterol, but this is far from certain.
It seems to be generally safe, though human research on its adverse effects is lacking, so smaller doses may be warranted.
The lowest active dose of Boron supplementation appears to be 3mg, which is effective in supporting hormonal parameters in postmenopausal women. Studies on osteoarthritis have used 6mg of Boron while studies in youth investigating hormonal changes have used 10mg.
The optimal dose is currently not known, but the above doses appear to be active for their aforementioned goals.
1.^Hunt CD, Shuler TR, Mullen LMConcentration of boron and other elements in human foods and personal-care productsJ Am Diet Assoc.(1991 May)
6.^Naghii MR1, Samman SThe effect of boron supplementation on its urinary excretion and selected cardiovascular risk factors in healthy male subjectsBiol Trace Elem Res.(1997 Mar)
7.^Zangi R1, Filella MTransport routes of metalloids into and out of the cell: a review of the current knowledgeChem Biol Interact.(2012 Apr 15)
8.^Dordas C1, Brown PHPermeability of boric acid across lipid bilayers and factors affecting itJ Membr Biol.(2000 May 15)
9.^NIP6;1 Is a Boric Acid Channel for Preferential Transport of Boron to Growing Shoot Tissues in Arabidopsis.()
10.^Dordas C1, Chrispeels MJ, Brown PHPermeability and channel-mediated transport of boric acid across membrane vesicles isolated from squash rootsPlant Physiol.(2000 Nov)
11.^Park M1, Li Q, Shcheynikov N, Zeng W, Muallem SNaBC1 is a ubiquitous electrogenic Na+ -coupled borate transporter essential for cellular boron homeostasis and cell growth and proliferationMol Cell.(2004 Nov 5)
12.^Liao SF1, Monegue JS, Lindemann MD, Cromwell GL, Matthews JCDietary supplementation of boron differentially alters expression of borate transporter (NaBCl) mRNA by jejunum and kidney of growing pigsBiol Trace Elem Res.(2011 Nov)
13.^Damkier HH1, Nielsen S, Praetorius JMolecular expression of SLC4-derived Na+-dependent anion transporters in selected human tissuesAm J Physiol Regul Integr Comp Physiol.(2007 Nov)
14.^Wallace JM, Hannon-Fletcher MP, Robson PJ, Gilmore WS, Hubbard SA, Strain JJBoron supplementation and activated factor VII in healthy menEur J Clin Nutr.(2002 Nov)
15.^Naghii MR, Mofid M, Asgari AR, Hedayati M, Daneshpour MSComparative effects of daily and weekly boron supplementation on plasma steroid hormones and proinflammatory cytokinesJ Trace Elem Med Biol.(2011 Jan)
16.^Samman S1, Naghii MR, Lyons Wall PM, Verus APThe nutritional and metabolic effects of boron in humans and animalsBiol Trace Elem Res.(1998 Winter)
17.^Hunt CD, Herbel JL, Nielsen FHMetabolic responses of postmenopausal women to supplemental dietary boron and aluminum during usual and low magnesium intake: boron, calcium, and magnesium absorption and retention and blood mineral concentrationsAm J Clin Nutr.(1997 Mar)
18.^Vanderpool RA, Hoff D, Johnson PEUse of inductively coupled plasma-mass spectrometry in boron-10 stable isotope experiments with plants, rats, and humansEnviron Health Perspect.(1994 Nov)
19.^Penland JGQuantitative analysis of EEG effects following experimental marginal magnesium and boron deprivationMagnes Res.(1995 Dec)
20.^Penland JGDietary boron, brain function, and cognitive performanceEnviron Health Perspect.(1994 Nov)
21.^The saga of boron in food: from a banished food preservative to a beneficial nutrient for humans.()
22.^Naghii MR, Samman SThe role of boron in nutrition and metabolismProg Food Nutr Sci.(1993 Oct-Dec)
25.^Meacham SL, Taper LJ, Volpe SLEffect of boron supplementation on blood and urinary calcium, magnesium, and phosphorus, and urinary boron in athletic and sedentary womenAm J Clin Nutr.(1995 Feb)
26.^Nielsen FH, Hunt CD, Mullen LM, Hunt JREffect of dietary boron on mineral, estrogen, and testosterone metabolism in postmenopausal womenFASEB J.(1987 Nov)
27.^The effect of boron supplementation on the distribution of boron in selected tissues and on testosterone synthesis in rats.()
28.^Ferrando AA, Green NRThe effect of boron supplementation on lean body mass, plasma testosterone levels, and strength in male bodybuildersInt J Sport Nutr.(1993 Jun)
29.^Lee IP, Sherins RJ, Dixon RLEvidence for induction of germinal aplasia in male rats by environmental exposure to boronToxicol Appl Pharmacol.(1978 Aug)
30.^Gonzalez A, Peters U, Lampe JW, White EBoron intake and prostate cancer riskCancer Causes Control.(2007 Dec)
31.^Barranco WT, Hudak PF, Eckhert CDEvaluation of ecological and in vitro effects of boron on prostate cancer risk (United States)Cancer Causes Control.(2007 Feb)
32.^Naghii MR, Einollahi B, Rostami ZPreliminary evidence hints at a protective role for boron in urolithiasisJ Altern Complement Med.(2012 Mar)
33.^Miljkovic D, Miljkovic N, McCarty MFUp-regulatory impact of boron on vitamin D function -- does it reflect inhibition of 24-hydroxylaseMed Hypotheses.(2004)
34.^Effect of Boron depletion and repletion on blood indicators of calcium status in Humans fed a Magnesium-low diet.()
35.^Trumbo P, Yates AA, Schlicker S, Poos MDietary reference intakes: vitamin A, vitamin K, arsenic, boron, chromium, copper, iodine, iron, manganese, molybdenum, nickel, silicon, vanadium, and zincJ Am Diet Assoc.(2001 Mar)
36.^Duydu Y, Başaran N, Üstündağ A, Aydin S, Ündeğer Ü, Ataman OY, Aydos K, Düker Y, Ickstadt K, Waltrup BS, Golka K, Bolt HMReproductive toxicity parameters and biological monitoring in occupationally and environmentally boron-exposed persons in Bandirma, TurkeyArch Toxicol.(2011 Jun)
37.^Pizent A, Tariba B, Živković TReproductive toxicity of metals in menArh Hig Rada Toksikol.(2012)
38.^Korkmaz M, Yenigün M, Bakırdere S, Ataman OY, Keskin S, Müezzinoğlu T, Lekili MEffects of chronic boron exposure on semen profileBiol Trace Elem Res.(2011 Nov)
39.^Robbins WA, Xun L, Jia J, Kennedy N, Elashoff DA, Ping LChronic boron exposure and human semen parametersReprod Toxicol.(2010 Apr)
40.^Weir RJ Jr, Fisher RSToxicologic studies on borax and boric acidToxicol Appl Pharmacol.(1972 Nov)