Last Updated: August 17 2022

Ganoderma lucidum is a potent immune system regulator, promising anti-cancer agent, and stress reducer. This mushroom is frequently used in traditional Chinese medicine.

Reishi is most often used for


Ganoderma lucidum, commonly known as the lingzi mushroom, is frequently used in traditional Chinese medicine. Its popularity extends to Japanese and Korean medicine, and it has been making its way west.

Ganoderma lucidum has anti-oxidative effects when supplemented. It also has a therapeutic effect on insulin resistance, reduces the risk of prostate cancer, and can help treat a variety of conditions associated with metabolic syndrome.

The lingzi mushroom is well known for its anti-cancer effects. It is able to activate natural killer cells, increasing their activity and the body’s ability to fight tumors. Supplementing Ganoderma lucidum reduces the chances of metastasis, which is when cancer spreads to another part of the body.

Ganoderma lucidum has a variety of mechanisms, but they are focused on moderating the immune system. The lingzi mushroom is able to reduce immune system activity when the system is overstimulated, and bolster the immune system when it is weakened. In general, Ganoderma lucidum increases the amount of active immune system cells.

Though further research is needed to confirm these effects, Ganoderma lucidum shows promise for a wide variety of cancer-related therapies. It has been shown to be an effective adjunct therapy, which means it improves health when taken alongside other medications, for breast cancer, hepatitis, fatigue syndrome, and prostate cancer. There are not many promising supplements with anti-cancer properties available over-the-counter but Ganoderma lucidum appears to be one of them.

What else is Reishi known as?
Note that Reishi is also known as:
  • Reishi
  • Lingzhi
  • Yeongji
  • Mannamtake
  • Mushroom Of Immortality
  • Antlered Reishi
  • Rokkaku-Reishi
  • Ganoderma Spores
  • Ganoderma Lucidum
  • 10000 Years Mushroom
Dosage information

The standard dose of Ganoderma lucidum depends on the form of the supplement.

A general Ganoderma lucidum extract does not separate the triterpenoids and the polysaccharides present in the mushroom, which make up the ethanolic and water-soluble extracts, respectively. The standard dose for the basic extract is 1.44g – 5.2g. The most popular dose is 5.2g, taken in three doses of 1,800mg.

The standard dosage for the ethanolic extract is 6mg.

The water-soluble extract should be dosed similarly to the basic extract.

The basic extract is essentially dehydrated mushroom powder, which makes it about 10 times as potent as the actual mushroom. This means that 5g of extract is similar to about 50g of whole mushroom.

