Rhodiola Rosea
•Last Updated: September 28 2022
Rhodiola rosea is an herbal supplement with adaptogen properties that help to provide general resistance to stress. Although its mechanisms of action are not completely understood, it is clear that rhodiola increases resilience to stress at both the cellular and systemic levels.
Rhodiola Rosea is most often used for
Last Updated: September 28 2022
Rhodiola rosea is a medicinal plant in the Rhodiola genera (Crassulaceae family) which has traditionally been used as an anti-fatigue agent and adaptogen compound.[1] The root contains a number of bioactive compounds, but the main two that are thought to mediate its effects are rosavin and salidroside. Rhodiola supplements are generally taken in the form of root powder or standardized extracts with 1–5% salidrosides. Although rhodiola supplements are usually taken for their stress-and fatigue-reducing effects, they may also have antidepressant,[2] anti-inflammatory,[3] and antioxidant[4] properties.
The main benefits of rhodiola are associated with its adaptogenic properties and include reduced stress and fatigue, as well as increased mental performance, particularly under stressful conditions. Rhodiola has an extensive track record for efficacy, with medicinal use dating back centuries, when it was used to promote healing, stress relief, and increased sense of wellbeing.[1] In preclinical studies involving model organisms such as fruit flies,[5] worms,[6] and yeast,[7] rhodiola has been shown to have anti-aging and longevity-promoting properties, as well as anti-cancer effects.[8] More research is needed to determine whether there are similar effects in humans.
In short-to-moderate intake durations (months to a year) and in moderate doses, rhodiola is safe, with little to no side effects. Although reports of adverse effects are rare, dizziness and dry mouth were noted in a small number of participants in one trial.[9] Rhodiola has been shown to interact with liver enzymes in vitro, indicating a possibility for drug interactions. It increased the concentration and decreased clearance of a particular antihypertensive drug in rabbits,[10] confirming interaction with at least one class of drugs in vivo.
Although it is known for its ability to alleviate psychological stress and anxiety, rhodiola has also been shown to interact with cellular stress-response signaling in in vitro studies, indicating that it may have benefits at the cellular level as well as the systemic level. The mechanisms behind rhodiola’s ability to mitigate stress in humans are complex and not well understood. The anti-stress effects of rhodiola may occur in part due to it being able to blunt cortisol release under stressful conditions.[11]
Note that Rhodiola Rosea is also known as:
- Rosavin
- Rosenroot
- Rhodiola Rhizome
- Golden Root
- Arctic Root
- Rhidola
Rhodiola Rosea should not be confused with:
- Other species of Rhodiola
- Rosa damascena
- Rosmarinic Acid
- Roselle
- Scutellaria baicalensis (also called Goldenroot)
Supplementation of rhodiola rosea tends to refer to either the SHR-5 extract in particular or an equivalent extract, any that confers both 3% rosavins and 1% salidroside.
Usage of rhodiola as a daily preventative against fatigue has been reported to be effective in doses as low as 50mg.
Acute usage of rhodiola for fatigue and anti-stress has been noted to be taken in the 288-680mg range.
As rhodiola has been shown to have a bell-curve response before, it is recommended to not exceed the aforementioned 680mg dosage as higher doses may be ineffective.
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1.^A Panossian, G Wikman, J SarrisRosenroot (Rhodiola rosea): traditional use, chemical composition, pharmacology and clinical efficacyPhytomedicine.(2010 Jun)
2.^Jay D Amsterdam, Alexander G PanossianRhodiola rosea L. as a putative botanical antidepressantPhytomedicine.(2016 Jun 15)
