Last Updated: September 28 2022

Beta-alanine is the building block of carnosine, a molecule that helps buffer acid in muscles. Beta-alanine supplementation improves performance during high-intensity exercise lasting from 1 to 10 minutes. Carnosine appears to be an antioxidant and may have effects on aging.

Beta-Alanine is most often used for

What is beta-alanine?

Beta-alanine is a nonproteinogenic amino acid (i.e., it is not incorporated into proteins during translation). It is synthesized in the liver and can be ingested in the diet through animal-based foods like beef and chicken. Once ingested, beta-alanine combines with histidine within skeletal muscle and other organs to form carnosine. Beta-alanine is the limiting factor in muscle carnosine synthesis.

What are beta-alanine’s main benefits?

Beta-alanine has been shown to enhance muscular endurance during high-intensity exercise lasting 1–10 minutes.[1] Examples of exercise that may be enhanced by beta-alanine supplementation include 400–1500 meter running and 100–400 meter swimming.

Carnosine also appears to exert antiaging effects, mainly by suppressing errors in protein metabolism, as the accumulation of altered proteins is strongly associated with the aging process. These antiaging effects may derive from its role as an antioxidant, a chelator of toxic metal ions, and an antiglycation agent.[2]

What are beta-alanine’s main drawbacks?

Large doses of beta-alanine may cause a tingling feeling called paresthesia.[3] It is a harmless side effect, but some people find the sensation uncomfortable.

How does beta-alanine work?

When beta-alanine is ingested, it turns into the molecule carnosine, which acts as an acid buffer in the body. Carnosine is stored in cells and released in response to drops in pH. During intense exercise, carnosine binds to hydrogen ions (H+) to attenuate the decline in intracellular pH, allowing for a longer duration of exercise at higher intensity.

What else is Beta-Alanine known as?
Note that Beta-Alanine is also known as:
  • b-alanine
  • β-alanine
  • carnosine precursor
Beta-Alanine should not be confused with:
  • L-alanine
  • L-carnitine
Dosage information

Studies have investigated a range of 3.2–6.4 grams per day of beta-alanine.[135] To avoid paraesthesia, a dose of 0.8-1.6 grams of beta-alanine every 3-4 hours is recommended. There are also sustained-release formulations available that permit the use of greater doses without the risk of paresthesia.[136][137] Although beta-alanine is commonly included in preworkout stacks, the timing of ingestion does not influence its effectiveness.

