Sodium Bicarbonate

Last Updated: September 28 2022

Sodium Bicarbonate (baking soda) is a molecule that acts as a buffering agent against acidity in the human body, and appears to enhance physical performance in elite and novice athletes. It also may have health benefits and intestinal side effects.

Sodium Bicarbonate is most often used for

Summary

Sodium bicarbonate (baking soda) is a supplement that provides dietary bicarbonate, which can increase serum levels of bicarbonate (normally produced by the kidneys) and subsequently buffer acid production in the body. The main mechanism of action of sodium bicarbonate is in negating the effects of acidosis. It provides benefits both in situations of chronic mild acidosis, commonly seen in metabolic ailments or during aging as kidney function slowly declines, and in exercise-induced acidosis.

In athletes, the standard doses of sodium bicarbonate supplementation (200-300 mg/kg) reliably benefits performance when performance on the exercise is heavily influenced by metabolic acidosis, aka “the burn.” Brief high-intensity exercise performance, such as a single-bout of a 30-second Wingate test, does not benefit from supplementation with sodium bicarbonate,[1] but exercise involving multiple 30-second maximal efforts does, especially if short rest intervals are used between efforts. Supplementation with sodium bicarbonate is also unlikely to enhance performance during low-intensity long-duration exercise, although the evidence is mixed.

Overall, supplementation with sodium bicarbonate can enhance performance in high-intensity single- and multiple-bout exercise that last between about 30 seconds and 12 minutes.[2]

Benefits of sodium bicarbonate can be observed with a single dose taken 60-150 minutes before exercise, but supplementation should be approached cautiously as it can cause gastrointestinal side effects if too much is taken at once or, if it’s consumed too rapidly.

Additionally, 5 g of sodium bicarbonate taken daily appears to be somewhat effective in reducing acidosis induced by the diet or the aging process (although using potassium bicarbonate appears to be better), and therefore it may reduce the rate of bone loss over time in susceptible populations.

There are mechanisms in place for sodium bicarbonate to be a fat-burning agent (it increases ketone production and lipolysis and causes a minor increase in metabolic rate), but these have not yet been linked to actual weight loss in trials.

What else is Sodium Bicarbonate known as?
Note that Sodium Bicarbonate is also known as:
  • Baking Soda
  • Bicarb
  • Bicarbonate
Dosage information

Supplemental sodium bicarbonate can be baking soda bought from the grocery store; they are the same molecule, so store-bought baking soda will work.

When used before exercise, supplemental dosages of sodium bicarbonate are in the 200–300 mg/kg range. While 200 mg/kg seems to produce an ergogenic effect in most people, 300 mg/kg appears to be the optimal dose. Doses of 400–500 mg/kg are also ergogenic when taken before exercise, but not necessarily more than lower doses. These higher doses also tend to be associated with a higher degree of intestinal side effects.

If taking sodium bicarbonate acutely for exercise, a dose can be taken 60-150 minutes before anaerobic activities associated with metabolic acidosis (i.e., “the burn”) for maximum benefit.

In studies that used a multiple day (3 to 7 days) supplementation protocol, an overall sodium bicarbondate dose of 500 mg/kg divided into four smaller doses taken throughout the day was more effective than an overall dose 300 mg/kg.[2]

Some health effects (increase in metabolic rate or attenuation of metabolic acidosis) can be achieved at more reasonable doses, such as 5-10 g, and may be more practical for nonathletes.

Additionally, as 27.3% of sodium bicarbonate's weight is due to sodium, every 100 mg/kg confers about 27 mg/kg sodium to the diet; this needs to be accounted for, and severely limits usage by persons with salt-sensitive hypertension.

As the doses are measured in reference to body weight, obesity may result in a falsely high oral dose. If you are not within a normal or overweight BMI range, estimate your oral dose based on your “ideal weight” instead.

The means of consuming bicarbonate is important, as excessively high doses or rapid ingestion can cause gastric upset due to a reaction between bicarbonate and stomach acid. Bicarbonate should be sipped slowly over a period of a few minutes with a moderate amount of water (500 mL), and the first time bicarbonate is used a half-dose should be ingested to assess tolerance.

Rapidly ingesting the drink, or taking too much, is likely to induce stomach pain and nausea within an hour followed by increased diarrhea and flatulence; sticking to 200 mg/kg may alleviate the risk of these side effects.

Independent of the dose taken, caution should be exercised with the manner by which sodium bicarbonate is ingested, so as to minimize intestinal and gastric side effects; these side effects occur with rapid or excessive consumption of bicarbonate, and include nausea and diarrhea.

