Grape Seed Extract

Last Updated: September 28 2022

Grape Seed Extract is a mixture of tannins and procyanidins (chains of catechins) that appears to exert anti-estrogenic effects and may enhance blood flow. More related to green tea catechins than to resveratrol mechanistically.

Grape Seed Extract is most often used for

What else is Grape Seed Extract known as?
Note that Grape Seed Extract is also known as:
  • GSE
  • OPC-3
  • Oligomeric Procyanidins
  • Procyanidin
Grape Seed Extract should not be confused with:
Dosage information

Studies conducted in humans used in the range of 150-300mg Grape Seed extract daily for heart health purposes, while doses up to 600mg have been used with no reported side effects.

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4.^Kijima I, Phung S, Hur G, Kwok SL, Chen SGrape seed extract is an aromatase inhibitor and a suppressor of aromatase expressionCancer Res.(2006 Jun 1)
5.^Yilmazer-Musa M, Griffith AM, Michels AJ, Schneider E, Frei BGrape Seed and Tea Extracts and Catechin 3-Gallates Are Potent Inhibitors of α-Amylase and α-Glucosidase ActivityJ Agric Food Chem.(2012 Sep 12)
6.^Overman A, Bumrungpert A, Kennedy A, Martinez K, Chuang CC, West T, Dawson B, Jia W, McIntosh MPolyphenol-rich grape powder extract (GPE) attenuates inflammation in human macrophages and in human adipocytes exposed to macrophage-conditioned mediaInt J Obes (Lond).(2010 May)
7.^Sano A, Yamakoshi J, Tokutake S, Tobe K, Kubota Y, Kikuchi MProcyanidin B1 is detected in human serum after intake of proanthocyanidin-rich grape seed extractBiosci Biotechnol Biochem.(2003 May)
8.^Tsang C, Auger C, Mullen W, Bornet A, Rouanet JM, Crozier A, Teissedre PLThe absorption, metabolism and excretion of flavan-3-ols and procyanidins following the ingestion of a grape seed extract by ratsBr J Nutr.(2005 Aug)
11.^Baba S, Osakabe N, Natsume M, Terao JAbsorption and urinary excretion of procyanidin B2 {epicatechin-(4beta-8)-epicatechin} in ratsFree Radic Biol Med.(2002 Jul 1)
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22.^Ono K, Condron MM, Ho L, Wang J, Zhao W, Pasinetti GM, Teplow DBEffects of grape seed-derived polyphenols on amyloid beta-protein self-assembly and cytotoxicityJ Biol Chem.(2008 Nov 21)
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25.^Narita K, Hisamoto M, Okuda T, Takeda SDifferential neuroprotective activity of two different grape seed extractsPLoS One.(2011 Jan 24)
26.^Belviranlı M, Gökbel H, Okudan N, Büyükbaş SEffects of Grape Seed Polyphenols on Oxidative Damage in Liver Tissue of Acutely and Chronically Exercised RatsPhytother Res.(2012 Jun 29)
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41.^Castell-Auví A, Cedó L, Pallarès V, Blay M, Pinent M, Ardévol AGrape seed procyanidins improve β-cell functionality under lipotoxic conditions due to their lipid-lowering effectJ Nutr Biochem.(2012 Sep 17)
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43.^Charradi K, Elkahoui S, Karkouch I, Limam F, Hassine FB, Aouani EGrape seed and skin extract prevents high-fat diet-induced brain lipotoxicity in ratNeurochem Res.(2012 Sep)
44.^Cedó L, Castell-Auví A, Pallarès V, Ubaida Mohien C, Baiges I, Blay M, Ardévol A, Pinent MPancreatic islet proteome profile in Zucker fatty rats chronically treated with a grape seed procyanidin extractFood Chem.(2012 Dec 1)
46.^Parcellier A, Gurbuxani S, Schmitt E, Solary E, Garrido CHeat shock proteins, cellular chaperones that modulate mitochondrial cell death pathwaysBiochem Biophys Res Commun.(2003 May 9)
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52.^Vogels N, Nijs IM, Westerterp-Plantenga MSThe effect of grape-seed extract on 24 h energy intake in humansEur J Clin Nutr.(2004 Apr)
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56.^Chacón MR, Ceperuelo-Mallafré V, Maymó-Masip E, Mateo-Sanz JM, Arola L, Guitiérrez C, Fernandez-Real JM, Ardèvol A, Simón I, Vendrell JGrape-seed procyanidins modulate inflammation on human differentiated adipocytes in vitroCytokine.(2009 Aug)
