Liver Enzymes
Research analysis lead by Kamal Patel
All content reviewed by Examine.com Team.
Published:
Last Updated:
All content reviewed by Examine.com Team.
Published:
Last Updated:
Human Effect Matrix
The Human Effect Matrix looks at human studies (it excludes animal and in vitro studies) to tell you what supplements affect liver enzymes
| Grade | Level of Evidence [show legend] |
|---|---|
|
Robust research conducted with repeated double-blind clinical trials |
|
Multiple studies where at least two are double-blind and placebo controlled |
|
Single double-blind study or multiple cohort studies |
|
Uncontrolled or observational studies only |
|
Level of Evidence
?
The amount of high quality evidence. The mo
re evidence, the more we can trust the results.
|
Outcome |
Magnitude of effect
?
The direction and size of the supplement's impact on
each outcome. Some supplements can have an increasing effect, others have a decreasing effect, and others have no effect.
|
Consistency of research results
?
Scientific research does not always agree. HIGH or
VERY HIGH means that most of the scientific research agrees.
|
Notes |
|---|---|---|---|---|
|
|
Tauroursodeoxycholic Acid |
Notable
|
Very High See all 5 studies |
The decrease in liver enzymes associated with cholestasis is quite strong, and TUDCA is a reference drug for these effects
|
|
|
Vitamin E |
Notable
|
Low See all 9 studies |
There appears to be a notable decrease in both ALT and γ-GPT in persons with non-alcoholic fatty liver (NAFLD) which may exceed 50% when vitamin E is supplemented above 300mg for half a year; there does not appear to be any influence whatsoever in healthy controls.
|
|
|
Trimethylglycine |
Minor
|
Low See all 5 studies |
Similar to liver fat and damage, the levels of liver enzymes in serum appears to be reduced potently in preliminary evidence with the currently largest trial showing no significant influence; there may be a role, but it needs to be further elucidated.
|
|
|
Chromium | - | Very High See all 3 studies |
No known influence on liver enzymes or other markers of hepatic health.
|
|
|
Conjugated Linoleic Acid | |||
|
|
Creatine | |||
|
|
Lactobacillus reuteri | |||
|
|
Nigella sativa | |||
|
|
Fucoxanthin | |||
|
|
Artichoke Extract | |||
|
|
Garlic | |||
|
|
Gynostemma pentaphyllum | |||
|
|
Hesperidin | |||
|
|
Hoodia gordonii | |||
|
|
L-Carnitine | |||
|
|
Melatonin | |||
|
|
Picrorhiza kurroa | |||
|
|
Resveratrol | |||
|
|
Anethum graveolens | |||
|
|
Astaxanthin | |||
|
|
Citrulline | |||
|
|
Citrullus colocynthis | |||
|
|
Cordyceps | |||
|
|
Curcumin | |||
|
|
Dehydroepiandrosterone | |||
|
|
Ecdysteroids | |||
|
|
Eleutherococcus senticosus | |||
|
|
Fish Oil | |||
|
|
Ganoderma lucidum | |||
|
|
Glutamine | |||
|
|
Green Coffee Extract | |||
|
|
HMB | |||
|
|
Inositol | |||
|
|
Kava | |||
|
|
Leucine | |||
|
|
Nattokinase | |||
|
|
Olive leaf extract | |||
|
|
Phosphatidylserine | |||
|
|
Pterostilbene | |||
|
|
Red Clover Extract | |||
|
|
Rose Hip | |||
|
|
S-Adenosyl Methionine | |||
|
|
Saffron | |||
|
|
Vitamin B3 (Niacin) | |||
|
|
Spirulina | |||
|
|
Andrographis paniculata | |||
|
|
Hibiscus sabdariffa | |||
|
|
Rubus coreanus | |||
|
|
Whey Protein | |||
|
|
Ashwagandha | |||
|
|
Black Cohosh | |||
|
|
Bulbine natalensis | |||
|
|
Cocoa Extract | |||
|
|
Perilla Oil | |||
|
|
Pyrroloquinoline quinone | |||
|
|
Royal Jelly | |||
|
|
Terminalia arjuna | |||
|
|
Tetradecyl Thioacetic Acid | |||
|
|
Tribulus terrestris | |||
|
|
Vitamin C | |||