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References
2.^Jozo Grgic, Zeljko Pedisic, Bryan Saunders, Guilherme G Artioli, Brad J Schoenfeld, Michael J McKenna, David J Bishop, Richard B Kreider, Jeffrey R Stout, Douglas S Kalman, Shawn M Arent, Trisha A VanDusseldorp, Hector L Lopez, Tim N Ziegenfuss, Louise M Burke, Jose Antonio, Bill I CampbellInternational Society of Sports Nutrition position stand: sodium bicarbonate and exercise performanceJ Int Soc Sports Nutr.(2021 Sep 9)
5.^Golembiewska E, Ciechanowski KRenal tubular acidosis--underrated problemActa Biochim Pol.(2012)
6.^SCHWARTZ WB, HALL PW 3rd, HAYS RM, RELMAN ASOn the mechanism of acidosis in chronic renal diseaseJ Clin Invest.(1959 Jan 1)
8.^GOODMAN AD, LEMANN J Jr, LENNON EJ, RELMAN ASPRODUCTION, EXCRETION, AND NET BALANCE OF FIXED ACID IN PATIENTS WITH RENAL ACIDOSISJ Clin Invest.(1965 Apr)
9.^Lemann J Jr, Bushinsky DA, Hamm LLBone buffering of acid and base in humansAm J Physiol Renal Physiol.(2003 Nov)
11.^Allen A, Flemström GGastroduodenal mucus bicarbonate barrier: protection against acid and pepsinAm J Physiol Cell Physiol.(2005 Jan)
14.^Flemström G, Mäkelä K, Purhonen AK, Sjöblom M, Jedstedt G, Walkowiak J, Herzig KHApelin stimulation of duodenal bicarbonate secretion: feeding-dependent and mediated via apelin-induced release of enteric cholecystokininActa Physiol (Oxf).(2011 Jan)
15.^Kawamata K, Hayashi H, Suzuki YChloride-dependent bicarbonate secretion in the mouse large intestineBiomed Res.(2006 Feb)
16.^Vidyasagar S, Rajendran VM, Binder HJThree distinct mechanisms of HCO3- secretion in rat distal colonAm J Physiol Cell Physiol.(2004 Sep)
17.^Price MJ, Singh MTime course of blood bicarbonate and pH three hours after sodium bicarbonate ingestionInt J Sports Physiol Perform.(2008 Jun)
18.^Carr AJ, Slater GJ, Gore CJ, Dawson B, Burke LMEffect of sodium bicarbonate on {HCO3-}, pH, and gastrointestinal symptomsInt J Sport Nutr Exerc Metab.(2011 Jun)
20.^Ishibashi K, Sasaki S, Marumo FMolecular cloning of a new sodium bicarbonate cotransporter cDNA from human retinaBiochem Biophys Res Commun.(1998 May 19)
21.^McMurtrie HL, Cleary HJ, Alvarez BV, Loiselle FB, Sterling D, Morgan PE, Johnson DE, Casey JRThe bicarbonate transport metabolonJ Enzyme Inhib Med Chem.(2004 Jun)
25.^Pushkin A, Abuladze N, Lee I, Newman D, Hwang J, Kurtz IMapping of the human NBC3 (SLC4A7) gene to chromosome 3p22Genomics.(1999 Apr 15)
26.^Abuladze N, Lee I, Newman D, Hwang J, Pushkin A, Kurtz IAxial heterogeneity of sodium-bicarbonate cotransporter expression in the rabbit proximal tubuleAm J Physiol.(1998 Mar)
27.^Abuladze N, Song M, Pushkin A, Newman D, Lee I, Nicholas S, Kurtz IStructural organization of the human NBC1 gene: kNBC1 is transcribed from an alternative promoter in intron 3Gene.(2000 Jun 27)
32.^De Sousa RC, Harrington JT, Ricanati ES, Shelkrot JW, Schwartz WBRenal regulation of acid-base equilibrium during chronic administration of mineral acidJ Clin Invest.(1974 Feb)
33.^Malnic G, Klose RM, Giebisch GMicropuncture study of distal tubular potassium and sodium transport in rat nephronAm J Physiol.(1966 Sep)
36.^Lindinger MI, Franklin TW, Lands LC, Pedersen PK, Welsh DG, Heigenhauser GJNaHCO(3) and KHCO(3) ingestion rapidly increases renal electrolyte excretion in humansJ Appl Physiol.(2000 Feb)
37.^van Buren M, Rabelink TJ, van Rijn HJ, Koomans HAEffects of acute NaCl, KCl and KHCO3 loads on renal electrolyte excretion in humansClin Sci (Lond).(1992 Nov)
39.^Lemann J Jr, Pleuss JA, Gray RWPotassium causes calcium retention in healthy adultsJ Nutr.(1993 Sep)
40.^Friese MA, Craner MJ, Etzensperger R, Vergo S, Wemmie JA, Welsh MJ, Vincent A, Fugger LAcid-sensing ion channel-1 contributes to axonal degeneration in autoimmune inflammation of the central nervous systemNat Med.(2007 Dec)
41.^Ziemann AE, Allen JE, Dahdaleh NS, Drebot II, Coryell MW, Wunsch AM, Lynch CM, Faraci FM, Howard MA 3rd, Welsh MJ, Wemmie JAThe amygdala is a chemosensor that detects carbon dioxide and acidosis to elicit fear behaviorCell.(2009 Nov 25)
42.^Wemmie JA, Price MP, Welsh MJAcid-sensing ion channels: advances, questions and therapeutic opportunitiesTrends Neurosci.(2006 Oct)
43.^Xiong ZG, Zhu XM, Chu XP, Minami M, Hey J, Wei WL, MacDonald JF, Wemmie JA, Price MP, Welsh MJ, Simon RPNeuroprotection in ischemia: blocking calcium-permeable acid-sensing ion channelsCell.(2004 Sep 17)
