Iron
Iron is an essential mineral best known for allowing blood to carry oxygen between tissues. Except in case of deficiency, iron supplementation has no proven benefit; on the contrary, it can lead to iron poisoning.
Iron is most often used for
Last Updated:October 3, 2022
What is iron?
Iron is an essential dietary mineral present in a wide variety of foods. In its main role in the body, iron is a critical component of hemoglobin — the oxygen carrier of red blood cells — and a deficiency in iron leads to poor oxygen transport (anemia). In addition, iron acts as a cofactor for many enzymes. The iron found in plants (notably grains and legumes) is less bioavailable than the iron found in meat (in the form of heme). Iron is the double-edged sword of the nutrient world. On the one hand, many people have insufficient levels, but on the other hand, iron overload can be toxic to a wide variety of cells. Iron deficiency is the only reason to consider iron supplementation, though getting more iron through foods is preferable when possible. For people who already have enough iron, taking an iron supplement has no proven benefit, and on the contrary, it can lead to iron overdose.
What are the benefits of iron?
A lack of iron tends to produce fatigue, depression, impaired cognitive function, restless leg syndrome, and other adverse effects. Correction of an iron deficiency tends to improve symptoms, and even among people who aren't anemic, more than the bare minimum amount of iron may be needed to produce the optimal amounts of hemoglobin and reap the benefits of greater oxygen delivery; however, the beneficial effect is probably limited to people whose iron levels are low according to conventional standards, though more research is needed. Iron supplements are also often used by athletes in an attempt to improve physical performance, however once again there does not appear to be any benefit when iron levels are not low. Iron deficiency is fairly common, and a great number of factors negatively affect iron status, so iron supplementation and iron-rich diets can be expected to benefit many people.
What are the downsides of iron?
Supplementation can produce nausea, headaches, and other symptoms. As previously mentioned, iron overload is a serious health risk.
Make sure that you get the recommended daily allowance (RDA) for your gender, age, and situation:
- 8 mg for men and nonmenstruating women
- 15 mg for menstruating women 14–18 years old
- 18 mg for menstruating women 19–50 years old
- 27 mg for pregnant women
- 10 mg for lactating women less than 18 years old
- 9 mg for lactating women, 19–50 years old
Those numbers include the iron in your diet. Getting enough iron from foods makes supplementation unnecessary. Be careful not to ingest more iron than the daily tolerable upper intake level (UL) for your age, e.g., 45 mg for people older than 13.
For more details, see the Recommended Intake section below.
Cast iron pans are popular, especially for searing, and are generally safe to use. But they can leach iron, which is a strong pro-oxidant. Those genetically at risk for iron overload should learn more about cast iron safety.
For well over a thousand years, cast iron has been used as a reliable cooking surface. Actually, it's been used since the appropriately named “Iron Age”, roughly 2500 years ago.
Fast forward a couple millennia, and we’ve been thrust into the “Spend all day on the Internet Age”. People are starting to question the healthiness of everything, including the venerable cast iron. And not without reason: just because cast iron’s been used for years, by many people who lived long and healthy lives, doesn’t necessarily mean it’s the healthiest option for your frying pan.
Let’s explore this issue in depth. What exactly is cast iron? Are there any plausible mechanisms by which it might harm health? What does the research say?
Aside from stone, iron is the oldest cooking surface still in use. This provides evidence for its lack of obvious harm, but doesn’t necessarily mean it’s totally safe.
Paying the iron price
Cast iron is relatively easy to analyze, as far as health effects go. It’s made out of … iron. Not like the more complex pans, which have multiple layers or man-made coatings. So let’s start by talking a little bit about iron.
You can’t just dig up pure iron from the ground. Pure iron is rare and mainly comes from fallen meteorites. And it's actually pretty soft, so not great for making pans without adding in some carbon for hardening. But still, around 97-98% of a cast iron pan is plain ol’ iron, which is why we’re so interested in its health effects. Our discussion also applies to carbon steel cookware (such as woks), which is made up of 99% iron.
Cast iron and carbon steel pans are very similar in their makeup and kitchen use, so potential health concerns from cast iron pans also apply to carbon steel pans, which are also known as “blue steel” or “black steel” pans.
