Last Updated: September 28 2022

Stevia rebaudiana (Stevia) is a herb where either the leaf extract or isolated 'steviosides' are used for sweetening. Unlike other sweeteners, stevia is 'natural' (rather than artificial) and associated with both beneficial pharmacological effects and some toxicity.

Stevia is most often used for


Stevia is the common word to refer to the plant stevia rebaudiana which is the sweetest of the stevia species of plants and historically used as a sweetening agent. This sweetness is traced back to glycoside (bound to sugar) compounds of steviol, with the two most important steviol glycosides being stevioside and rebaudioside A.

Unlike other sweetening agents such as aspartame or sucralose, ingestion of stevia in feasible doses confers pharmacological activity. Ingestion of either stevioside or rebaudioside A will result in a circulating level of steviol and its conjugate (steviol glucuronide) which can then exert effects in the body.

In low doses, stevia consumption appears to be associated with general anti-inflammatory and anti-oxidative effects; these effects have been linked to protection of the kidneys, pancreas, liver, and brain when they precede damaging stressors (so although there is some organ protective effects, it is merely due to the general properties of steviol rather than a unique mechanism). Higher doses appear to be linked to fertility problems in animals, and although it is somewhat contested of an issue (some studies in male rats not showing anti-fertility actions, lack of human studies) it may be prudent to not overconsume stevia due to this.

In regards to the genotoxic effects, although overconsumption (or selective choosing of bacterial plates to conduct an Ames test in) is associated with genotoxic effects the potency of this genotoxic effect when it occurs appears to be quite minimal. Cancer causing effects of stevia overconsumption may not be overly relevant due to the low potency of the steviol glycosides and the inherent antioxidant properties also conferring a protective effects (perhaps regulating its own genotoxicity, definitely reduces the reliability) and as such should not be too much of a concern.

What else is Stevia known as?
Note that Stevia is also known as:
  • Rebiana
  • rebaudioside A
  • stevioside
  • steviol
  • steviol glycosides
  • sweetleaf
  • sugarleaf
Stevia should not be confused with:
Dosage information

Preferentially, stevia is dosed according to taste (as it is used as a sweetener). For prudency, and due to some toxicological data on this herb, an estimated upper daily intake of around 8mg/kg should be used (for a 150lb human, this is 540mg). This dose is within the current recommended intake limits, and is sufficient for anti-inflammatory and anti-oxidant effects but insufficient for any observed toxic or infertility inducing effects of stevia.

That being said, some human studies using prolonged intake of up to 1.5g daily show no adverse effects.