3.^Wei-Ling Pu, Meng-Ying Zhang, Ru-Yu Bai, Li-Kang Sun, Wen-Hua Li, Ying-Li Yu, Yue Zhang, Lei Song, Zhao-Xin Wang, Yan-Fei Peng, Hong Shi, Kun Zhou, Tian-Xiang LiAnti-inflammatory effects of Rhodiola rosea L.: A reviewBiomed Pharmacother.(2020 Jan)
4.^Dorota M Radomska-Leśniewska, Piotr Skopiński, Barbara J Bałan, Agata Białoszewska, Jarosław Jóźwiak, Dariusz Rokicki, Ewa Skopińska-Różewska, Anna Borecka, Agata HevelkeAngiomodulatory properties of Rhodiola spp. and other natural antioxidantsCent Eur J Immunol.(2015)
5.^Samuel E Schriner, Volkan Coskun, Sean P Hogan, Cindy T Nguyen, Terry E Lopez, Mahtab JafariExtension of Drosophila Lifespan by Rhodiola rosea Depends on Dietary Carbohydrate and Caloric Content in a Simplified DietJ Med Food.(2016 Mar)
6.^Cong Chen, Jiangbo Song, Min Chen, Zhiquan Li, Xiaoling Tong, Hai Hu, Zhonghuai Xiang, Cheng Lu, Fangyin DaiRhodiola rosea extends lifespan and improves stress tolerance in silkworm, Bombyx moriBiogerontology.(2016 Apr)
7.^F A C Wiegant, S Surinova, E Ytsma, M Langelaar-Makkinje, G Wikman, J A PostPlant adaptogens increase lifespan and stress resistance in C. elegansBiogerontology.(2009 Feb)
8.^E Skopińska-Rózewska, M Malinowski, A Wasiutyński, E Sommer, M Furmanowa, M Mazurkiewicz, A K SiwickiThe influence of Rhodiola quadrifida 50% hydro-alcoholic extract and salidroside on tumor-induced angiogenesis in micePol J Vet Sci.(2008)
9.^Alexander Bystritsky, Lauren Kerwin, Jamie D FeusnerA pilot study of Rhodiola rosea (Rhodax) for generalized anxiety disorder (GAD)J Altern Complement Med.(2008 Mar)
10.^M Spanakis, I S Vizirianakis, G Batzias, I NiopasPharmacokinetic interaction between losartan and Rhodiola rosea in rabbitsPharmacology.(2013)
11.^Alexander Panossian, Marina Hambardzumyan, Areg Hovhanissyan, Georg WikmanThe adaptogens rhodiola and schizandra modify the response to immobilization stress in rabbits by suppressing the increase of phosphorylated stress-activated protein kinase, nitric oxide and cortisolDrug Target Insights.(2007)
13.^Panossian A, Wikman G, Sarris JRosenroot (Rhodiola rosea): traditional use, chemical composition, pharmacology and clinical efficacyPhytomedicine.(2010 Jun)
14.^Jafari M, Felgner JS, Bussel II, Hutchili T, Khodayari B, Rose MR, Vince-Cruz C, Mueller LDRhodiola: a promising anti-aging Chinese herbRejuvenation Res.(2007 Dec)
15.^Yousef GG, Grace MH, Cheng DM, Belolipov IV, Raskin I, Lila MAComparative phytochemical characterization of three Rhodiola speciesPhytochemistry.(2006 Nov)
16.^Effects of Adaptogens on the Central Nervous System and the Molecular Mechanisms associated with their Stress - Protective Activity.()
17.^Mudge E, Lopes-Lutz D, Brown PN, Schieber APurification of Phenylalkanoids and monoterpene glycosides from rhodiola rosea L. roots by high-speed counter-current chromatographyPhytochem Anal.(2013 Feb)
18.^Akgul Y, Ferreira D, Abourashed EA, Khan IALotaustralin from Rhodiola rosea rootsFitoterapia.(2004 Sep)
19.^Ming DS, Hillhouse BJ, Guns ES, Eberding A, Xie S, Vimalanathan S, Towers GHBioactive compounds from Rhodiola rosea (Crassulaceae)Phytother Res.(2005 Sep)
23.^Guo N, Hu Z, Fan X, Zheng J, Zhang D, Xu T, Yu T, Wang Y, Li HSimultaneous determination of salidroside and its aglycone metabolite p-tyrosol in rat plasma by liquid chromatography-tandem mass spectrometryMolecules.(2012 Apr 23)
24.^Panossian A, Wikman G, Kaur P, Asea AAdaptogens stimulate neuropeptide y and hsp72 expression and release in neuroglia cellsFront Neurosci.(2012)
25.^Darbinyan V, Aslanyan G, Amroyan E, Gabrielyan E, Malmström C, Panossian AClinical trial of Rhodiola rosea L. extract SHR-5 in the treatment of mild to moderate depressionNord J Psychiatry.(2007)
26.^Olsson EM, von Schéele B, Panossian AGA randomised, double-blind, placebo-controlled, parallel-group study of the standardised extract shr-5 of the roots of Rhodiola rosea in the treatment of subjects with stress-related fatiguePlanta Med.(2009 Feb)