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1.^Saunders B, Elliott-Sale K, Artioli GG, Swinton PA, Dolan E, Roschel H, Sale C, Gualano Bβ-alanine supplementation to improve exercise capacity and performance: a systematic review and meta-analysisBr J Sports Med.(2017 Apr)
2.^Alexander A Boldyrev, Giancarlo Aldini, Wim DeravePhysiology and pathophysiology of carnosinePhysiol Rev.(2013 Oct)
3.^Eimear Dolan, Paul A Swinton, Vitor de Salles Painelli, Benedict Stephens Hemingway, Bruna Mazzolani, Fabiana Infante Smaira, Bryan Saunders, Guilherme G Artioli, Bruno GualanoA Systematic Risk Assessment and Meta-Analysis on the Use of Oral β-Alanine SupplementationAdv Nutr.(2019 May 1)
4.^Miyaji K, Nagao K, Bannai M, Asakawa H, Kohyama K, Ohtsu D, Terasawa F, Ito S, Iwao H, Ohtani N, Ohta MCharacteristic metabolism of free amino acids in cetacean plasma: cluster analysis and comparison with micePLoS One.(2010 Nov 2)
6.^Yeum KJ, Orioli M, Regazzoni L, Carini M, Rasmussen H, Russell RM, Aldini GProfiling histidine dipeptides in plasma and urine after ingesting beef, chicken or chicken broth in humansAmino Acids.(2010 Mar)
7.^Gil-Agustí M1, Esteve-Romero J, Carda-Broch SAnserine and carnosine determination in meat samples by pure micellar liquid chromatographyJ Chromatogr A.(2008 May 2)
8.^Abe H, Dobson GP, Hoeger U, Parkhouse WSRole of histidine-related compounds to intracellular buffering in fish skeletal muscleAm J Physiol.(1985 Oct)
9.^Drozak J, Veiga-da-Cunha M, Vertommen D, Stroobant V, Van Schaftingen EMolecular identification of carnosine synthase as ATP-grasp domain-containing protein 1 (ATPGD1)J Biol Chem.(2010 Mar 26)
10.^Miyaji T, Sato M, Maemura H, Takahata Y, Morimatsu FExpression profiles of carnosine synthesis-related genes in mice after ingestion of carnosine or ß-alanineJ Int Soc Sports Nutr.(2012 Apr 17)
12.^Chez MG, Buchanan CP, Aimonovitch MC, Becker M, Schaefer K, Black C, Komen JDouble-blind, placebo-controlled study of L-carnosine supplementation in children with autistic spectrum disordersJ Child Neurol.(2002 Nov)
13.^Hipkiss AROn the enigma of carnosine’s anti-ageing actionsExp Gerontol.(2009 Apr)
14.^Boldyrev AADoes carnosine possess direct antioxidant activityInt J Biochem.(1993 Aug)
19.^Derave W, Ozdemir MS, Harris RC, Pottier A, Reyngoudt H, Koppo K, Wise JA, Achten Ebeta-Alanine supplementation augments muscle carnosine content and attenuates fatigue during repeated isokinetic contraction bouts in trained sprintersJ Appl Physiol (1985).(2007 Nov)
20.^Hill CA, Harris RC, Kim HJ, Harris BD, Sale C, Boobis LH, Kim CK, Wise JAInfluence of beta-alanine supplementation on skeletal muscle carnosine concentrations and high intensity cycling capacityAmino Acids.(2007 Feb)
21.^Everaert I, Stegen S, Vanheel B, Taes Y, Derave WEffect of beta-alanine and carnosine supplementation on muscle contractility in miceMed Sci Sports Exerc.(2012 Aug 14)
22.^Teufel M, Saudek V, Ledig JP, Bernhardt A, Boularand S, Carreau A, Cairns NJ, Carter C, Cowley DJ, Duverger D, Ganzhorn AJ, Guenet C, Heintzelmann B, Laucher V, Sauvage C, Smirnova TSequence identification and characterization of human carnosinase and a closely related non-specific dipeptidaseJ Biol Chem.(2003 Feb 21)
23.^Sauerhöfer S, Yuan G, Braun GS, Deinzer M, Neumaier M, Gretz N, Floege J, Kriz W, van der Woude F, Moeller MJL-carnosine, a substrate of carnosinase-1, influences glucose metabolismDiabetes.(2007 Oct)
25.^Tamaki N, Tsunemori F, Wakabayashi M, Hama TEffect of histidine-free and -excess diets on anserine and carnosine contents in rat gastrocnemius muscleJ Nutr Sci Vitaminol (Tokyo).(1977)