44.^Magnotta VA, Heo HY, Dlouhy BJ, Dahdaleh NS, Follmer RL, Thedens DR, Welsh MJ, Wemmie JADetecting activity-evoked pH changes in human brainProc Natl Acad Sci U S A.(2012 May 22)
45.^Chvátal A, Jendelová P, Kríz N, Syková EStimulation-evoked changes in extracellular pH, calcium and potassium activity in the frog spinal cordPhysiol Bohemoslov.(1988)
46.^Neeper SA, Gómez-Pinilla F, Choi J, Cotman CExercise and brain neurotrophinsNature.(1995 Jan 12)
47.^Vaynman S, Ying Z, Gomez-Pinilla FHippocampal BDNF mediates the efficacy of exercise on synaptic plasticity and cognitionEur J Neurosci.(2004 Nov)
48.^Cotman CW, Berchtold NCExercise: a behavioral intervention to enhance brain health and plasticityTrends Neurosci.(2002 Jun)
49.^Gold SM, Schulz KH, Hartmann S, Mladek M, Lang UE, Hellweg R, Reer R, Braumann KM, Heesen CBasal serum levels and reactivity of nerve growth factor and brain-derived neurotrophic factor to standardized acute exercise in multiple sclerosis and controlsJ Neuroimmunol.(2003 May)
50.^Ströhle A, Stoy M, Graetz B, Scheel M, Wittmann A, Gallinat J, Lang UE, Dimeo F, Hellweg RAcute exercise ameliorates reduced brain-derived neurotrophic factor in patients with panic disorderPsychoneuroendocrinology.(2010 Apr)
51.^Rojas Vega S, Abel T, Lindschulten R, Hollmann W, Bloch W, Strüder HKImpact of exercise on neuroplasticity-related proteins in spinal cord injured humansNeuroscience.(2008 Jun 2)
52.^De Meirleir KL, Baeyens L, L'Hermite-Baleriaux M, L'Hermite M, Hollmann WExercise-induced prolactin release is related to anaerobiosisJ Clin Endocrinol Metab.(1985 Jun)
53.^Gordon SE, Kraemer WJ, Vos NH, Lynch JM, Knuttgen HGEffect of acid-base balance on the growth hormone response to acute high-intensity cycle exerciseJ Appl Physiol.(1994 Feb)
54.^Rojas Vega S, Hollmann W, Vera Wahrmann B, Strüder HKpH buffering does not influence BDNF responses to exerciseInt J Sports Med.(2012 Jan)
55.^Dalsgaard MK, Ide K, Cai Y, Quistorff B, Secher NHThe intent to exercise influences the cerebral O(2)/carbohydrate uptake ratio in humansJ Physiol.(2002 Apr 15)
56.^Ide K, Schmalbruch IK, Quistorff B, Horn A, Secher NHLactate, glucose and O2 uptake in human brain during recovery from maximal exerciseJ Physiol.(2000 Jan 1)
57.^Volianitis S, Fabricius-Bjerre A, Overgaard A, Strømstad M, Bjarrum M, Carlson C, Petersen NT, Rasmussen P, Secher NH, Nielsen HBThe cerebral metabolic ratio is not affected by oxygen availability during maximal exercise in humansJ Physiol.(2008 Jan 1)
58.^van Hall G, Strømstad M, Rasmussen P, Jans O, Zaar M, Gam C, Quistorff B, Secher NH, Nielsen HBBlood lactate is an important energy source for the human brainJ Cereb Blood Flow Metab.(2009 Jun)
59.^Volianitis S, Rasmussen P, Seifert T, Nielsen HB, Secher NHPlasma pH does not influence the cerebral metabolic ratio during maximal whole body exerciseJ Physiol.(2011 Jan 15)
60.^Oldendorf W, Braun L, Cornford EpH dependence of blood-brain barrier permeability to lactate and nicotineStroke.(1979 Sep-Oct)
61.^Busija DW, Heistad DDFactors involved in the physiological regulation of the cerebral circulationRev Physiol Biochem Pharmacol.(1984)
62.^Kontos HA, Raper AJ, Patterson JLAnalysis of vasoactivity of local pH, PCO2 and bicarbonate on pial vesselsStroke.(1977 May-Jun)
63.^Aalkjaer C, Poston LEffects of pH on vascular tension: which are the important mechanismsJ Vasc Res.(1996 Sep-Oct)
66.^Lindauer U, Kunz A, Schuh-Hofer S, Vogt J, Dreier JP, Dirnagl UNitric oxide from perivascular nerves modulates cerebral arterial pH reactivityAm J Physiol Heart Circ Physiol.(2001 Sep)
68.^van Alfen-van der Velden AA, Hopman JC, Klaessens JH, Feuth T, Sengers RC, Liem KDEffects of rapid versus slow infusion of sodium bicarbonate on cerebral hemodynamics and oxygenation in preterm infantsBiol Neonate.(2006)
69.^Buckley EM, Naim MY, Lynch JM, Goff DA, Schwab PJ, Diaz LK, Nicolson SC, Montenegro LM, Lavin NA, Durduran T, Spray TL, Gaynor JW, Putt ME, Yodh AG, Fogel MA, Licht DJSodium bicarbonate causes dose-dependent increases in cerebral blood flow in infants and children with single-ventricle physiologyPediatr Res.(2013 May)
70.^Maddock RJ, Buonocore MH, Copeland LE, Richards ALElevated brain lactate responses to neural activation in panic disorder: a dynamic 1H-MRS studyMol Psychiatry.(2009 May)
71.^Esquivel G, Schruers KR, Maddock RJ, Colasanti A, Griez EJAcids in the brain: a factor in panicJ Psychopharmacol.(2010 May)
