Chlorogenic Acid

Last Updated: September 28 2022

Chlorogenic acid is found in coffee mostly and a lot of plant compounds; it holds promise in many aspects of health and cognition similar to bioflavonoids and shares some effects similar to caffeine but less potent. May decrease the absorption of dietary carbohydrate.

Chlorogenic Acid is most often used for


Chlorogenic acid is a phytochemical found in coffee and coffee beans. It has been touted as being able to reduce blood sugar levels and potentially exert an anti-diabetic effect. It has also been implicated in weight loss and exerting an anti-obesity effect, but that is insofar correlation and not necessarily due to chlorogenic acid.

It can be beneficial to supplement, although doses found in food sources are enough for a long-term preventative (anti-diabetic) measure.

What else is Chlorogenic Acid known as?
Note that Chlorogenic Acid is also known as:
  • Coffee bean extract
  • 5-O-caffeoylquinic acid
  • 3-O-caffeoylquinic acid Green coffee extract
Chlorogenic Acid should not be confused with:
  • Chlorine
  • Corosolic Acid
Dosage information

Supplemental chlorogenic acid appears to have benefit in the range of 120-300mg oral intake, with higher doses still possibly beneficial (not really tested sufficiently). These doses appear to benefit blood pressure and circulation mostly.

This dose seems to be low enough that moderate to high doses of plants with a rich chlorogenic acid content may confer the benefits listed on this page, this most notably includes green coffee extract.

Join our supplement information course

Examine Database: Chlorogenic Acid
What works and what doesn't?