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1.^Goyal SK, Samsher, Goyal RKStevia (Stevia rebaudiana) a bio-sweetener: a reviewInt J Food Sci Nutr.(2010 Feb)
4.^Hanson JR, De Oliveira BHStevioside and related sweet diterpenoid glycosidesNat Prod Rep.(1993 Jun)
5.^Gardana C, Simonetti P, Canzi E, Zanchi R, Pietta PMetabolism of stevioside and rebaudioside A from Stevia rebaudiana extracts by human microfloraJ Agric Food Chem.(2003 Oct 22)
7.^Hellfritsch C, Brockhoff A, Stähler F, Meyerhof W, Hofmann THuman Psychometric and Taste Receptor Responses to Steviol GlycosidesJ Agric Food Chem.(2012 Jun 27)
8.^Nunes AP, Ferreira-Machado SC, Nunes RM, Dantas FJ, De Mattos JC, Caldeira-de-Araújo AAnalysis of genotoxic potentiality of stevioside by comet assayFood Chem Toxicol.(2007 Apr)
9.^Kolb N, Herrera JL, Ferreyra DJ, Uliana RFAnalysis of sweet diterpene glycosides from Stevia rebaudiana: improved HPLC methodJ Agric Food Chem.(2001 Oct)
11.^Geuns JMSteviosidePhytochemistry.(2003 Nov)
15.^Takahashi K, Sun Y, Yanagiuchi I, Hosokawa T, Saito T, Komori M, Okino T, Kurasaki MStevioside enhances apoptosis induced by serum deprivation in PC12 cellsToxicol Mech Methods.(2012 May)
16.^Muanprasat C, Sirianant L, Sawasvirojwong S, Homvisasevongsa S, Suksamrarn A, Chatsudthipong VActivation of AMP-activated protein kinase by a plant-derived dihydroisosteviol in human intestinal epithelial cellBiol Pharm Bull.(2013 Jan 24)
17.^Steinmetz WE, Lin ANMR studies of the conformation of the natural sweetener rebaudioside ACarbohydr Res.(2009 Dec 14)
18.^Chaturvedula VS, Rhea J, Milanowski D, Mocek U, Prakash ITwo minor diterpene glycosides from the leaves of Stevia rebaudianaNat Prod Commun.(2011 Feb)
19.^Chaturvedula VS, Upreti M, Prakash IDiterpene glycosides from Stevia rebaudianaMolecules.(2011 Apr 28)
20.^Chaturvedula VS, Prakash IStructures of the novel diterpene glycosides from Stevia rebaudianaCarbohydr Res.(2011 Jun 1)
21.^Chaturvedula VS, Prakash IAdditional minor diterpene glycosides from Stevia rebaudianaNat Prod Commun.(2011 Aug)
22.^Chaturvedula VS, Prakash IA new diterpene glycoside from Stevia rebaudianaMolecules.(2011 Apr 4)
24.^Shivanna N, Naika M, Khanum F, Kaul VKAntioxidant, anti-diabetic and renal protective properties of Stevia rebaudianaJ Diabetes Complications.(2013 Mar)
26.^Thompson AL, Michalik A, Nash RJ, Wilson FX, van Well R, Johnson P, Fleet GW, Yu CY, Hu XG, Cooper RI, Watkin DJSteviamine, a new class of indolizidine alkaloid {(1R,2S,3R,5R,8aR)-3-hydroxy-meth-yl-5-methyl-octa-hydro-indolizine-1,2-diol hydro-bromide}Acta Crystallogr Sect E Struct Rep Online.(2009 Oct 28)
28.^Hu XG, Bartholomew B, Nash RJ, Wilson FX, Fleet GW, Nakagawa S, Kato A, Jia YM, van Well R, Yu CYSynthesis and glycosidase inhibition of the enantiomer of (-)-steviamine, the first example of a new class of indolizidine alkaloidOrg Lett.(2010 Jun 4)
29.^Li G, Wang R, Quampah AJ, Rong Z, Shi C, Wu JCalibration and prediction of amino acids in stevia leaf powder using near infrared reflectance spectroscopyJ Agric Food Chem.(2011 Dec 28)
30.^Shah R, De Jager LS, Begley THSimultaneous determination of steviol and steviol glycosides by liquid chromatography-mass spectrometryFood Addit Contam Part A Chem Anal Control Expo Risk Assess.(2012)
31.^Shukla S, Mehta A, Mehta P, Bajpai VKAntioxidant ability and total phenolic content of aqueous leaf extract of Stevia rebaudiana BertExp Toxicol Pathol.(2012 Nov)
32.^Clos JF, DuBois GE, Prakash IPhotostability of rebaudioside A and stevioside in beveragesJ Agric Food Chem.(2008 Sep 24)
33.^Wölwer-Rieck U, Tomberg W, Wawrzun AInvestigations on the Stability of Stevioside and Rebaudioside A in Soft DrinksJ Agric Food Chem.(2010 Nov 10)