72.^Friedman SD, Mathis CM, Hayes C, Renshaw P, Dager SRBrain pH response to hyperventilation in panic disorder: preliminary evidence for altered acid-base regulationAm J Psychiatry.(2006 Apr)
73.^Gorman JM, Fyer AJ, Ross DC, Cohen BS, Martinez JM, Liebowitz MR, Klein DFNormalization of venous pH, pCO2, and bicarbonate levels after blockade of panic attacksPsychiatry Res.(1985 Jan)
74.^Adolphs RNeural systems for recognizing emotionCurr Opin Neurobiol.(2002 Apr)
75.^Coryell MW, Ziemann AE, Westmoreland PJ, Haenfler JM, Kurjakovic Z, Zha XM, Price M, Schnizler MK, Wemmie JATargeting ASIC1a reduces innate fear and alters neuronal activity in the fear circuitBiol Psychiatry.(2007 Nov 15)
76.^Wemmie JA, Askwith CC, Lamani E, Cassell MD, Freeman JH Jr, Welsh MJAcid-sensing ion channel 1 is localized in brain regions with high synaptic density and contributes to fear conditioningJ Neurosci.(2003 Jul 2)
77.^Papp LA, Klein DF, Gorman JMCarbon dioxide hypersensitivity, hyperventilation, and panic disorderAm J Psychiatry.(1993 Aug)
78.^Di Lorenzo R, Bernardi M, Genedani S, Zirilli E, Grossi G, Guaraldi GP, Bertolini AAcute alkalosis, but not acute hypocalcemia, increases panic behavior in an animal modelPhysiol Behav.(1987)
79.^Gorman JM, Battista D, Goetz RR, Dillon DJ, Liebowitz MR, Fyer AJ, Kahn JP, Sandberg D, Klein DFA comparison of sodium bicarbonate and sodium lactate infusion in the induction of panic attacksArch Gen Psychiatry.(1989 Feb)
80.^Kraemer WJ, Dziados JE, Marchitelli LJ, Gordon SE, Harman EA, Mello R, Fleck SJ, Frykman PN, Triplett NTEffects of different heavy-resistance exercise protocols on plasma beta-endorphin concentrationsJ Appl Physiol.(1993 Jan)
81.^Goldfarb AH, Hatfield BD, Potts J, Armstrong DBeta-endorphin time course response to intensity of exercise: effect of training statusInt J Sports Med.(1991 Jun)
82.^Viru A, Tendzegolskis Z, Smirnova TChanges of beta-endorphin level in blood during prolonged exerciseEndocrinol Exp.(1990 Mar)
83.^Taylor DV, Boyajian JG, James N, Woods D, Chicz-Demet A, Wilson AF, Sandman CAAcidosis stimulates beta-endorphin release during exerciseJ Appl Physiol.(1994 Oct)
84.^Goldsmith SR, Iber C, McArthur CD, Davies SFInfluence of acid-base status on plasma catecholamines during exercise in normal humansAm J Physiol.(1990 Jun)
85.^Marx JO, Gordon SE, Vos NH, Nindl BC, Gómez AL, Volek JS, Pedro J, Ratamess N, Newton RU, French DN, Rubin MR, Häkkinen K, Kraemer WJEffect of alkalosis on plasma epinephrine responses to high intensity cycle exercise in humansEur J Appl Physiol.(2002 May)
86.^Bouissou P, Defer G, Guezennec CY, Estrade PY, Serrurier BMetabolic and blood catecholamine responses to exercise during alkalosisMed Sci Sports Exerc.(1988 Jun)
87.^Mitchell TH, Abraham G, Wing S, Magder SA, Cosio MG, Deschamps A, Marliss EBIntravenous bicarbonate and sodium chloride both prolong endurance during intense cycle ergometer exerciseAm J Med Sci.(1990 Aug)
88.^Schoppen S, Pérez-Granados AM, Carbajal A, Sarriá B, Sánchez-Muniz FJ, Gómez-Gerique JA, Pilar Vaquero MSodium bicarbonated mineral water decreases postprandial lipaemia in postmenopausal women compared to a low mineral waterBr J Nutr.(2005 Oct)
92.^Carey RM, Schoeffel CD, Gildea JJ, Jones JE, McGrath HE, Gordon LN, Park MJ, Sobota RS, Underwood PC, Williams J, Sun B, Raby B, Lasky-Su J, Hopkins PN, Adler GK, Williams SM, Jose PA, Felder RASalt sensitivity of blood pressure is associated with polymorphisms in the sodium-bicarbonate cotransporterHypertension.(2012 Nov)
93.^Hunt SC, Xin Y, Wu LL, Cawthon RM, Coon H, Hasstedt SJ, Hopkins PNSodium bicarbonate cotransporter polymorphisms are associated with baseline and 10-year follow-up blood pressuresHypertension.(2006 Mar)
94.^Barkley RA, Chakravarti A, Cooper RS, Ellison RC, Hunt SC, Province MA, Turner ST, Weder AB, Boerwinkle E; Family Blood Pressure ProgramPositional identification of hypertension susceptibility genes on chromosome 2Hypertension.(2004 Feb)
97.^Coppoolse R, Barstow TJ, Stringer WW, Carithers E, Casaburi REffect of acute bicarbonate administration on exercise responses of COPD patientsMed Sci Sports Exerc.(1997 Jun)
99.^DeFronzo RA, Beckles ADGlucose intolerance following chronic metabolic acidosis in manAm J Physiol.(1979 Apr)
101.^Schoppen S, Sánchez-Muniz FJ, Pérez-Granados M, Gómez-Gerique JA, Sarriá B, Navas-Carretero S, Pilar Vaquero MDoes bicarbonated mineral water rich in sodium change insulin sensitivity of postmenopausal womenNutr Hosp.(2007 Sep-Oct)
