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Yohimbine

Yohimbine is a fat burning compound. Although effective, it may cause anxiety, it adversely interacts with many pharmaceuticals, and the labeled dose of supplements that contain it often does not match the actual dose.

Our evidence-based analysis on yohimbine features 100 unique references to scientific papers.

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Summary of Yohimbine

Primary information, health benefits, side effects, usage, and other important details

Yohimbe, and its subset yohimbine, are fat-burning compounds, primarily used to lose fat during short term fasting.

Yohimbine is also an aphrodisiac and can aid erectile dysfunction. It is also a general stimulant.

Yohimbine works by increasing adrenaline levels in the body, as well as inhibiting a regulatory process in fat cells, which normally suppresses fat burning.

The effects of yohimbine are partially negated by food intake, which is why it is often taken in a fasted state.

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How to Take

Medical Disclaimer

Recommended dosage, active amounts, other details

Dosages of 0.2mg/kg bodyweight have been successfully used to increase fat burning without significant implications on cardiovascular parameters like heart rate and blood pressure. This results in a dosage of:

  • 14 mg for a 150lb person

  • 18 mg for a 200lb person

  • 22 mg for a 250lb person

Supplementation is most effective between meals or during short term fasting.

Caution should be exercised at higher body weight, since the cardiovascular system may not be prepared to handle a stimulatory agent such as yohimbine. When supplementing yohimbine for the first time, always start with a half-dose and assess tolerance before proceeding.

Caution should also be exercised since many supplements containing yohimbine either do not list how much yohimbine is included, or if they do, the actual dose ranges from 25-150% of the dose listed. Since the dosage may be higher than listed, this is extra reason to start with a lower dose.

When pairing yohimbine with other stimulatory agents, half-dose both supplements and work up to the recommended dose cautiously, as two supplements can interact negatively.

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Human Effect Matrix

Unlocked for Examine Plus members

The Human Effect Matrix summarizes human studies to tell you what effects Yohimbine has on your body, how much evidence there is, and how strong these effects are.

Full details are available to Examine Plus members.
Grade Level of Evidence
Robust research conducted with repeated double-blind clinical trials
Multiple studies where at least two are double-blind and placebo controlled
Single double-blind study or multiple cohort studies
Uncontrolled or observational studies only
Level of Evidence
? The amount of high quality evidence. The more evidence, the more we can trust the results.
Outcome Magnitude of effect
? The direction and size of the supplement's impact on each outcome. Some supplements can have an increasing effect, others have a decreasing effect, and others have no effect.
Consistency of research results
? Scientific research does not always agree. HIGH or VERY HIGH means that most of the scientific research agrees.
Notes
grade-b Minor - See study
Erections are increased following yohimbine ingestion which is thought to be a combination of alpha-2-adrenergic antagonism (enhancing relaxation of the penile tissue so engorgement of blood can ensure) and increasing blood pressure (which would increase the amount of force in an erection). However, may not be able to overcome organic erectile dysfunction associated with poor blood flow
grade-c Notable - See study
Fat mass is reduced with yohimbine ingestion and appears to affect both obese and lean individuals
grade-c Minor - See study
Injections of yohimbine have been noted to increase cravings for alcohol, which although not demonstrated with oral intake is thought to be related to the reduction in inhibition
grade-c Minor Moderate See 2 studies
Although unreliable, an increase in anxiety may occur following yohimbine ingestion
grade-c Minor Very High See 2 studies
Appears to increase blood pressure, which may aid the proerectile effects (as it is an acute increase) but is a cardiovascular risk factor
grade-c Minor Very High See 2 studies
Appears to increase cortisol following ingestion
grade-c Minor - See study
There appears to be an increased urge to urinate following supplementation of yohimbine
grade-c Minor Very High See 2 studies
Due to stimulatory effects, an increase in heart rate follows yohimbine ingestion
grade-c Minor Moderate See 2 studies
Thought to decrease symptoms of phobia via noradrenaline release (causing densensitization to the stress response) but studies looking at its efficacy are mixed.
grade-c - - See study
No significant influence on lean mass detected with yohimbine ingestion
grade-c - - See study
Despite increased rates of melatonin elimination from the body (via urinartion), there does not appear to be a significant influence on plasma melatonin concentrations.
grade-c - - See study
No significant influence on power output noted with yohimbine
grade-c - - See study
No significant effect on gastric emptying rate
grade-d Minor - See study
A decrease in cerebral blood flow has been noted to be independent of cognitive impairment
grade-d Minor - See study
An increase in penile girth has been noted (similar to L-DOPA) which was not to a large degree, only detectable when dividing the group into responders and nonresponders
grade-d Minor - See study
Orthostatic hypotension (light headedness upon rapidly standing up) appears to have reduced symptoms associated with yohimbine usage
grade-d - - See study
No significant influence on testosterone seen with yohimbine supplementation

Studies Excluded from Consideration

  • Excluded due to being confounded with a variety of nutrients such as Synephrine and Hordenine[1]

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Things to Note

Is a Form Of

Other Functions:

Primary Function:

Also Known As

Yohimbe, Corynanthe Yohimbe, Yohimbe Bark, Pausinystalia Yohimbe

Goes Well With

Caution Notice

  • Yohimbine can cause extreme anxiety in individuals predisposed to anxiety. Yohimbine may trigger manic psychosis or suicidal episodes in people with bipolar disorder

  • Yohimbine can interact with a large amount of neurological medications and should not be used in conjunction with these medication without consultation with a doctor

  • The actual dose of yohimbine in many supplements has been found to vary from the labeled dose from 25-150%

  • Yohimbe is highly stimulatory

  • There is a high chance of yohimbine interacting with neurological medication

  • Many supplements containing yohimbine either do not list its dose, or its dose is inaccurate by up to 150%

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Click here to see all 100 references.