Alpha-Lipoic Acid
•Last Updated: September 28 2022
Alpha-lipoic acid (ALA) is a mitochondrial compound involved in energy metabolism. It is commonly taken with L-Carnitine supplements, as they are related in mechanisms. ALA provides a short but potent reduction of oxidation by increasing antioxidant enzymes, and may decrease blood glucose acutely.
Alpha-Lipoic Acid is most often used for
Last Updated: September 28 2022
Alpha-Lipoic Acid (ALA) is a mitochondrial compound that is highly involved in energy metabolism. It is synthesized in the body and can be consumed through eating meat. It is also minimally present in some fruits and vegetables.
In supplement form, it has shown benefits for various forms of oxidation and inflammation. These effects protect against heart diseases, liver diseases, diabetes, and neurological decline associated with aging.
ALA is a potent antioxidant compound. It works with mitochondria and the body's natural anti-oxidant defenses. ALA is also seen as an anti-aging compound since it can reverse some of the oxidant damage related to the effects of aging.
Note that Alpha-Lipoic Acid is also known as:
- ALA
- thioctic acid
- 1 2-dithiolane-3-pentanoic acid
Alpha-Lipoic Acid should not be confused with:
- Alpha-Linolenic Acid (omega-3 fatty acid)
Standard dosages of Alpha-Lipoic Acid (ALA) tend to be in the range of 300-600mg, with little differentiation based on whether the racemic mixture of ALA (S- and R- isomers) or Na-R-ALA results in higher blood levels.
ALA appears to be absorbed via transporter-related means, and despite being inherently fat-soluble it does not require dietary fatty acids to be absorbed from the gut. ALA supplementation can be taken in a fasted state.
Research feed
2.^Akiba S, Matsugo S, Packer L, Konishi TAssay of protein-bound lipoic acid in tissues by a new enzymatic methodAnal Biochem.(1998 May 1)
4.^Moini H, Packer L, Saris NEAntioxidant and prooxidant activities of alpha-lipoic acid and dihydrolipoic acidToxicol Appl Pharmacol.(2002 Jul 1)
5.^Merry BJ, Kirk AJ, Goyns MHDietary lipoic acid supplementation can mimic or block the effect of dietary restriction on life spanMech Ageing Dev.(2008 Jun)
6.^Satoh S, Shindoh M, Min JZ, Toyo'oka T, Fukushima T, Inagaki SSelective and sensitive determination of lipoyllysine (protein-bound alpha-lipoic acid) in biological specimens by high-performance liquid chromatography with fluorescence detectionAnal Chim Acta.(2008 Jun 23)
7.^Backman-Gullers B, Hannestad U, Nilsson L, Sörbo BStudies on lipoamidase: characterization of the enzyme in human serum and breast milkClin Chim Acta.(1990 Oct 31)
8.^Hiltunen JK, Schonauer MS, Autio KJ, Mittelmeier TM, Kastaniotis AJ, Dieckmann CLMitochondrial fatty acid synthesis type II: more than just fatty acidsJ Biol Chem.(2009 Apr 3)
9.^Shay KP, Moreau RF, Smith EJ, Smith AR, Hagen TMAlpha-lipoic acid as a dietary supplement: molecular mechanisms and therapeutic potentialBiochim Biophys Acta.(2009 Oct)
11.^Park CH, Youn HR, Lee J, Lee KU, Park JY, Koh EH, Kim HSImproved efficacy of appetite suppression by lipoic acid particles prepared by nanocomminutionDrug Dev Ind Pharm.(2009 Nov)
12.^The Chemistry of 1,2-Dithiolane (Trimethylene Disulfide) As a Model for the Primary Quantum Conversion Act in Photosynthesis.()
13.^Kinetics of the thiol-disulfide exchange. II. Oxygen-promoted free-radical exchange between aromatic thiols and disulfides.()
14.^Saito G, Swanson JA, Lee KDDrug delivery strategy utilizing conjugation via reversible disulfide linkages: role and site of cellular reducing activitiesAdv Drug Deliv Rev.(2003 Feb 10)