27.^Aslanyan G, Amroyan E, Gabrielyan E, Nylander M, Wikman G, Panossian ADouble-blind, placebo-controlled, randomised study of single dose effects of ADAPT-232 on cognitive functionsPhytomedicine.(2010 Jun)
28.^Sodium-dependent Glucose Transporter Was Involved in Salidroside Absorption in Intestine of Rats.()
29.^Mizuma T, Ohta K, Hayashi M, Awazu SIntestinal active absorption of sugar-conjugated compounds by glucose transport system: implication of improvement of poorly absorbable drugsBiochem Pharmacol.(1992 May 8)
30.^Morand C, Manach C, Crespy V, Remesy CQuercetin 3-O-beta-glucoside is better absorbed than other quercetin forms and is not present in rat plasmaFree Radic Res.(2000 Nov)
31.^Yu S, Liu L, Wen T, Liu Y, Wang D, He Y, Liang Y, Liu X, Xie L, Wang G, Wei WDevelopment and validation of a liquid chromatographic/electrospray ionization mass spectrometric method for the determination of salidroside in rat plasma: application to the pharmacokinetics studyJ Chromatogr B Analyt Technol Biomed Life Sci.(2008 Jan 1)
32.^Chang YW, Yao HT, Hsieh SH, Lu TJ, Yeh TKQuantitative determination of salidroside in rat plasma by on-line solid-phase extraction integrated with high-performance liquid chromatography/electrospray ionization tandem mass spectrometryJ Chromatogr B Analyt Technol Biomed Life Sci.(2007 Sep 15)
33.^Hellum BH, Tosse A, Hoybakk K, Thomsen M, Rohloff J, Georg Nilsen OPotent in vitro inhibition of CYP3A4 and P-glycoprotein by Rhodiola roseaPlanta Med.(2010 Mar)
34.^Panossian A, Hovhannisyan A, Abrahamyan H, Gabrielyan E, Wikman GPharmacokinetic and pharmacodynamic study of interaction of Rhodiola rosea SHR-5 extract with warfarin and theophylline in ratsPhytother Res.(2009 Mar)
35.^Wiegant FA, Surinova S, Ytsma E, Langelaar-Makkinje M, Wikman G, Post JAPlant adaptogens increase lifespan and stress resistance in C. elegansBiogerontology.(2009 Feb)
37.^McElwee JJ, Schuster E, Blanc E, Piper MD, Thomas JH, Patel DS, Selman C, Withers DJ, Thornton JM, Partridge L, Gems DEvolutionary conservation of regulated longevity assurance mechanismsGenome Biol.(2007)
39.^Panossian A, Wikman GEvidence-based efficacy of adaptogens in fatigue, and molecular mechanisms related to their stress-protective activityCurr Clin Pharmacol.(2009 Sep)
40.^Schriner SE, Abrahamyan A, Avanessian A, Bussel I, Maler S, Gazarian M, Holmbeck MA, Jafari MDecreased mitochondrial superoxide levels and enhanced protection against paraquat in Drosophila melanogaster supplemented with Rhodiola roseaFree Radic Res.(2009 Sep)
41.^Schriner SE, Lee K, Truong S, Salvadora KT, Maler S, Nam A, Lee T, Jafari MExtension of Drosophila Lifespan by Rhodiola rosea through a Mechanism Independent from Dietary RestrictionPLoS One.(2013 May 21)
42.^Bayliak MM, Lushchak VIThe golden root, Rhodiola rosea, prolongs lifespan but decreases oxidative stress resistance in yeast Saccharomyces cerevisiaePhytomedicine.(2011 Nov 15)
43.^van Diermen D, Marston A, Bravo J, Reist M, Carrupt PA, Hostettmann KMonoamine oxidase inhibition by Rhodiola rosea L. rootsJ Ethnopharmacol.(2009 Mar 18)
45.^Mannucci C, Navarra M, Calzavara E, Caputi AP, Calapai GSerotonin involvement in Rhodiola rosea attenuation of nicotine withdrawal signs in ratsPhytomedicine.(2012 Sep 15)
46.^Blum K, Chen TJ, Meshkin B, Waite RL, Downs BW, Blum SH, Mengucci JF, Arcuri V, Braverman ER, Palomo TManipulation of catechol-O-methyl-transferase (COMT) activity to influence the attenuation of substance seeking behavior, a subtype of Reward Deficiency Syndrome (RDS), is dependent upon gene polymorphisms: a hypothesisMed Hypotheses.(2007)
47.^Ciumaşu-Rîmbu M, Popa L, Vulpoi CNeuropeptide Y stimulation as primary target for preventive measures of maladaptative cardiovascular reactions in occupational chronic stress exposureRev Med Chir Soc Med Nat Iasi.(2012 Jul-Sep)
48.^Panossian A, Wikman G, Kaur P, Asea AAdaptogens exert a stress-protective effect by modulation of expression of molecular chaperonesPhytomedicine.(2009 Jun)
