Brown Seaweed Extract

Last Updated: September 28 2022

Fucoxanthin is a carotenoid found in brown seaweed that is being investigated for its fat burning abilities. It reduces fat mass, but has a time delay due to build up in fat tissue and does not stimulate the brain. Also appears healthy, but needs more corroborating evidence.

Brown Seaweed Extract is most often used for

Summary

Fucoxanthin is a brown seaweed pigment that is found in most brown seaweeds, as well as a few other marine sources. It is a xanthophyll, which is a molecule structurally similar to beta-carotene and vitamin A; yet fucoxanthin does not possess vitamin-like activity in the body.

Fucoxanthin, via its metabolites, seems to be stored in fat cells for a prolonged period of time and can induce fat loss while inhibiting fat cell differentiation and proliferation. Although only one human study has been published, it appears to be a promising non-stimulatory fat loss agent but requires time to work (5-16 weeks).

It also possesses other health benefits, such as correcting abnormalities in glucose metabolism in muscle tissue which can help diabetics and might reduce cholesterol levels and triglycerides by currently unverified mechanisms. Reductions in blood pressure and reductions in both liver fat stores and liver enzyme values have been noted with fucoxanthin supplementation in humans.

Fucoxanthin, although usage as a supplement is preliminary, appears to be a very promising joint fat loss and health boosting agent.

What else is Brown Seaweed Extract known as?
Note that Brown Seaweed Extract is also known as:
  • Seaweed Extract
  • Undaria Pinnatifida
  • Fuco
  • Fucothin
  • Fucoxanthin
Brown Seaweed Extract should not be confused with:
  • Astaxanthin
Dosage information

A daily dosage of 2.4-8mg fucoxanthin has shown benefit in some human studies over a prolonged period of time, and while within this range the benefits are dose-dependent higher doses have not been tested sufficiently.

If buying a seaweed standardized for fucoxanthin, look for the extract percentage and then backtrack. Buying an undaria pinnafitida supplement that is 1% fucoxanthin by weight would require 240-800mg of the supplement to get 2.4-8mg fucoxanthin.

Assuming this page on consuming seaweed is read and understood, then daily consumption of dietary seaweed may be sufficient to get enough fucoxanthin for optimal antioxidative and fat burning effects.