26.^Baguet A, Everaert I, De Naeyer H, Reyngoudt H, Stegen S, Beeckman S, Achten E, Vanhee L, Volkaert A, Petrovic M, Taes Y, Derave WEffects of sprint training combined with vegetarian or mixed diet on muscle carnosine content and buffering capacityEur J Appl Physiol.(2011 Oct)
30.^Baguet A, Bourgois J, Vanhee L, Achten E, Derave WImportant role of muscle carnosine in rowing performanceJ Appl Physiol.(2010 Oct)
31.^Parkhouse WS, McKenzie DC, Hochachka PW, Ovalle WKBuffering capacity of deproteinized human vastus lateralis muscleJ Appl Physiol (1985).(1985 Jan)
32.^Tallon MJ, Harris RC, Boobis LH, Fallowfield JL, Wise JAThe carnosine content of vastus lateralis is elevated in resistance-trained bodybuildersJ Strength Cond Res.(2005 Nov)
33.^Suzuki Y, Ito O, Takahashi H, Takamatus KThe effect of sprint training on skeletal muscle Carnosine in humansInt J Sport Health Sci.(2004)
36.^Peñafiel R, Ruzafa C, Monserrat F, Cremades AGender-related differences in carnosine, anserine and lysine content of murine skeletal muscleAmino Acids.(2004 Feb)
37.^Aruoma OI, Laughton MJ, Halliwell BCarnosine, homocarnosine and anserine: could they act as antioxidants in vivo?Biochem J.(1989 Dec 15)
44.^Hama T, Tamaki N, Miyamoto F, Kita M, Tsunemori FIntestinal absorption of beta-alanine, anserine and carnosine in ratsJ Nutr Sci Vitaminol (Tokyo).(1976)
45.^Kamal MA, Jiang H, Hu Y, Keep RF, Smith DEInfluence of genetic knockout of Pept2 on the in vivo disposition of endogenous and exogenous carnosine in wild-type and Pept2 null miceAm J Physiol Regul Integr Comp Physiol.(2009 Apr)
46.^Geissler S, Zwarg M, Knütter I, Markwardt F, Brandsch MThe bioactive dipeptide anserine is transported by human proton-coupled peptide transportersFEBS J.(2010 Feb)
47.^Stellingwerff T, Anwander H, Egger A, Buehler T, Kreis R, Decombaz J, Boesch CEffect of two β-alanine dosing protocols on muscle carnosine synthesis and washoutAmino Acids.(2012 Jun)
48.^Kendrick IP, Kim HJ, Harris RC, Kim CK, Dang VH, Lam TQ, Bui TT, Wise JAThe effect of 4 weeks beta-alanine supplementation and isokinetic training on carnosine concentrations in type I and -II human skeletal muscle fibresEur J Appl Physiol.(2009 May)
49.^Stegen S, Blancquaert L, Everaert I, Bex T, Taes Y, Calders P, Achten E, Derave WMeal and beta-alanine coingestion enhances muscle carnosine loadingMed Sci Sports Exerc.(2013 Aug)
52.^Shao L, Li QH, Tan ZL-carnosine reduces telomere damage and shortening rate in cultured normal fibroblastsBiochem Biophys Res Commun.(2004 Nov 12)
54.^Rosenberger RFSenescence and the accumulation of abnormal proteinsMutat Res.(1991 Mar-Nov)
55.^Hansen M, Taubert S, Crawford D, Libina N, Lee SJ, Kenyon CLifespan extension by conditions that inhibit translation in Caenorhabditis elegansAging Cell.(2007 Feb)
56.^Hipkiss AROn why decreasing protein synthesis can increase lifespanMech Ageing Dev.(2007 May-Jun)
57.^Naudí A, Caro P, Jové M, Gómez J, Boada J, Ayala V, Portero-Otín M, Barja G, Pamplona RMethionine restriction decreases endogenous oxidative molecular damage and increases mitochondrial biogenesis and uncoupling protein 4 in rat brainRejuvenation Res.(2007 Dec)
59.^Hipkiss ARCarnosine, a protective, anti-ageing peptideInt J Biochem Cell Biol.(1998 Aug)
60.^Kohen R, Yamamoto Y, Cundy KC, Ames BNAntioxidant activity of carnosine, homocarnosine, and anserine present in muscle and brainProc Natl Acad Sci U S A.(1988 May)