16.^Jones W, Li X, Qu ZC, Perriott L, Whitesell RR, May JMUptake, recycling, and antioxidant actions of alpha-lipoic acid in endothelial cellsFree Radic Biol Med.(2002 Jul 1)
18.^Dosage forms containing thioctic acid or solid salts of thioctic acid with improved release and bioavailability.()
19.^Takaishi N, Yoshida K, Satsu H, Shimizu MTransepithelial transport of alpha-lipoic acid across human intestinal Caco-2 cell monolayersJ Agric Food Chem.(2007 Jun 27)
20.^Prasad PD, Wang H, Kekuda R, Fujita T, Fei YJ, Devoe LD, Leibach FH, Ganapathy VCloning and functional expression of a cDNA encoding a mammalian sodium-dependent vitamin transporter mediating the uptake of pantothenate, biotin, and lipoateJ Biol Chem.(1998 Mar 27)
21.^Balamurugan K, Vaziri ND, Said HMBiotin uptake by human proximal tubular epithelial cells: cellular and molecular aspectsAm J Physiol Renal Physiol.(2005 Apr)
22.^Teichert J, Kern J, Tritschler HJ, Ulrich H, Preiss RInvestigations on the pharmacokinetics of alpha-lipoic acid in healthy volunteersInt J Clin Pharmacol Ther.(1998 Dec)
23.^Teichert J, Hermann R, Ruus P, Preiss RPlasma kinetics, metabolism, and urinary excretion of alpha-lipoic acid following oral administration in healthy volunteersJ Clin Pharmacol.(2003 Nov)
24.^Carlson DA, Smith AR, Fischer SJ, Young KL, Packer LThe plasma pharmacokinetics of R-(+)-lipoic acid administered as sodium R-(+)-lipoate to healthy human subjectsAltern Med Rev.(2007 Dec)
25.^Breithaupt-Grögler K, Niebch G, Schneider E, Erb K, Hermann R, Blume HH, Schug BS, Belz GGDose-proportionality of oral thioctic acid--coincidence of assessments via pooled plasma and individual dataEur J Pharm Sci.(1999 Apr)
26.^Harrison EH, McCormick DBThe metabolism of dl-(1,6-14C)lipoic acid in the ratArch Biochem Biophys.(1974 Feb)
27.^Panigrahi M, Sadguna Y, Shivakumar BR, Kolluri SV, Roy S, Packer L, Ravindranath Valpha-Lipoic acid protects against reperfusion injury following cerebral ischemia in ratsBrain Res.(1996 Apr 22)
28.^Arivazhagan P, Shila S, Kumaran S, Panneerselvam CEffect of DL-alpha-lipoic acid on the status of lipid peroxidation and antioxidant enzymes in various brain regions of aged ratsExp Gerontol.(2002 Jun)
29.^Mignini F, Capacchietti M, Napolioni V, Reggiardo G, Fasani R, Ferrari PSingle dose bioavailability and pharmacokinetic study of a innovative formulation of α-lipoic acid (ALA600) in healthy volunteersMinerva Med.(2011 Dec)
30.^Schupke H, Hempel R, Peter G, Hermann R, Wessel K, Engel J, Kronbach TNew metabolic pathways of alpha-lipoic acidDrug Metab Dispos.(2001 Jun)
31.^Ou P, Tritschler HJ, Wolff SPThioctic (lipoic) acid: a therapeutic metal-chelating antioxidantBiochem Pharmacol.(1995 Jun 29)
32.^Cakatay U, Kayali R, Kiziler AR, Aydemir BPostmitotic tissue selenium and manganese levels in alpha-lipoic acid-supplemented aged ratsChem Biol Interact.(2008 Feb 15)
33.^Suh JH, Moreau R, Heath SH, Hagen TMDietary supplementation with (R)-alpha-lipoic acid reverses the age-related accumulation of iron and depletion of antioxidants in the rat cerebral cortexRedox Rep.(2005)
34.^Bush AIMetal complexing agents as therapies for Alzheimer's diseaseNeurobiol Aging.(2002 Nov-Dec)
35.^McCarty MF, Barroso-Aranda J, Contreras FThe "rejuvenatory" impact of lipoic acid on mitochondrial function in aging rats may reflect induction and activation of PPAR-gamma coactivator-1alphaMed Hypotheses.(2009 Jan)