49.^Panossian A, Wagner HStimulating effect of adaptogens: an overview with particular reference to their efficacy following single dose administrationPhytother Res.(2005 Oct)
50.^Sheng QS, Wang ZJ, Zhang J, Zhang YGSalidroside promotes peripheral nerve regeneration following crush injury to the sciatic nerve in ratsNeuroreport.(2013 Mar 27)
51.^Ma J, Li W, Tian R, Lei WGinsenoside Rg1 promotes peripheral nerve regeneration in rat model of nerve crush injuryNeurosci Lett.(2010 Jul 5)
52.^Tidwell JL, Houenou LJ, Tytell MAdministration of Hsp70 in vivo inhibits motor and sensory neuron degenerationCell Stress Chaperones.(2004 Mar)
53.^Houenou LJ, Li L, Lei M, Kent CR, Tytell MExogenous heat shock cognate protein Hsc 70 prevents axotomy-induced death of spinal sensory neuronsCell Stress Chaperones.(1996 Sep)
54.^Protective Effects of a Rhodiola Crenulata Extract and Salidroside on Hippocampal Neurogenesis against Streptozotocin-Induced Neural Injury in the Rat.()
55.^Pretreatment with Rhodiola Rosea Extract Reduces Cognitive Impairment Induced by Intracerebroventricular Streptozotocin in Rats: Implication of Anti-oxidative and Neuroprotective Effects.()
57.^Petkov VD, Yonkov D, Mosharoff A, Kambourova T, Alova L, Petkov VV, Todorov IEffects of alcohol aqueous extract from Rhodiola rosea L. roots on learning and memoryActa Physiol Pharmacol Bulg.(1986)
58.^Lazarova MB, Petkov VD, Markovska VL, Petkov VV, Mosharrof AEffects of meclofenoxate and Extr. Rhodiolae roseae L. on electroconvulsive shock-impaired learning and memory in ratsMethods Find Exp Clin Pharmacol.(1986 Sep)
59.^Zhang J, Zhen YF, Pu-Bu-Ci-Ren, Song LG, Kong WN, Shao TM, Li X, Chai XQSalidroside attenuates beta amyloid-induced cognitive deficits via modulating oxidative stress and inflammatory mediators in rat hippocampusBehav Brain Res.(2013 May 1)
60.^Qu ZQ, Zhou Y, Zeng YS, Li Y, Chung PPretreatment with Rhodiola rosea extract reduces cognitive impairment induced by intracerebroventricular streptozotocin in rats: implication of anti-oxidative and neuroprotective effectsBiomed Environ Sci.(2009 Aug)
61.^Fintelmann V, Gruenwald JEfficacy and tolerability of a Rhodiola rosea extract in adults with physical and cognitive deficienciesAdv Ther.(2007 Jul-Aug)
62.^Neuroprotective Effects of Salidroside in the PC12 Cell Model Exposed to Hypoglycemia and Serum Limitation.()
63.^Zhang L, Yu H, Zhao X, Lin X, Tan C, Cao G, Wang ZNeuroprotective effects of salidroside against beta-amyloid-induced oxidative stress in SH-SY5Y human neuroblastoma cellsNeurochem Int.(2010 Nov)
64.^Chen X, Zhang Q, Cheng Q, Ding FProtective effect of salidroside against H2O2-induced cell apoptosis in primary culture of rat hippocampal neuronsMol Cell Biochem.(2009 Dec)
65.^Shi TY, Feng SF, Xing JH, Wu YM, Li XQ, Zhang N, Tian Z, Liu SB, Zhao MGNeuroprotective effects of Salidroside and its analogue tyrosol galactoside against focal cerebral ischemia in vivo and H2O2-induced neurotoxicity in vitroNeurotox Res.(2012 May)
66.^Cao LL, Du GH, Wang MWThe effect of salidroside on cell damage induced by glutamate and intracellular free calcium in PC12 cellsJ Asian Nat Prod Res.(2006 Jan-Mar)
67.^Chen X, Liu J, Gu X, Ding FSalidroside attenuates glutamate-induced apoptotic cell death in primary cultured hippocampal neurons of ratsBrain Res.(2008 Oct 31)
68.^Palumbo DR, Occhiuto F, Spadaro F, Circosta CRhodiola rosea extract protects human cortical neurons against glutamate and hydrogen peroxide-induced cell death through reduction in the accumulation of intracellular calciumPhytother Res.(2012 Jun)
69.^Chen QG, Zeng YS, Qu ZQ, Tang JY, Qin YJ, Chung P, Wong R, Hägg UThe effects of Rhodiola rosea extract on 5-HT level, cell proliferation and quantity of neurons at cerebral hippocampus of depressive ratsPhytomedicine.(2009 Sep)
70.^Panossian A, Hamm R, Kadioglu O, Wikman G, Efferth TSynergy and Antagonism of Active Constituents of ADAPT-232 on Transcriptional Level of Metabolic Regulation of Isolated Neuroglial CellsFront Neurosci.(2013)