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      References
      1.^Maoka TCarotenoids in marine animalsMar Drugs.(2011 Feb 22)
      2.^Dembitsky VM, Maoka TAllenic and cumulenic lipidsProg Lipid Res.(2007 Nov)
      7.^Lachnit T, Fischer M, Künzel S, Baines JF, Harder TCompounds associated with algal surfaces mediate epiphytic colonization of the marine macroalga Fucus vesiculosusFEMS Microbiol Ecol.(2013 May)
      9.^Heo SJ, Yoon WJ, Kim KN, Ahn GN, Kang SM, Kang DH, Affan A, Oh C, Jung WK, Jeon YJEvaluation of anti-inflammatory effect of fucoxanthin isolated from brown algae in lipopolysaccharide-stimulated RAW 264.7 macrophagesFood Chem Toxicol.(2010 Aug-Sep)
      11.^Kang SI, Shin HS, Kim HM, Yoon SA, Kang SW, Kim JH, Ko HC, Kim SJPetalonia binghamiae extract and its constituent fucoxanthin ameliorate high-fat diet-induced obesity by activating AMP-activated protein kinaseJ Agric Food Chem.(2012 Apr 4)
      12.^Quitain AT, Kai T, Sasaki M, Goto MSupercritical Carbon Dioxide Extraction of Fucoxanthin from Undaria pinnatifidaJ Agric Food Chem.(2013 Jun 6)
      13.^D'Orazio N, Gemello E, Gammone MA, de Girolamo M, Ficoneri C, Riccioni GFucoxantin: a treasure from the seaMar Drugs.(2012 Mar)
      16.^Kim SM, Jung YJ, Kwon ON, Cha KH, Um BH, Chung D, Pan CHA potential commercial source of fucoxanthin extracted from the microalga Phaeodactylum tricornutumAppl Biochem Biotechnol.(2012 Apr)
      18.^Strand A, Herstad O, Liaaen-Jensen SFucoxanthin metabolites in egg yolks of laying hensComp Biochem Physiol A Mol Integr Physiol.(1998 Apr)
      19.^Beppu F, Niwano Y, Tsukui T, Hosokawa M, Miyashita KSingle and repeated oral dose toxicity study of fucoxanthin (FX), a marine carotenoid, in miceJ Toxicol Sci.(2009 Oct)
      20.^Hu T, Liu D, Chen Y, Wu J, Wang SAntioxidant activity of sulfated polysaccharide fractions extracted from Undaria pinnitafida in vitroInt J Biol Macromol.(2010 Mar 1)
      21.^Nishino H, Tsushima M, Matsuno T, Tanaka Y, Okuzumi J, Murakoshi M, Satomi Y, Takayasu J, Tokuda H, Nishino A, et alAnti-neoplastic effect of halocynthiaxanthin, a metabolite of fucoxanthinAnticancer Drugs.(1992 Oct)
      22.^Maeda H, Hosokawa M, Sashima T, Funayama K, Miyashita KEffect of medium-chain triacylglycerols on anti-obesity effect of fucoxanthinJ Oleo Sci.(2007)
      23.^Sangeetha RK, Bhaskar N, Divakar S, Baskaran VBioavailability and metabolism of fucoxanthin in rats: structural characterization of metabolites by LC-MS (APCI)Mol Cell Biochem.(2010 Jan)
      25.^Hashimoto T, Ozaki Y, Mizuno M, Yoshida M, Nishitani Y, Azuma T, Komoto A, Maoka T, Tanino Y, Kanazawa KPharmacokinetics of fucoxanthinol in human plasma after the oral administration of kombu extractBr J Nutr.(2012 Jun)
      26.^Hashimoto T, Ozaki Y, Taminato M, Das SK, Mizuno M, Yoshimura K, Maoka T, Kanazawa KThe distribution and accumulation of fucoxanthin and its metabolites after oral administration in miceBr J Nutr.(2009 Jul)
      27.^Sugawara T, Yamashita K, Asai A, Nagao A, Shiraishi T, Imai I, Hirata TEsterification of xanthophylls by human intestinal Caco-2 cellsArch Biochem Biophys.(2009 Mar 15)
      28.^Matsumoto M, Hosokawa M, Matsukawa N, Hagio M, Shinoki A, Nishimukai M, Miyashita K, Yajima T, Hara HSuppressive effects of the marine carotenoids, fucoxanthin and fucoxanthinol on triglyceride absorption in lymph duct-cannulated ratsEur J Nutr.(2010 Jun)
      32.^Asai A, Yonekura L, Nagao ALow bioavailability of dietary epoxyxanthophylls in humansBr J Nutr.(2008 Aug)
      34.^Yonekura L, Kobayashi M, Terasaki M, Nagao AKeto-carotenoids are the major metabolites of dietary lutein and fucoxanthin in mouse tissuesJ Nutr.(2010 Oct)
      35.^Tsuboi M, Etoh H, Kato K, Nakatugawa H, Kato H, Maejima Y, Matsumoto G, Mori H, Hosokawa M, Miyashita K, Tokuda H, Suzuki N, Maoka TNitrocapsanthin and nitrofucoxanthin, respective products of capsanthin and fucoxanthin reaction with peroxynitriteJ Agric Food Chem.(2011 Oct 12)
      37.^Guengerich FPCytochrome P-450 3A4: regulation and role in drug metabolismAnnu Rev Pharmacol Toxicol.(1999)
      38.^Ransohoff RM, Perry VHMicroglial physiology: unique stimuli, specialized responsesAnnu Rev Immunol.(2009)
      39.^Block ML, Zecca L, Hong JSMicroglia-mediated neurotoxicity: uncovering the molecular mechanismsNat Rev Neurosci.(2007 Jan)
      40.^Lull ME, Block MLMicroglial activation and chronic neurodegenerationNeurotherapeutics.(2010 Oct)
