Last Updated: September 28 2022

Phosphatidylserine (PS) is an amino acid derivative compound that is fat-soluble and found in high amounts in the brain, where it contributes to cognitive functioning. Found in high amounts in fish, it may improve memory in the elderly and lowers cortisol.

Phosphatidylserine is most often used for


Phosphatidylserine, or PS, is a compound similar to a dietary fat which is highly prevalent in human neural tissue. It can be synthesized as well as consumed through the diet , but further benefits can be gained through supplementation.

It is vital for cognitive function, but is not necessarily needed as the body synthesizes it. However, Phosphatidylserine (PS) supplementation in older individuals seems to improve memory and cognitive capacity.

What else is Phosphatidylserine known as?
Note that Phosphatidylserine is also known as:
  • PS
Phosphatidylserine should not be confused with:
  • Serine
Dosage information

A standard dose of phosphatidylserine (PS) is 100mg, taken 3 times a day to total 300mg daily. This dose seems to be effective as a daily preventative against cognitive decline, and 100mg once daily may provide some degree of benefit (but may be lesser than 300mg).

Studies in children and adolescents for the purpose of attention improvement tend to use 200mg, and a dose of 200-400mg has been used in adult non-elderly humans with success. Animal evidence tends to use a dose correlating to 550mg as well.

Join our supplement information course

Examine Database: Phosphatidylserine
What works and what doesn't?

