Quick Navigation

C-Reactive Protein

C-Reactive Protein is an inflammatory biomarker for cardiovascular disease and artherosclerosis (arterial plaque). Its reduction is thought to be protective and reduces the risk of cardiovascular incidents.

Research analysis lead by Kamal Patel
All content reviewed by Examine.com Team. Published:
Last Updated:

Human Effect Matrix

The Human Effect Matrix looks at human studies (it excludes animal and in vitro studies) to tell you what supplements affect c-reactive protein
Grade Level of Evidence
Robust research conducted with repeated double-blind clinical trials
Multiple studies where at least two are double-blind and placebo controlled
Single double-blind study or multiple cohort studies
Uncontrolled or observational studies only
Level of Evidence
? The amount of high quality evidence. The more evidence, the more we can trust the results.
Outcome Magnitude of effect
? The direction and size of the supplement's impact on each outcome. Some supplements can have an increasing effect, others have a decreasing effect, and others have no effect.
Consistency of research results
? Scientific research does not always agree. HIGH or VERY HIGH means that most of the scientific research agrees.
grade-a Fish Oil - Very High See all 16 studies
Although some decreases have been noted, the vast majority of the evidence suggests that there is no significant influence
grade-b Curcumin Minor High See all 3 studies
May decrease C-reactive protein if elevated
grade-b Hesperidin Minor High See all 3 studies
There is a decrease in C-Reactive Protein (inflammatory biomarker) in those with higher baseline inflammation or inflammatory disease conditions, but not in healthy persons.
grade-b Zinc  
grade-b Cocoa Extract  
grade-b Conjugated Linoleic Acid  
grade-b L-Carnitine  
grade-b Vitamin E  
grade-c Ashwagandha  
grade-c Krill Oil  
grade-c Fucoxanthin  
grade-c Ginkgo biloba  
grade-c Grape Seed Extract  
grade-c Irvingia gabonensis  
grade-c Magnesium  
grade-c Rhodiola Rosea  
grade-c Salvia hispanica  
grade-c Stinging Nettle  
grade-c Vitamin C  
grade-c Alanylglutamine  
grade-c Alpha-Lipoic Acid  
grade-c Black Cohosh  
grade-c Blueberry  
grade-c Chromium  
grade-c Citrulline  
grade-c Coenzyme Q10  
grade-c Colostrum  
grade-c Creatine  
grade-c Feverfew  
grade-c Ganoderma lucidum  
grade-c Garlic  
grade-c Glutamine  
grade-c HMB  
grade-c Lactobacillus casei  
grade-c Lactobacillus reuteri  
grade-c Melatonin  
grade-c Nigella sativa  
grade-c Panax ginseng  
grade-c Pycnogenol  
grade-c Resveratrol  
grade-c Rooibos  
grade-c Rose Hip  
grade-c S-Adenosyl Methionine  
grade-c Sea Buckthorn  
grade-c Type-II Collagen  
grade-c Vitamin B2  
grade-c Vitamin B3 (Niacin)  
grade-c Vitamin K  
grade-c Whey Protein  
grade-d Ecklonia cava  
grade-d Pyrroloquinoline quinone  
grade-d Iodine  
grade-d Safflower Oil  
grade-d Boron  
grade-d Inositol  
grade-d Perilla Oil  
grade-d Royal Jelly  
grade-d Rubus coreanus  
grade-d Tetradecyl Thioacetic Acid  
grade-d Vitamin B1  

All comparative evidence is now gathered in our ​A-to-Z Supplement Reference.

The evidence for each separate supplement is still freely available ​here.