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Anatabine

Anatabine is an alkaloid compound found in tobacco and plants in the nightshade family, which includes eggplant and peppers. Anatabine possesses anti-inflammatory properties but further research is needed to determine if supplementation is practical.

Our evidence-based analysis on anatabine features 20 unique references to scientific papers.

Kamal Patel
Research analysis led by and reviewed by the Examine team.
Last Updated:

Summary of Anatabine

Primary information, health benefits, side effects, usage, and other important details

Anatabine is an alkaloid found in tobacco and other plants in the nightshade family.

Anatabine is being researched for its anti-inflammatory properties. Preliminary evidence suggests it may be useful to treat autoimmune diseases and Alzheimer’s disease.

Unfortunately, current research uses doses that are significantly higher than the anatabine supplements available on the market. Oral studies tend to use a dose of 1.6mg/kg of bodyweight for people, which translates to dose between 68-110mg for a 150lb person. One human study even failed to find anti-inflammatory effects at a dose that was 6 – 12 times higher than the doses found in today’s anatabine supplements.

Anatabine’s main mechanism works by inhibiting the signal transducer and activator of transcription 3 protein (STAT3), which inhibits a protein responsible for DNA transcription, called nuclear factor kappa-light-chain-enhancer of activated B cells (nF-kB). Both Boswellia serrata and Feverfew have a similar mechanism.

Due to limitation of anatabine supplements on the market, it is not a practical anti-inflammatory supplement.

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How to Take

Recommended dosage, active amounts, other details

Animal research on anatabine used an oral dose of 12.5 – 20mg/kg of bodyweight in mice, for the purpose of autoimmune diseases. This suggests a preliminary human dose of:

• 70-110 mg for a 150lb person

• 90-150 mg for a 200lb person

• 110-180 mg for a 250lb person

These dosages are based on preliminary animal evidence, not human studies. Anatabine supplementation cannot be recommended at this time due to a lack of human evidence for its effects.

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Human Effect Matrix

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The Human Effect Matrix summarizes human studies to tell you what effects Anatabine has on your body, how much evidence there is, and how strong these effects are.

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Grade Level of Evidence
Robust research conducted with repeated double-blind clinical trials
Multiple studies where at least two are double-blind and placebo controlled
Single double-blind study or multiple cohort studies
Uncontrolled or observational studies only
Level of Evidence
? The amount of high quality evidence. The more evidence, the more we can trust the results.
Outcome Magnitude of effect
? The direction and size of the supplement's impact on each outcome. Some supplements can have an increasing effect, others have a decreasing effect, and others have no effect.
Consistency of research results
? Scientific research does not always agree. HIGH or VERY HIGH means that most of the scientific research agrees.
Notes
grade-c
Blood Pressure
- - See study
6-12mg anatabine does not appear to significantly influence blood pressure in otherwise healthy persons.
grade-c
Heart Rate
- - See study
There is no significant influence on heart rate seen with 6-12mg anatabine in otherwise healthy persons
grade-c
Muscle Damage
- - See study
The progression of recovery after a novel workout (when measured over three days) was unaffected by 6-12mg anatabine
grade-c
Muscle Soreness
- - See study
Perceived muscle soreness and pain from a workout was unaffected by anatabine supplementation.
grade-c
Power Output
- - See study
Strength recovery over the course of three days recovery was not significantly improved by 6-12mg anatabine

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Things to Note

Primary Function:

Also Known As

Anatabloc (Brand Name)

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This page is regularly updated, to include the most recently available clinical trial evidence.

Each member of our research team is required to have no conflicts of interest, including with supplement manufacturers, food companies, and industry funders. The team includes nutrition researchers, registered dietitians, physicians, and pharmacists. We have a strict editorial process.

This page features 20 references. All factual claims are followed by specifically-applicable references. Click here to see the full set of research information and references for Anatabine.

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