61.^Calabrese V, Colombrita C, Guagliano E, Sapienza M, Ravagna A, Cardile V, Scapagnini G, Santoro AM, Mangiameli A, Butterfield DA, Giuffrida Stella AM, Rizzarelli EProtective effect of carnosine during nitrosative stress in astroglial cell culturesNeurochem Res.(2005 Jun-Jul)
62.^Cai W, He JC, Zhu L, Chen X, Wallenstein S, Striker GE, Vlassara HReduced oxidant stress and extended lifespan in mice exposed to a low glycotoxin diet: association with increased AGER1 expressionAm J Pathol.(2007 Jun)
64.^Hipkiss AR, Preston JE, Himswoth DT, Worthington VC, Abbot NJProtective effects of carnosine against malondialdehyde-induced toxicity towards cultured rat brain endothelial cellsNeurosci Lett.(1997 Dec 5)
65.^Hipkiss AR, Chana HCarnosine protects proteins against methylglyoxal-mediated modificationsBiochem Biophys Res Commun.(1998 Jul 9)
66.^Aldini G, Carini M, Beretta G, Bradamante S, Facino RMCarnosine is a quencher of 4-hydroxy-nonenal: through what mechanism of reaction?Biochem Biophys Res Commun.(2002 Dec)
70.^Ikeda D, Wada S, Yoneda C, Abe H, Watabe SCarnosine stimulates vimentin expression in cultured rat fibroblastsCell Struct Funct.(1999 Apr)
71.^Kueper T, Grune T, Prahl S, Lenz H, Welge V, Biernoth T, Vogt Y, Muhr GM, Gaemlich A, Jung T, Boemke G, Elsässer HP, Wittern KP, Wenck H, Stäb F, Blatt TVimentin is the specific target in skin glycation. Structural prerequisites, functional consequences, and role in skin agingJ Biol Chem.(2007 Aug 10)
73.^Hipkiss AR, Preston JE, Himsworth DT, Worthington VC, Keown M, Michaelis J, Lawrence J, Mateen A, Allende L, Eagles PA, Abbott NJPluripotent protective effects of carnosine, a naturally occurring dipeptideAnn N Y Acad Sci.(1998 Nov 20)
75.^Bonner AB, Swann ME, Marway JS, Heap LC, Preedy VRLysosomal and nonlysosomal protease activities of the brain in response to ethanol feedingAlcohol.(1995 Nov-Dec)
76.^Odashima M, Otaka M, Jin M, Konishi N, Sato T, Kato S, Matsuhashi T, Nakamura C, Watanabe SInduction of a 72-kDa heat-shock protein in cultured rat gastric mucosal cells and rat gastric mucosa by zinc L-carnosineDig Dis Sci.(2002 Dec)
77.^Odashima M, Otaka M, Jin M, Wada I, Horikawa Y, Matsuhashi T, Ohba R, Hatakeyama N, Oyake J, Watanabe SZinc L-carnosine protects colonic mucosal injury through induction of heat shock protein 72 and suppression of NF-kappaB activationLife Sci.(2006 Nov 10)
78.^Ohkawara T, Nishihira J, Nagashima R, Takeda H, Asaka MPolaprezinc protects human colon cells from oxidative injury induced by hydrogen peroxide: relevant to cytoprotective heat shock proteinsWorld J Gastroenterol.(2006 Oct 14)
79.^Yuneva AO, Kramarenko GG, Vetreshchak TV, Gallant S, Boldyrev AAEffect of carnosine on Drosophila melanogaster lifespanBull Exp Biol Med.(2002 Jun)
80.^Stvolinsky S, Antipin M, Meguro K, Sato T, Abe H, Boldyrev AEffect of carnosine and its Trolox-modified derivatives on life span of Drosophila melanogasterRejuvenation Res.(2010 Aug)
81.^Yuneva MO, Bulygina ER, Gallant SC, Kramarenko GG, Stvolinsky SL, Boldyrev AAEffect of Carnosine on Age-Induced Changes in Senescence-Accelerated MiceJ Anti-Aging Med.(1999)
82.^Gallant S, Semyonova M, Yuneva MCarnosine as a potential anti-senescence drugBiochemistry (Mosc).(2000 Jul)
85.^Jong CJ, Azuma J, Schaffer SWRole of mitochondrial permeability transition in taurine deficiency-induced apoptosisExp Clin Cardiol.(2011 Winter)
86.^Jong CJ, Ito T, Mozaffari M, Azuma J, Schaffer SEffect of beta-alanine treatment on mitochondrial taurine level and 5-taurinomethyluridine contentJ Biomed Sci.(2010 Aug 24)