36.^Hagen TM, Ingersoll RT, Lykkesfeldt J, Liu J, Wehr CM, Vinarsky V, Bartholomew JC, Ames AB(R)-alpha-lipoic acid-supplemented old rats have improved mitochondrial function, decreased oxidative damage, and increased metabolic rateFASEB J.(1999 Feb)
37.^Liu J, Head E, Gharib AM, Yuan W, Ingersoll RT, Hagen TM, Cotman CW, Ames BNMemory loss in old rats is associated with brain mitochondrial decay and RNA/DNA oxidation: partial reversal by feeding acetyl-L-carnitine and/or R-alpha -lipoic acidProc Natl Acad Sci U S A.(2002 Feb 19)
38.^Liu J, Killilea DW, Ames BNAge-associated mitochondrial oxidative decay: improvement of carnitine acetyltransferase substrate-binding affinity and activity in brain by feeding old rats acetyl-L- carnitine and/or R-alpha -lipoic acidProc Natl Acad Sci U S A.(2002 Feb 19)
39.^Feeding acetyl-L-carnitine and lipoic acid to old rats significantly improves metabolic function while decreasing oxidative stress.()
40.^Arivazhagan P, Ramanathan K, Panneerselvam CEffect of DL-alpha-lipoic acid on the status of lipid peroxidation and antioxidants in mitochondria of aged ratsJ Nutr Biochem.(2001 Jan)
41.^Arivazhagan P, Ramanathan K, Panneerselvam CEffect of DL-alpha-lipoic acid on mitochondrial enzymes in aged ratsChem Biol Interact.(2001 Nov 28)
42.^Freisleben HJ, Neeb A, Lehr F, Ackermann HInfluence of selegiline and lipoic acid on the life expectancy of immunosuppressed miceArzneimittelforschung.(1997 Jun)
43.^Kim MS, Park JY, Namkoong C, Jang PG, Ryu JW, Song HS, Yun JY, Namgoong IS, Ha J, Park IS, Lee IK, Viollet B, Youn JH, Lee HK, Lee KUAnti-obesity effects of alpha-lipoic acid mediated by suppression of hypothalamic AMP-activated protein kinaseNat Med.(2004 Jul)
44.^Cheng PY, Lee YM, Yen MH, Peng JC, Lam KKReciprocal effects of α-lipoic acid on adenosine monophosphate-activated protein kinase activity in obesity induced by ovariectomy in ratsMenopause.(2011 Sep)
45.^Wang Y, Li X, Guo Y, Chan L, Guan Xalpha-Lipoic acid increases energy expenditure by enhancing adenosine monophosphate-activated protein kinase-peroxisome proliferator-activated receptor-gamma coactivator-1alpha signaling in the skeletal muscle of aged miceMetabolism.(2010 Jul)
46.^Timmers S, de Vogel-van den Bosch J, Towler MC, Schaart G, Moonen-Kornips E, Mensink RP, Hesselink MK, Hardie DG, Schrauwen PPrevention of high-fat diet-induced muscular lipid accumulation in rats by alpha lipoic acid is not mediated by AMPK activationJ Lipid Res.(2010 Feb)
47.^Fernández-Galilea M, Pérez-Matute P, Prieto-Hontoria P, Martínez JA, Moreno-Aliaga MJEffects of lipoic acid on apelin in 3T3-L1 adipocytes and in high-fat fed ratsJ Physiol Biochem.(2011 Sep)
48.^El Midaoui A, Lungu C, Wang H, Wu L, Robillard C, Deblois D, Couture RImpact of α-lipoic acid on liver peroxisome proliferator-activated receptor-α, vascular remodeling, and oxidative stress in insulin-resistant ratsCan J Physiol Pharmacol.(2011 Oct)
49.^Prieto-Hontoria PL, Pérez-Matute P, Fernández-Galilea M, Barber A, Martínez JA, Moreno-Aliaga MJLipoic acid prevents body weight gain induced by a high fat diet in rats: effects on intestinal sugar transportJ Physiol Biochem.(2009 Mar)
50.^Seo EY, Ha AW, Kim WKα-Lipoic acid reduced weight gain and improved the lipid profile in rats fed with high fat dietNutr Res Pract.(2012 Jun)
51.^Prieto-Hontoria PL, Pérez-Matute P, Fernández-Galilea M, Martínez JA, Moreno-Aliaga MJLipoic acid inhibits leptin secretion and Sp1 activity in adipocytesMol Nutr Food Res.(2011 Jul)
52.^Gupte AA, Bomhoff GL, Morris JK, Gorres BK, Geiger PCLipoic acid increases heat shock protein expression and inhibits stress kinase activation to improve insulin signaling in skeletal muscle from high-fat-fed ratsJ Appl Physiol.(2009 Apr)
