How to TakeMedical Disclaimer
Recommended dosage, active amounts, other details
Collagen supplements are taken in one of two different forms, either in the form of hydrolyzed collagen or in the form of an undenatured type II collagen; both forms have different dosing strategies and while their benefits may share some similarities can be considered two different supplements.
Hydrolyzed collagen is taken in doses of around 10g a day for skin health and some benefits to joints, and can be taken with meals. It should not be taken in higher doses as a protein supplement (for muscle gain and fat loss) due to having less efficacy than other protein sources and a lackluster amino acid profile.
Undenatured collagen is taken at a lower dose of approximately 40mg once daily for the treatment of osteoarthritis and rheumatoid arthritis when there is an autoimmune component to it, and while it doesn't need to be taken at any particular time of the day it may be ideal to take it on an empty stomach before breakfast.
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Human Effect Matrix
The Human Effect Matrix looks at human studies (it excludes animal and in vitro studies) to tell you what effects type-ii collagen has on your body, and how strong these effects are.
|Grade||Level of Evidence [show legend]|
|Robust research conducted with repeated double-blind clinical trials|
|Multiple studies where at least two are double-blind and placebo controlled|
|Single double-blind study or multiple cohort studies|
|Uncontrolled or observational studies only|
Level of Evidence
? The amount of high quality evidence. The more evidence, the more we can trust the results.
Magnitude of effect
? The direction and size of the supplement's impact on each outcome. Some supplements can have an increasing effect, others have a decreasing effect, and others have no effect.
Consistency of research results
? Scientific research does not always agree. HIGH or VERY HIGH means that most of the scientific research agrees.
|Minor||High See all 5 studies|
|Minor||- See study|
|Minor||- See 2 studies|
|Minor||Very High See all 3 studies|
|-||- See study|
|-||- See study|
|-||- See study|
Studies Excluded from Consideration
Note: The above HEM contains information on both hydrolyzed collagen supplements and undenatured collagen supplements despite significant dose differences between the two
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Things to Note
CII supplements are derived from animals and thus not vegan-friendly
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