90.^Stvolinskii SL, Fedorova TN, Yuneva MO, Boldyrev AAProtective effect of carnosine on Cu,Zn-superoxide dismutase during impaired oxidative metabolism in the brain in vivoBull Exp Biol Med.(2003 Feb)
91.^Boldyrev A, Fedorova T, Stepanova M, Dobrotvorskaya I, Kozlova E, Boldanova N, Bagyeva G, Ivanova-Smolenskaya I, Illarioshkin SCarnosine {corrected} increases efficiency of DOPA therapy of Parkinson’s disease: a pilot studyRejuvenation Res.(2008 Aug)
93.^Dobrota D, Fedorova T, Stvolinsky S, Babusikova E, Likavcanova K, Drgova A, Strapkova A, Boldyrev ACarnosine protects the brain of rats and Mongolian gerbils against ischemic injury: after-stroke-effectNeurochem Res.(2005 Oct)
96.^Seidler NW, Yeargans GS, Morgan TGCarnosine disaggregates glycated alpha-crystallin: an in vitro studyArch Biochem Biophys.(2004 Jul 1)
97.^Ericson M, Clarke RB, Chau P, Adermark L, Söderpalm BBeta-alanine elevates dopamine levels in the rat nucleus accumbens: antagonism by strychnineAmino Acids.(2010 Apr)
98.^McGregor NR, Dunstan RH, Zerbes M, Butt HL, Roberts TK, Klineberg IJPreliminary determination of a molecular basis of chronic fatigue syndromeBiochem Mol Med.(1996 Apr)
99.^McGregor NR, Dunstan RH, Zerbes M, Butt HL, Roberts TK, Klineberg IJPreliminary determination of the association between symptom expression and urinary metabolites in subjects with chronic fatigue syndromeBiochem Mol Med.(1996 Jun)
100.^Hannestad U, Theodorsson E, Evengård BBeta-alanine and gamma-aminobutyric acid in chronic fatigue syndromeClin Chim Acta.(2007 Feb)
102.^Harris RC, Tallon MJ, Dunnett M, Boobis L, Coakley J, Kim HJ, Fallowfield JL, Hill CA, Sale C, Wise JAThe absorption of orally supplied beta-alanine and its effect on muscle carnosine synthesis in human vastus lateralisAmino Acids.(2006 May)
104.^Fitts RHCellular mechanisms of muscle fatiguePhysiol Rev.(1994 Jan)
105.^Artioli GG, Gualano B, Smith A, Stout J, Lancha AH JrRole of beta-alanine supplementation on muscle carnosine and exercise performanceMed Sci Sports Exerc.(2010 Jun)
106.^Stout JR, Cramer JT, Zoeller RF, Torok D, Costa P, Hoffman JR, Harris RC, O'Kroy JEffects of beta-alanine supplementation on the onset of neuromuscular fatigue and ventilatory threshold in womenAmino Acids.(2007)
107.^Stout JR, Graves BS, Smith AE, Hartman MJ, Cramer JT, Beck TW, Harris RCThe effect of beta-alanine supplementation on neuromuscular fatigue in elderly (55-92 years): a double-blind randomized studyJ Int Soc Sports Nutr.(2008 Nov 7)
108.^Hoffman JR, Ratamess NA, Faigenbaum AD, Ross R, Kang J, Stout JR, Wise JAShort-duration beta-alanine supplementation increases training volume and reduces subjective feelings of fatigue in college football playersNutr Res.(2008 Jan)
110.^Hoffman J, Ratamess NA, Ross R, Kang J, Magrelli J, Neese K, Faigenbaum AD, Wise JABeta-alanine and the hormonal response to exerciseInt J Sports Med.(2008 Dec)
111.^Hobson RM, Saunders B, Ball G, Harris RC, Sale CEffects of β-alanine supplementation on exercise performance: a meta-analysisAmino Acids.(2012 Jul)
112.^Hoffman J1, Ratamess N, Kang J, Mangine G, Faigenbaum A, Stout JEffect of creatine and beta-alanine supplementation on performance and endocrine responses in strength/power athletesInt J Sport Nutr Exerc Metab.(2006 Aug)
113.^Ducker KJ, Dawson B, Wallman KEEffect of beta-alanine supplementation on 2,000-m rowing-ergometer performanceInt J Sport Nutr Exerc Metab.(2012 Dec 7)
116.^Sweeney KM, Wright GA, Glenn Brice A, Doberstein STThe effect of beta-alanine supplementation on power performance during repeated sprint activityJ Strength Cond Res.(2010 Jan)