71.^Kennett GA, Bright F, Trail B, Blackburn TP, Sanger GJAnxiolytic-like actions of the selective 5-HT4 receptor antagonists SB 204070A and SB 207266A in ratsNeuropharmacology.(1997 Apr-May)
72.^Hung SK, Perry R, Ernst EThe effectiveness and efficacy of Rhodiola rosea L.: a systematic review of randomized clinical trialsPhytomedicine.(2011 Feb 15)
73.^Spasov AA, Wikman GK, Mandrikov VB, Mironova IA, Neumoin VVA double-blind, placebo-controlled pilot study of the stimulating and adaptogenic effect of Rhodiola rosea SHR-5 extract on the fatigue of students caused by stress during an examination period with a repeated low-dose regimenPhytomedicine.(2000 Apr)
74.^Spasov AA, Mandrikov VB, Mironova IAThe effect of the preparation rodakson on the psychophysiological and physical adaptation of students to an academic loadEksp Klin Farmakol.(2000 Jan-Feb)
75.^De Bock K, Eijnde BO, Ramaekers M, Hespel PAcute Rhodiola rosea intake can improve endurance exercise performanceInt J Sport Nutr Exerc Metab.(2004 Jun)
76.^Darbinyan V, Kteyan A, Panossian A, Gabrielian E, Wikman G, Wagner HRhodiola rosea in stress induced fatigue--a double blind cross-over study of a standardized extract SHR-5 with a repeated low-dose regimen on the mental performance of healthy physicians during night dutyPhytomedicine.(2000 Oct)
77.^Shevtsov VA, Zholus BI, Shervarly VI, Vol'skij VB, Korovin YP, Khristich MP, Roslyakova NA, Wikman GA randomized trial of two different doses of a SHR-5 Rhodiola rosea extract versus placebo and control of capacity for mental workPhytomedicine.(2003 Mar)
78.^Edwards D, Heufelder A, Zimmermann ATherapeutic effects and safety of Rhodiola rosea extract WS® 1375 in subjects with life-stress symptoms--results of an open-label studyPhytother Res.(2012 Aug)
79.^Rhodiola Rosea for Mental and Physical Fatigue in Nursing Students: A Randomized Controlled Trial.()
80.^Cifani C, Micioni Di B MV, Vitale G, Ruggieri V, Ciccocioppo R, Massi MEffect of salidroside, active principle of Rhodiola rosea extract, on binge eatingPhysiol Behav.(2010 Dec 2)
81.^Mattioli L, Perfumi MRhodiola rosea L. extract reduces stress- and CRF-induced anorexia in ratsJ Psychopharmacol.(2007 Sep)
82.^Micioni Di Bonaventura MV, Vitale G, Massi M, Cifani CEffect of Hypericum perforatum Extract in an Experimental Model of Binge Eating in Female RatsJ Obes.(2012)
83.^Cifani C, Polidori C, Melotto S, Ciccocioppo R, Massi MA preclinical model of binge eating elicited by yo-yo dieting and stressful exposure to food: effect of sibutramine, fluoxetine, topiramate, and midazolamPsychopharmacology (Berl).(2009 May)
84.^Perfumi M, Mattioli LAdaptogenic and central nervous system effects of single doses of 3% rosavin and 1% salidroside Rhodiola rosea L. extract in micePhytother Res.(2007 Jan)
85.^The Use of Herbal Adaptogens together with Tricyclic Antidepressants in Patients with Psychogenic Depressions.()
86.^Bystritsky A, Kerwin L, Feusner JDA pilot study of Rhodiola rosea (Rhodax) for generalized anxiety disorder (GAD)J Altern Complement Med.(2008 Mar)
87.^Sun L, Isaak CK, Zhou Y, Petkau JC, O K, Liu Y, Siow YLSalidroside and tyrosol from Rhodiola protect H9c2 cells from ischemia/reperfusion-induced apoptosisLife Sci.(2012 Sep 4)
88.^Zhong H, Xin H, Wu LX, Zhu YZSalidroside attenuates apoptosis in ischemic cardiomyocytes: a mechanism through a mitochondria-dependent pathwayJ Pharmacol Sci.(2010)
89.^He H, Li HL, Lin A, Gottlieb RAActivation of the JNK pathway is important for cardiomyocyte death in response to simulated ischemiaCell Death Differ.(1999 Oct)
91.^Aggeli IK, Gaitanaki C, Beis IInvolvement of JNKs and p38-MAPK/MSK1 pathways in H2O2-induced upregulation of heme oxygenase-1 mRNA in H9c2 cellsCell Signal.(2006 Oct)
92.^Lee OH, Kwon YI, Apostolidis E, Shetty K, Kim YCRhodiola-induced inhibition of adipogenesis involves antioxidant enzyme response associated with pentose phosphate pathwayPhytother Res.(2011 Jan)
