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Chlorogenic Acid

Chlorogenic acid is found in coffee mostly and a lot of plant compounds; it holds promise in many aspects of health and cognition similar to bioflavonoids and shares some effects similar to caffeine but less potent. May decrease the absorption of dietary carbohydrate.

Our evidence-based analysis on chlorogenic acid features 66 unique references to scientific papers.

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Summary of Chlorogenic Acid

Primary information, health benefits, side effects, usage, and other important details

Chlorogenic acid is a phytochemical found in coffee and coffee beans. It has been touted as being able to reduce blood sugar levels and potentially exert an anti-diabetic effect. It has also been implicated in weight loss and exerting an anti-obesity effect, but that is insofar correlation and not necessarily due to chlorogenic acid.

It can be beneficial to supplement, although doses found in food sources are enough for a long-term preventative (anti-diabetic) measure.

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How to Take

Recommended dosage, active amounts, other details

Supplemental chlorogenic acid appears to have benefit in the range of 120-300mg oral intake, with higher doses still possibly beneficial (not really tested sufficiently). These doses appear to benefit blood pressure and circulation mostly.

This dose seems to be low enough that moderate to high doses of plants with a rich chlorogenic acid content may confer the benefits listed on this page, this most notably includes green coffee extract.

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Human Effect Matrix

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The Human Effect Matrix summarizes human studies to tell you what effects Chlorogenic Acid has on your body, how much evidence there is, and how strong these effects are.

Full details are available to Examine members.
Grade Level of Evidence
Robust research conducted with repeated double-blind clinical trials
Multiple studies where at least two are double-blind and placebo controlled
Single double-blind study or multiple cohort studies
Uncontrolled or observational studies only
Level of Evidence
? The amount of high quality evidence. The more evidence, the more we can trust the results.
Outcome Magnitude of effect
? The direction and size of the supplement's impact on each outcome. Some supplements can have an increasing effect, others have a decreasing effect, and others have no effect.
Consistency of research results
? Scientific research does not always agree. HIGH or VERY HIGH means that most of the scientific research agrees.
grade-c Notable - See study
The decrease in systolic blood pressure with chlorogenic acid has reached 15 points systolic in hypertensives (150mmHg systolic initially) and appears to maintain at that level until supplement cessation.
grade-c Minor - See study
Not overly remarkable reductions in blood glucose
grade-c Minor - See study
Slight increase in glycemic control possibly secondary to reducing carbohydrate absorption
grade-c Minor - See study
Somewhat high acute spike of homocysteine, which is normally a negative thing. Practical significance of this unknown
grade-c Minor - See study
Spike in insulin was attenuated a bit, secondary to attenuating the rate of glucose absorption. Not overly remarkable
grade-c Minor - See study
Chlorogenic acid may have a mood enhancing effect independent of caffeine
grade-c Minor Moderate See 2 studies
Although the reductions seen with chlorogenic acid seem remarkable, the studies conducted at this moment in time are somewhat industry influenced

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Things to Note

Is a Form Of

Other Functions:

Primary Function:

Also Known As

Coffee bean extract, 5-O-caffeoylquinic acid, 3-O-caffeoylquinic acid Green coffee extract

Do Not Confuse With

Chlorine, Corosolic Acid

Goes Well With

  • Some oral hypoglycemics (see full summary)

Caution Notice

May interact with anti-diabetic medication

  • Chlorogenic acid is found in coffee and espresso, although the amount appears to be unreliable[1]

  • Chlorogenic acid may be one of the compounds in prunes that aids in the laxative effect.[2] It is also in coffee, another well known food laxative

  • Chlorogenic acid has a weak psychostimulatory effect, about a third as potent as caffeine

  • Chlorogenic acid and Caffeic acid were once thought to be anti-thaminases (compounds that can induce a thiamin (Vitamin B1) deficiency), however, this has since been shown to be false.[3]

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Click here to see all 66 references.