Kutki

Last Updated: September 28 2022

Picrorhiza kurroa (Kutki or Picroliv) is a liver tonic from Ayurveda that, when used at low doses, appears to exceed milk thistle silymarins in potency. It is underresearched, but its liver protective effects and some other immunomodulatory properties hold potential.

Kutki is most often used for

Summary

Picrorhiza kurroa is a herb from Ayurveda that is commonly called Kutki or Kutaki. It contains a 'bitter principle' which is a mixture of two molecules, the irioid glycosides known as picroside I and picroside II (picroside II also being called kutkoside) and the mixture overall is then called kutkin or picroliv. Overall, these are the active components.

The herb itself, due solely to the kutkin molecules, appears to be potently hepatoprotective (protective of the liver) when ingested prior to or taken after exposure to a toxin. The protective effects seem to extend to all tested toxins or stressors that are known to alter liver function, and appear to also extend to states of intrinsic liver dysfunction (viral hepatitis and NAFLD from a high fat diet). Most notably it is protective against Tylenol, alcohol, and the deathcap mushroom with a potency that is greater than silymarins (the active parts of milk thistle supplementation).

This fairly remarkable hepatoprotection from picrorhiza kurroa is limited by its lack of human studies, as despite the multitude of animal research on the topic there appears to only be one study in humans which showed that a very low dose of the supplement (25mg kutkin) was effective against viral hepatitis. Future studies in humans are needed to confirm its protective effects, and currently picrorhiza kurroa is a remarkably promising herb.

What else is Kutki known as?
Note that Kutki is also known as:
  • Kutki
  • Picrorhiza Scrophulariiflora
  • Katuki
  • Kurro
  • Kutkin
  • Picroliv
  • Picrolax
  • Picrorhiza Kurroa
Dosage information

Supplementation of picroliv (picroside I plus picroside II) appears to be most effective in at 12mg/kg (the higher dose, 24mg/kg, is not significantly more effective than 12mg/kg in most cases) and this leads to a preliminary human dosage of:

  • 130 mg for a 150lb person
  • 170 mg for a 200lb person
  • 220 mg for a 250lb person

Although the above dosage levels are ideal, lower doses also appear to be effective and the lone human study used a total picroside I and II dosage of around 25mg.

If using an extract of picrorhiza kurroa, then the above dosage refers to the total picroside I and II content (kutkin or picroliv) rather than the weight of the plant itself. For example, a plant extract that is 1,000 mg and contains 4% picroliv will confer 40 mg picroliv.