Unlock the full potential of Examine

Get started

Don't miss out on the latest research

3.^Miranda DT, Batista VG, Grando FC, Paula FM, Felício CA, Rubbo GF, Fernandes LC, Curi R, Nishiyama ASoy lecithin supplementation alters macrophage phagocytosis and lymphocyte response to concanavalin A: a study in alloxan-induced diabetic ratsCell Biochem Funct.(2008 Dec)
4.^Prusiner SBMolecular biology of prion diseasesScience.(1991 Jun 14)
5.^Calderini G, Bonetti AC, Battistella A, Crews FT, Toffano GBiochemical changes of rat brain membranes with agingNeurochem Res.(1983 Apr)
6.^Schroeder FRole of membrane lipid asymmetry in agingNeurobiol Aging.(1984 Winter)
7.^Franco RS, Puchulu-Campanella ME, Barber LA, Palascak MB, Joiner CH, Low PS, Cohen RMChanges in the properties of normal human red blood cells during in vivo agingAm J Hematol.(2013 Jan)
15.^Suzuki S, Yamatoya H, Sakai M, Kataoka A, Furushiro M, Kudo SOral administration of soybean lecithin transphosphatidylated phosphatidylserine improves memory impairment in aged ratsJ Nutr.(2001 Nov)
16.^Monteleone P, Beinat L, Tanzillo C, Maj M, Kemali DEffects of phosphatidylserine on the neuroendocrine response to physical stress in humansNeuroendocrinology.(1990 Sep)
18.^Parker AG, Gordon J, Thornton A, Byars A, Lubker J, Bartlett M, Byrd M, Oliver J, Simbo S, Rasmussen C, Greenwood M, Kreider RBThe effects of IQPLUS Focus on cognitive function, mood and endocrine response before and following acute exerciseJ Int Soc Sports Nutr.(2011 Oct 21)
21.^Manor I, Magen A, Keidar D, Rosen S, Tasker H, Cohen T, Richter Y, Zaaroor-Regev D, Manor Y, Weizman ASafety of phosphatidylserine containing omega3 fatty acids in ADHD children: A double-blind placebo-controlled trial followed by an open-label extensionEur Psychiatry.(2013 Jan 8)
25.^Hellhammer J, Hero T, Franz N, Contreras C, Schubert MOmega-3 fatty acids administered in phosphatidylserine improved certain aspects of high chronic stress in menNutr Res.(2012 Apr)
26.^Baumeister J, Barthel T, Geiss KR, Weiss MInfluence of phosphatidylserine on cognitive performance and cortical activity after induced stressNutr Neurosci.(2008 Jun)
28.^Rosadini G, Sannita WG, Nobili F, Cenacchi TPhosphatidylserine: quantitative EEG effects in healthy volunteersNeuropsychobiology.(1990-1991)
32.^Calderini G, Aporti F, Bellini F, Bonetti AC, Teolato S, Zanotti A, Toffano GPharmacological effect of phosphatidylserine on age-dependent memory dysfunctionAnn N Y Acad Sci.(1985)
36.^Engel RR, Satzger W, Günther W, Kathmann N, Bove D, Gerke S, Münch U, Hippius HDouble-blind cross-over study of phosphatidylserine vs. placebo in patients with early dementia of the Alzheimer typeEur Neuropsychopharmacol.(1992 Jun)
37.^Crook T, Petrie W, Wells C, Massari DCEffects of phosphatidylserine in Alzheimer's diseasePsychopharmacol Bull.(1992)
40.^Fünfgeld EW, Baggen M, Nedwidek P, Richstein B, Mistlberger GDouble-blind study with phosphatidylserine (PS) in parkinsonian patients with senile dementia of Alzheimer's type (SDAT)Prog Clin Biol Res.(1989)
41.^Delwaide PJ, Gyselynck-Mambourg AM, Hurlet A, Ylieff MDouble-blind randomized controlled study of phosphatidylserine in senile demented patientsActa Neurol Scand.(1986 Feb)
42.^Maggioni M, Picotti GB, Bondiolotti GP, Panerai A, Cenacchi T, Nobile P, Brambilla FEffects of phosphatidylserine therapy in geriatric patients with depressive disordersActa Psychiatr Scand.(1990 Mar)
43.^Zanotti A, Valzelli L, Toffano GChronic phosphatidylserine treatment improves spatial memory and passive avoidance in aged ratsPsychopharmacology (Berl).(1989)
44.^Drago F, Canonico PL, Scapagnini UBehavioral effects of phosphatidylserine in aged ratsNeurobiol Aging.(1981 Fall)
48.^Schreiber S, Kampf-Sherf O, Gorfine M, Kelly D, Oppenheim Y, Lerer BAn open trial of plant-source derived phosphatydilserine for treatment of age-related cognitive declineIsr J Psychiatry Relat Sci.(2000)
49.^Wilson B, Cockburn J, Baddeley A, Hiorns RThe development and validation of a test battery for detecting and monitoring everyday memory problemsJ Clin Exp Neuropsychol.(1989 Dec)
51.^Kato-Kataoka A, Sakai M, Ebina R, Nonaka C, Asano T, Miyamori TSoybean-derived phosphatidylserine improves memory function of the elderly Japanese subjects with memory complaintsJ Clin Biochem Nutr.(2010 Nov)
53.^Crook TH, Tinklenberg J, Yesavage J, Petrie W, Nunzi MG, Massari DCEffects of phosphatidylserine in age-associated memory impairmentNeurology.(1991 May)
54.^Jorissen BL, Brouns F, Van Boxtel MP, Ponds RW, Verhey FR, Jolles J, Riedel WJThe influence of soy-derived phosphatidylserine on cognition in age-associated memory impairmentNutr Neurosci.(2001)
56.^Kingsley MI, Miller M, Kilduff LP, McEneny J, Benton DEffects of phosphatidylserine on exercise capacity during cycling in active malesMed Sci Sports Exerc.(2006 Jan)
57.^Kingsley MI, Kilduff LP, McEneny J, Dietzig RE, Benton DPhosphatidylserine supplementation and recovery following downhill runningMed Sci Sports Exerc.(2006 Sep)
58.^Ottestad I, Hassani S, Borge GI, Kohler A, Vogt G, Hyötyläinen T, Orešič M, Brønner KW, Holven KB, Ulven SM, Myhrstad MCFish oil supplementation alters the plasma lipidomic profile and increases long-chain PUFAs of phospholipids and triglycerides in healthy subjectsPLoS One.(2012)
59.^Kennedy DO, Haskell CF, Mauri PL, Scholey ABAcute cognitive effects of standardised Ginkgo biloba extract complexed with phosphatidylserineHum Psychopharmacol.(2007 Jun)
60.^Jorissen BL, Brouns F, Van Boxtel MP, Riedel WJSafety of soy-derived phosphatidylserine in elderly peopleNutr Neurosci.(2002 Oct)