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Liver Enzymes

Liver enzymes are a commonly used biomarker to test the toxicity of a supplement, and are elevated in instances of fatty or cirrhotic livers. Their reduction in the blood is thought to reflect less damage to liver cells.

Research analysis led by Kamal Patel.
All content reviewed by the Examine.com Team. Published: Jul 5, 2013
Last Updated:

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Human Effect Matrix

The Human Effect Matrix looks at human studies (it excludes animal and in vitro studies) to tell you what supplements affect liver enzymes
Grade Level of Evidence
Robust research conducted with repeated double-blind clinical trials
Multiple studies where at least two are double-blind and placebo controlled
Single double-blind study or multiple cohort studies
Uncontrolled or observational studies only
Level of Evidence
? The amount of high quality evidence. The more evidence, the more we can trust the results.
Outcome Magnitude of effect
? The direction and size of the supplement's impact on each outcome. Some supplements can have an increasing effect, others have a decreasing effect, and others have no effect.
Consistency of research results
? Scientific research does not always agree. HIGH or VERY HIGH means that most of the scientific research agrees.
Notes
grade-b Notable Very High See all 5 studies
The decrease in liver enzymes associated with cholestasis is quite strong, and TUDCA is a reference drug for these effects
grade-b Notable Low See all 9 studies
There appears to be a notable decrease in both ALT and γ-GPT in persons with non-alcoholic fatty liver (NAFLD) which may exceed 50% when vitamin E is supplemented above 300mg for half a year; there does not appear to be any influence whatsoever in healthy controls.
grade-b Minor Moderate See all 14 studies
No significant influence on liver enzymes associated with curcumin supplementation in most people, however, a small reduction is more likely in people with elevated liver enzymes.

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