Feverfew

Last Updated: September 28 2022

Feverfew is an herb with anti-inflammatory properties used to prevent migraines. It is also claimed to alleviate arthritis, but more research is needed to confirm this effect.

Feverfew is most often used for

Summary

Feverfew, also known as medieval aspirin or wild chamomile, is an herb with anti-inflammatory properties.

Feverfew is most often used to prevent migraines. Feverfew’s effect increases in strength for the first 12 weeks of supplementation, at which point it can be taken indefinitely. Feverfew appears to be effective at reducing the severity and frequency of migraines when supplemented in this way. Limited evidence suggests feverfew supplementation may also reduce the length of a migraine and alleviate the increased sensory sensitivity that occurs during a migraine.

Traditionally, feverfew has been used to alleviate arthritis and inflammation. In vitro evidence suggests that feverfew is a very potent anti-inflammatory herb, but limited human evidence suggests supplementation has no effect on rheumatoid arthritis.

The active compound in feverfew is called parthenolide. It is responsible for feverfew’s anti-inflammatory effects, and it may also have a potent anti-cancer mechanism. Since no human studies have investigated feverfew in the context of cancer, more research is needed to confirm this effect.

Feverfew is safe to supplement, but topical application may result in an allergic reaction. If feverfew supplementation results in reddening or scaly skin, cease supplementation. Pregnant women should not supplement feverfew.

What else is Feverfew known as?
Note that Feverfew is also known as:
  • Tanacetum parthenium
  • Wild Chamomile
  • Featherfew
  • Chrysanthemum parthenium
  • Matricaria parthenium
  • Pyrenthrum parthenium
  • Leucanthemum parthenium
  • mutterroot
  • midsummer daisy
  • nosebleed
  • Medieval Aspirin
  • 18th century Aspirin
Dosage information

The standard adult dose for feverfew supplementation is 100-300 mg of a feverfew supplement containing 0.2%-0.4% parthenolide, taken one to four times a day.

Children younger than two should not be given feverfew. The standard feverfew dose for children is based off of a standard adult weight of 150 lbs. For example, if a child weighs 50lbs, the dose is one-third of the adult dose.

Liquid and tincture feverfew supplements are sometimes used to alleviate arthritis. The suggested dose is 60 – 120 drops of 1:1 (fluid) supplement or a 1:5 (tincture) supplement, taken twice a day.