      41.^Pangestuti R, Vo TS, Ngo DH, Kim SKFucoxanthin Ameliorates Inflammation and Oxidative Reponses in MicrogliaJ Agric Food Chem.(2013 Apr 12)
      45.^Maeda H, Hosokawa M, Sashima T, Murakami-Funayama K, Miyashita KAnti-obesity and anti-diabetic effects of fucoxanthin on diet-induced obesity conditions in a murine modelMol Med Report.(2009 Nov-Dec)
      47.^Hosokawa M, Miyashita T, Nishikawa S, Emi S, Tsukui T, Beppu F, Okada T, Miyashita KFucoxanthin regulates adipocytokine mRNA expression in white adipose tissue of diabetic/obese KK-Ay miceArch Biochem Biophys.(2010 Dec 1)
      48.^Tsukui T, Konno K, Hosokawa M, Maeda H, Sashima T, Miyashita KFucoxanthin and fucoxanthinol enhance the amount of docosahexaenoic acid in the liver of KKAy obese/diabetic miceJ Agric Food Chem.(2007 Jun 27)
      50.^Maeda H, Hosokawa M, Sashima T, Funayama K, Miyashita KFucoxanthin from edible seaweed, Undaria pinnatifida, shows antiobesity effect through UCP1 expression in white adipose tissuesBiochem Biophys Res Commun.(2005 Jul 1)
      51.^Nicholls DG, Locke RMThermogenic mechanisms in brown fatPhysiol Rev.(1984 Jan)
      52.^Maeda H, Tsukui T, Sashima T, Hosokawa M, Miyashita KSeaweed carotenoid, fucoxanthin, as a multi-functional nutrientAsia Pac J Clin Nutr.(2008)
      53.^Boss O, Farmer SRRecruitment of brown adipose tissue as a therapy for obesity-associated diseasesFront Endocrinol (Lausanne).(2012)
      54.^Jeon SM, Kim HJ, Woo MN, Lee MK, Shin YC, Park YB, Choi MSFucoxanthin-rich seaweed extract suppresses body weight gain and improves lipid metabolism in high-fat-fed C57BL/6J miceBiotechnol J.(2010 Sep)
      56.^Yim MJ, Hosokawa M, Mizushina Y, Yoshida H, Saito Y, Miyashita KSuppressive effects of Amarouciaxanthin A on 3T3-L1 adipocyte differentiation through down-regulation of PPARγ and C/EBPα mRNA expressionJ Agric Food Chem.(2011 Mar 9)
      58.^Maeda H, Hosokawa M, Sashima T, Takahashi N, Kawada T, Miyashita KFucoxanthin and its metabolite, fucoxanthinol, suppress adipocyte differentiation in 3T3-L1 cellsInt J Mol Med.(2006 Jul)
      60.^Kanda H, Tateya S, Tamori Y, Kotani K, Hiasa K, Kitazawa R, Kitazawa S, Miyachi H, Maeda S, Egashira K, Kasuga MMCP-1 contributes to macrophage infiltration into adipose tissue, insulin resistance, and hepatic steatosis in obesityJ Clin Invest.(2006 Jun)
      61.^Nieto-Vazquez I, Fernández-Veledo S, Krämer DK, Vila-Bedmar R, Garcia-Guerra L, Lorenzo MInsulin resistance associated to obesity: the link TNF-alphaArch Physiol Biochem.(2008 Jul)
      63.^Das SK, Ren R, Hashimoto T, Kanazawa KFucoxanthin induces apoptosis in osteoclast-like cells differentiated from RAW264.7 cellsJ Agric Food Chem.(2010 May 26)
      64.^Sachindra NM, Sato E, Maeda H, Hosokawa M, Niwano Y, Kohno M, Miyashita KRadical scavenging and singlet oxygen quenching activity of marine carotenoid fucoxanthin and its metabolitesJ Agric Food Chem.(2007 Oct 17)
      65.^Nomura T, Kikuchi M, Kubodera A, Kawakami YProton-donative antioxidant activity of fucoxanthin with 1,1-diphenyl-2-picrylhydrazyl (DPPH)Biochem Mol Biol Int.(1997 Jun)
      68.^Takashima M, Shichiri M, Hagihara Y, Yoshida Y, Niki ECapacity of fucoxanthin for scavenging peroxyl radicals and inhibition of lipid peroxidation in model systemsFree Radic Res.(2012 Nov)
      69.^Sies HStrategies of antioxidant defenseEur J Biochem.(1993 Jul 15)
      74.^Shiratori K, Ohgami K, Ilieva I, Jin XH, Koyama Y, Miyashita K, Yoshida K, Kase S, Ohno SEffects of fucoxanthin on lipopolysaccharide-induced inflammation in vitro and in vivoExp Eye Res.(2005 Oct)
      76.^Ishikawa C, Tafuku S, Kadekaru T, Sawada S, Tomita M, Okudaira T, Nakazato T, Toda T, Uchihara JN, Taira N, Ohshiro K, Yasumoto T, Ohta T, Mori NAnti-adult T-cell leukemia effects of brown algae fucoxanthin and its deacetylated product, fucoxanthinolInt J Cancer.(2008 Dec 1)
      77.^Heo SJ, Yoon WJ, Kim KN, Oh C, Choi YU, Yoon KT, Kang DH, Qian ZJ, Choi IW, Jung WKAnti-inflammatory effect of fucoxanthin derivatives isolated from Sargassum siliquastrum in lipopolysaccharide-stimulated RAW 264.7 macrophageFood Chem Toxicol.(2012 Jun 23)
      80.^Nakanishi C, Toi MNuclear factor-kappaB inhibitors as sensitizers to anticancer drugsNat Rev Cancer.(2005 Apr)
      84.^Beppu F, Niwano Y, Sato E, Kohno M, Tsukui T, Hosokawa M, Miyashita KIn vitro and in vivo evaluation of mutagenicity of fucoxanthin (FX) and its metabolite fucoxanthinol (FXOH)J Toxicol Sci.(2009 Dec)