58.^Charradi K, Sebai H, Elkahoui S, Ben Hassine F, Limam F, Aouani EGrape seed extract alleviates high-fat diet-induced obesity and heart dysfunction by preventing cardiac siderosisCardiovasc Toxicol.(2011 Mar)
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67.^Velmurugan B, Singh RP, Kaul N, Agarwal R, Agarwal CDietary feeding of grape seed extract prevents intestinal tumorigenesis in APCmin/+ miceNeoplasia.(2010 Jan)
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73.^Wahner-Roedler DL1, Bauer BA, Loehrer LL, Cha SS, Hoskin TL, Olson JEThe effect of grape seed extract on estrogen levels of postmenopausal women: a pilot studyJ Diet Suppl.(2014 Jun)
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75.^Kampa M, Theodoropoulou K, Mavromati F, Pelekanou V, Notas G, Lagoudaki ED, Nifli AP, Morel-Salmi C, Stathopoulos EN, Vercauteren J, Castanas ENovel oligomeric proanthocyanidin derivatives interact with membrane androgen sites and induce regression of hormone-independent prostate cancerJ Pharmacol Exp Ther.(2011 Apr)
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77.^Cuevas VM, Calzado YR, Guerra YP, Yera AO, Despaigne SJ, Ferreiro RM, Quintana DCEffects of grape seed extract, vitamin C, and vitamin e on ethanol- and aspirin-induced ulcersAdv Pharmacol Sci.(2011)
79.^Ye X, Krohn RL, Liu W, Joshi SS, Kuszynski CA, McGinn TR, Bagchi M, Preuss HG, Stohs SJ, Bagchi DThe cytotoxic effects of a novel IH636 grape seed proanthocyanidin extract on cultured human cancer cellsMol Cell Biochem.(1999 Jun)
80.^Ramchandani AG, Karibasappa GS, Pakhale SSAntitumor-promoting effects of polyphenolic extracts from seedless and seeded Indian grapesJ Environ Pathol Toxicol Oncol.(2008)
82.^Ulusoy S, Ozkan G, Yucesan FB, Ersöz Ş, Orem A, Alkanat M, Yuluğ E, Kaynar K, Al SAnti-apoptotic and anti-oxidant effects of grape seed proanthocyanidin extract in preventing cyclosporine A-induced nephropathyNephrology (Carlton).(2012 May)
83.^Ulusoy S, Ozkan G, Ersoz S, Orem A, Alkanat M, Yucesan FB, Kaynar K, Al SThe effect of grape seed proanthocyanidin extract in preventing amikacin-induced nephropathyRen Fail.(2012)
85.^Mohanasundari M, Sabesan M, Sethupathy SRenoprotective effect of grape seeds extract in ethylene glycol induced nephrotoxic miceIndian J Exp Biol.(2005 Apr)
88.^Mansouri E, Panahi M, Ghaffari MA, Ghorbani AEffects of grape seed proanthocyanidin extract on oxidative stress induced by diabetes in rat kidneyIran Biomed J.(2011)
89.^Li X, Xiao Y, Gao H, Li B, Xu L, Cheng M, Jiang B, Ma YGrape seed proanthocyanidins ameliorate diabetic nephropathy via modulation of levels of AGE, RAGE and CTGFNephron Exp Nephrol.(2009)
91.^Cheng M, Gao HQ, Xu L, Li BY, Zhang H, Li XHCardioprotective effects of grape seed proanthocyanidins extracts in streptozocin induced diabetic ratsJ Cardiovasc Pharmacol.(2007 Nov)
92.^Dinicola S, Cucina A, Pasqualato A, D'Anselmi F, Proietti S, Lisi E, Pasqua G, Antonacci D, Bizzarri MAntiproliferative and Apoptotic Effects Triggered by Grape Seed Extract (GSE) versus Epigallocatechin and Procyanidins on Colon Cancer Cell LinesInt J Mol Sci.(2012)
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95.^Brooker S, Martin S, Pearson A, Bagchi D, Earl J, Gothard L, Hall E, Porter L, Yarnold JDouble-blind, placebo-controlled, randomised phase II trial of IH636 grape seed proanthocyanidin extract (GSPE) in patients with radiation-induced breast indurationRadiother Oncol.(2006 Apr)
97.^Skovgaard GR, Jensen AS, Sigler MLEffect of a novel dietary supplement on skin aging in post-menopausal womenEur J Clin Nutr.(2006 Oct)
98.^Yamakoshi J, Sano A, Tokutake S, Saito M, Kikuchi M, Kubota Y, Kawachi Y, Otsuka FOral intake of proanthocyanidin-rich extract from grape seeds improves chloasmaPhytother Res.(2004 Nov)
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