Alanylglutamine

Last Updated: September 28 2022

L-Alanyl-L-Glutamine, also known by the brand name Sustamine, is a dipeptide molecule of glutamine and alanine, which makes it more stable and water-soluble than glutamine by itself. Current evidence does not support L-alanyl-L-glutamine’s use as a performance-enhancing supplement.

Alanylglutamine is most often used for

Summary

L-Alanyl-L-Glutamine (alanylglutamine) is a dipeptide molecule, consisting of L-glutamine and L-alanine, two amino acids.

Alanylglutamine is sometimes supplemented before prolonged physical exercise to enhance electrolyte absorption and improve endurance.

Preliminary rodent evidence suggests alanylglutamine is more effective at increasing muscular glutamine content after supplementation than glutamine itself. This is because glutamine is absorbed by the liver and intestines after supplementation. Since alanylglutamine is a dipeptide molecule, it contains more than one amino acid for the intestines to absorb, allowing glutamine to reach the muscles.

Though alanylglutamine supplementation results in greater glutamine muscular content, this has not been shown to provide a performance enhancing effect.

Current evidence suggests alanylglutamine may be a more effective supplement than glutamine because of its increased stability and water solubility, but more research is needed to determine if it actually has an effect on performance.

What else is Alanylglutamine known as?
Note that Alanylglutamine is also known as:
  • L-Alanyl-L-Glutamine
  • Alanyl-Glutamine
  • Sustamine (brand name)
Alanylglutamine should not be confused with:
Dosage information

Current studies on L-alanyl-L-glutamine use a dose of 1-3g a day. More research is needed to determine the optimal dose.

L-Alanyl-L-Glutamine supplementation may be similar to glutamine supplementation, in terms of dose, timing, and purpose.

Examine Database
References
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