53.^Butler JA, Hagen TM, Moreau RLipoic acid improves hypertriglyceridemia by stimulating triacylglycerol clearance and downregulating liver triacylglycerol secretionArch Biochem Biophys.(2009 May 1)
54.^Prieto-Hontoria PL, Pérez-Matute P, Fernández-Galilea M, Martínez JA, Moreno-Aliaga MJEffects of lipoic acid on AMPK and adiponectin in adipose tissue of low- and high-fat-fed ratsEur J Nutr.(2012 Jun 5)
55.^Valdecantos MP, Pérez-Matute P, González-Muniesa P, Prieto-Hontoria PL, Moreno-Aliaga MJ, Martínez JALipoic acid administration prevents nonalcoholic steatosis linked to long-term high-fat feeding by modulating mitochondrial functionJ Nutr Biochem.(2012 Mar 28)
56.^Valdecantos MP, Pérez-Matute P, González-Muniesa P, Prieto-Hontoria PL, Moreno-Aliaga MJ, Martínez JALipoic Acid Improves Mitochondrial Function in Nonalcoholic Steatosis Through the Stimulation of Sirtuin 1 and Sirtuin 3Obesity (Silver Spring).(2012 Feb 13)
57.^Kim E, Park DW, Choi SH, Kim JJ, Cho HSA preliminary investigation of alpha-lipoic acid treatment of antipsychotic drug-induced weight gain in patients with schizophreniaJ Clin Psychopharmacol.(2008 Apr)
58.^Zhang L, Xing GQ, Barker JL, Chang Y, Maric D, Ma W, Li BS, Rubinow DRAlpha-lipoic acid protects rat cortical neurons against cell death induced by amyloid and hydrogen peroxide through the Akt signalling pathwayNeurosci Lett.(2001 Oct 26)
59.^Poon HF, Farr SA, Thongboonkerd V, Lynn BC, Banks WA, Morley JE, Klein JB, Butterfield DAProteomic analysis of specific brain proteins in aged SAMP8 mice treated with alpha-lipoic acid: implications for aging and age-related neurodegenerative disordersNeurochem Int.(2005 Jan)
60.^Farr SA, Poon HF, Dogrukol-Ak D, Drake J, Banks WA, Eyerman E, Butterfield DA, Morley JEThe antioxidants alpha-lipoic acid and N-acetylcysteine reverse memory impairment and brain oxidative stress in aged SAMP8 miceJ Neurochem.(2003 Mar)
61.^Sharma M, Gupta YKEffect of alpha lipoic acid on intracerebroventricular streptozotocin model of cognitive impairment in ratsEur Neuropsychopharmacol.(2003 Aug)
62.^Richard MJ, Connell BJ, Khan BV, Saleh TMCellular mechanisms by which lipoic acid confers protection during the early stages of cerebral ischemia: a possible role for calciumNeurosci Res.(2011 Apr)
63.^Lee WY, Orestes P, Latham J, Naik AK, Nelson MT, Vitko I, Perez-Reyes E, Jevtovic-Todorovic V, Todorovic SMMolecular mechanisms of lipoic acid modulation of T-type calcium channels in pain pathwayJ Neurosci.(2009 Jul 29)
64.^Wang SJ, Chen HHPresynaptic mechanisms underlying the alpha-lipoic acid facilitation of glutamate exocytosis in rat cerebral cortex nerve terminalsNeurochem Int.(2007 Jan)
65.^Kleinkauf-Rocha J, Bobermin LD, Machado Pde M, Gonçalves CA, Gottfried C, Quincozes-Santos ALipoic acid increases glutamate uptake, glutamine synthetase activity and glutathione content in C6 astrocyte cell lineInt J Dev Neurosci.(2013 May)
66.^Tang LH, Aizenman EAllosteric modulation of the NMDA receptor by dihydrolipoic and lipoic acid in rat cortical neurons in vitroNeuron.(1993 Nov)
67.^Stoll S, Hartmann H, Cohen SA, Müller WEThe potent free radical scavenger alpha-lipoic acid improves memory in aged mice: putative relationship to NMDA receptor deficitsPharmacol Biochem Behav.(1993 Dec)
68.^Han D, Sen CK, Roy S, Kobayashi MS, Tritschler HJ, Packer LProtection against glutamate-induced cytotoxicity in C6 glial cells by thiol antioxidantsAm J Physiol.(1997 Nov)