Unlock the full potential of Examine

Get started

Don't miss out on the latest research

2.^Andrade KS, Gonçalvez RT, Maraschin M, Ribeiro-do-Valle RM, Martínez J, Ferreira SRSupercritical fluid extraction from spent coffee grounds and coffee husks: antioxidant activity and effect of operational variables on extract compositionTalanta.(2012 Jan 15)
3.^Watanabe T, Arai Y, Mitsui Y, Kusaura T, Okawa W, Kajihara Y, Saito IThe blood pressure-lowering effect and safety of chlorogenic acid from green coffee bean extract in essential hypertensionClin Exp Hypertens.(2006 Jul)
6.^Gonthier MP, Verny MA, Besson C, Rémésy C, Scalbert AChlorogenic acid bioavailability largely depends on its metabolism by the gut microflora in ratsJ Nutr.(2003 Jun)
7.^Cho AS, Jeon SM, Kim MJ, Yeo J, Seo KI, Choi MS, Lee MKChlorogenic acid exhibits anti-obesity property and improves lipid metabolism in high-fat diet-induced-obese miceFood Chem Toxicol.(2010 Mar)
11.^Chellan N, Muller CJ, de Beer D, Joubert E, Page BJ, Louw JAn in vitro assessment of the effect of Athrixia phylicoides DC. aqueous extract on glucose metabolismPhytomedicine.(2012 Apr 17)
12.^Kozuma K, Tsuchiya S, Kohori J, Hase T, Tokimitsu IAntihypertensive effect of green coffee bean extract on mildly hypertensive subjectsHypertens Res.(2005 Sep)
13.^Ochiai R, Jokura H, Suzuki A, Tokimitsu I, Ohishi M, Komai N, Rakugi H, Ogihara TGreen coffee bean extract improves human vasoreactivityHypertens Res.(2004 Oct)
14.^Suzuki A, Kagawa D, Ochiai R, Tokimitsu I, Saito IGreen coffee bean extract and its metabolites have a hypotensive effect in spontaneously hypertensive ratsHypertens Res.(2002 Jan)
16.^Yamaguchi T, Chikama A, Mori K, Watanabe T, Shioya Y, Katsuragi Y, Tokimitsu IHydroxyhydroquinone-free coffee: a double-blind, randomized controlled dose-response study of blood pressureNutr Metab Cardiovasc Dis.(2008 Jul)
17.^Ochiai R, Chikama A, Kataoka K, Tokimitsu I, Maekawa Y, Ohishi M, Rakugi H, Mikami HEffects of hydroxyhydroquinone-reduced coffee on vasoreactivity and blood pressureHypertens Res.(2009 Nov)
19.^Jin XL, Wei X, Qi FM, Yu SS, Zhou B, Bai SCharacterization of hydroxycinnamic acid derivatives binding to bovine serum albuminOrg Biomol Chem.(2012 May 7)
20.^Yabuta G, Koizumi Y, Namiki K, Hida M, Namiki MStructure of green pigment formed by the reaction of caffeic acid esters (or chlorogenic acid) with a primary amino compoundBiosci Biotechnol Biochem.(2001 Oct)
21.^Lafay S, Morand C, Manach C, Besson C, Scalbert AAbsorption and metabolism of caffeic acid and chlorogenic acid in the small intestine of ratsBr J Nutr.(2006 Jul)
22.^Azuma K, Ippoushi K, Nakayama M, Ito H, Higashio H, Terao JAbsorption of chlorogenic acid and caffeic acid in rats after oral administrationJ Agric Food Chem.(2000 Nov)
23.^Olthof MR, Hollman PC, Buijsman MN, van Amelsvoort JM, Katan MBChlorogenic acid, quercetin-3-rutinoside and black tea phenols are extensively metabolized in humansJ Nutr.(2003 Jun)
24.^Couteau D, McCartney AL, Gibson GR, Williamson G, Faulds CBIsolation and characterization of human colonic bacteria able to hydrolyse chlorogenic acidJ Appl Microbiol.(2001 Jun)
27.^Ohnishi R, Ito H, Iguchi A, Shinomiya K, Kamei C, Hatano T, Yoshida TEffects of chlorogenic acid and its metabolites on spontaneous locomotor activity in miceBiosci Biotechnol Biochem.(2006 Oct)
28.^Ishimoto H, Tai A, Yoshimura M, Amakura Y, Yoshida T, Hatano T, Ito HAntioxidative properties of functional polyphenols and their metabolites assessed by an ORAC assayBiosci Biotechnol Biochem.(2012)
29.^Urgert R, van Vliet T, Zock PL, Katan MBHeavy coffee consumption and plasma homocysteine: a randomized controlled trial in healthy volunteersAm J Clin Nutr.(2000 Nov)
30.^Verhoef P, Pasman WJ, Van Vliet T, Urgert R, Katan MBContribution of caffeine to the homocysteine-raising effect of coffee: a randomized controlled trial in humansAm J Clin Nutr.(2002 Dec)
32.^Mennen LI, de Courcy GP, Guilland JC, Ducros V, Bertrais S, Nicolas JP, Maurel M, Zarebska M, Favier A, Franchisseur C, Hercberg S, Galan PHomocysteine, cardiovascular disease risk factors, and habitual diet in the French Supplementation with Antioxidant Vitamins and Minerals StudyAm J Clin Nutr.(2002 Dec)
33.^Mesas AE, Leon-Muñoz LM, Rodriguez-Artalejo F, Lopez-Garcia EThe effect of coffee on blood pressure and cardiovascular disease in hypertensive individuals: a systematic review and meta-analysisAm J Clin Nutr.(2011 Oct)
35.^Cho ES, Jang YJ, Hwang MK, Kang NJ, Lee KW, Lee HJAttenuation of oxidative neuronal cell death by coffee phenolic phytochemicalsMutat Res.(2009 Feb 10)
37.^Higdon JV, Frei BCoffee and health: a review of recent human researchCrit Rev Food Sci Nutr.(2006)
38.^Shen W, Qi R, Zhang J, Wang Z, Wang H, Hu C, Zhao Y, Bie M, Wang Y, Fu Y, Chen M, Lu DChlorogenic acid inhibits LPS-induced microglial activation and improves survival of dopaminergic neuronsBrain Res Bull.(2012 May 2)
39.^Greenberg JA, Axen KV, Schnoll R, Boozer CNCoffee, tea and diabetes: the role of weight loss and caffeineInt J Obes (Lond).(2005 Sep)
41.^Bracco D, Ferrarra JM, Arnaud MJ, Jéquier E, Schutz YEffects of caffeine on energy metabolism, heart rate, and methylxanthine metabolism in lean and obese womenAm J Physiol.(1995 Oct)
42.^van Dijk AE, Olthof MR, Meeuse JC, Seebus E, Heine RJ, van Dam RMAcute effects of decaffeinated coffee and the major coffee components chlorogenic acid and trigonelline on glucose toleranceDiabetes Care.(2009 Jun)
44.^Rosengren A, Dotevall A, Wilhelmsen L, Thelle D, Johansson SCoffee and incidence of diabetes in Swedish women: a prospective 18-year follow-up studyJ Intern Med.(2004 Jan)
46.^van Dam RM, Feskens EJCoffee consumption and risk of type 2 diabetes mellitusLancet.(2002 Nov 9)
47.^Greenberg JA, Boozer CN, Geliebter ACoffee, diabetes, and weight controlAm J Clin Nutr.(2006 Oct)
48.^Mackenzie T, Brooks B, O'Connor GBeverage intake, diabetes, and glucose control of adults in AmericaAnn Epidemiol.(2006 Sep)
50.^Huxley R, Lee CM, Barzi F, Timmermeister L, Czernichow S, Perkovic V, Grobbee DE, Batty D, Woodward MCoffee, decaffeinated coffee, and tea consumption in relation to incident type 2 diabetes mellitus: a systematic review with meta-analysisArch Intern Med.(2009 Dec 14)
51.^Benalla W, Bellahcen S, Bnouham MAntidiabetic medicinal plants as a source of alpha glucosidase inhibitorsCurr Diabetes Rev.(2010 Jul)
52.^Tunnicliffe JM, Eller LK, Reimer RA, Hittel DS, Shearer JChlorogenic acid differentially affects postprandial glucose and glucose-dependent insulinotropic polypeptide response in ratsAppl Physiol Nutr Metab.(2011 Oct)
56.^Bassoli BK, Cassolla P, Borba-Murad GR, Constantin J, Salgueiro-Pagadigorria CL, Bazotte RB, da Silva RS, de Souza HMChlorogenic acid reduces the plasma glucose peak in the oral glucose tolerance test: effects on hepatic glucose release and glycaemiaCell Biochem Funct.(2008 Apr)
61.^Li BQ, Dong X, Yang GQ, Fang SH, Gao JY, Zhang JX, Gu FM, Miao XM, Zhao HRole of chlorogenic acid in the toxicity induced by Chinese herbal injectionsDrug Chem Toxicol.(2010 Oct)
62.^Wu X, Yang H, Lin D, Zhang J, Luo F, Xu XComprehensive research and evaluation of chlorogenic acid allergyZhongguo Zhong Yao Za Zhi.(2010 Dec)