7-Keto DHEA

Last Updated: September 28 2022

7-Keto DHEA is a metabolite of DHEA that is nonhormonal, and it appears to be a fat loss agent as it may increase the metabolic rate. Studies in humans show promise for helping during a fat loss diet, but currently are of questionable quality due to potential conflicts of interest.

7-Keto DHEA is most often used for

Summary

7-oxodehydroepiandrosterone (7-oxo DHEA and more commonly known as the brand name 7-keto) is one of three oxygenated metabolites of dehydroepiandrosterone, and these three oxygenated metabolites interconvert with one another but do not convert back into parent DHEA; 7-keto supplementation is a way to get these three oxygenated metabolites without using DHEA supplementation, and DHEA may form androgenic and estrogenic hormones via an alternate metabolic pathway (which 7-keto does not participate in).

7-keto supplementation is mostly known to not be hormonal; it can interact with steroid metabolism but the exact manner in which it does it not fully elucidated. It does appear to have anti-cortisol mechanisms as the enzymes that activate cortisol (from the relatively inactive precursors of cortisone and corticosterone) are the same that interconvert these oxygenated metabolites. Although it appears to be anti-cortisol by its mechanisms, there is insufficient evidence to support these mechanisms in the body following oral supplementation.

Studies using 7-keto supplementation tend to note an increased metabolic rate later on during a caloric restriction period (which is secondary to reducing the rate of metabolic rate decline associated with dieting, and becoming a relative increase) although the quantity of data on this is pretty minimal if we exclude studies with possible conflicts of interest or those that use 7-keto alongside a multitude of supplements.

7-keto appears to be a somewhat promising non-hormonal fat burning agent but requires more evidence on both of those claims.

What else is 7-Keto DHEA known as?
Note that 7-Keto DHEA is also known as:
  • 7-ketodehydroepiandrosterone
  • 7-oxodehydroepiandrosterone
  • 7-ketoDHEA
  • 7-oxoDHEA
  • 7-oxo
  • 7-keto
7-Keto DHEA should not be confused with:
Dosage information

A typical supplemental dosage of 7-keto is 200-400mg daily in two divided doses (100-200mg), some limited evidence suggests that lower doses of 50-100mg may be effective for neural purposes.

The optimal dosing schedule and overall dose of 7-keto is not yet known, and the above dosages are just based on what is known to have efficacy.

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References
2.^Kazihnitková H, Zamrazilová L, Hill M, Lapcík O, Pouzar V, Hampl RA novel radioimmunoassay of 7-oxo-DHEA and its physiological levelsSteroids.(2007 Apr)
3.^Davidson M, Marwah A, Sawchuk RJ, Maki K, Marwah P, Weeks C, Lardy HSafety and pharmacokinetic study with escalating doses of 3-acetyl-7-oxo-dehydroepiandrosterone in healthy male volunteersClin Invest Med.(2000 Oct)
7.^Rijk JC, Bovee TF, Peijnenburg AA, Groot MJ, Rietjens IM, Nielen MWBovine liver slices: A multifunctional in vitro model to study the prohormone dehydroepiandrosterone (DHEA)Toxicol In Vitro.(2012 Sep)
8.^Wu Z, Martin KO, Javitt NB, Chiang JYStructure and functions of human oxysterol 7alpha-hydroxylase cDNAs and gene CYP7B1J Lipid Res.(1999 Dec)
9.^Fitzpatrick JL, Ripp SL, Smith NB, Pierce WM Jr, Prough RAMetabolism of DHEA by cytochromes P450 in rat and human liver microsomal fractionsArch Biochem Biophys.(2001 May 15)
15.^Lund-Pero M, Jeppson B, Arneklo-Nobin B, Sjögren HO, Holmgren K, Pero RWNon-specific steroidal esterase activity and distribution in human and other mammalian tissuesClin Chim Acta.(1994 Jan 14)
18.^Mitić T, Shave S, Semjones N, McNae I, Cobice DF, Lavery GG, Webster SP, Hadoke PW, Walker BR, Andrew R11β-Hydroxysteroid Dehydrogenase type 1 contributes to the Balance Between 7-Keto- and 7-Hydroxy-Oxysterols in vivoBiochem Pharmacol.(2013 Feb 13)
19.^Nashev LG, Chandsawangbhuwana C, Balazs Z, Atanasov AG, Dick B, Frey FJ, Baker ME, Odermatt AHexose-6-phosphate dehydrogenase modulates 11beta-hydroxysteroid dehydrogenase type 1-dependent metabolism of 7-keto- and 7beta-hydroxy-neurosteroidsPLoS One.(2007 Jun 27)
23.^Flood JF, Smith GE, Roberts EDehydroepiandrosterone and its sulfate enhance memory retention in miceBrain Res.(1988 May 3)
24.^Flood JF, Roberts EDehydroepiandrosterone sulfate improves memory in aging miceBrain Res.(1988 May 10)
30.^Sedláčková B, Dušátková L, Zamrazilová H, Matucha P, Bičíková M, Stárka L7-oxygenated derivatives of dehydroepiandrosterone and obesityPrague Med Rep.(2012)
31.^Bobyleva V, Kneer N, Bellei M, Battelli D, Lardy HAConcerning the mechanism of increased thermogenesis in rats treated with dehydroepiandrosteroneJ Bioenerg Biomembr.(1993 Jun)
32.^Lardy H, Kneer N, Bellei M, Bobyleva VInduction of thermogenic enzymes by DHEA and its metabolitesAnn N Y Acad Sci.(1995 Dec 29)
36.^Zenk JL, Leikam SA, Kassen LJ, Kuskowski MAEffect of lean system 7 on metabolic rate and body compositionNutrition.(2005 Feb)
38.^Tomlinson JW, Walker EA, Bujalska IJ, Draper N, Lavery GG, Cooper MS, Hewison M, Stewart PM11beta-hydroxysteroid dehydrogenase type 1: a tissue-specific regulator of glucocorticoid responseEndocr Rev.(2004 Oct)
40.^Balázs Z, Nashev LG, Chandsawangbhuwana C, Baker ME, Odermatt AHexose-6-phosphate dehydrogenase modulates the effect of inhibitors and alternative substrates of 11beta-hydroxysteroid dehydrogenase 1Mol Cell Endocrinol.(2009 Mar 25)
41.^Hennebert O, Pernelle C, Ferroud C, Morfin R7alpha- and 7beta-hydroxy-epiandrosterone as substrates and inhibitors for the human 11beta-hydroxysteroid dehydrogenase type 1J Steroid Biochem Mol Biol.(2007 Jun-Jul)
45.^Miller KK, Al-Rayyan N, Ivanova MM, Mattingly KA, Ripp SL, Klinge CM, Prough RADHEA metabolites activate estrogen receptors alpha and betaSteroids.(2013 Jan)
46.^Granata OM, Cocciadifero L, Campisi I, Miceli V, Montalto G, Polito LM, Agostara B, Carruba GAndrogen metabolism and biotransformation in nontumoral and malignant human liver tissues and cellsJ Steroid Biochem Mol Biol.(2009 Feb)
47.^Hu Y, Ghosh S, Amleh A, Yue W, Lu Y, Katz A, Li RModulation of aromatase expression by BRCA1: a possible link to tissue-specific tumor suppressionOncogene.(2005 Dec 15)
48.^Hammond GL, Wu TS, Simard MEvolving utility of sex hormone-binding globulin measurements in clinical medicineCurr Opin Endocrinol Diabetes Obes.(2012 Jun)