Other than being such an important material for making pans and skyscrapers, iron is also an essential dietary mineral. And cooking on a cast iron pan can transfer some of that mineral from the pan to the food to your body. Some will see this as a good thing, especially considering that 1.6 billion people around the world are anemic, with iron deficiency being the main cause.[reference|url=https://pubmed.ncbi.nlm.nih.gov/18498676|title=Worldwide prevalence of anaemia, WHO Vitamin and Mineral Nutrition Information System, 1993-2005|published=2009 Apr|authors=McLean E, Cogswell M, Egli I, Wojdyla D, de Benoist B|journal=Public Health Nutr|] But iron-deficiency anemia in the US is much less common, with 5 million people having iron-deficiency anemia.[reference|url=https://pubmed.ncbi.nlm.nih.gov/18390780|title=Iron deficiency anemia|published=2008 Apr-May|authors=Clark SF|journal=Nutr Clin Pract|]
So when most people think of iron, they think of getting enough iron. Iron is one of the few nutrients that a doctor will ask you about, and iron even takes up one of the coveted nutrient spots on the US nutrition label! But the same property that makes iron so useful in the body, its ability to give or receive electrons, makes it potentially harmful when you ingest too much, due to increased production of free radicals.[reference|url=https://pubmed.ncbi.nlm.nih.gov/11478586|title=Iron metabolism, free radicals, and oxidative injury|published=2001 Jul|authors=Emerit J, Beaumont C, Trivin F|journal=Biomed Pharmacother|][reference|url=https://pubmed.ncbi.nlm.nih.gov/9460805|title=Iron, free radicals, and oxidative injury|published=1998 Jan|authors=McCord JM|journal=Semin Hematol|]
Too much iron has been linked to a wide variety of conditions, such as Alzheimer’s, heart disease, and colorectal cancer to name just a few.[reference|url=https://pubmed.ncbi.nlm.nih.gov/20967426|title=Towards a unifying, systems biology understanding of large-scale cellular death and destruction caused by poorly liganded iron: Parkinson's, Huntington's, Alzheimer's, prions, bactericides, chemical toxicology and others as examples|published=2010 Nov|authors=Kell DB|journal=Arch Toxicol|][reference|url=https://pubmed.ncbi.nlm.nih.gov/25439662|title=Dietary intake of heme iron and risk of cardiovascular disease: a dose-response meta-analysis of prospective cohort studies|published=2015 Jan|authors=Fang X, An P, Wang H, Wang X, Shen X, Li X, Min J, Liu S, Wang F|journal=Nutr Metab Cardiovasc Dis|][reference|url=https://pubmed.ncbi.nlm.nih.gov/23568532|title=Intakes of heme iron and zinc and colorectal cancer incidence: a meta-analysis of prospective studies|published=2013 Jun|authors=Qiao L, Feng Y|journal=Cancer Causes Control|] There’s a couple groups of people who don’t have to worry quite as much about iron overload though: menstruating women and vegetarians/vegans. But for others, especially those who regularly eat red meat, it doesn’t take much to push yourself into excess iron territory.
Out of all the micronutrients, iron may be the riskiest to supplement with, due to a higher chance of overloading. Excess iron levels are linked to a wide variety of serious health conditions.
Chances of iron overload in different people
For the nearly one million Americans who have hereditary hemochromatosis, a condition that typically emerges in adulthood where you absorb too much dietary iron, the risk is much more serious. As is the risk of iron poisoning in children, which started being recognized in the 1980s and led to removal of iron from some children’s multivitamins.[reference|url=https://pubmed.ncbi.nlm.nih.gov/10798501|title=Pediatric iron poisonings in the United States|published=2000 Apr|authors=Morris CC|journal=South Med J|][reference|url=https://pubmed.ncbi.nlm.nih.gov/3354178|title=Multiple vitamins and vitamins with iron: accidental poisoning in children|published=1988 Feb|authors=Dean BS, Krenzelok EP|journal=Vet Hum Toxicol|]
Iron is almost universally labeled as “good” among laypeople and even some health professionals. But too much iron is uniquely harmful, as the body cannot get rid of it, and iron has a tendency to produce free radicals. Thus, excess iron is linked to many diseases.
Certain multivitamins and foods (especially breakfast cereals) have iron added in, which can contribute to iron buildup over time in those that don’t get rid of iron once a month, namely all males and all non-menstruating females. One of the most popular multivitamins on pharmacy shelves has 100% of the iron RDA per pill, and that one extremely popular breakfast cereal (the one with the bee who’s always up in your business for some reason) contains almost 50% of the iron RDA. A bowl or two of cereal a day, plus red meat a few times a week, a few iron-fortified energy bars, a multivitamin … the iron can add up really quickly.