93.^Wu T, Zhou H, Jin Z, Bi S, Yang X, Yi D, Liu WCardioprotection of salidroside from ischemia/reperfusion injury by increasing N-acetylglucosamine linkage to cellular proteinsEur J Pharmacol.(2009 Jun 24)
94.^Zhang J, Liu A, Hou R, Zhang J, Jia X, Jiang W, Chen JSalidroside protects cardiomyocyte against hypoxia-induced death: a HIF-1alpha-activated and VEGF-mediated pathwayEur J Pharmacol.(2009 Apr 1)
95.^Zhu Y, Shi YP, Wu D, Ji YJ, Wang X, Chen HL, Wu SS, Huang DJ, Jiang WSalidroside protects against hydrogen peroxide-induced injury in cardiac H9c2 cells via PI3K-Akt dependent pathwayDNA Cell Biol.(2011 Oct)
96.^Cheng YZ, Chen LJ, Lee WJ, Chen MF, Jung Lin H, Cheng JTIncrease of myocardial performance by Rhodiola-ethanol extract in diabetic ratsJ Ethnopharmacol.(2012 Nov 21)
97.^Cheng L, Ding G, Qin Q, Huang Y, Lewis W, He N, Evans RM, Schneider MD, Brako FA, Xiao Y, Chen YE, Yang QCardiomyocyte-restricted peroxisome proliferator-activated receptor-delta deletion perturbs myocardial fatty acid oxidation and leads to cardiomyopathyNat Med.(2004 Nov)
98.^Cheng L, Ding G, Qin Q, Xiao Y, Woods D, Chen YE, Yang QPeroxisome proliferator-activated receptor delta activates fatty acid oxidation in cultured neonatal and adult cardiomyocytesBiochem Biophys Res Commun.(2004 Jan 9)
99.^Barish GD, Narkar VA, Evans RMPPAR delta: a dagger in the heart of the metabolic syndromeJ Clin Invest.(2006 Mar)
100.^Minotti G, Menna P, Salvatorelli E, Cairo G, Gianni LAnthracyclines: molecular advances and pharmacologic developments in antitumor activity and cardiotoxicityPharmacol Rev.(2004 Jun)
102.^Zhang H, Shen WS, Gao CH, Deng LC, Shen DProtective effects of salidroside on epirubicin-induced early left ventricular regional systolic dysfunction in patients with breast cancerDrugs R D.(2012 Jun 1)
104.^Li X, Sipple J, Pang Q, Du WSalidroside stimulates DNA repair enzyme Parp-1 activity in mouse HSC maintenanceBlood.(2012 May 3)
105.^Qian EW, Ge DT, Kong SKSalidroside promotes erythropoiesis and protects erythroblasts against oxidative stress by up-regulating glutathione peroxidase and thioredoxinJ Ethnopharmacol.(2011 Jan 27)
106.^Zheng KY, Zhang ZX, Guo AJ, Bi CW, Zhu KY, Xu SL, Zhan JY, Lau DT, Dong TT, Choi RC, Tsim KWSalidroside stimulates the accumulation of HIF-1α protein resulted in the induction of EPO expression: a signaling via blocking the degradation pathway in kidney and liver cellsEur J Pharmacol.(2012 Mar 15)
107.^Apostolidis E, Kwon YI, Shetty KPotential of cranberry-based herbal synergies for diabetes and hypertension managementAsia Pac J Clin Nutr.(2006)
108.^Kwon YI, Jang HD, Shetty KEvaluation of Rhodiola crenulata and Rhodiola rosea for management of type II diabetes and hypertensionAsia Pac J Clin Nutr.(2006)
109.^Anti-diabetes functionality of Kefir culture-mediated fermented soymilk supplemented with Rhodiola extracts.()
110.^Wei H, Li L, Song Q, Ai H, Chu J, Li WBehavioural study of the D-galactose induced aging model in C57BL/6J miceBehav Brain Res.(2005 Feb 28)
111.^Cui X, Zuo P, Zhang Q, Li X, Hu Y, Long J, Packer L, Liu JChronic systemic D-galactose exposure induces memory loss, neurodegeneration, and oxidative damage in mice: protective effects of R-alpha-lipoic acidJ Neurosci Res.(2006 Jun)
112.^Song X, Bao M, Li D, Li YMAdvanced glycation in D-galactose induced mouse aging modelMech Ageing Dev.(1999 May 17)
113.^Mao GX, Deng HB, Yuan LG, Li DD, Li YY, Wang ZProtective role of salidroside against aging in a mouse model induced by D-galactoseBiomed Environ Sci.(2010 Apr)
114.^Li F, Tang H, Xiao F, Gong J, Peng Y, Meng XProtective effect of salidroside from Rhodiolae Radix on diabetes-induced oxidative stress in miceMolecules.(2011 Dec 1)
115.^Kim SH, Hyun SH, Choung SYAntioxidative effects of Cinnamomi cassiae and Rhodiola rosea extracts in liver of diabetic miceBiofactors.(2006)
116.^Lu L, Yuan J, Zhang SRejuvenating activity of salidroside (SDS): dietary intake of SDS enhances the immune response of aged ratsAge (Dordr).(2012 Feb 26)
