Anatabine Research Analysis

Kamal Patel

Anatabine

•Last Updated: September 28 2022

Anatabine is an alkaloid compound found in tobacco and plants in the nightshade family, which includes eggplant and peppers. Anatabine possesses anti-inflammatory properties but further research is needed to determine if supplementation is practical.

Dosage

Examine Database

Anatabine is most often used for

:

Kamal Patel, MPH, MBA

Last Updated: September 28 2022

summary
Dosage information
Examine Database
Research breakdown
References

Summary

Anatabine is an alkaloid found in tobacco and other plants in the nightshade family.

Anatabine is being researched for its anti-inflammatory properties. Preliminary evidence suggests it may be useful to treat autoimmune diseases and Alzheimer’s disease.

Unfortunately, current research uses doses that are significantly higher than the anatabine supplements available on the market. Oral studies tend to use a dose of 1.6mg/kg of bodyweight for people, which translates to dose between 68-110mg for a 150lb person. One human study even failed to find anti-inflammatory effects at a dose that was 6 – 12 times higher than the doses found in today’s anatabine supplements.

Anatabine’s main mechanism works by inhibiting the signal transducer and activator of transcription 3 protein (STAT3), which inhibits a protein responsible for DNA transcription, called nuclear factor kappa-light-chain-enhancer of activated B cells (nF-kB). Both Boswellia serrata and Feverfew have a similar mechanism.

Due to limitation of anatabine supplements on the market, it is not a practical anti-inflammatory supplement.

What else is Anatabine known as?

Note that Anatabine is also known as:

Anatabloc (Brand Name)

Dosage information

Animal research on anatabine used an oral dose of 12.5 – 20mg/kg of bodyweight in mice, for the purpose of autoimmune diseases. This suggests a preliminary human dose of:

• 70-110 mg for a 150lb person

• 90-150 mg for a 200lb person

• 110-180 mg for a 250lb person

These dosages are based on preliminary animal evidence, not human studies. Anatabine supplementation cannot be recommended at this time due to a lack of human evidence for its effects.

Examine Database: Anatabine

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Research Breakdown

1

Sources and Structure

1.1

Sources

1.2

Structure and Properties

2

Neurology

2.1

Cholinergic Neurotransmission

2.2

Alzheimer& #039;s Disease

3

Cardiovascular Health

3.1

Blood Pressure

4

Inflammation and Immunology

4.1

Mechanisms

4.2

Autoimmune Diseases

5

Physical Exercise and Skeletal Muscle

5.1

Muscle Soreness and Damage

References

1.^Wu W, Ashley DL, Watson CHDetermination of nicotine and other minor alkaloids in international cigarettes by solid-phase microextraction and gas chromatography/mass spectrometryAnal Chem.(2002 Oct 1)

2.^Lisko JG, Stanfill SB, Duncan BW, Watson CHApplication of GC-MS/MS for the analysis of tobacco alkaloids in cigarette filler and various tobacco speciesAnal Chem.(2013 Mar 19)

3.^Screening of Tobacco Smoke Condensate for Nicotinic Acetylcholine Receptor Ligands using Cellular Membrane Affinity Chromatography Columns and Missing Peak Chromatography.()

4.^Paris D, Beaulieu-Abdelahad D, Bachmeier C, Reed J, Ait-Ghezala G, Bishop A, Chao J, Mathura V, Crawford F, Mullan MAnatabine lowers Alzheimer's Aβ production in vitro and in vivoEur J Pharmacol.(2011 Nov 30)

5.^Paris D, Patel N, Quadros A, Linan M, Bakshi P, Ait-Ghezala G, Mullan MInhibition of Abeta production by NF-kappaB inhibitorsNeurosci Lett.(2007 Mar 19)

