Capsaicin
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Human Effect Matrix
The Human Effect Matrix looks at human studies (it excludes animal and in vitro studies) to tell you what effects capsaicin has on your body, and how strong these effects are.
| Grade | Level of Evidence [show legend] |
|---|---|
|
Robust research conducted with repeated double-blind clinical trials |
|
Multiple studies where at least two are double-blind and placebo controlled |
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Single double-blind study or multiple cohort studies |
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Uncontrolled or observational studies only |
|
Level of Evidence
?
The amount of high quality evidence. The more
evidence, the more we can trust the results.
|
Outcome |
Magnitude of effect
?
The direction and size of the supplement's impact on
each outcome. Some supplements can have an increasing effect, others have a decreasing effect, and others have no effect.
|
Consistency of research results
?
Scientific research does not always agree. HIGH or
VERY HIGH means that most of the scientific research agrees.
|
Notes |
|---|---|---|---|---|
|
|
Minor
|
- See study |
A possible reduction in blood glucose may occur secondary to pancreatic stimulation with high doses of capsaicin
|
|
|
|
Minor
|
- See study |
High doses of capsaicin may induce insulin release from the pancreas
|
|
|
|
- | - See study |
|
|
|
|
- | - See study |
|
|
|
|
- | - See study |
|
|
|
|
- | - See 2 studies |
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|
|
|
- | - See study |
|
Studies Excluded from Consideration
Used peppers (vegetables) rather than isolated capsaicin[1]
Confounded with caffeine and/or black pepper[2][3]
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Things to Note
Is a Form Of
Other Functions:
Primary Function:
Also Known As
Chili extract, Hot pepper extract, trans-8-methyl-N-Vanilyl-6-nonenamide, Capsaicinoids
Do Not Confuse With
Piperine (Black Pepper extract)
Caution Notice
Known to interact with enzymes of drug metabolism
Although technically a CYP3A4 inhibitor, it appears chronic ingestion causes an upregulation (increase) in CYP3A4 related activity
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