69.^Tirosh O, Sen CK, Roy S, Kobayashi MS, Packer LNeuroprotective effects of alpha-lipoic acid and its positively charged amide analogueFree Radic Biol Med.(1999 Jun)
70.^Kobayashi MS, Han D, Packer LAntioxidants and herbal extracts protect HT-4 neuronal cells against glutamate-induced cytotoxicityFree Radic Res.(2000 Feb)
71.^Greenamyre JT, Garcia-Osuna M, Greene JGThe endogenous cofactors, thioctic acid and dihydrolipoic acid, are neuroprotective against NMDA and malonic acid lesions of striatumNeurosci Lett.(1994 Apr 25)
72.^Santos PS, Campêlo LM, Freitas RL, Feitosa CM, Saldanha GB, Freitas RMLipoic acid effects on glutamate and taurine concentrations in rat hippocampus after pilocarpine-induced seizuresArq Neuropsiquiatr.(2011)
73.^de Freitas RM, de Oliveira Silva F, Saldanha GB, Jordán JLipoic acid alters amino acid neurotransmitters content in rat hippocampus after pilocarpine-induced seizuresFundam Clin Pharmacol.(2011 Aug)
74.^Patel MN, Ardelt BK, Yim GK, Isom GECyanide induces Ca(2+)-dependent and -independent release of glutamate from mouse brain slicesNeurosci Lett.(1991 Sep 30)
75.^Sun P, Rane SG, Gunasekar PG, Borowitz JL, Isom GEModulation of the NMDA receptor by cyanide: enhancement of receptor-mediated responsesJ Pharmacol Exp Ther.(1997 Mar)
76.^Abdel-Zaher AO, Abdel-Hady RH, Abdel Moneim WM, Salim SYAlpha-lipoic acid protects against potassium cyanide-induced seizures and mortalityExp Toxicol Pathol.(2011 Jan)
77.^Freitas RM, Jordán J, Feng DLipoic acid effects on monoaminergic system after pilocarpine-induced seizuresNeurosci Lett.(2010 Jun 25)
78.^Santos IM, Freitas RL, Saldanha GB, Tomé Ada R, Jordán J, Freitas RMAlterations on monoamines concentration in rat hippocampus produced by lipoic acidArq Neuropsiquiatr.(2010 Jun)
79.^Ferreira PM, Militão GC, Freitas RMLipoic acid effects on lipid peroxidation level, superoxide dismutase activity and monoamines concentration in rat hippocampusNeurosci Lett.(2009 Oct 23)
80.^Ranieri M, Sciuscio M, Cortese AM, Santamato A, Di Teo L, Ianieri G, Bellomo RG, Stasi M, Megna MThe use of alpha-lipoic acid (ALA), gamma linolenic acid (GLA) and rehabilitation in the treatment of back pain: effect on health-related quality of lifeInt J Immunopathol Pharmacol.(2009 Jul-Sep)
81.^Di Geronimo G, Caccese AF, Caruso L, Soldati A, Passaretti UTreatment of carpal tunnel syndrome with alpha-lipoic acidEur Rev Med Pharmacol Sci.(2009 Mar-Apr)
82.^Bertolotto F, Massone ACombination of alpha lipoic acid and superoxide dismutase leads to physiological and symptomatic improvements in diabetic neuropathyDrugs R D.(2012 Mar 1)
83.^Ziegler D, Low PA, Litchy WJ, Boulton AJ, Vinik AI, Freeman R, Samigullin R, Tritschler H, Munzel U, Maus J, Schütte K, Dyck PJEfficacy and safety of antioxidant treatment with α-lipoic acid over 4 years in diabetic polyneuropathy: the NATHAN 1 trialDiabetes Care.(2011 Sep)
84.^Zechner R, Kienesberger PC, Haemmerle G, Zimmermann R, Lass AAdipose triglyceride lipase and the lipolytic catabolism of cellular fat storesJ Lipid Res.(2009 Jan)
85.^Kuo YT, Lin TH, Chen WL, Lee HMAlpha-lipoic acid induces adipose triglyceride lipase expression and decreases intracellular lipid accumulation in HepG2 cellsEur J Pharmacol.(2012 Oct 5)
86.^Park KG, Min AK, Koh EH, Kim HS, Kim MO, Park HS, Kim YD, Yoon TS, Jang BK, Hwang JS, Kim JB, Choi HS, Park JY, Lee IK, Lee KUAlpha-lipoic acid decreases hepatic lipogenesis through adenosine monophosphate-activated protein kinase (AMPK)-dependent and AMPK-independent pathwaysHepatology.(2008 Nov)
