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PMS

Premenstrual syndrome (PMS) is a collection of unpleasant symptoms that begin each month during the luteal phase of the menstrual cycle and end with the onset of menstruation. Common symptoms include hot flushes, cramps, bloating, acne, mood swings, headaches, anxiety, and more. Premenstrual dysphoric disorder (PMDD) is when the symptoms are severe, particularly those related to mood.

Our evidence-based analysis on pms features 8 unique references to scientific papers.

Research analysis led by .
Reviewed by
Examine.com Team
Last Updated:

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Human Effect Matrix

Unlocked for Examine members

The Human Effect Matrix looks at human studies to tell you what supplements affect PMS.

Full details on all PMS supplements are available to Examine members.
Grade Level of Evidence
Robust research conducted with repeated double-blind clinical trials
Multiple studies where at least two are double-blind and placebo controlled
Single double-blind study or multiple cohort studies
Uncontrolled or observational studies only
Level of Evidence
? The amount of high quality evidence. The more evidence, the more we can trust the results.
Supplement Magnitude of effect
? The direction and size of the supplement's impact on each outcome. Some supplements can have an increasing effect, others have a decreasing effect, and others have no effect.
Consistency of research results
? Scientific research does not always agree. HIGH or VERY HIGH means that most of the scientific research agrees.
Notes
grade-b Strong Very High See all 11 studies
It appears to be quite potent in numerous placebo-controlled trials, and studies are overwhelmingly in agreement. However, the studies are generally at notable risk for bias, and publication bias was found in one meta-analysis from 2017, suggesting the possibility that its efficacy is inflated.
grade-c Notable Very High See all 4 studies
Studies are supportive a notable improvement in symptoms, largely psychological but even physical. However, the current research is of fairly low quality and largely conducted by many of the same authors, thus more research is needed.
grade-c Notable - See study
One study assessing saffron on PMS symptoms noted that supplementation caused 76% of the participants to have more than a halving of overall symptoms (placebo reaching 8%), suggesting relatively potent effects.

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Frequently Asked Questions and Articles on PMS

PMS update
We’ve updated the HEM for PMS. Alas, there’s little research on supplements other than Vitex agnus-castus, and besides a few vitamins and minerals, it’s unclear what’s worth looking into.
Can I take something to alleviate premenstrual symptoms?

Things to Note

Also Known As

Premenstrual syndrome

Click here to see all 8 references.