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Subjective Well-Being

Self-reported ratings of well being and happiness; either in general (euphoria-inducing compound) or reducing a disease state to enough of a degree to make the persons relatively happy.

Research analysis lead by Kamal Patel
All content reviewed by Examine.com Team. Published:
Last Updated:

Human Effect Matrix

The Human Effect Matrix looks at human studies (it excludes animal and in vitro studies) to tell you what supplements affect subjective well-being
Grade Level of Evidence
Robust research conducted with repeated double-blind clinical trials
Multiple studies where at least two are double-blind and placebo controlled
Single double-blind study or multiple cohort studies
Uncontrolled or observational studies only
Level of Evidence
? The amount of high quality evidence. The more evidence, the more we can trust the results.
Outcome Magnitude of effect
? The direction and size of the supplement's impact on each outcome. Some supplements can have an increasing effect, others have a decreasing effect, and others have no effect.
Consistency of research results
? Scientific research does not always agree. HIGH or VERY HIGH means that most of the scientific research agrees.
grade-b Kava Notable Very High See all 4 studies
The increase in well being appears to be quite large, but secondary to reducing anxiety. At least one study has noted that, in healthy persons subject to a minor stressor (testing) that kava enhanced cheerfulness
grade-b Rhodiola Rosea Notable Very High See all 4 studies
Increases in subjective well being and contentment in fatigued or stressed individuals appears to be greater than other supplements.
grade-b Creatine Minor Moderate See all 11 studies
The influence of creatine on well being and general happiness is usually dependent on it treating a disease state; there does not appear to be a per se benefit to well being.
grade-b Ganoderma lucidum  
grade-b Ginkgo biloba  
grade-b Panax ginseng  
grade-b Pelargonium sidoides  
grade-b Dehydroepiandrosterone  
grade-b Vitamin E  
grade-c Modafinil  
grade-c Nigella sativa  
grade-c Ashwagandha  
grade-c Blueberry  
grade-c Caffeine  
grade-c Chlorogenic Acid  
grade-c D-Serine  
grade-c Ephedrine  
grade-c Eurycoma Longifolia Jack  
grade-c Fish Oil  
grade-c Green Tea Catechins  
grade-c L-Tyrosine  
grade-c Maca  
grade-c Mucuna pruriens  
grade-c Peppermint  
grade-c Pycnogenol  
grade-c Pyruvate  
grade-c Vitamin C  
grade-c Zinc  
grade-c Arginine  
grade-c Centella asiatica  
grade-c Cocoa Extract  
grade-c Conjugated Linoleic Acid  
grade-c L-Carnitine  
grade-c N-Acetylcysteine  
grade-c Phosphatidylserine  
grade-c Red Clover Extract  
grade-c Ruscus aculeatus  
grade-c Sceletium tortuosum  
grade-c Theanine  
grade-d Black Cohosh  
grade-d Boswellia serrata  
grade-d Bromelain  
grade-d Lavender  
grade-d Vinpocetine  
grade-d D-Ribose  

All comparative evidence is now gathered in our ​A-to-Z Supplement Reference.

The evidence for each separate supplement is still freely available ​here.