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References
1.^Pareek A, Suthar M, Rathore GS, Bansal VFeverfew (Tanacetum parthenium L.): A systematic reviewPharmacogn Rev.(2011 Jan)
5.^Murch SJ, Simmons CB, Saxena PKMelatonin in feverfew and other medicinal plantsLancet.(1997 Nov 29)
9.^Mittra S, Datta A, Singh SK, Singh A5-Hydroxytryptamine-inhibiting property of Feverfew: role of parthenolide contentActa Pharmacol Sin.(2000 Dec)
11.^Svenningsen AB, Madsen KD, Liljefors T, Stafford GI, van Staden J, Jäger AKBiflavones from Rhus species with affinity for the GABA(A)/benzodiazepine receptorJ Ethnopharmacol.(2006 Jan 16)
12.^Viola H, Wasowski C, Levi de Stein M, Wolfman C, Silveira R, Dajas F, Medina JH, Paladini ACApigenin, a component of Matricaria recutita flowers, is a central benzodiazepine receptors-ligand with anxiolytic effectsPlanta Med.(1995 Jun)
13.^Medina JH, Viola H, Wolfman C, Marder M, Wasowski C, Calvo D, Paladini ACOverview--flavonoids: a new family of benzodiazepine receptor ligandsNeurochem Res.(1997 Apr)
14.^Pagán OR, Rowlands AL, Azam M, Urban KR, Bidja AH, Roy DM, Feeney RB, Afshari LKReversal of cocaine-induced planarian behavior by parthenolide and related sesquiterpene lactonesPharmacol Biochem Behav.(2008 Apr)
16.^Schwarz D, Bloom D, Castro R, Pagán OR, Jiménez-Rivera CAParthenolide Blocks Cocaine's Effect on Spontaneous Firing Activity of Dopaminergic Neurons in the Ventral Tegmental AreaCurr Neuropharmacol.(2011 Mar)
17.^Magni P, Ruscica M, Dozio E, Rizzi E, Beretta G, Facino RMParthenolide Inhibits the LPS-induced Secretion of IL-6 and TNF-α and NF-κB Nuclear Translocation in BV-2 MicrogliaPhytother Res.(2012 Sep)
18.^Cady RK, Goldstein J, Nett R, Mitchell R, Beach ME, Browning RA double-blind placebo-controlled pilot study of sublingual feverfew and ginger (LipiGesic™ M) in the treatment of migraineHeadache.(2011 Jul-Aug)
21.^Pfaffenrath V, Diener HC, Fischer M, Friede M, Henneicke-von Zepelin HH; InvestigatorsThe efficacy and safety of Tanacetum parthenium (feverfew) in migraine prophylaxis--a double-blind, multicentre, randomized placebo-controlled dose-response studyCephalalgia.(2002 Sep)
23.^Murphy JJ, Heptinstall S, Mitchell JRRandomised double-blind placebo-controlled trial of feverfew in migraine preventionLancet.(1988 Jul 23)
25.^Henneicke-von Zepelin HHFeverfew for migraine prophylaxisHeadache.(2006 Mar)
26.^Saranitzky E, White CM, Baker EL, Baker WL, Coleman CIFeverfew for migraine prophylaxis: a systematic reviewJ Diet Suppl.(2009)
28.^Kim IH, Kim SW, Kim SH, Lee SO, Lee ST, Kim DG, Lee MJ, Park WHParthenolide-induced apoptosis of hepatic stellate cells and anti-fibrotic effects in an in vivo rat modelExp Mol Med.(2012 Jul 31)
30.^Sur R, Martin K, Liebel F, Lyte P, Shapiro S, Southall MAnti-inflammatory activity of parthenolide-depleted Feverfew (Tanacetum parthenium)Inflammopharmacology.(2009 Feb)
33.^Collier HO, Butt NM, McDonald-Gibson WJ, Saeed SAExtract of feverfew inhibits prostaglandin biosynthesisLancet.(1980 Oct 25)
34.^Makheja AN, Bailey JMThe active principle in feverfewLancet.(1981 Nov 7)
35.^Pugh WJ, Sambo KProstaglandin synthetase inhibitors in feverfewJ Pharm Pharmacol.(1988 Oct)
37.^Aviram A, Tsoukias NM, Melnick SJ, Resek AP, Ramachandran CInhibition of nitric oxide synthesis in mouse macrophage cells by feverfew supercritical extractPhytother Res.(2012 Apr)
38.^Spinelli SL, Casey AE, Pollock SJ, Gertz JM, McMillan DH, Narasipura SD, Mody NA, King MR, Maggirwar SB, Francis CW, Taubman MB, Blumberg N, Phipps RPPlatelets and megakaryocytes contain functional nuclear factor-kappaBArterioscler Thromb Vasc Biol.(2010 Mar)
41.^Lösche W, Mazurov AV, Heptinstall S, Groenewegen WA, Repin VS, Till UAn extract of feverfew inhibits interactions of human platelets with collagen substratesThromb Res.(1987 Dec 1)
42.^Heptinstall S, Groenewegen WA, Spangenberg P, Loesche WExtracts of feverfew may inhibit platelet behaviour via neutralization of sulphydryl groupsJ Pharm Pharmacol.(1987 Jun)