6.^Paris D, Ganey NJ, Laporte V, Patel NS, Beaulieu-Abdelahad D, Bachmeier C, March A, Ait-Ghezala G, Mullan MJReduction of beta-amyloid pathology by celastrol in a transgenic mouse model of Alzheimer's diseaseJ Neuroinflammation.(2010 Mar 8)

7.^Paris D, Beaulieu-Abdelahad D, Abdullah L, Bachmeier C, Ait-Ghezala G, Reed J, Verma M, Crawford F, Mullan MAnti-inflammatory activity of anatabine via inhibition of STAT3 phosphorylationEur J Pharmacol.(2013 Jan 5)

8.^Nicotine decreases beta-amyloid through regulating BACE1 transcription in SH-EP1-α4β2 nAChR-APP695 cells.()

9.^Buggia-Prevot V, Sevalle J, Rossner S, Checler FNFkappaB-dependent control of BACE1 promoter transactivation by Abeta42J Biol Chem.(2008 Apr 11)

10.^Yoshikawa H, Kurokawa M, Ozaki N, Nara K, Atou K, Takada E, Kamochi H, Suzuki NNicotine inhibits the production of proinflammatory mediators in human monocytes by suppression of I-kappaB phosphorylation and nuclear factor-kappaB transcriptional activity through nicotinic acetylcholine receptor alpha7Clin Exp Immunol.(2006 Oct)

11.^Peña G, Cai B, Liu J, van der Zanden EP, Deitch EA, de Jonge WJ, Ulloa LUnphosphorylated STAT3 modulates alpha 7 nicotinic receptor signaling and cytokine production in sepsisEur J Immunol.(2010 Sep)

12.^Haass M, Kübler WNicotine and sympathetic neurotransmissionCardiovasc Drugs Ther.(1997 Jan)

13.^Jenkins ND, Housh TJ, Johnson GO, Traylor DA, Bergstrom HC, Cochrane KC, Lewis RW Jr, Schmidt RJ, Cramer JTThe effects of anatabine on non-invasive indicators of muscle damage: a randomized, double-blind, placebo-controlled, crossover studyJ Int Soc Sports Nutr.(2013 Jul 22)

14.^Caturegli P, De Remigis A, Ferlito M, Landek-Salgado MA, Iwama S, Tzou SC, Ladenson PWAnatabine ameliorates experimental autoimmune thyroiditisEndocrinology.(2012 Sep)

15.^Boyko EJ, Perera DR, Koepsell TD, Keane EM, Inui TSEffects of cigarette smoking on the clinical course of ulcerative colitisScand J Gastroenterol.(1988 Nov)

16.^Calabrese E, Yanai H, Shuster D, Rubin DT, Hanauer SBLow-dose smoking resumption in ex-smokers with refractory ulcerative colitisJ Crohns Colitis.(2012 Aug)

17.^Belin RM, Astor BC, Powe NR, Ladenson PWSmoke exposure is associated with a lower prevalence of serum thyroid autoantibodies and thyrotropin concentration elevation and a higher prevalence of mild thyrotropin concentration suppression in the third National Health and Nutrition Examination Survey (NHANES III)J Clin Endocrinol Metab.(2004 Dec)

18.^Pedersen IB, Laurberg P, Knudsen N, Jørgensen T, Perrild H, Ovesen L, Rasmussen LBSmoking is negatively associated with the presence of thyroglobulin autoantibody and to a lesser degree with thyroid peroxidase autoantibody in serum: a population studyEur J Endocrinol.(2008 Mar)

19.^Bencherif M, Lippiello PM, Lucas R, Marrero MBAlpha7 nicotinic receptors as novel therapeutic targets for inflammation-based diseasesCell Mol Life Sci.(2011 Mar)

20.^Paris D, Beaulieu-Abdelahad D, Mullan M, Ait-Ghezala G, Mathura V, Bachmeier C, Crawford F, Mullan MJAmelioration of experimental autoimmune encephalomyelitis by anatabinePLoS One.(2013)

Primary Use

Autoimmune Disease

Anatabine

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