102.^Smellie WS, O'Donnell J, Davidson H, Couper J, Logue FCEffects of changes in acid base and calcium concentration on fasting serum insulin, proinsulin, and glucose concentrationsJ Clin Pathol.(1994 Nov)
104.^Hood VL, Keller U, Haymond MW, Küry DSystemic pH modifies ketone body production rates and lipolysis in humansAm J Physiol.(1990 Sep)
107.^Galloway SD, Maughan RJThe effects of induced alkalosis on the metabolic response to prolonged exercise in humansEur J Appl Physiol Occup Physiol.(1996)
109.^Bouffard Y, Viale JP, Annat G, Guillaume C, Percival C, Bertrand O, Motin JPulmonary gas exchange during hemodialysisKidney Int.(1986 Dec)
112.^Patterson RW, Sullivan SFDeterminants of oxygen uptake during sodium bicarbonate infusionJ Appl Physiol.(1978 Sep)
113.^Bouffard Y, Tissot S, Delafosse B, Viale JP, Annat G, Bertrand O, Motin JMetabolic effects of hemodialysis with and without glucose in the dialysateKidney Int.(1993 May)
114.^De Backer WA, Verpooten GA, Borgonjon DJ, Vermeire PA, Lins RR, De Broe MEHypoxemia during hemodialysis: effects of different membranes and dialysate compositionsKidney Int.(1983 May)
117.^Greenhaff PL, Gleeson M, Maughan RJThe effects of dietary manipulation on blood acid-base status and the performance of high intensity exerciseEur J Appl Physiol Occup Physiol.(1987)
118.^Greenhaff PL, Gleeson M, Whiting PH, Maughan RJDietary composition and acid-base status: limiting factors in the performance of maximal exercise in manEur J Appl Physiol Occup Physiol.(1987)
120.^Morris LR, Murphy MB, Kitabchi AEBicarbonate therapy in severe diabetic ketoacidosisAnn Intern Med.(1986 Dec)
121.^Hale PJ, Crase J, Nattrass MMetabolic effects of bicarbonate in the treatment of diabetic ketoacidosisBr Med J (Clin Res Ed).(1984 Oct 20)
123.^Sahlin K, Alvestrand A, Brandt R, Hultman EAcid-base balance in blood during exhaustive bicycle exercise and the following recovery periodActa Physiol Scand.(1978 Nov)
124.^Osnes JB, Hermansen LAcid-base balance after maximal exercise of short durationJ Appl Physiol.(1972 Jan)
126.^Kilding AE, Overton C, Gleave JEffects of caffeine, sodium bicarbonate, and their combined ingestion on high-intensity cycling performanceInt J Sport Nutr Exerc Metab.(2012 Jun)
127.^Sale C, Saunders B, Hudson S, Wise JA, Harris RC, Sunderland CDEffect of β-alanine plus sodium bicarbonate on high-intensity cycling capacityMed Sci Sports Exerc.(2011 Oct)
128.^Douroudos II, Fatouros IG, Gourgoulis V, Jamurtas AZ, Tsitsios T, Hatzinikolaou A, Margonis K, Mavromatidis K, Taxildaris KDose-related effects of prolonged NaHCO3 ingestion during high-intensity exerciseMed Sci Sports Exerc.(2006 Oct)
129.^Driller MW, Gregory JR, Williams AD, Fell JWThe effects of serial and acute NaHCO3 loading in well-trained cyclistsJ Strength Cond Res.(2012 Oct)
130.^Carr AJ, Gore CJ, Dawson BInduced alkalosis and caffeine supplementation: effects on 2,000-m rowing performanceInt J Sport Nutr Exerc Metab.(2011 Oct)
131.^Kupcis PD, Slater GJ, Pruscino CL, Kemp JGInfluence of sodium bicarbonate on performance and hydration in lightweight rowingInt J Sports Physiol Perform.(2012 Mar)
132.^Cameron SL, McLay-Cooke RT, Brown RC, Gray AR, Fairbairn KAIncreased blood pH but not performance with sodium bicarbonate supplementation in elite rugby union playersInt J Sport Nutr Exerc Metab.(2010 Aug)
133.^Vanhatalo A, McNaughton LR, Siegler J, Jones AMEffect of induced alkalosis on the power-duration relationship of "all-out" exerciseMed Sci Sports Exerc.(2010 Mar)
134.^McNaughton L, Dalton B, Palmer GSodium bicarbonate can be used as an ergogenic aid in high-intensity, competitive cycle ergometry of 1 h durationEur J Appl Physiol Occup Physiol.(1999 Jun)
135.^Stephens TJ, McKenna MJ, Canny BJ, Snow RJ, McConell GKEffect of sodium bicarbonate on muscle metabolism during intense endurance cyclingMed Sci Sports Exerc.(2002 Apr)
136.^Gaitanos GC, Nevill ME, Brooks S, Williams CRepeated bouts of sprint running after induced alkalosisJ Sports Sci.(1991 Winter)
137.^Costill DL, Verstappen F, Kuipers H, Janssen E, Fink WAcid-base balance during repeated bouts of exercise: influence of HCO3Int J Sports Med.(1984 Oct)
138.^Bishop D, Edge J, Davis C, Goodman CInduced metabolic alkalosis affects muscle metabolism and repeated-sprint abilityMed Sci Sports Exerc.(2004 May)
139.^Spriet LL, Lindinger MI, Heigenhauser GJ, Jones NLEffects of alkalosis on skeletal muscle metabolism and performance during exerciseAm J Physiol.(1986 Nov)