There are three general strategies for limiting iron. The first is to simply eat less of it, like by switching to an iron-free multivitamin if you choose to take one at all. Second, you can take advantage of the various iron-absorption inhibitors, such as coffee and certain plant phytochemicals.[reference|url=https://pubmed.ncbi.nlm.nih.gov/2598894|title=Iron absorption and phenolic compounds: importance of different phenolic structures|published=1989 Aug|authors=Brune M, Rossander L, Hallberg L|journal=Eur J Clin Nutr|] The third method seems like the most radical option: donate blood every once in awhile, and ditch some of the iron trapped in your red blood cells.[reference|url=https://pubmed.ncbi.nlm.nih.gov/6373083|title=Iron and blood donation|published=1984 Feb|authors=Skikne B, Lynch S, Borek D, Cook J|journal=Clin Haematol|]
Note that while regular blood donation helps both you and others, and is quite effective at normalizing iron levels according to a randomized trial,[reference|url=https://pubmed.ncbi.nlm.nih.gov/29195602|title=Reduction of Body Iron in HFE-related Haemochromatosis and Moderate Iron Overload (Mi-Iron): A Multicentre, Participant-Blinded, Randomised Controlled Trial|published=2017 Dec|authors=Sim Y Ong, Lyle C Gurrin, Lara Dolling, Jeanette Dixon, Amanda J Nicoll, Michelle Wolthuizen, Erica M Wood, Gregory J Anderson, Grant A Ramm, Katrina J Allen, John K Olynyk, Darrell Crawford, Louise E Ramm, Paul Gow, Simon Durrant, Lawrie W Powell, Martin B Delatycki|journal=Lancet Haematol|] it's not always well tolerated.[reference|url=https://pubmed.ncbi.nlm.nih.gov/27685251|title=Metabolic and Hepatic Effects of Bloodletting in Dysmetabolic Iron Overload Syndrome: A Randomized Controlled Study in 274 Patients|published=2017 Feb|authors=Fabrice Lainé, Marc Ruivard, Véronique Loustaud-Ratti, Fabrice Bonnet, Paul Calès, Edouard Bardou-Jacquet, Sylvie Sacher-Huvelin, Xavier Causse, Christine Beusnel, Alain Renault, Eric Bellissant, Yves Deugnier, Study Group|journal=Hepatology|] Other than reducing iron in the diet, certain supplements may be able to reduce iron levels, and curcumin has shown efficacy specifically for iron overload.[reference|url=https://pubmed.ncbi.nlm.nih.gov/29806132|title=An Investigation of the Effects of Curcumin on Iron Overload, Hepcidin Level, and Liver Function in β-Thalassemia Major Patients: A Double-Blind Randomized Controlled Clinical Trial|published=2018 Sep|authors=Elahe Mohammadi, Ahmad Tamaddoni, Durdi Qujeq, Esmat Nasseri, Farid Zayeri, Hamid Zand, Mahdi Gholami, Seyed Mostafa Mir|journal=Phytother Res|]
It’s easy to build up too much iron, from a combination of fortified foods, supplements, and red meat. Two ways to mitigate this build up are donating blood and adding in iron-absorption inhibitors to the diet. Supplements may be an adjunct treatment as well, but probably shouldn't be the sole treatment modality.
How much iron are we talking?
We’re talking a pretty decent amount of iron, depending on the condition of your cast iron pan, and what specifically you’re cooking.
To put it into context: men need 8 mg of iron a day, and a serving of tomato sauce cooked in a cast iron skillet can provide 5 mg of iron![reference|url=https://pubmed.ncbi.nlm.nih.gov/3722654|title=Iron content of food cooked in iron utensils|published=1986 Jul|authors=Brittin HC, Nossaman CE|journal=J Am Diet Assoc|]
Iron content of foods cooked in a cast iron pan
This effect is so reliable that iron cookware has occasionally been used to combat anemia. A variety of studies have shown that iron pots and pans can boost your iron status, substantially increasing the iron content of certain foods (like eggs and applesauce) but not others (like hamburgers).[reference|url=https://pubmed.ncbi.nlm.nih.gov/12859709|title=Food prepared in iron cooking pots as an intervention for reducing iron deficiency anaemia in developing countries: a systematic review|published=2003 Aug|authors=Geerligs PD, Brabin BJ, Omari AA|journal=J Hum Nutr Diet|][reference|url=https://pubmed.ncbi.nlm.nih.gov/10073514|title=Effect of consumption of food cooked in iron pots on iron status and growth of young children: a randomised trial|published=1999 Feb 27|authors=Adish AA, Esrey SA, Gyorkos TW, Jean-Baptiste J, Rojhani A|journal=Lancet|] The pan’s iron is in the non-heme form, which isn’t absorbed as well as heme iron from meat. But vitamin C can greatly increase absorption, as can acidity, so recipes containing things like lemon or tomato sauce can boost absorption.