87.^Kuhla A, Derbenev M, Shih HY, Vollmar BProphylactic and abundant intake of α-lipoic acid causes hepatic steatosis and should be reconsidered in usage as an anti-aging drugBiofactors.(2016 Mar-Apr)
88.^Park KG, Min AK, Koh EH, Kim HS, Kim MO, Park HS, Kim YD, Yoon TS, Jang BK, Hwang JS, Kim JB, Choi HS, Park JY, Lee IK, Lee KUAlpha-lipoic acid decreases hepatic lipogenesis through adenosine monophosphate-activated protein kinase (AMPK)-dependent and AMPK-independent pathwaysHepatology.(2008 Nov)
89.^Yi X, Pashaj A, Xia M, Moreau RReversal of obesity-induced hypertriglyceridemia by (R)-α-lipoic acid in ZDF (fa/fa) ratsBiochem Biophys Res Commun.(2013 Sep 27)
90.^Alkhouri N, Dixon LJ, Feldstein AELipotoxicity in nonalcoholic fatty liver disease: not all lipids are created equalExpert Rev Gastroenterol Hepatol.(2009 Aug)
91.^Browning JD, Horton JDMolecular mediators of hepatic steatosis and liver injuryJ Clin Invest.(2004 Jul)
92.^Koh EH, Lee WJ, Lee SA, Kim EH, Cho EH, Jeong E, Kim DW, Kim MS, Park JY, Park KG, Lee HJ, Lee IK, Lim S, Jang HC, Lee KH, Lee KUEffects of alpha-lipoic Acid on body weight in obese subjectsAm J Med.(2011 Jan)
93.^Park HS, Lee JS, Huh SH, Seo JS, Choi EJHsp72 functions as a natural inhibitory protein of c-Jun N-terminal kinaseEMBO J.(2001 Feb 1)
94.^Park KJ, Gaynor RB, Kwak YTHeat shock protein 27 association with the I kappa B kinase complex regulates tumor necrosis factor alpha-induced NF-kappa B activationJ Biol Chem.(2003 Sep 12)
95.^Antioxidants preserve redox balance and inhibit c-Jun-N-terminal kinase pathway while improving insulin signaling in fat-fed rats: evidence for the role of oxidative stress on IRS-1 serine phosphorylation and insulin resistance.()
96.^Chen WL, Kang CH, Wang SG, Lee HMα-Lipoic acid regulates lipid metabolism through induction of sirtuin 1 (SIRT1) and activation of AMP-activated protein kinaseDiabetologia.(2012 Jun)
97.^Shen QW, Zhu MJ, Tong J, Ren J, Du MCa2+/calmodulin-dependent protein kinase kinase is involved in AMP-activated protein kinase activation by alpha-lipoic acid in C2C12 myotubesAm J Physiol Cell Physiol.(2007 Oct)
98.^Chou TC, Shih CY, Chen YTInhibitory effect of α-lipoic acid on platelet aggregation is mediated by PPARsJ Agric Food Chem.(2011 Apr 13)
99.^α-Lipoic Acid Prevents Endothelial Dysfunction in Obese Rats via Activation of AMP-Activated Protein Kinase.()
100.^G D X, J H P, H L S, L S ZAlpha-lipoic acid improves endothelial dysfunction in patients with subclinical hypothyroidismExp Clin Endocrinol Diabetes.(2010 Oct)
101.^Heinisch BB, Francesconi M, Mittermayer F, Schaller G, Gouya G, Wolzt M, Pleiner JAlpha-lipoic acid improves vascular endothelial function in patients with type 2 diabetes: a placebo-controlled randomized trialEur J Clin Invest.(2010 Feb)
102.^Xiang G, Pu J, Yue L, Hou J, Sun Hα-lipoic acid can improve endothelial dysfunction in subjects with impaired fasting glucoseMetabolism.(2011 Apr)
103.^Xiang GD, Sun HL, Zhao LS, Hou J, Yue L, Xu LThe antioxidant alpha-lipoic acid improves endothelial dysfunction induced by acute hyperglycaemia during OGTT in impaired glucose toleranceClin Endocrinol (Oxf).(2008 May)
104.^Xiao C, Giacca A, Lewis GFShort-term oral α-lipoic acid does not prevent lipid-induced dysregulation of glucose homeostasis in obese and overweight nondiabetic menAm J Physiol Endocrinol Metab.(2011 Oct)
105.^Porasuphatana S, Suddee S, Nartnampong A, Konsil J, Harnwong B, Santaweesuk AGlycemic and oxidative status of patients with type 2 diabetes mellitus following oral administration of alpha-lipoic acid: a randomized double-blinded placebo-controlled studyAsia Pac J Clin Nutr.(2012)