140.^Hollidge-Horvat MG, Parolin ML, Wong D, Jones NL, Heigenhauser GJEffect of induced metabolic acidosis on human skeletal muscle metabolism during exerciseAm J Physiol.(1999 Oct)
142.^Kleger GR, Turgay M, Imoberdorf R, McNurlan MA, Garlick PJ, Ballmer PEAcute metabolic acidosis decreases muscle protein synthesis but not albumin synthesis in humansAm J Kidney Dis.(2001 Dec)
144.^May RC, Hara Y, Kelly RA, Block KP, Buse MG, Mitch WEBranched-chain amino acid metabolism in rat muscle: abnormal regulation in acidosisAm J Physiol.(1987 Jun)
145.^Combaret L, Taillandier D, Attaix DNutritional and hormonal control of protein breakdownAm J Kidney Dis.(2001 Jan)
146.^Pickering WP, Price SR, Bircher G, Marinovic AC, Mitch WE, Walls JNutrition in CAPD: serum bicarbonate and the ubiquitin-proteasome system in muscleKidney Int.(2002 Apr)
147.^Nielsen HB, Hein L, Svendsen LB, Secher NH, Quistorff BBicarbonate attenuates intracellular acidosisActa Anaesthesiol Scand.(2002 May)
148.^Gonzalez NC, Zamagni M, Clancy RLEffect of alkalosis on maximum oxygen uptake in rats acclimated to simulated altitudeJ Appl Physiol.(1991 Sep)
149.^Nielsen HB, Bredmose PP, Strømstad M, Volianitis S, Quistorff B, Secher NHBicarbonate attenuates arterial desaturation during maximal exercise in humansJ Appl Physiol.(2002 Aug)
150.^Hollidge-Horvat MG, Parolin ML, Wong D, Jones NL, Heigenhauser GJEffect of induced metabolic alkalosis on human skeletal muscle metabolism during exerciseAm J Physiol Endocrinol Metab.(2000 Feb)
155.^Siegler JC, Midgley AW, Polman RC, Lever REffects of various sodium bicarbonate loading protocols on the time-dependent extracellular buffering profileJ Strength Cond Res.(2010 Sep)
156.^Poole DC, Schaffartzik W, Knight DR, Derion T, Kennedy B, Guy HJ, Prediletto R, Wagner PDContribution of exercising legs to the slow component of oxygen uptake kinetics in humansJ Appl Physiol.(1991 Oct)
157.^Rossiter HB, Ward SA, Howe FA, Kowalchuk JM, Griffiths JR, Whipp BJDynamics of intramuscular 31P-MRS P(i) peak splitting and the slow components of PCr and O2 uptake during exerciseJ Appl Physiol.(2002 Dec)
158.^Berger NJ, McNaughton LR, Keatley S, Wilkerson DP, Jones AMSodium bicarbonate ingestion alters the slow but not the fast phase of VO2 kineticsMed Sci Sports Exerc.(2006 Nov)
159.^Kolkhorst FW, Rezende RS, Levy SS, Buono MJEffects of sodium bicarbonate on VO2 kinetics during heavy exerciseMed Sci Sports Exerc.(2004 Nov)
160.^Forbes SC, Raymer GH, Kowalchuk JM, Marsh GDNaHCO3-induced alkalosis reduces the phosphocreatine slow component during heavy-intensity forearm exerciseJ Appl Physiol.(2005 Nov)
161.^Santalla A, Pérez M, Montilla M, Vicente L, Davison R, Earnest C, Lucía ASodium bicarbonate ingestion does not alter the slow component of oxygen uptake kinetics in professional cyclistsJ Sports Sci.(2003 Jan)
162.^Heck KL, Potteiger JA, Nau KL, Schroeder JMSodium bicarbonate ingestion does not attenuate the VO2 slow component during constant-load exerciseInt J Sport Nutr.(1998 Mar)
164.^Hunter AM, De Vito G, Bolger C, Mullany H, Galloway SDThe effect of induced alkalosis and submaximal cycling on neuromuscular response during sustained isometric contractionJ Sports Sci.(2009 Oct)
165.^Siegler JC, Hirscher KSodium bicarbonate ingestion and boxing performanceJ Strength Cond Res.(2010 Jan)
166.^Wu CL, Shih MC, Yang CC, Huang MH, Chang CKSodium bicarbonate supplementation prevents skilled tennis performance decline after a simulated matchJ Int Soc Sports Nutr.(2010 Oct 26)
167.^Zabala M, Requena B, Sánchez-Muñoz C, González-Badillo JJ, García I, Oöpik V, Pääsuke MEffects of sodium bicarbonate ingestion on performance and perceptual responses in a laboratory-simulated BMX cycling qualification seriesJ Strength Cond Res.(2008 Sep)
168.^Zabala M, Peinado AB, Calderón FJ, Sampedro J, Castillo MJ, Benito PJBicarbonate ingestion has no ergogenic effect on consecutive all out sprint tests in BMX elite cyclistsEur J Appl Physiol.(2011 Dec)
169.^Carr AJ, Slater GJ, Gore CJ, Dawson B, Burke LMReliability and effect of sodium bicarbonate: buffering and 2000-m rowing performanceInt J Sports Physiol Perform.(2012 Jun)
170.^Lidor R, Melnik Y, Bilkevitz A, Arnon M, Falk BMeasurement of talent in judo using a unique, judo-specific ability testJ Sports Med Phys Fitness.(2005 Mar)
171.^Artioli GG, Gualano B, Coelho DF, Benatti FB, Gailey AW, Lancha AH JrDoes sodium-bicarbonate ingestion improve simulated judo performanceInt J Sport Nutr Exerc Metab.(2007 Apr)