If you don’t want your cast iron pan to leach so much iron, make sure it’s well seasoned. Since acidic foods help transfer iron from the pan into your food, you want to put a barrier between the acid and the iron. And that barrier is seasoning, which we’ll talk about in the next section. A pan that is newer and more likely to stick food will also leach more iron than an ancient and heavily seasoned pan. Three other factors that cause more leaching are: using liquid, increased cooking time, and mixing the food more often.
Cast iron pans can leach a sizeable amount of iron into your food, exceeding dietary intake in some cases. Acidic foods will contribute to much more leaching while an old, heavily-seasoned pan will leach much less iron than a newer one.
Some of you may be wondering why cast iron (and carbon steel) are uniquely susceptible to this leaching process. What about stainless steel? Steel is made out of iron, after all.
Well the key to the anti-stain property of stainless pans is chromium, which makes up about 10% or more of the pan. A thin layer of chromium oxide makes stainless steel pans moisture and rust resistant, unlike cast iron pans which can rust very easily. While moisture finds it hard to get INTO the stainless steel pan, a side-benefit is that iron finds it hard to get OUT of the pan. So iron leaching isn’t a big concern here.
That doesn’t mean stainless steel is 100% safe for everyone. While iron overload is a risk that applies to many millions of people, a far smaller number of people are allergic to nickel and chromium, and both of these metals can theoretically leach from stainless steel pans.[reference|url=https://pubmed.ncbi.nlm.nih.gov/19831422|title=Metal allergy--a review on exposures, penetration, genetics, prevalence, and clinical implications|published=2010 Feb 15|authors=Thyssen JP, Menné T|journal=Chem Res Toxicol|][reference|url=https://pubmed.ncbi.nlm.nih.gov/1514841|title=Stainless steel cookware as a significant source of nickel, chromium, and iron|published=1992 Aug|authors=Kuligowski J, Halperin KM|journal=Arch Environ Contam Toxicol|] For people with severe nickel or other metal allergies, an enameled pan may be a safe bet.
Stainless steel doesn’t leach much iron, due to its protective shield of chromium oxide. But it may still leach small amounts of other metals such as nickel, which some people have allergic reactions to.
Cast iron seasoning … aka oxidizing oil on purpose
Aside from iron, there are two other possible dangers of using cast iron pans. One is that you could drop a heavy pan onto your foot or hurt your wrist maneuvering it around. This is only partially a joke, as some cast iron pans can get EXTREMELY heavy compared to all other types of pans. The other possible danger is only theoretical at this point: the risk from eating tiny bits of flaked-off seasoning from the pan’s surface.
So what exactly is seasoning? Well, cast iron pans can easily collect moisture and develop rust. To prevent that, and also get a nice non-stick finish, you have to season the pan with oil rich in polyunsaturated fats. Ideally, you’d continue to season it over the course of years, with more usage adding to the seasoning layers. Like wine and cheese, cast iron is one of the few things that get better with time.
The chemistry is pretty simple. First, get a largely unsaturated fat, like flaxseed oil. For the same reason you don’t want to overload your body with a ton of polyunsaturated fats, that they’re easily oxidized, these fats can be useful on cast iron. When exposed to high heat, on top of iron which acts as a catalyst, the unsaturated fatty acids oxidize then polymerize into a coating that fills in pores, and then further heating carbonizes/hardens the coating.
A well-seasoned pan will appear deep black, and will be almost non-stick. Pans that are pre-seasoned in the factory are not actually well-seasoned, they’re just seasoned enough to prevent rust. You have to keep adding thin layers of fat over time to get that perfect seasoning, since attempting to add one thick layer all at once will result in a greasy pan, with largish pieces chunking off. And it takes a certain heat range to form a good seasoning layer. Really high heats (like above 500° F) will burn off all the seasoning, while low heats (like less than 300° F) won’t encourage enough polymerization of the fatty acids.