44.^Loesche W, Groenewegen WA, Krause S, Spangenberg P, Heptinstall SEffects of an extract of feverfew (Tanacetum parthenium) on arachidonic acid metabolism in human blood plateletsBiomed Biochim Acta.(1988)
45.^Heptinstall S, Groenewegen WA, Spangenberg P, Lösche WInhibition of platelet behaviour by feverfew: a mechanism of action involving sulphydryl groupsFolia Haematol Int Mag Klin Morphol Blutforsch.(1988)
46.^Fischedick JT, Standiford M, Johnson DA, De Vos RC, Todorović S, Banjanac T, Verpoorte R, Johnson JAActivation of Antioxidant Response Element in Mouse Primary Cortical Cultures with Sesquiterpene Lactones Isolated from Tanacetum partheniumPlanta Med.(2012 Aug 24)
49.^Wang W, Adachi M, Kawamura R, Sakamoto H, Hayashi T, Ishida T, Imai K, Shinomura YParthenolide-induced apoptosis in multiple myeloma cells involves reactive oxygen species generation and cell sensitivity depends on catalase activityApoptosis.(2006 Dec)
50.^Bours V, Bentires-Alj M, Hellin AC, Viatour P, Robe P, Delhalle S, Benoit V, Merville MPNuclear factor-kappa B, cancer, and apoptosisBiochem Pharmacol.(2000 Oct 15)
51.^Sweeney CJ, Mehrotra S, Sadaria MR, Kumar S, Shortle NH, Roman Y, Sheridan C, Campbell RA, Murry DJ, Badve S, Nakshatri HThe sesquiterpene lactone parthenolide in combination with docetaxel reduces metastasis and improves survival in a xenograft model of breast cancerMol Cancer Ther.(2005 Jun)
52.^Kim JH, Liu L, Lee SO, Kim YT, You KR, Kim DGSusceptibility of cholangiocarcinoma cells to parthenolide-induced apoptosisCancer Res.(2005 Jul 15)
53.^Pedranzini L, Leitch A, Bromberg JStat3 is required for the development of skin cancerJ Clin Invest.(2004 Sep)
54.^Ma XT, Wang S, Ye YJ, Du RY, Cui ZR, Somsouk MConstitutive activation of Stat3 signaling pathway in human colorectal carcinomaWorld J Gastroenterol.(2004 Jun 1)
56.^Sheen-Chen SM, Huang CC, Tang RP, Yang CH, Chou FF, Eng HLSignal transducer and activator of transcription 1 in breast cancer: analysis with tissue microarrayAnticancer Res.(2007 Jul-Aug)
58.^Pajak B, Gajkowska B, Orzechowski AMolecular basis of parthenolide-dependent proapoptotic activity in cancer cellsFolia Histochem Cytobiol.(2008)
59.^Ferrajoli A, Faderl S, Ravandi F, Estrov ZThe JAK-STAT pathway: a therapeutic target in hematological malignanciesCurr Cancer Drug Targets.(2006 Dec)
60.^Kanda N, Seno H, Konda Y, Marusawa H, Kanai M, Nakajima T, Kawashima T, Nanakin A, Sawabu T, Uenoyama Y, Sekikawa A, Kawada M, Suzuki K, Kayahara T, Fukui H, Sawada M, Chiba TSTAT3 is constitutively activated and supports cell survival in association with survivin expression in gastric cancer cellsOncogene.(2004 Jun 17)
63.^Guzman ML, Rossi RM, Karnischky L, Li X, Peterson DR, Howard DS, Jordan CTThe sesquiterpene lactone parthenolide induces apoptosis of human acute myelogenous leukemia stem and progenitor cellsBlood.(2005 Jun 1)
65.^Iredale JP, Benyon RC, Pickering J, McCullen M, Northrop M, Pawley S, Hovell C, Arthur MJMechanisms of spontaneous resolution of rat liver fibrosis. Hepatic stellate cell apoptosis and reduced hepatic expression of metalloproteinase inhibitorsJ Clin Invest.(1998 Aug 1)
67.^Agarwal KK, Nath AK, Jaisankar TJ, D'Souza MParthenium dermatitis presenting as erythrodermaContact Dermatitis.(2008 Sep)
68.^Lakshmi C, Srinivas CRParthenium: a wide angle viewIndian J Dermatol Venereol Leprol.(2007 Sep-Oct)
69.^Killoran CE, Crawford GH, Pedvis-Leftick ATwo cases of compositae dermatitis exacerbated by moisturizer containing feverfewDermatitis.(2007 Dec)
70.^Paulsen E, Christensen LP, Fretté XC, Andersen KEPatch test reactivity to feverfew-containing creams in feverfew-allergic patientsContact Dermatitis.(2010 Sep)
71.^Yao M, Ritchie HE, Brown-Woodman PDA reproductive screening test of feverfew: is a full reproductive study warrantedReprod Toxicol.(2006 Nov)