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      References
      1.^[No authors listedPicrorhiza kurroa. MonographAltern Med Rev.(2001 Jun)
      7.^Dorsch W, Stuppner H, Wagner H, Gropp M, Demoulin S, Ring JAntiasthmatic effects of Picrorhiza kurroa: androsin prevents allergen- and PAF-induced bronchial obstruction in guinea pigsInt Arch Allergy Appl Immunol.(1991)
      8.^Stuppner H, Wagner HNew cucurbitacin glycosides from Picrorhiza kurrooaPlanta Med.(1989 Dec)
      9.^Vaidya AB, Antarkar DS, Doshi JC, Bhatt AD, Ramesh V, Vora PV, Perissond D, Baxi AJ, Kale PMPicrorhiza kurroa (Kutaki) Royle ex Benth as a hepatoprotective agent--experimental & clinical studiesJ Postgrad Med.(1996 Oct-Dec)
      10.^Zhang DK, Yu JJ, Li YM, Wei LN, Yu Y, Feng YH, Wang XA Picrorhiza kurroa derivative, picroliv, attenuates the development of dextran-sulfate-sodium-induced colitis in miceMediators Inflamm.(2012)
      13.^Wang CH, Wang ZT, Bligh SW, White KN, White CJPharmacokinetics and tissue distribution of gentiopicroside following oral and intravenous administration in miceEur J Drug Metab Pharmacokinet.(2004 Jul-Sep)
      14.^Park EJ, Lee HS, Oh SR, Lee HK, Lee HSPharmacokinetics of verproside after intravenous and oral administration in ratsArch Pharm Res.(2009 Apr)
      20.^Simons JM, Hart BA, Ip Vai Ching TR, Van Dijk H, Labadie RPMetabolic activation of natural phenols into selective oxidative burst agonists by activated human neutrophilsFree Radic Biol Med.(1990)
      22.^Chamorro G, Pérez-Albiter M, Serrano-García N, Mares-Sámano JJ, Rojas PSpirulina maxima pretreatment partially protects against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine neurotoxicityNutr Neurosci.(2006 Oct-Dec)
      23.^Hussain A, Shadma W, Maksood A, Ansari SHProtective effects of Picrorhiza kurroa on cyclophosphamide-induced immunosuppression in micePharmacognosy Res.(2013 Jan)
      24.^Dorsch W, Wagner HNew antiasthmatic drugs from traditional medicineInt Arch Allergy Appl Immunol.(1991)
      26.^Antarkar DS, Vaidya AB, Doshi JC, Athavale AV, Vinchoo KS, Natekar MR, Tathed PS, Ramesh V, Kale NA double-blind clinical trial of Arogya-wardhani--an ayurvedic drug--in acute viral hepatitisIndian J Med Res.(1980 Oct)
      28.^Rastogi R, Srivastava AK, Srivastava M, Rastogi AKHepatocurative effect of picroliv and silymarin against aflatoxin B1 induced hepatotoxicity in ratsPlanta Med.(2000 Dec)
      29.^Dwivedi Y, Rastogi R, Mehrotra R, Garg NK, Dhawan BNPicroliv protects against aflatoxin B1 acute hepatotoxicity in ratsPharmacol Res.(1993 Feb-Mar)
      31.^Santra A, Das S, Maity A, Rao SB, Mazumder DNPrevention of carbon tetrachloride-induced hepatic injury in mice by Picrorhiza kurrooaIndian J Gastroenterol.(1998 Jan)
      33.^Dwivedi Y, Rastogi R, Sharma SK, Garg NK, Dhawan BNPicroliv affords protection against thioacetamide-induced hepatic damage in ratsPlanta Med.(1991 Feb)
      34.^Girish C, Koner BC, Jayanthi S, Ramachandra Rao K, Rajesh B, Pradhan SCHepatoprotective activity of picroliv, curcumin and ellagic acid compared to silymarin on paracetamol induced liver toxicity in miceFundam Clin Pharmacol.(2009 Dec)
      35.^Shukla B, Visen PK, Patnaik GK, Dhawan BNCholeretic effect of picroliv, the hepatoprotective principle of Picrorhiza kurroaPlanta Med.(1991 Feb)
      36.^Yadav N, Khandelwal SEffect of Picroliv on cadmium-induced hepatic and renal damage in the ratHum Exp Toxicol.(2006 Oct)
      37.^Yadav N, Khandelwal STherapeutic efficacy of Picroliv in chronic cadmium toxicityFood Chem Toxicol.(2009 Apr)
      38.^Singh AK, Mani H, Seth P, Gaddipati JP, Kumari R, Banuadha KK, Sharma SC, Kulshreshtha DK, Maheshwari RKPicroliv preconditioning protects the rat liver against ischemia-reperfusion injuryEur J Pharmacol.(2000 May 3)
      40.^Dwivedi Y, Rastogi R, Sharma SK, Mehrotra R, Garg NK, Dhawan BNPicroliv protects against monocrotaline-induced hepatic damage in ratsPharmacol Res.(1991 May)
      41.^Vivekanandan P, Gobianand K, Priya S, Vijayalakshmi P, Karthikeyan SProtective effect of picroliv against hydrazine-induced hyperlipidemia and hepatic steatosis in ratsDrug Chem Toxicol.(2007)
      43.^Rastogi R, Saksena S, Garg NK, Kapoor NK, Agarwal DP, Dhawan BNPicroliv protects against alcohol-induced chronic hepatotoxicity in ratsPlanta Med.(1996 Jun)
      44.^Floersheim GL, Bieri A, Koenig R, Pletscher AProtection against Amanita phalloides by the iridoid glycoside mixture of Picrorhiza kurroa (kutkin)Agents Actions.(1990 Mar)
      48.^Rogler G, Andus TCytokines in inflammatory bowel diseaseWorld J Surg.(1998 Apr)
      50.^Xiang JY, Wu LG, Huang XL, Zhang M, Pen L, Ouyan Q, Gan HTAmelioration of murine dextran sulfate sodium-induced colitis by nuclear factor-kappaB decoy oligonucleotidesAm J Surg.(2009 Jun)
      52.^Yadav N, Khandelwal SEffect of Picroliv on cadmium induced testicular damage in ratFood Chem Toxicol.(2008 Feb)
      53.^Yadav N, Dogra RK, Khan MY, Khandelwal SPrevention of acute cadmium toxicity by PicrolivHum Exp Toxicol.(2005 Oct)
      54.^Bedi KL, Zutshi U, Chopra CL, Amla VPicrorhiza kurroa, an ayurvedic herb, may potentiate photochemotherapy in vitiligoJ Ethnopharmacol.(1989 Dec)