Examine Database
1.^Mau JL, Lin HC, Chen CCAntioxidant properties of several medicinal mushroomsJ Agric Food Chem.(2002 Oct 9)
2.^Boh B, Berovic M, Zhang J, Zhi-Bin LGanoderma lucidum and its pharmaceutically active compoundsBiotechnol Annu Rev.(2007)
4.^Lindequist U, Niedermeyer TH, Jülich WDThe pharmacological potential of mushroomsEvid Based Complement Alternat Med.(2005 Sep)
8.^Lv GP, Zhao J, Duan JA, Tang YP, Li SPComparison of sterols and fatty acids in two species of GanodermaChem Cent J.(2012 Jan 31)
9.^Xie J, Zhao J, Hu DJ, Duan JA, Tang YP, Li SPComparison of polysaccharides from two species of GanodermaMolecules.(2012 Jan 13)
10.^Lu J, Qin JZ, Chen P, Chen X, Zhang YZ, Zhao SJQuality Difference Study of Six Varieties of Ganoderma lucidum with Different OriginsFront Pharmacol.(2012)
12.^Borchers AT, Stern JS, Hackman RM, Keen CL, Gershwin MEMushrooms, tumors, and immunityProc Soc Exp Biol Med.(1999 Sep)
14.^Bao XF, Dong Q, Fang JNStructure and Conformation Behavior of a Glucan from Spores of Ganoderma lucidum (Fr.) KarstSheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao (Shanghai).(2000)
17.^Bao XF, Wang XS, Dong Q, Fang JN, Li XYStructural features of immunologically active polysaccharides from Ganoderma lucidumPhytochemistry.(2002 Jan)
18.^Ye L, Li J, Zhang J, Pan YNMR characterization for polysaccharide moiety of a glycopeptideFitoterapia.(2010 Mar)
21.^Ji Z, Tang Q, Zhang J, Yang Y, Jia W, Pan YImmunomodulation of RAW264.7 macrophages by GLIS, a proteopolysaccharide from Ganoderma lucidumJ Ethnopharmacol.(2007 Jul 25)
23.^Chien CM, Cheng JL, Chang WT, Tien MH, Tsao CM, Chang YH, Chang HY, Hsieh JF, Wong CH, Chen STPolysaccharides of Ganoderma lucidum alter cell immunophenotypic expression and enhance CD56+ NK-cell cytotoxicity in cord bloodBioorg Med Chem.(2004 Nov 1)
25.^Dong Q, Wang Y, Shi L, Yao J, Li J, Ma F, Ding KA novel water-soluble β-D-glucan isolated from the spores of Ganoderma lucidumCarbohydr Res.(2012 May 15)
26.^Wang XM, Guan SH, Liu RX, Sun JH, Liang Y, Yang M, Wang W, Bi KS, Guo DAHPLC determination of four triterpenoids in rat urine after oral administration of total triterpenoids from Ganoderma lucidumJ Pharm Biomed Anal.(2007 Feb 19)
28.^Weng CJ, Chau CF, Chen KD, Chen DH, Yen GCThe anti-invasive effect of lucidenic acids isolated from a new Ganoderma lucidum strainMol Nutr Food Res.(2007 Dec)
30.^Gao JL, Leung KS, Wang YT, Lai CM, Li SP, Hu LF, Lu GH, Jiang ZH, Yu ZLQualitative and quantitative analyses of nucleosides and nucleobases in Ganoderma spp. by HPLC-DAD-MSJ Pharm Biomed Anal.(2007 Jul 27)
31.^van der Hem LG, van der Vliet JA, Bocken CF, Kino K, Hoitsma AJ, Tax WJLing Zhi-8: studies of a new immunomodulating agentTransplantation.(1995 Sep 15)
33.^Thakur A, Rana M, Lakhanpal TN, Ahmad A, Khan MIPurification and characterization of lectin from fruiting body of Ganoderma lucidum: lectin from Ganoderma lucidumBiochim Biophys Acta.(2007 Sep)
35.^Ma J, Ye Q, Hua Y, Zhang D, Cooper R, Chang MN, Chang JY, Sun HHNew lanostanoids from the mushroom Ganoderma lucidumJ Nat Prod.(2002 Jan)
36.^Liu JJ, Huang WH, Lv ML, Si JP, Guo BL, Li SJDetermination of ergosterol in Ganoderma lucidum from different varieties and cultured tree species by HPLCZhong Yao Cai.(2011 Feb)
38.^Fukuzawa M, Yamaguchi R, Hide I, Chen Z, Hirai Y, Sugimoto A, Yasuhara T, Nakata YPossible involvement of long chain fatty acids in the spores of Ganoderma lucidum (Reishi Houshi) to its anti-tumor activityBiol Pharm Bull.(2008 Oct)
39.^Matute RG, Serra A, Figlas D, Curvetto NCopper and zinc bioaccumulation and bioavailability of Ganoderma lucidumJ Med Food.(2011 Oct)
40.^Falandysz JSelenium in edible mushroomsJ Environ Sci Health C Environ Carcinog Ecotoxicol Rev.(2008 Jul-Sep)
