Alpha-Lipoic Acid

Last Updated: September 28 2022

Alpha-lipoic acid (ALA) is a mitochondrial compound involved in energy metabolism. It is commonly taken with L-Carnitine supplements, as they are related in mechanisms. ALA provides a short but potent reduction of oxidation by increasing antioxidant enzymes, and may decrease blood glucose acutely.

Alpha-Lipoic Acid is most often used for

Summary

Alpha-Lipoic Acid (ALA) is a mitochondrial compound that is highly involved in energy metabolism. It is synthesized in the body and can be consumed through eating meat. It is also minimally present in some fruits and vegetables.

In supplement form, it has shown benefits for various forms of oxidation and inflammation. These effects protect against heart diseases, liver diseases, diabetes, and neurological decline associated with aging.

ALA is a potent antioxidant compound. It works with mitochondria and the body's natural anti-oxidant defenses. ALA is also seen as an anti-aging compound since it can reverse some of the oxidant damage related to the effects of aging.

What else is Alpha-Lipoic Acid known as?
Note that Alpha-Lipoic Acid is also known as:
  • ALA
  • thioctic acid
  • 1 2-dithiolane-3-pentanoic acid
Alpha-Lipoic Acid should not be confused with:
  • Alpha-Linolenic Acid (omega-3 fatty acid)
Dosage information

Standard dosages of Alpha-Lipoic Acid (ALA) tend to be in the range of 300-600mg, with little differentiation based on whether the racemic mixture of ALA (S- and R- isomers) or Na-R-ALA results in higher blood levels.

ALA appears to be absorbed via transporter-related means, and despite being inherently fat-soluble it does not require dietary fatty acids to be absorbed from the gut. ALA supplementation can be taken in a fasted state.

Examine Database
References
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