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TNF-Alpha

Tumor necrosis factor alpha (TNF-α) is a proinflammatory cytokine that is used as a marker of inflammation. Its reduction is thought to reflect a lesser state of inflammation in the body.

Research analysis led by Kamal Patel.
All content reviewed by the Examine.com Team. Published: Jul 5, 2013
Last Updated:

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Things To Know & Note

Also Known As

TNF-α, TNF, Tumor necrosis factor alpha

Human Effect Matrix

The Human Effect Matrix looks at human studies (it excludes animal and in vitro studies) to tell you what supplements affect tnf-alpha
Grade Level of Evidence
Robust research conducted with repeated double-blind clinical trials
Multiple studies where at least two are double-blind and placebo controlled
Single double-blind study or multiple cohort studies
Uncontrolled or observational studies only
Level of Evidence
? The amount of high quality evidence. The more evidence, the more we can trust the results.
Outcome Magnitude of effect
? The direction and size of the supplement's impact on each outcome. Some supplements can have an increasing effect, others have a decreasing effect, and others have no effect.
Consistency of research results
? Scientific research does not always agree. HIGH or VERY HIGH means that most of the scientific research agrees.
Notes
grade-b Minor High See all 6 studies
May decrease TNF-a
grade-b - High See all 4 studies
Insufficient evidence to support changes in TNFa, a biomarker of inflammmation.
grade-c Minor Very High See 2 studies
A reduction in TNF-alpha levels have been noted in persons with elevated baseline TNF-alpha levels

All comparative evidence is now gathered in our ​A-to-Z Supplement Reference.

The evidence for each separate supplement is still freely available ​here.

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