43.^Fatmawati S, Shimizu K, Kondo RInhibition of aldose reductase in vitro by constituents of Ganoderma lucidumPlanta Med.(2010 Oct)
45.^Tang W, Gao Y, Chen G, Gao H, Dai X, Ye J, Chan E, Huang M, Zhou SA randomized, double-blind and placebo-controlled study of a Ganoderma lucidum polysaccharide extract in neurastheniaJ Med Food.(2005 Spring)
46.^Kohguchi M, Kunikata T, Watanabe H, Kudo N, Shibuya T, Ishihara T, Iwaki K, Ikeda M, Fukuda S, Kurimoto MImmuno-potentiating effects of the antler-shaped fruiting body of Ganoderma lucidum (Rokkaku-Reishi)Biosci Biotechnol Biochem.(2004 Apr)
47.^Watanabe K, Shuto T, Sato M, Onuki K, Mizunoe S, Suzuki S, Sato T, Koga T, Suico MA, Kai H, Ikeda TLucidenic acids-rich extract from antlered form of Ganoderma lucidum enhances TNFα induction in THP-1 monocytic cells possibly via its modulation of MAP kinases p38 and JNKBiochem Biophys Res Commun.(2011 Apr 29)
48.^Nonaka Y, Shibata H, Nakai M, Kurihara H, Ishibashi H, Kiso Y, Tanaka T, Yamaguchi H, Abe SAnti-tumor activities of the antlered form of Ganoderma lucidum in allogeneic and syngeneic tumor-bearing miceBiosci Biotechnol Biochem.(2006 Sep)
49.^Min BS, Nakamura N, Miyashiro H, Bae KW, Hattori MTriterpenes from the spores of Ganoderma lucidum and their inhibitory activity against HIV-1 proteaseChem Pharm Bull (Tokyo).(1998 Oct)
50.^Wang JL, Li YB, Liu RM, Zhong JJA new ganoderic acid from Ganoderma lucidum myceliaJ Asian Nat Prod Res.(2010 Aug)
53.^Chan WK, Lam DT, Law HK, Wong WT, Koo MW, Lau AS, Lau YL, Chan GCGanoderma lucidum mycelium and spore extracts as natural adjuvants for immunotherapyJ Altern Complement Med.(2005 Dec)
57.^Shao BM, Dai H, Xu W, Lin ZB, Gao XMImmune receptors for polysaccharides from Ganoderma lucidumBiochem Biophys Res Commun.(2004 Oct 8)
58.^Tsai CC, Yang FL, Huang ZY, Chen CS, Yang YL, Hua KF, Li J, Chen ST, Wu SHOligosaccharide and peptidoglycan of Ganoderma lucidum activate the immune response in human mononuclear cellsJ Agric Food Chem.(2012 Mar 21)
59.^Yu Q, Nie SP, Li WJ, Zheng WY, Yin PF, Gong DM, Xie MYMacrophage Immunomodulatory Activity of a Purified Polysaccharide Isolated from Ganoderma atrumPhytother Res.(2012 Apr 18)
60.^Dudhgaonkar S, Thyagarajan A, Sliva DSuppression of the inflammatory response by triterpenes isolated from the mushroom Ganoderma lucidumInt Immunopharmacol.(2009 Oct)
61.^Jiang J, Slivova V, Harvey K, Valachovicova T, Sliva DGanoderma lucidum suppresses growth of breast cancer cells through the inhibition of Akt/NF-kappaB signalingNutr Cancer.(2004)
63.^Chen HS, Tsai YF, Lin S, Lin CC, Khoo KH, Lin CH, Wong CHStudies on the immuno-modulating and anti-tumor activities of Ganoderma lucidum (Reishi) polysaccharidesBioorg Med Chem.(2004 Nov 1)
64.^Gao Y, Gao H, Chan E, Tang W, Xu A, Yang H, Huang M, Lan J, Li X, Duan W, Xu C, Zhou SAntitumor activity and underlying mechanisms of ganopoly, the refined polysaccharides extracted from Ganoderma lucidum, in miceImmunol Invest.(2005)
66.^Chung WT, Lee SH, Kim JD, Park YS, Hwang B, Lee SY, Lee HYEffect of mycelial culture broth of Ganoderma lucidum on the growth characteristics of human cell linesJ Biosci Bioeng.(2001)
69.^Lin CC, Tseng HW, Hsieh HL, Lee CW, Wu CY, Cheng CY, Yang CMTumor necrosis factor-alpha induces MMP-9 expression via p42/p44 MAPK, JNK, and nuclear factor-kappaB in A549 cellsToxicol Appl Pharmacol.(2008 Jun 15)
76.^Lee I, Ahn B, Choi J, Hattori M, Min B, Bae KSelective cholinesterase inhibition by lanostane triterpenes from fruiting bodies of Ganoderma lucidumBioorg Med Chem Lett.(2011 Nov 1)
77.^Zhang XQ, Ip FC, Zhang DM, Chen LX, Zhang W, Li YL, Ip NY, Ye WCTriterpenoids with neurotrophic activity from Ganoderma lucidumNat Prod Res.(2011 Oct)
