Quick Navigation

Blood Pressure

A relation of how much blood is in your veins and how much diameter the vein is given to accomodate the blood, and measured in systolic over diastolic (average of 120/80). Many supplements interact, either acutely or chronically, with Blood Pressure.

Our evidence-based analysis on blood pressure features 8 unique references to scientific papers.

Research analysis lead by Kamal Patel
All content reviewed by Examine.com Team. Published:
Last Updated:

Frequently Asked Questions about Blood Pressure

The downsides of caffeine intake
Caffeine can have a determinetal impact on your blood pressure, eye pressure, and acid reflux.

Human Effect Matrix

The Human Effect Matrix looks at human studies (it excludes animal and in vitro studies) to tell you what supplements affect blood pressure
Grade Level of Evidence
Robust research conducted with repeated double-blind clinical trials
Multiple studies where at least two are double-blind and placebo controlled
Single double-blind study or multiple cohort studies
Uncontrolled or observational studies only
Level of Evidence
? The amount of high quality evidence. The more evidence, the more we can trust the results.
Outcome Magnitude of effect
? The direction and size of the supplement's impact on each outcome. Some supplements can have an increasing effect, others have a decreasing effect, and others have no effect.
Consistency of research results
? Scientific research does not always agree. HIGH or VERY HIGH means that most of the scientific research agrees.
grade-a Cocoa Extract
- See all 23 studies
While not affecting everybody, there appears to be a decrease in blood pressure when assessing mildly hypertensive people; the increase in blood flow seen in healthy people is not accompanied by a decrease in blood pressure, while the xanthine (caffeine) content of chocolate products may cause a mild and transient increase in blood pressure in some subjects.
grade-a Fish Oil Minor Very High See all 8 studies
May decrease blood pressure in persons with high blood pressure, but does not appear to have efficacy in persons with normal blood pressure
grade-b Garlic Notable High See all 12 studies
Garlic supplementation appears to reduce blood pressure, and the magnitude is quite respectable in persons with hypertension (around 10 points systolic or 8-10%) whereas there is a smaller but present reduction in persons with normal blood pressure.
grade-b Hibiscus sabdariffa  
grade-b Magnesium  
grade-b Nitrate  
grade-b Olive leaf extract  
grade-b Arginine  
grade-b Caffeine  
grade-b Coenzyme Q10  
grade-b Curcumin  
grade-b Ephedrine  
grade-b Grape Seed Extract  
grade-b Inositol  
grade-b Marijuana  
grade-b Melatonin  
grade-b Modafinil  
grade-b Nigella sativa  
grade-b Pycnogenol  
grade-b Stevia  
grade-b Vitamin D  
grade-b Vitamin E  
grade-b Alpha-Lipoic Acid  
grade-b Chromium  
grade-b Creatine  
grade-b Ginkgo biloba  
grade-b L-Tyrosine  
grade-b Nicotine  
grade-b Panax ginseng  
grade-b Psyllium  
grade-b Quercetin  
grade-b Red Clover Extract  
grade-c 1,3-Dimethylamylamine  
grade-c Chlorogenic Acid  
grade-c Green Coffee Extract  
grade-c Hoodia gordonii  
grade-c Spirulina  
grade-c Ashwagandha  
grade-c Blueberry  
grade-c CDP-choline  
grade-c Chlorella  
grade-c Citrulline  
grade-c Ecklonia cava  
grade-c Fucoxanthin  
grade-c Green Tea Catechins  
grade-c Hesperidin  
grade-c Irvingia gabonensis  
grade-c L-Carnitine  
grade-c Lavender  
grade-c Microlactin  
grade-c Nattokinase  
grade-c Policosanol  
grade-c Pterostilbene  
grade-c Pyruvate  
grade-c Resveratrol  
grade-c Rose Essential Oil  
grade-c Rose Hip  
grade-c Saffron  
grade-c Salvia sclarea  
grade-c Sesamin  
grade-c Tribulus terrestris  
grade-c Vitamin B2  
grade-c Vitamin C  
grade-c Yohimbine  
grade-c 7-Keto DHEA  
grade-c Alanylglutamine  
grade-c Anatabine  
grade-c Anethum graveolens  
grade-c Astaxanthin  
grade-c Bacopa monnieri  
grade-c Benfotiamine  
grade-c Capsaicin  
grade-c Centella asiatica  
grade-c Citrullus colocynthis  
grade-c Coleus forskohlii  
grade-c Conjugated Linoleic Acid  
grade-c ECA  
grade-c Echinacea  
grade-c Eucommia ulmoides  
grade-c Ganoderma lucidum  
grade-c Lactobacillus casei  
grade-c Lactobacillus reuteri  
grade-c Ornithine  
grade-c Phosphatidylserine  
grade-c Rhodiola Rosea  
grade-c Rooibos  
grade-c Royal Jelly  
grade-c Salvia hispanica  
grade-c Sceletium tortuosum  
grade-c Shilajit  
grade-c Sodium Bicarbonate  
grade-c Synephrine  
grade-c Taurine  
grade-c Trimethylglycine  
grade-c Vitamin B3 (Niacin)  
grade-c Whey Protein  
grade-c Yerba mate  
grade-c Zinc  
grade-d Eclipta alba  
grade-d Licorice  
grade-d Berberine  
grade-d Kava  
grade-d Tetradecyl Thioacetic Acid  
grade-d Vitamin B1  
grade-d Black Cohosh  
grade-d Calcium  
grade-d Cissus quadrangularis  
grade-d Mangifera indica  
grade-d Vanadium  

All comparative evidence is now gathered in our ​A-to-Z Supplement Reference.

The evidence for each separate supplement is still freely available ​here.


  1. Verster JC, Koenig J. Caffeine intake and its sources: A review of national representative studies. Crit Rev Food Sci Nutr. (2018)
  2. Guessous I, Eap CB, Bochud M. Blood pressure in relation to coffee and caffeine consumption. Curr Hypertens Rep. (2014)
  3. Nurminen ML, et al. Coffee, caffeine and blood pressure: a critical review. Eur J Clin Nutr. (1999)
  4. Noordzij M, et al. Blood pressure response to chronic intake of coffee and caffeine: a meta-analysis of randomized controlled trials. J Hypertens. (2005)
  5. Greenberg JA, Chow G, Ziegelstein RC. Caffeinated coffee consumption, cardiovascular disease, and heart valve disease in the elderly (from the Framingham Study). Am J Cardiol. (2008)
  6. Li M, et al. The effect of caffeine on intraocular pressure: a systematic review and meta-analysis. Graefes Arch Clin Exp Ophthalmol. (2011)
  7. Chandrasekaran S, Rochtchina E, Mitchell P. Effects of caffeine on intraocular pressure: the Blue Mountains Eye Study. J Glaucoma. (2005)
  8. Lohsiriwat S, Puengna N, Leelakusolvong S. Effect of caffeine on lower esophageal sphincter pressure in Thai healthy volunteers. Dis Esophagus. (2006)