106.^Anuradha B, Varalakshmi PProtective role of DL-alpha-lipoic acid against mercury-induced neural lipid peroxidationPharmacol Res.(1999 Jan)
107.^Bast A, Haenen GRInterplay between lipoic acid and glutathione in the protection against microsomal lipid peroxidationBiochim Biophys Acta.(1988 Dec 16)
108.^Moini H, Tirosh O, Park YC, Cho KJ, Packer LR-alpha-lipoic acid action on cell redox status, the insulin receptor, and glucose uptake in 3T3-L1 adipocytesArch Biochem Biophys.(2002 Jan 15)
109.^Suh JH, Shenvi SV, Dixon BM, Liu H, Jaiswal AK, Liu RM, Hagen TMDecline in transcriptional activity of Nrf2 causes age-related loss of glutathione synthesis, which is reversible with lipoic acidProc Natl Acad Sci U S A.(2004 Mar 9)
110.^Zhang DD, Lo SC, Cross JV, Templeton DJ, Hannink MKeap1 is a redox-regulated substrate adaptor protein for a Cul3-dependent ubiquitin ligase complexMol Cell Biol.(2004 Dec)
111.^Dinkova-Kostova AT, Holtzclaw WD, Cole RN, Itoh K, Wakabayashi N, Katoh Y, Yamamoto M, Talalay PDirect evidence that sulfhydryl groups of Keap1 are the sensors regulating induction of phase 2 enzymes that protect against carcinogens and oxidantsProc Natl Acad Sci U S A.(2002 Sep 3)
112.^Kobayashi A, Kang MI, Watai Y, Tong KI, Shibata T, Uchida K, Yamamoto MOxidative and electrophilic stresses activate Nrf2 through inhibition of ubiquitination activity of Keap1Mol Cell Biol.(2006 Jan)
113.^Hong F, Sekhar KR, Freeman ML, Liebler DCSpecific patterns of electrophile adduction trigger Keap1 ubiquitination and Nrf2 activationJ Biol Chem.(2005 Sep 9)
114.^Lykkesfeldt J, Hagen TM, Vinarsky V, Ames BNAge-associated decline in ascorbic acid concentration, recycling, and biosynthesis in rat hepatocytes--reversal with (R)-alpha-lipoic acid supplementationFASEB J.(1998 Sep)
115.^Suh JH, Shigeno ET, Morrow JD, Cox B, Rocha AE, Frei B, Hagen TMOxidative stress in the aging rat heart is reversed by dietary supplementation with (R)-(alpha)-lipoic acidFASEB J.(2001 Mar)
116.^Michels AJ, Joisher N, Hagen TMAge-related decline of sodium-dependent ascorbic acid transport in isolated rat hepatocytesArch Biochem Biophys.(2003 Feb 1)
117.^Xu DP, Wells WWalpha-Lipoic acid dependent regeneration of ascorbic acid from dehydroascorbic acid in rat liver mitochondriaJ Bioenerg Biomembr.(1996 Feb)
118.^Mollo R, Zaccardi F, Scalone G, Scavone G, Rizzo P, Navarese EP, Manto A, Pitocco D, Lanza GA, Ghirlanda G, Crea FEffect of α-lipoic acid on platelet reactivity in type 1 diabetic patientsDiabetes Care.(2012 Feb)
119.^Packer L, Witt EH, Tritschler HJalpha-Lipoic acid as a biological antioxidantFree Radic Biol Med.(1995 Aug)
120.^Chaudhary P, Marracci GH, Bourdette DNLipoic acid inhibits expression of ICAM-1 and VCAM-1 by CNS endothelial cells and T cell migration into the spinal cord in experimental autoimmune encephalomyelitisJ Neuroimmunol.(2006 Jun)
121.^Kunt T, Forst T, Wilhelm A, Tritschler H, Pfuetzner A, Harzer O, Engelbach M, Zschaebitz A, Stofft E, Beyer JAlpha-lipoic acid reduces expression of vascular cell adhesion molecule-1 and endothelial adhesion of human monocytes after stimulation with advanced glycation end productsClin Sci (Lond).(1999 Jan)
122.^Kim HS, Kim HJ, Park KG, Kim YN, Kwon TK, Park JY, Lee KU, Kim JG, Lee IKAlpha-lipoic acid inhibits matrix metalloproteinase-9 expression by inhibiting NF-kappaB transcriptional activityExp Mol Med.(2007 Feb 28)