79.^Aguirre Moreno AC, Campos Peña V, Villeda Hernández J, León Rivera I, Montiel Arcos EGanoderma lucidum reduces kainic acid-induced hippocampal neuronal damage via inflammatory cytokines and glial fibrillary acid protein expressionProc West Pharmacol Soc.(2011)
81.^Zhang R, Xu S, Cai Y, Zhou M, Zuo X, Chan PGanoderma lucidum Protects Dopaminergic Neuron Degeneration through Inhibition of Microglial ActivationEvid Based Complement Alternat Med.(2011)
84.^Hickie I, Davenport T, Issakidis C, Andrews GNeurasthenia: prevalence, disability and health care characteristics in the Australian communityBr J Psychiatry.(2002 Jul)
85.^Parker G, Gladstone G, Chee KTDepression in the planet's largest ethnic group: the ChineseAm J Psychiatry.(2001 Jun)
86.^Cui XY, Cui SY, Zhang J, Wang ZJ, Yu B, Sheng ZF, Zhang XQ, Zhang YHExtract of Ganoderma lucidum prolongs sleep time in ratsJ Ethnopharmacol.(2012 Feb 15)
87.^Chu QP, Wang LE, Cui XY, Fu HZ, Lin ZB, Lin SQ, Zhang YHExtract of Ganoderma lucidum potentiates pentobarbital-induced sleep via a GABAergic mechanismPharmacol Biochem Behav.(2007 Apr)
89.^Honda K, Komoda Y, Inoué SSleep-promoting effects of Ganoderma extracts in rats: comparison between long-term and acute administrationsTokyo Ika Shika Daigaku Iyo Kizai Kenkyusho Hokoku.(1988)
93.^Seto SW, Lam TY, Tam HL, Au AL, Chan SW, Wu JH, Yu PH, Leung GP, Ngai SM, Yeung JH, Leung PS, Lee SM, Kwan YWNovel hypoglycemic effects of Ganoderma lucidum water-extract in obese/diabetic (+db/+db) micePhytomedicine.(2009 May)
94.^Berger A, Rein D, Kratky E, Monnard I, Hajjaj H, Meirim I, Piguet-Welsch C, Hauser J, Mace K, Niederberger PCholesterol-lowering properties of Ganoderma lucidum in vitro, ex vivo, and in hamsters and minipigsLipids Health Dis.(2004 Feb 18)
95.^Hajjaj H, Macé C, Roberts M, Niederberger P, Fay LBEffect of 26-oxygenosterols from Ganoderma lucidum and their activity as cholesterol synthesis inhibitorsAppl Environ Microbiol.(2005 Jul)
96.^Komoda Y, Shimizu M, Sonoda Y, Sato YGanoderic acid and its derivatives as cholesterol synthesis inhibitorsChem Pharm Bull (Tokyo).(1989 Feb)
99.^Krause BR, Sliskovic DR, Anderson M, Homan RLipid-lowering effects of WAY-121,898, an inhibitor of pancreatic cholesteryl ester hydrolaseLipids.(1998 May)
100.^Zheng J, Yang B, Yu Y, Chen Q, Huang T, Li DGanoderma Lucidum Polysaccharides Exert Anti-hyperglycemic Effect on Streptozotocin-induced Diabetic Rats through Affecting β-cellsComb Chem High Throughput Screen.(2012 Feb 9)
101.^Teng BS, Wang CD, Zhang D, Wu JS, Pan D, Pan LF, Yang HJ, Zhou PHypoglycemic effect and mechanism of a proteoglycan from ganoderma lucidum on streptozotocin-induced type 2 diabetic ratsEur Rev Med Pharmacol Sci.(2012 Feb)
103.^Hsu HY1, Kuan YC, Lin TY, Tsao SM, Hsu J, Ma LJ, Sheu FReishi Protein LZ-8 Induces FOXP3(+) Treg Expansion via a CD45-Dependent Signaling Pathway and Alleviates Acute Intestinal Inflammation in MiceEvid Based Complement Alternat Med.(2013)
104.^Hsu HY1, Hua KF, Wu WC, Hsu J, Weng ST, Lin TL, Liu CY, Hseu RS, Huang CTReishi immuno-modulation protein induces interleukin-2 expression via protein kinase-dependent signaling pathways within human T cellsJ Cell Physiol.(2008 Apr)
106.^Al-Mehdi AB, Tozawa K, Fisher AB, Shientag L, Lee A, Muschel RJIntravascular origin of metastasis from the proliferation of endothelium-attached tumor cells: a new model for metastasisNat Med.(2000 Jan)
108.^Gorelik E, Wiltrout RH, Okumura K, Habu S, Herberman RBRole of NK cells in the control of metastatic spread and growth of tumor cells in miceInt J Cancer.(1982 Jul 15)
110.^Chen X, Hu ZP, Yang XX, Huang M, Gao Y, Tang W, Chan SY, Dai X, Ye J, Ho PC, Duan W, Yang HY, Zhu YZ, Zhou SFMonitoring of immune responses to a herbal immuno-modulator in patients with advanced colorectal cancerInt Immunopharmacol.(2006 Mar)