172.^Portington KJ, Pascoe DD, Webster MJ, Anderson LH, Rutland RR, Gladden LBEffect of induced alkalosis on exhaustive leg press performanceMed Sci Sports Exerc.(1998 Apr)
173.^Webster MJ, Webster MN, Crawford RE, Gladden LBEffect of sodium bicarbonate ingestion on exhaustive resistance exercise performanceMed Sci Sports Exerc.(1993 Aug)
174.^McNaughton L, Backx K, Palmer G, Strange NEffects of chronic bicarbonate ingestion on the performance of high-intensity workEur J Appl Physiol Occup Physiol.(1999 Sep)
175.^Robergs R, Hutchinson K, Hendee S, Madden S, Siegler JInfluence of pre-exercise acidosis and alkalosis on the kinetics of acid-base recovery following intense exerciseInt J Sport Nutr Exerc Metab.(2005 Feb)
176.^Kozak-Collins K, Burke ER, Schoene RBSodium bicarbonate ingestion does not improve performance in women cyclistsMed Sci Sports Exerc.(1994 Dec)
177.^Price M, Moss P, Rance SEffects of sodium bicarbonate ingestion on prolonged intermittent exerciseMed Sci Sports Exerc.(2003 Aug)
179.^Lavender G, Bird SREffect of sodium bicarbonate ingestion upon repeated sprintsBr J Sports Med.(1989 Mar)
180.^Lambert CP, Greenhaff PL, Ball D, Maughan RJInfluence of sodium bicarbonate ingestion on plasma ammonia accumulation during incremental exercise in manEur J Appl Physiol Occup Physiol.(1993)
182.^Driller MW, Gregory JR, Williams AD, Fell JWThe effects of chronic sodium bicarbonate ingestion and interval training in highly trained rowersInt J Sport Nutr Exerc Metab.(2013 Feb)
183.^Brien DM, McKenzie DCThe effect of induced alkalosis and acidosis on plasma lactate and work output in elite oarsmenEur J Appl Physiol Occup Physiol.(1989)
184.^Siegler JC, McNaughton LR, Midgley AW, Keatley S, Hillman AMetabolic alkalosis, recovery and sprint performanceInt J Sports Med.(2010 Nov)
185.^Potteiger JA, Webster MJ, Nickel GL, Haub MD, Palmer RJThe effects of buffer ingestion on metabolic factors related to distance running performanceEur J Appl Physiol Occup Physiol.(1996)
186.^Tiryaki GR, Atterbom HAThe effects of sodium bicarbonate and sodium citrate on 600 m running time of trained femalesJ Sports Med Phys Fitness.(1995 Sep)
187.^Bird SR, Wiles J, Robbins JThe effect of sodium bicarbonate ingestion on 1500-m racing timeJ Sports Sci.(1995 Oct)
188.^Brooks GAThe lactate shuttle during exercise and recoveryMed Sci Sports Exerc.(1986 Jun)
189.^Bryner RW, Hornsby WG, Chetlin R, Ullrich IH, Yeater RAEffect of lactate consumption on exercise performanceJ Sports Med Phys Fitness.(1998 Jun)
190.^Fahey TD, Larsen JD, Brooks GA, Colvin W, Henderson S, Lary DThe effects of ingesting polylactate or glucose polymer drinks during prolonged exerciseInt J Sport Nutr.(1991 Sep)
191.^Van Montfoort MC, Van Dieren L, Hopkins WG, Shearman JPEffects of ingestion of bicarbonate, citrate, lactate, and chloride on sprint runningMed Sci Sports Exerc.(2004 Jul)
192.^Siegler JC, Gleadall-Siddall DOSodium bicarbonate ingestion and repeated swim sprint performanceJ Strength Cond Res.(2010 Nov)
193.^Tan F, Polglaze T, Cox G, Dawson B, Mujika I, Clark SEffects of induced alkalosis on simulated match performance in elite female water polo playersInt J Sport Nutr Exerc Metab.(2010 Jun)
194.^Pruscino CL, Ross ML, Gregory JR, Savage B, Flanagan TREffects of sodium bicarbonate, caffeine, and their combination on repeated 200-m freestyle performanceInt J Sport Nutr Exerc Metab.(2008 Apr)
195.^Lindh AM, Peyrebrune MC, Ingham SA, Bailey DM, Folland JPSodium bicarbonate improves swimming performanceInt J Sports Med.(2008 Jun)
196.^Mero AA, Keskinen KL, Malvela MT, Sallinen JMCombined creatine and sodium bicarbonate supplementation enhances interval swimmingJ Strength Cond Res.(2004 May)
197.^Gao JP, Costill DL, Horswill CA, Park SHSodium bicarbonate ingestion improves performance in interval swimmingEur J Appl Physiol Occup Physiol.(1988)
198.^Mc Naughton L, Thompson DAcute versus chronic sodium bicarbonate ingestion and anaerobic work and power outputJ Sports Med Phys Fitness.(2001 Dec)
200.^Mueller SM, Gehrig SM, Frese S, Wagner CA, Boutellier U, Toigo MMultiday acute sodium bicarbonate intake improves endurance capacity and reduces acidosis in menJ Int Soc Sports Nutr.(2013 Mar 26)
206.^Heer M, Frings-Meuthen P, Titze J, Boschmann M, Frisch S, Baecker N, Beck LIncreasing sodium intake from a previous low or high intake affects water, electrolyte and acid-base balance differentlyBr J Nutr.(2009 May)