117.^Li HB, Ge YK, Zheng XX, Zhang LSalidroside stimulated glucose uptake in skeletal muscle cells by activating AMP-activated protein kinaseEur J Pharmacol.(2008 Jul 7)
118.^Parisi A, Tranchita E, Duranti G, Ciminelli E, Quaranta F, Ceci R, Cerulli C, Borrione P, Sabatini SEffects of chronic Rhodiola Rosea supplementation on sport performance and antioxidant capacity in trained male: preliminary resultsJ Sports Med Phys Fitness.(2010 Mar)
119.^Wing SL, Askew EW, Luetkemeier MJ, Ryujin DT, Kamimori GH, Grissom CKLack of effect of Rhodiola or oxygenated water supplementation on hypoxemia and oxidative stressWilderness Environ Med.(2003 Spring)
120.^Walker TB, Altobelli SA, Caprihan A, Robergs RAFailure of Rhodiola rosea to alter skeletal muscle phosphate kinetics in trained menMetabolism.(2007 Aug)
121.^Abidov M, Grachev S, Seifulla RD, Ziegenfuss TNExtract of Rhodiola rosea radix reduces the level of C-reactive protein and creatinine kinase in the bloodBull Exp Biol Med.(2004 Jul)
122.^Schutgens FW, Neogi P, van Wijk EP, van Wijk R, Wikman G, Wiegant FAThe influence of adaptogens on ultraweak biophoton emission: a pilot-experimentPhytother Res.(2009 Aug)
123.^Noreen EE, Buckley JG, Lewis SL, Brandauer J, Stuempfle KJThe Effects of an Acute Dose of Rhodiola Rosea on Endurance Exercise PerformanceJ Strength Cond Res.(2012 May 24)
124.^Noreen EE, Buckley JG, Lewis SL, Brandauer J, Stuempfle KJThe Effects of an Acute Dose of Rhodiola rosea on Endurance Exercise PerformanceJ Strength Cond Res.(2013 Mar)
125.^Colson SN, Wyatt FB, Johnston DL, Autrey LD, FitzGerald YL, Earnest CPCordyceps sinensis- and Rhodiola rosea-based supplementation in male cyclists and its effect on muscle tissue oxygen saturationJ Strength Cond Res.(2005 May)
126.^Earnest CP, Morss GM, Wyatt F, Jordan AN, Colson S, Church TS, Fitzgerald Y, Autrey L, Jurca R, Lucia AEffects of a commercial herbal-based formula on exercise performance in cyclistsMed Sci Sports Exerc.(2004 Mar)
127.^Skarpanska-Stejnborn A, Pilaczynska-Szczesniak L, Basta P, Deskur-Smielecka EThe influence of supplementation with Rhodiola rosea L. extract on selected redox parameters in professional rowersInt J Sport Nutr Exerc Metab.(2009 Apr)
128.^Zhang JK, Yang L, Meng GL, Yuan Z, Fan J, Li D, Chen JZ, Shi TY, Hu HM, Wei BY, Luo ZJ, Liu JProtection by Salidroside against Bone Loss via Inhibition of Oxidative Stress and Bone-Resorbing MediatorsPLoS One.(2013)
129.^Oka S, Hsu CP, Sadoshima JRegulation of cell survival and death by pyridine nucleotidesCirc Res.(2012 Aug 17)
130.^Xu J, Li YEffects of salidroside on exhaustive exercise‑induced oxidative stress in ratsMol Med Rep.(2012 Nov)
131.^Schriner SE, Avanesian A, Liu Y, Luesch H, Jafari MProtection of human cultured cells against oxidative stress by Rhodiola rosea without activation of antioxidant defensesFree Radic Biol Med.(2009 Sep 1)
132.^Qian EW, Ge DT, Kong SKSalidroside protects human erythrocytes against hydrogen peroxide-induced apoptosisJ Nat Prod.(2012 Apr 27)
133.^Qu ZQ, Zhou Y, Zeng YS, Lin YK, Li Y, Zhong ZQ, Chan WYProtective effects of a Rhodiola crenulata extract and salidroside on hippocampal neurogenesis against streptozotocin-induced neural injury in the ratPLoS One.(2012)
134.^Mao GX, Wang Y, Qiu Q, Deng HB, Yuan LG, Li RG, Song DQ, Li YY, Li DD, Wang ZSalidroside protects human fibroblast cells from premature senescence induced by H(2)O(2) partly through modulating oxidative statusMech Ageing Dev.(2010 Nov-Dec)
135.^Guan S, Wang W, Lu J, Qian W, Huang G, Deng X, Wang XSalidroside attenuates hydrogen peroxide-induced cell damage through a cAMP-dependent pathwayMolecules.(2011 Apr 19)
137.^Ouyang JF, Lou J, Yan C, Ren ZH, Qiao HX, Hong DSIn-vitro promoted differentiation of mesenchymal stem cells towards hepatocytes induced by salidrosideJ Pharm Pharmacol.(2010 Apr)
138.^Huang SC, Lee FT, Kuo TY, Yang JH, Chien CTAttenuation of long-term Rhodiola rosea supplementation on exhaustive swimming-evoked oxidative stress in the ratChin J Physiol.(2009 Oct 31)