34.^Prakash I, Dubois GE, Clos JF, Wilkens KL, Fosdick LEDevelopment of rebiana, a natural, non-caloric sweetenerFood Chem Toxicol.(2008 Jul)
35.^Wheeler A, Boileau AC, Winkler PC, Compton JC, Prakash I, Jiang X, Mandarino DAPharmacokinetics of rebaudioside A and stevioside after single oral doses in healthy menFood Chem Toxicol.(2008 Jul)
36.^Koyama E, Kitazawa K, Ohori Y, Izawa O, Kakegawa K, Fujino A, Ui MIn vitro metabolism of the glycosidic sweeteners, stevia mixture and enzymatically modified stevia in human intestinal microfloraFood Chem Toxicol.(2003 Mar)
37.^Wingard RE Jr, Brown JP, Enderlin FE, Dale JA, Hale RL, Seitz CTIntestinal degradation and absorption of the glycosidic sweeteners stevioside and rebaudioside AExperientia.(1980 May 15)
38.^Anton SD, Martin CK, Han H, Coulon S, Cefalu WT, Geiselman P, Williamson DAEffects of stevia, aspartame, and sucrose on food intake, satiety, and postprandial glucose and insulin levelsAppetite.(2010 Aug)
39.^Batistatou A, Greene LAInternucleosomal DNA cleavage and neuronal cell survival/deathJ Cell Biol.(1993 Aug)
41.^Maki KC, Curry LL, Carakostas MC, Tarka SM, Reeves MS, Farmer MV, McKenney JM, Toth PD, Schwartz SL, Lubin BC, Dicklin MR, Boileau AC, Bisognano JDThe hemodynamic effects of rebaudioside A in healthy adults with normal and low-normal blood pressureFood Chem Toxicol.(2008 Jul)
43.^Hsieh MH, Chan P, Sue YM, Liu JC, Liang TH, Huang TY, Tomlinson B, Chow MS, Kao PF, Chen YJEfficacy and tolerability of oral stevioside in patients with mild essential hypertension: a two-year, randomized, placebo-controlled studyClin Ther.(2003 Nov)
44.^Chan P, Tomlinson B, Chen YJ, Liu JC, Hsieh MH, Cheng JTA double-blind placebo-controlled study of the effectiveness and tolerability of oral stevioside in human hypertensionBr J Clin Pharmacol.(2000 Sep)
46.^Saravanan R, Vengatash babu K, Ramachandran VEffect of Rebaudioside A, a diterpenoid on glucose homeostasis in STZ-induced diabetic ratsJ Physiol Biochem.(2012 Sep)
47.^Misra H, Soni M, Silawat N, Mehta D, Mehta BK, Jain DCAntidiabetic activity of medium-polar extract from the leaves of Stevia rebaudiana Bert. (Bertoni) on alloxan-induced diabetic ratsJ Pharm Bioallied Sci.(2011 Apr)
48.^Kujur RS, Singh V, Ram M, Yadava HN, Singh KK, Kumari S, Roy BKAntidiabetic activity and phytochemical screening of crude extract of Stevia rebaudiana in alloxan-induced diabetic ratsPharmacognosy Res.(2010 Jul)
49.^Gregersen S, Jeppesen PB, Holst JJ, Hermansen KAntihyperglycemic effects of stevioside in type 2 diabetic subjectsMetabolism.(2004 Jan)
50.^Mourkioti F, Kratsios P, Luedde T, Song YH, Delafontaine P, Adami R, Parente V, Bottinelli R, Pasparakis M, Rosenthal NTargeted ablation of IKK2 improves skeletal muscle strength, maintains mass, and promotes regenerationJ Clin Invest.(2006 Nov)
51.^Bunprajun T, Yimlamai T, Soodvilai S, Muanprasat C, Chatsudthipong VStevioside enhances satellite cell activation by inhibiting of NF-κB signaling pathway in regenerating muscle after cardiotoxin-induced injuryJ Agric Food Chem.(2012 Mar 21)
52.^Yingkun N, Zhenyu W, Jing L, Xiuyun L, Huimin YStevioside protects LPS-induced acute lung injury in miceInflammation.(2013 Feb)
53.^Fengyang L, Yunhe F, Bo L, Zhicheng L, Depeng L, Dejie L, Wen Z, Yongguo C, Naisheng Z, Xichen Z, Zhengtao YStevioside suppressed inflammatory cytokine secretion by downregulation of NF-κB and MAPK signaling pathways in LPS-stimulated RAW264.7 cellsInflammation.(2012 Oct)
54.^Boonkaewwan C, Toskulkao C, Vongsakul MAnti-Inflammatory and Immunomodulatory Activities of Stevioside and Its Metabolite Steviol on THP-1 CellsJ Agric Food Chem.(2006 Feb 8)