207.^Frings-Meuthen P, Buehlmeier J, Baecker N, Stehle P, Fimmers R, May F, Kluge G, Heer MHigh sodium chloride intake exacerbates immobilization-induced bone resorption and protein lossesJ Appl Physiol.(2011 Aug)
208.^Krieger NS, Sessler NE, Bushinsky DAAcidosis inhibits osteoblastic and stimulates osteoclastic activity in vitroAm J Physiol.(1992 Mar)
209.^Kraut JA, Mishler DR, Singer FR, Goodman WGThe effects of metabolic acidosis on bone formation and bone resorption in the ratKidney Int.(1986 Nov)
210.^Hanson DA, Weis MA, Bollen AM, Maslan SL, Singer FR, Eyre DRA specific immunoassay for monitoring human bone resorption: quantitation of type I collagen cross-linked N-telopeptides in urineJ Bone Miner Res.(1992 Nov)
212.^Maurer M, Riesen W, Muser J, Hulter HN, Krapf RNeutralization of Western diet inhibits bone resorption independently of K intake and reduces cortisol secretion in humansAm J Physiol Renal Physiol.(2003 Jan)
214.^Buehlmeier J, Frings-Meuthen P, Remer T, Maser-Gluth C, Stehle P, Biolo G, Heer MAlkaline salts to counteract bone resorption and protein wasting induced by high salt intake: results of a randomized controlled trialJ Clin Endocrinol Metab.(2012 Dec)
215.^Schoppen S, Pérez-Granados AM, Carbajal A, Sarriá B, Navas-Carretero S, Pilar Vaquero MSodium-bicarbonated mineral water decreases aldosterone levels without affecting urinary excretion of bone mineralsInt J Food Sci Nutr.(2008 Jun)
216.^Dawson-Hughes B, Harris SS, Palermo NJ, Castaneda-Sceppa C, Rasmussen HM, Dallal GETreatment with potassium bicarbonate lowers calcium excretion and bone resorption in older men and womenJ Clin Endocrinol Metab.(2009 Jan)
219.^Sebastian A, Harris ST, Ottaway JH, Todd KM, Morris RC JrImproved mineral balance and skeletal metabolism in postmenopausal women treated with potassium bicarbonateN Engl J Med.(1994 Jun 23)
221.^McCombs GB, Green ML, Root JEffects of a chewable sodium bicarbonate oral composition on plaque and gingivitisJ Contemp Dent Pract.(2001 Feb 15)
223.^Kleber CJ, Putt MS, Milleman JL, Davidson KR, Proskin HMAn evaluation of sodium bicarbonate chewing gum in reducing dental plaque and gingivitis in conjunction with regular toothbrushingCompend Contin Educ Dent.(2001 Jul)
225.^Mankodi SM, Conforti N, Berkowitz HEfficacy of baking soda-containing chewing gum in removing natural tooth stainCompend Contin Educ Dent.(2001 Jul)
228.^Tamaki N, Kasuyama K, Esaki M, Toshikawa T, Honda S, Ekuni D, Tomofuji T, Morita MA new portable monitor for measuring odorous compounds in oral, exhaled and nasal airBMC Oral Health.(2011 Apr 20)
229.^Tessier JF, Kulkarni GVBad breath: etiology, diagnosis and treatmentOral Health.(1991 Oct)
230.^Bosy AOral malodor: philosophical and practical aspectsJ Can Dent Assoc.(1997 Mar)
232.^Brunette DMEffects of baking-soda-containing dentifrices on oral malodorCompend Contin Educ Dent Suppl.(1996)
233.^Brunette DM, Proskin HM, Nelson BJThe effects of dentifrice systems on oral malodorJ Clin Dent.(1998)
235.^Wild JE, Nelson BJ, Hubbard ME, Bowman JPOral malodor control afforded through the use of sodium bicarbonate-containing chewing gumCompend Contin Educ Dent.(2001 Jul)
237.^Cogan MG, Carneiro AV, Tatsuno J, Colman J, Krapf R, Morris RC Jr, Sebastian ANormal diet NaCl variation can affect the renal set-point for plasma pH-(HCO3-) maintenanceJ Am Soc Nephrol.(1990 Aug)
238.^Kurtz I, Maher T, Hulter HN, Schambelan M, Sebastian AEffect of diet on plasma acid-base composition in normal humansKidney Int.(1983 Nov)
239.^Hoste EA, Colpaert K, Vanholder RC, Lameire NH, De Waele JJ, Blot SI, Colardyn FASodium bicarbonate versus THAM in ICU patients with mild metabolic acidosisJ Nephrol.(2005 May-Jun)
242.^Bellinger PM, Howe ST, Shing CM, Fell JWEffect of combined β-alanine and sodium bicarbonate supplementation on cycling performanceMed Sci Sports Exerc.(2012 Aug)
244.^Ceglia L, Harris SS, Abrams SA, Rasmussen HM, Dallal GE, Dawson-Hughes BPotassium bicarbonate attenuates the urinary nitrogen excretion that accompanies an increase in dietary protein and may promote calcium absorptionJ Clin Endocrinol Metab.(2009 Feb)
245.^He FJ, Marciniak M, Carney C, Markandu ND, Anand V, Fraser WD, Dalton RN, Kaski JC, MacGregor GAEffects of potassium chloride and potassium bicarbonate on endothelial function, cardiovascular risk factors, and bone turnover in mild hypertensivesHypertension.(2010 Mar)
247.^Huber L, Gennari FJSevere metabolic alkalosis in a hemodialysis patientAm J Kidney Dis.(2011 Jul)