119.^Bishop D, Edge J, Davis C, Goodman CInduced metabolic alkalosis affects muscle metabolism and repeated-sprint abilityMed Sci Sports Exerc.(2004 May)
121.^Chung W, Shaw G, Anderson ME, Pyne DB, Saunders PU, Bishop DJ, Burke LMEffect of 10-week beta-alanine supplementation on competition and training performance in elite swimmersNutrients.(2012 Oct 9)
122.^Smith AE, Walter AA, Graef JL, Kendall KL, Moon JR, Lockwood CM, Fukuda DH, Beck TW, Cramer JT, Stout JREffects of beta-alanine supplementation and high-intensity interval training on endurance performance and body composition in men; a double-blind trialJ Int Soc Sports Nutr.(2009 Feb 11)
125.^Goto K, Maemura H, Takamatsu K, Ishii NHormonal responses to resistance exercise after ingestion of carnosine and anserineJ Strength Cond Res.(2011 Feb)
126.^Kerai MD, Waterfield CJ, Kenyon SH, Asker DS, Timbrell JAThe effect of taurine depletion by beta-alanine treatment on the susceptibility to ethanol-induced hepatic dysfunction in ratsAlcohol Alcohol.(2001 Jan-Feb)
127.^Dawson R Jr, Biasetti M, Messina S, Dominy JThe cytoprotective role of taurine in exercise-induced muscle injuryAmino Acids.(2002 Jun)
128.^Pansani MC, Azevedo PS, Rafacho BP, Minicucci MF, Chiuso-Minicucci F, Zorzella-Pezavento SG, Marchini JS, Padovan GJ, Fernandes AA, Matsubara BB, Matsubara LS, Zornoff LA, Paiva SAAtrophic cardiac remodeling induced by taurine deficiency in Wistar ratsPLoS One.(2012)
129.^Parildar H, Dogru-Abbasoglu S, Mehmetçik G, Ozdemirler G, Koçak-Toker N, Uysal MLipid peroxidation potential and antioxidants in the heart tissue of beta-alanine- or taurine-treated old ratsJ Nutr Sci Vitaminol (Tokyo).(2008 Feb)
130.^Sale C, Saunders B, Hudson S, Wise JA, Harris RC, Sunderland CDEffect of β-alanine plus sodium bicarbonate on high-intensity cycling capacityMed Sci Sports Exerc.(2011 Oct)
131.^Bellinger PM, Howe ST, Shing CM, Fell JWEffect of combined β-alanine and sodium bicarbonate supplementation on cycling performanceMed Sci Sports Exerc.(2012 Aug)
134.^Pansani MC, Azevedo PS, Rafacho BP, Minicucci MF, Chiuso-Minicucci F, Zorzella-Pezavento SG, Marchini JS, Padovan GJ, Fernandes AA, Matsubara BB, Matsubara LS, Zornoff LA, Paiva SAAtrophic cardiac remodeling induced by taurine deficiency in Wistar ratsPLoS One.(2012)
135.^Pedro Perim, Felipe Miguel Marticorena, Felipe Ribeiro, Gabriel Barreto, Nathan Gobbi, Chad Kerksick, Eimear Dolan, Bryan SaundersCan the Skeletal Muscle Carnosine Response to Beta-Alanine Supplementation Be Optimized?Front Nutr.(2019 Aug 27)
136.^Alyssa N Varanoske, Jay R Hoffman, David D Church, Nicholas A Coker, Kayla M Baker, Sarah J Dodd, Roger C Harris, Leonardo P Oliveira, Virgil L Dawson, Ran Wang, David H Fukuda, Jeffrey R StoutComparison of sustained-release and rapid-release β-alanine formulations on changes in skeletal muscle carnosine and histidine content and isometric performance following a muscle-damaging protocolAmino Acids.(2019 Jan)
137.^David D Church, Jay R Hoffman, Alyssa N Varanoske, Ran Wang, Kayla M Baker, Michael B La Monica, Kyle S Beyer, Sarah J Dodd, Leonardo P Oliveira, Roger C Harris, David H Fukuda, Jeffrey R StoutComparison of Two β-Alanine Dosing Protocols on Muscle Carnosine ElevationsJ Am Coll Nutr.(Nov-Dec 2017)
138.^Hoffman J, Ratamess N, Kang J, Mangine G, Faigenbaum A, Stout JEffect of creatine and beta-alanine supplementation on performance and endocrine responses in strength/power athletesInt J Sport Nutr Exerc Metab.(2006 Aug)