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Capsaicin

The exact molecule found in hot peppers that burns your face off, acts via adrenaline receptors and TRPV1 (like Evodia) to increase heat quickly. Can burn body fat with minimal potency, fight inflammation with decent potency, and prevent cancer with indeterminate potency.

Our evidence-based analysis on capsaicin features 108 unique references to scientific papers.

Research analysis led by .
Reviewed by
Examine.com Team
Last Updated:

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Human Effect Matrix

The Human Effect Matrix looks at human studies (it excludes animal and in vitro studies) to tell you what effects capsaicin has on your body, and how strong these effects are.
Grade Level of Evidence
Robust research conducted with repeated double-blind clinical trials
Multiple studies where at least two are double-blind and placebo controlled
Single double-blind study or multiple cohort studies
Uncontrolled or observational studies only
Level of Evidence
? The amount of high quality evidence. The more evidence, the more we can trust the results.
Outcome Magnitude of effect
? The direction and size of the supplement's impact on each outcome. Some supplements can have an increasing effect, others have a decreasing effect, and others have no effect.
Consistency of research results
? Scientific research does not always agree. HIGH or VERY HIGH means that most of the scientific research agrees.
Notes
grade-c Minor - See study
A possible reduction in blood glucose may occur secondary to pancreatic stimulation with high doses of capsaicin
grade-c Minor - See study
High doses of capsaicin may induce insulin release from the pancreas
grade-c - - See study
grade-c - - See study
grade-c - - See study
grade-c - - See 2 studies
grade-c - - See study

Studies Excluded from Consideration

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Things to Note

Primary Function:

Also Known As

Chili extract, Hot pepper extract, trans-8-methyl-N-Vanilyl-6-nonenamide, Capsaicinoids

Do Not Confuse With

Piperine (Black Pepper extract)

Caution Notice

Known to interact with enzymes of drug metabolism

  • Although technically a CYP3A4 inhibitor, it appears chronic ingestion causes an upregulation (increase) in CYP3A4 related activity

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Click here to see all 108 references.