Clary sage

Last Updated: June 14 2018

Salvia sclarea (Clary Sage) is a herb commonly used as an aromatic. Belonging to the Mint family of plants, the 'relaxing' effects of the aromas may be related to preliminary evidence suggesting anti-depressant effects.

Clary sage is most often used for

Summary

Salvia Sclarea (Clary Sage) is a herb in the mint family traditionally used as a relaxing agent and aromatic, with a fair bit of literature suggesting it is used for for menopausal women.

There is a lack of large-scale studies to support the usage of Clary Sage as an aromatic, but the evidence that exists currently is supportive. One study in rodents (in which the rodents were essentially hot boxed with Clary Sage) noted anti-depressive effects after a single exposure and one study in female humans has noted a reduction in systolic blood pressure and respiratory rate 60 minutes after inhalation (study was placebo controlled and blinded, as to omit the possibility of the placebo effect).

Two studies exist using combination therapy of Clary Sage, Lavender, and another herb (one study used Rose oil, the other Marjoram) which have confirmed that this herbal aromatic therapy appears to be more effective than placebo in relieving menstrual pain in persons who self-report that they have more menstrual pain than average (on a scale of 1-10, participants had to rate a 5 or higher to be included in the study).

There are some immunological interactions with may be important to anti-cancer effects, but currently these studies are investigating the activity of the bioactive known as (-)-Sclareol which is unlikely to be located in the aroma. The anti-cancer effects, although interesting, are currently preliminary and not associated with aromatherapy.

What else is Clary sage known as?
Note that Clary sage is also known as:
  • Clary Sage
  • Salvia Sclarea
Clary sage should not be confused with:
  • Salvia divinorum (street drug)
Dosage information

If using Clary Sage for aromatherapy, enough should be lit (if using incense) to confer a pleasant aroma. The two studies using combination therapy noted that a cream containing 1 concentration drop of Clary Sage to 2 drops of Lavender in 5cc of volume was rubbed on the abdomen (the scent would remain on the body for a while).

Due to the exact bioactives not being known, quantifying the right dose for aromatherapy is difficult.

There is insufficient evidence to suggest an optimal oral dose of Clary Sage for any purpose.

Examine Database
References
3.^Conti B, Benelli G, Leonardi M, Afifi FU, Cervelli C, Profeti R, Pistelli L, Canale ARepellent effect of Salvia dorisiana, S. longifolia, and S. sclarea (Lamiaceae) essential oils against the mosquito Aedes albopictus Skuse (Diptera: Culicidae)Parasitol Res.(2012 Jul)
4.^Caissard JC, Olivier T, Delbecque C, Palle S, Garry PP, Audran A, Valot N, Moja S, Nicolé F, Magnard JL, Legrand S, Baudino S, Jullien FExtracellular localization of the diterpene sclareol in clary sage (Salvia sclarea L., Lamiaceae)PLoS One.(2012)
5.^Caniard A, Zerbe P, Legrand S, Cohade A, Valot N, Magnard JL, Bohlmann J, Legendre LDiscovery and functional characterization of two diterpene synthases for sclareol biosynthesis in Salvia sclarea (L.) and their relevance for perfume manufactureBMC Plant Biol.(2012 Jul 26)
6.^Laville R, Castel C, Filippi JJ, Delbecque C, Audran A, Garry PP, Legendre L, Fernandez XAmphilectane diterpenes from Salvia sclarea: biosynthetic considerationsJ Nat Prod.(2012 Feb 24)
8.^Asadi S, Ahmadiani A, Esmaeili MA, Sonboli A, Ansari N, Khodagholi FIn vitro antioxidant activities and an investigation of neuroprotection by six Salvia species from Iran: a comparative studyFood Chem Toxicol.(2010 May)
9.^Seol GH, Shim HS, Kim PJ, Moon HK, Lee KH, Shim I, Suh SH, Min SSAntidepressant-like effect of Salvia sclarea is explained by modulation of dopamine activities in ratsJ Ethnopharmacol.(2010 Jul 6)
10.^Han SH, Hur MH, Buckle J, Choi J, Lee MSEffect of aromatherapy on symptoms of dysmenorrhea in college students: A randomized placebo-controlled clinical trialJ Altern Complement Med.(2006 Jul-Aug)
11.^Sundell G, Milsom I, Andersch BFactors influencing the prevalence and severity of dysmenorrhoea in young womenBr J Obstet Gynaecol.(1990 Jul)
14.^Mahvi DM, Henry MB, Albertini MR, Weber S, Meredith K, Schalch H, Rakhmilevich A, Hank J, Sondel PIntratumoral injection of IL-12 plasmid DNA--results of a phase I/IB clinical trialCancer Gene Ther.(2007 Aug)
16.^Hori S, Nomura T, Sakaguchi SControl of regulatory T cell development by the transcription factor Foxp3Science.(2003 Feb 14)
18.^Woo EY, Chu CS, Goletz TJ, Schlienger K, Yeh H, Coukos G, Rubin SC, Kaiser LR, June CHRegulatory CD4(+)CD25(+) T cells in tumors from patients with early-stage non-small cell lung cancer and late-stage ovarian cancerCancer Res.(2001 Jun 15)
19.^Noori S, Hassan ZM, Mohammadi M, Habibi Z, Sohrabi N, Bayanolhagh SSclareol modulates the Treg intra-tumoral infiltrated cell and inhibits tumor growth in vivoCell Immunol.(2010)
20.^Hatziantoniou S, Dimas K, Georgopoulos A, Sotiriadou N, Demetzos CCytotoxic and antitumor activity of liposome-incorporated sclareol against cancer cell lines and human colon cancer xenograftsPharmacol Res.(2006 Jan)
21.^Dimas K, Hatziantoniou S, Tseleni S, Khan H, Georgopoulos A, Alevizopoulos K, Wyche JH, Pantazis P, Demetzos CSclareol induces apoptosis in human HCT116 colon cancer cells in vitro and suppression of HCT116 tumor growth in immunodeficient miceApoptosis.(2007 Apr)
22.^Dimas K, Kokkinopoulos D, Demetzos C, Vaos B, Marselos M, Malamas M, Tzavaras TThe effect of sclareol on growth and cell cycle progression of human leukemic cell linesLeuk Res.(1999 Mar)