Alanylglutamine

    Researchedby:
    Kamal Patel
    Last Updated: September 28, 2022

    L-Alanyl-L-Glutamine, also known by the brand name Sustamine, is a dipeptide molecule of glutamine and alanine, which makes it more stable and water-soluble than glutamine by itself. Current evidence does not support L-alanyl-L-glutamine’s use as a performance-enhancing supplement.

    examine-databaseExamine Database

    Alanylglutamine is most often used for .

    65 participants in 4 trials

    Summary

    L-Alanyl-L-Glutamine (alanylglutamine) is a dipeptide molecule, consisting of L-glutamine and L-alanine, two amino acids.

    Alanylglutamine is sometimes supplemented before prolonged physical exercise to enhance electrolyte absorption and improve endurance.

    Preliminary rodent evidence suggests alanylglutamine is more effective at increasing muscular glutamine content after supplementation than glutamine itself. This is because glutamine is absorbed by the liver and intestines after supplementation. Since alanylglutamine is a dipeptide molecule, it contains more than one amino acid for the intestines to absorb, allowing glutamine to reach the muscles.

    Though alanylglutamine supplementation results in greater glutamine muscular content, this has not been shown to provide a performance enhancing effect.

    Current evidence suggests alanylglutamine may be a more effective supplement than glutamine because of its increased stability and water solubility, but more research is needed to determine if it actually has an effect on performance.

    What are other names for Alanylglutamine

    Note that Alanylglutamine is also known as:
    • L-Alanyl-L-Glutamine
    • Alanyl-Glutamine
    • Sustamine (brand name)
    Alanylglutamine should not be confused with:

    Dosage information

    Current studies on L-alanyl-L-glutamine use a dose of 1-3g a day. More research is needed to determine the optimal dose.

    L-Alanyl-L-Glutamine supplementation may be similar to glutamine supplementation, in terms of dose, timing, and purpose.

    Examine Database: Alanylglutamine

    Examine Database References

    1. HIV Viral Load - Leite RD, Lima NL, Leite CA, Farhat CK, Guerrant RL, Lima AAImprovement of intestinal permeability with alanyl-glutamine in HIV patients: a randomized, double blinded, placebo-controlled clinical trialArq Gastroenterol.(2013 Jan-Mar)
    2. Blood Lactate (Exercise) - Hoffman JR, Ratamess NA, Kang J, Rashti SL, Kelly N, Gonzalez AM, Stec M, Anderson S, Bailey BL, Yamamoto LM, Hom LL, Kupchak BR, Faigenbaum AD, Maresh CMExamination of the efficacy of acute L-alanyl-L-glutamine ingestion during hydration stress in endurance exerciseJ Int Soc Sports Nutr.(2010 Feb 3)
    3. Power Output - Hoffman JR, Williams DR, Emerson NS, Hoffman MW, Wells AJ, McVeigh DM, McCormack WP, Mangine GT, Gonzalez AM, Fragala MSL-alanyl-L-glutamine ingestion maintains performance during a competitive basketball gameJ Int Soc Sports Nutr.(2012 Mar 7)
    4. Plasma Glutamine - Roger C Harris, Jay R Hoffman, Adrian Allsopp, Naomi B H RoutledgeL-glutamine absorption is enhanced after ingestion of L-alanylglutamine compared with the free amino acid or wheat proteinNutr Res.(2012 Apr)