55.^Boonkaewwan C, Ao M, Toskulkao C, Rao MCSpecific immunomodulatory and secretory activities of stevioside and steviol in intestinal cellsJ Agric Food Chem.(2008 May 28)
56.^Kramer HF, Goodyear LJExercise, MAPK, and NF-kappaB signaling in skeletal muscleJ Appl Physiol.(2007 Jul)
57.^Dreesen O, Brivanlou AHSignaling pathways in cancer and embryonic stem cellsStem Cell Rev.(2007 Jan)
59.^DORFMAN RI, NES WRAnti-androgenic activity of dihydroisosteviolEndocrinology.(1960 Aug)
61.^Oliveira-Filho RM, Uehara OA, Minetti CA, Valle LBChronic administration of aqueous extract of Stevia rebaudiana (Bert.) Bertoni in rats: endocrine effectsGen Pharmacol.(1989)
62.^Pariwat P, Homvisasevongsa S, Muanprasat C, Chatsudthipong VA natural plant-derived dihydroisosteviol prevents cholera toxin-induced intestinal fluid secretionJ Pharmacol Exp Ther.(2008 Feb)
66.^Melis MS, Rocha ST, Augusto ASteviol effect, a glycoside of Stevia rebaudiana, on glucose clearances in ratsBraz J Biol.(2009 May)
67.^Paul S, Sengupta S, Bandyopadhyay TK, Bhattacharyya AStevioside induced ROS-mediated apoptosis through mitochondrial pathway in human breast cancer cell line MCF-7Nutr Cancer.(2012)
68.^Takasaki M, Konoshima T, Kozuka M, Tokuda H, Takayasu J, Nishino H, Miyakoshi M, Mizutani K, Lee KHCancer preventive agents. Part 8: Chemopreventive effects of stevioside and related compoundsBioorg Med Chem.(2009 Jan 15)
69.^Xili L, Chengjiany B, Eryi X, Reiming S, Yuengming W, Haodong S, Zhiyian HChronic oral toxicity and carcinogenicity study of stevioside in ratsFood Chem Toxicol.(1992 Nov)
70.^Aze Y, Toyoda K, Imaida K, Hayashi S, Imazawa T, Hayashi Y, Takahashi MSubchronic oral toxicity study of stevioside in F344 ratsEisei Shikenjo Hokoku.(1991)
71.^Yodyingyuad V, Bunyawong SEffect of stevioside on growth and reproductionHum Reprod.(1991 Jan)
72.^Toskulkao C, Chaturat L, Temcharoen P, Glinsukon TAcute toxicity of stevioside, a natural sweetener, and its metabolite, steviol, in several animal speciesDrug Chem Toxicol.(1997 Feb-May)
73.^Planas GM, Kucacute JContraceptive Properties of Stevia rebaudianaScience.(1968 Nov 29)
74.^Saenphet K, Aritajat S, Saenphet S, Manosroi J, Manosroi ASafety evaluation of aqueous extracts from Aegle marmelos and Stevia rebaudiana on reproduction of female ratsSoutheast Asian J Trop Med Public Health.(2006)
76.^Klongpanichpak S, Temcharoen P, Toskulkao C, Apibal S, Glinsukon TLack of mutagenicity of stevioside and steviol in Salmonella typhimurium TA 98 and TA 100J Med Assoc Thai.(1997 Sep)
77.^Suttajit M, Vinitketkaumnuen U, Meevatee U, Buddhasukh DMutagenicity and human chromosomal effect of stevioside, a sweetener from Stevia rebaudiana BertoniEnviron Health Perspect.(1993 Oct)
78.^Matsui M, Matsui K, Kawasaki Y, Oda Y, Noguchi T, Kitagawa Y, Sawada M, Hayashi M, Nohmi T, Yoshihira K, Ishidate M Jr, Sofuni TEvaluation of the genotoxicity of stevioside and steviol using six in vitro and one in vivo mutagenicity assaysMutagenesis.(1996 Nov)
79.^Terai T, Ren H, Mori G, Yamaguchi Y, Hayashi TMutagenicity of steviol and its oxidative derivatives in Salmonella typhimurium TM677Chem Pharm Bull (Tokyo).(2002 Jul)
82.^Sekihashi K, Saitoh H, Sasaki YGenotoxicity studies of stevia extract and steviol by the comet assayJ Toxicol Sci.(2002 Dec)
83.^Curry LL, Roberts ASubchronic toxicity of rebaudioside AFood Chem Toxicol.(2008 Jul)
84.^Curry LL, Roberts A, Brown NRebaudioside A: two-generation reproductive toxicity study in ratsFood Chem Toxicol.(2008 Jul)
85.^Williams LD, Burdock GAGenotoxicity studies on a high-purity rebaudioside A preparationFood Chem Toxicol.(2009 Aug)