Liver Enzymes
Research analysis led by Kamal Patel.
All content reviewed by the Examine.com Team. Published:
Last Updated:
All content reviewed by the Examine.com Team. Published:
Last Updated:
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Human Effect Matrix
The Human Effect Matrix looks at human studies (it excludes animal and in vitro studies) to tell you what supplements affect liver enzymes
| Grade | Level of Evidence [show legend] |
|---|---|
|
Robust research conducted with repeated double-blind clinical trials |
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Multiple studies where at least two are double-blind and placebo controlled |
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Single double-blind study or multiple cohort studies |
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Uncontrolled or observational studies only |
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Level of Evidence
?
The amount of high quality evidence. The more
evidence, the more we can trust the results.
|
Outcome |
Magnitude of effect
?
The direction and size of the supplement's impact on
each outcome. Some supplements can have an increasing effect, others have a decreasing effect, and others have no effect.
|
Consistency of research results
?
Scientific research does not always agree. HIGH or
VERY HIGH means that most of the scientific research agrees.
|
Notes |
|---|---|---|---|---|
|
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Notable
|
Very High See all 5 studies |
The decrease in liver enzymes associated with cholestasis is quite strong, and TUDCA is a reference drug for these effects
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Notable
|
Low See all 9 studies |
There appears to be a notable decrease in both ALT and γ-GPT in persons with non-alcoholic fatty liver (NAFLD) which may exceed 50% when vitamin E is supplemented above 300mg for half a year; there does not appear to be any influence whatsoever in healthy controls.
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Minor
|
Low See all 5 studies |
Similar to liver fat and damage, the levels of liver enzymes in serum appears to be reduced potently in preliminary evidence with the currently largest trial showing no significant influence; there may be a role, but it needs to be further elucidated.
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