123.^Lee EY, Lee CK, Lee KU, Park JY, Cho KJ, Cho YS, Lee HR, Moon SH, Moon HB, Yoo BAlpha-lipoic acid suppresses the development of collagen-induced arthritis and protects against bone destruction in miceRheumatol Int.(2007 Jan)
124.^Zhang WJ, Frei BAlpha-lipoic acid inhibits TNF-alpha-induced NF-kappaB activation and adhesion molecule expression in human aortic endothelial cellsFASEB J.(2001 Nov)
125.^Sola S, Mir MQ, Cheema FA, Khan-Merchant N, Menon RG, Parthasarathy S, Khan BVIrbesartan and lipoic acid improve endothelial function and reduce markers of inflammation in the metabolic syndrome: results of the Irbesartan and Lipoic Acid in Endothelial Dysfunction (ISLAND) studyCirculation.(2005 Jan 25)
126.^Bae SC, Jung WJ, Lee EJ, Yu R, Sung MKEffects of antioxidant supplements intervention on the level of plasma inflammatory molecules and disease severity of rheumatoid arthritis patientsJ Am Coll Nutr.(2009 Feb)
127.^Jung TS, Kim SK, Shin HJ, Jeon BT, Hahm JR, Roh GSα-lipoic acid prevents non-alcoholic fatty liver disease in OLETF ratsLiver Int.(2012 Aug 3)
128.^Kandeil MA, Amin KA, Hassanin KA, Ali KM, Mohammed ETRole of lipoic acid on insulin resistance and leptin in experimentally diabetic ratsJ Diabetes Complications.(2011 Jan-Feb)
129.^Shen W, Liu K, Tian C, Yang L, Li X, Ren J, Packer L, Cotman CW, Liu JR-alpha-lipoic acid and acetyl-L-carnitine complementarily promote mitochondrial biogenesis in murine 3T3-L1 adipocytesDiabetologia.(2008 Jan)
130.^Jun DW, Cho WK, Jun JH, Kwon HJ, Jang KS, Kim HJ, Jeon HJ, Lee KN, Lee HL, Lee OY, Yoon BC, Choi HS, Hahm JS, Lee MHPrevention of free fatty acid-induced hepatic lipotoxicity by carnitine via reversal of mitochondrial dysfunctionLiver Int.(2011 Oct)
131.^Ide T, Azechi A, Kitade S, Kunimatsu Y, Suzuki N, Nakajima CCombined effect of sesamin and α-lipoic acid on hepatic fatty acid metabolism in ratsEur J Nutr.(2012 Jun 30)
132.^György P, Rose CS, Eakin RE, Snell EE, Williams RJEGG-WHITE INJURY AS THE RESULT OF NONABSORPTION OR INACTIVATION OF BIOTINScience.(1941 May 16)
133.^Sydenstricker VP, Singal SA, Briggs AP, Devaughn NM, Isbell HPRELIMINARY OBSERVATIONS ON "EGG WHITE INJURY" IN MAN AND ITS CURE WITH A BIOTIN CONCENTRATEScience.(1942 Feb 13)
134.^Hale G1, Wallis NG, Perham RNInteraction of avidin with the lipoyl domains in the pyruvate dehydrogenase multienzyme complex: three-dimensional location and similarity to biotinyl domains in carboxylasesProc Biol Sci.(1992 Jun 22)
135.^Cremer DR, Rabeler R, Roberts A, Lynch BLong-term safety of alpha-lipoic acid (ALA) consumption: A 2-year studyRegul Toxicol Pharmacol.(2006 Dec)
136.^Ziegler D, Hanefeld M, Ruhnau KJ, Hasche H, Lobisch M, Schütte K, Kerum G, Malessa RTreatment of symptomatic diabetic polyneuropathy with the antioxidant alpha-lipoic acid: a 7-month multicenter randomized controlled trial (ALADIN III Study). ALADIN III Study Group. Alpha-Lipoic Acid in Diabetic NeuropathyDiabetes Care.(1999 Aug)
137.^Ziegler D, Hanefeld M, Ruhnau KJ, Meissner HP, Lobisch M, Schütte K, Gries FATreatment of symptomatic diabetic peripheral neuropathy with the anti-oxidant alpha-lipoic acid. A 3-week multicentre randomized controlled trial (ALADIN Study)Diabetologia.(1995 Dec)
138.^Cakatay U, Kayali RPlasma protein oxidation in aging rats after alpha-lipoic acid administrationBiogerontology.(2005)
139.^Kayali R, Cakatay U, Akçay T, Altuğ TEffect of alpha-lipoic acid supplementation on markers of protein oxidation in post-mitotic tissues of ageing ratCell Biochem Funct.(2006 Jan-Feb)
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