139.^Bocharova OA, Matveev BP, Baryshnikov AIu, Figurin KM, Serebriakova RV, Bodrova NBThe effect of a Rhodiola rosea extract on the incidence of recurrences of a superficial bladder cancer (experimental clinical research)Urol Nefrol (Mosk).(1995 Mar-Apr)
140.^Liu Z, Li X, Simoneau AR, Jafari M, Zi XRhodiola rosea extracts and salidroside decrease the growth of bladder cancer cell lines via inhibition of the mTOR pathway and induction of autophagyMol Carcinog.(2012 Mar)
141.^Hu X, Zhang X, Qiu S, Yu D, Lin SSalidroside induces cell-cycle arrest and apoptosis in human breast cancer cellsBiochem Biophys Res Commun.(2010 Jul 16)
142.^Hu X, Lin S, Yu D, Qiu S, Zhang X, Mei RA preliminary study: the anti-proliferation effect of salidroside on different human cancer cell linesCell Biol Toxicol.(2010 Dec)
143.^Mattioli L, Perfumi MEvaluation of Rhodiola rosea L. extract on affective and physical signs of nicotine withdrawal in miceJ Psychopharmacol.(2011 Mar)
144.^Huo J, Qin F, Cai X, Ju J, Hu C, Wang Z, Lu W, Wang X, Cao PChinese medicine formula "Weikang Keli" induces autophagic cell death on human gastric cancer cell line SGC-7901Phytomedicine.(2013 Jan 15)
145.^Booker A, Jalil B, Frommenwiler D, Reich E, Zhai L, Kulic Z, Heinrich MThe authenticity and quality of Rhodiola rosea productsPhytomedicine.(2015 Oct)
146.^Colson SN, Wyatt FB, Johnston DL, Autrey LD, FitzGerald YL, Earnest CPCordyceps sinensis- and Rhodiola rosea-based supplementation in male cyclists and its effect on muscle tissue oxygen saturationJ Strength Cond Res.(2005 May)
147.^Bangratz M, Ait Abdellah S, Berlin A, Blondeau C, Guilbot A, Dubourdeaux M, Lemoine PA preliminary assessment of a combination of rhodiola and saffron in the management of mild-moderate depressionNeuropsychiatr Dis Treat.(2018 Jul 13)
148.^H J Engels, J C WirthNo ergogenic effects of ginseng (Panax ginseng C.A. Meyer) during graded maximal aerobic exerciseJ Am Diet Assoc.(1997 Oct)
149.^Skarpanska-Stejnborn A, Pilaczynska-Szczesniak L, Basta P, Deskur-Smielecka EThe influence of supplementation with Rhodiola rosea L. extract on selected redox parameters in professional rowersInt J Sport Nutr Exerc Metab.(2009 Apr)
150.^Ha Z, Zhu Y, Zhang X, Cui J, Zhang S, Ma Y, Wang W, Jian XThe effect of rhodiola and acetazolamide on the sleep architecture and blood oxygen saturation in men living at high altitudeZhonghua Jie He He Hu Xi Za Zhi.(2002 Sep)
151.^Yu HL, Zhang PP, Zhang C, Zhang X, Li ZZ, Li WQ, Fu ASEffects of rhodiola rosea on oxidative stress and negative emotional states in patients with obstructive sleep apneaLin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi.(2019 Oct)
152.^Shi ZF, Zhou QQ, Xiang L, Ma SD, Yan CJ, Luo HThree preparations of compound Chinese herbal medicines for de-adaptation to high altitude: a randomized, placebo-controlled trialZhong Xi Yi Jie He Xue Bao.(2011 Apr)
153.^Xu KJ, Zhang SF, Li QXPreventive and treatment effect of composite Rhodiolae on acute lung injury in patients with severe pulmonary hypertension during extracorporeal circulationZhongguo Zhong Xi Yi Jie He Za Zhi.(2003 Sep)
154.^Zhang S, Gao W, Xu K, Guo Y, Lin S, Xue X, Lu G, Li N, Liu H, Liu WEarly use of Chinese drug rhodiola compound for patients with post-trauma and inflammation in prevention of ALI/ARDSZhonghua Wai Ke Za Zhi.(1999 Apr)
155.^Shen WS, Gao CH, Zhang HEffect of rhodiola on serum troponin 1, cardiac integral backscatter and left ventricle ejective fraction of patients who received epirubicin-contained chemotherapyZhongguo Zhong Xi Yi Jie He Za Zhi.(2010 Dec)
156.^Ballmann CG, Maze SB, Wells AC, Marshall MM, Rogers RREffects of short-term Rhodiola Rosea (Golden Root Extract) supplementation on anaerobic exercise performanceJ Sports Sci.(2019 May)
157.^Mao Jun, et alA Randomized Placebo Controlled Trial of Rhodiola Rosea and Sertraline for Major Depressive Disorder.(2014 May)
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