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Artichoke Extract

Artichoke Extract (Cynara scolymus) is an extract from the common bulb vegetable that appears to have the ability to stimulate bile secretion; this may underlie a weak reduction in cholesterol and improved fat digestion.

Our evidence-based analysis on artichoke extract features 41 unique references to scientific papers.

Research analysis led by .
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Examine.com Team
Last Updated:

How to Take

Recommended dosage, active amounts, other details

A few doses have been used in human studies, including 6,000 mg of the basic extract (no concentrations) and also a 25-35:1 concentrated extract dosed at 1,800 mg. Both of these doses showed bioactivity, but there is no clear indication of which is the optimal dosage.

It is unclear whether artichoke extract needs to be taken alongside a meal or not.

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Human Effect Matrix

Unlocked for Examine members

The Human Effect Matrix summarizes human studies to tell you what effects Artichoke Extract has on your body, how much evidence there is, and how strong these effects are.

Full details are available to Examine members.
Grade Level of Evidence
Robust research conducted with repeated double-blind clinical trials
Multiple studies where at least two are double-blind and placebo controlled
Single double-blind study or multiple cohort studies
Uncontrolled or observational studies only
Level of Evidence
? The amount of high quality evidence. The more evidence, the more we can trust the results.
Outcome Magnitude of effect
? The direction and size of the supplement's impact on each outcome. Some supplements can have an increasing effect, others have a decreasing effect, and others have no effect.
Consistency of research results
? Scientific research does not always agree. HIGH or VERY HIGH means that most of the scientific research agrees.
grade-c Minor Moderate See all 4 studies
Nothing remarkable about the reductions in LDL-C, seem to occur somewhat reliably and are minor in magnitude
grade-c Minor - See study
More evidence is required to establish the potency of the hepatoprotective effects (with liver enzymes as a biomarker)
grade-c Minor Moderate See all 4 studies
Despite its traditional usage, the decreases in cholesterol are not remarkable and are quite small in magnitude.
grade-c - Very High See 2 studies
There is still a possibility that artichoke extract is able to aid the blood glucose of diabetics, but currently the best evidence does not support this conclusion
grade-c - Very High See all 3 studies
There does not appear to be an inherent effect of Artichoke on HDL-C, although the one study in diabetics suggest that HDL-C might increase when glucose is decreased.
grade-c - Very High See all 4 studies
The two better controlled trials noted no change, whereas a decrease and increase has been noted otherwise. Unclear overall effects on triglycerides
grade-d Minor - See study
The increase in blood flow was relatively minor in magnitude, possibly related to antioxidant effects.
grade-d Minor - See study
ICAM-1 and VCAM-1 decreased, not to a remarkable degree that would be indicative of immunosuppression.

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Things to Note

Is a Form Of

Primary Function:

Also Known As


Do Not Confuse With

Milk Thistle (Wild Artichoke)

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Click here to see all 41 references.