Seasoning isn’t just recommended for cast iron pans, it’s a requirement. The seasoning layer is comprised of broken down then polymerized unsaturated fatty acids. Multiple thin layers of seasoning built up over time are a sign of a well-used and largely non-stick cast iron pan.
The pros of the seasoning process are numerous: you can eventually cook eggs without them sticking, you don’t have to re-season as often, the pan won’t rust, and you can get much cooking cred from your foodie friends.
The cons are harder to quantify. Bits of the seasoning will come off over time (and be replaced by more seasoning). Nobody knows exactly how much comes off over time, nor do they know what the health effects are of eating tiny bits of this type of broken down fat. If you heat the pan up fairly high over long periods, might carcinogenic fumes or free radicals develop from the oxidized oil?[reference|url=https://pubmed.ncbi.nlm.nih.gov/10361022|title=Identification of carcinogens in cooking oil fumes|published=1999 Jul|authors=Chiang TA, Wu PF, Ko YC|journal=Environ Res|] Would small amounts of these hypothetical byproducts even be of concern, given the natural antioxidant defenses our bodies employ?
Despite this uncertainty, you shouldn’t be overly alarmed. The flaxseed oil seasoning on your cast iron pan may be oxidized, but it’s not rancid. Meaning, it doesn’t impart undesirable odors or flavors (for the most part). This may seem confusing at first, since all the double bonds in a bottle of flaxseed oil mean that it can go rancid easily, when not refrigerated. This is because the double bonds are easily attacked by air and light, among other factors.
But when you season your pan using flaxseed oil and heat, the double bonds don’t get randomly attacked. Rather, the double bonds in the flaxseed oil open up and form bonds with neighboring flaxseed fatty acids, with the help of iron and air. It’s a delicate game -- gently heating a pot of flaxseed oil would be a recipe for rancidity, but doing it in a thin layer with the help of a really hot iron pan and air … that creates the oh-so-useful seasoning.
Given the lack of certainty about health effects, it’s easy to get alarmed. But if you want to get really up in arms about seasoning, you’d better make sure to also stay away from other heated foods that contain known carcinogens, like the acrylamide in browned potatoes and in breakfast cereals, heterocyclic amines in cooked meat, etc etc.[reference|url=https://pubmed.ncbi.nlm.nih.gov/18320571|title=Acrylamide in home-prepared roasted potatoes|published=2008 Mar|authors=Skog K, Viklund G, Olsson K, Sjöholm I|journal=Mol Nutr Food Res|][reference|url=https://pubmed.ncbi.nlm.nih.gov/15072585|title=Heterocyclic amines: Mutagens/carcinogens produced during cooking of meat and fish|published=2004 Apr|authors=Sugimura T, Wakabayashi K, Nakagama H, Nagao M|journal=Cancer Sci|][reference|url=https://pubmed.ncbi.nlm.nih.gov/17687699|title=Acrylamide in cereal and cereal products: a review on progress in level reduction|published=2007|authors=Konings EJ, Ashby P, Hamlet CG, Thompson GA|journal=Food Addit Contam|] Remember that toxicity lies in the dose. You don’t have to boil or steam all your foods in order to live a long and healthy life.
Seasoning is basically oxidized then polymerized polyunsaturated oil. The risks, if any, of eating tiny amounts of seasoning every day for years is unknown. But they’re probably not very large.
I hate science, just tell me if I should ditch my cast iron
If cast iron has been used for so many centuries, and hasn’t shown obvious harm, why even question it at all? There are at least two good reasons.
First, many other types of pans are available, and it’s a buyer’s market. Cast iron is actually not an optimal material for many types of cooking (which we’ll get into in a second), so you definitely don’t need to own a cast iron pan.
Second, and most important, people often cook with their pan on a near-daily basis. Over the years, that adds up to a lot of exposure to whatever the pan gives off.
Cast iron is great for a lot of reasons. It’s cheap, it can and will last a lifetime and get better with age, and you can safely throw it into a super hot oven. All that heavy iron also means that these pans retain heat really well, so they excel in tasks like searing a thick and juicy steak. Some other, thinner pans wouldn’t do as well, since a cold steak would drop down the pan’s temperature upon contact. Another benefit is that the fairly-nonstick nature of cast iron pans will still allow it to develop a “fond” (which is French for “base” or “foundation”) on the bottom, if you happen to enjoy making delicious fond-based sauces.
On the con side, cast iron is extremely heavy and not that easy to take care of (at least until it’s older and well-seasoned). Carbon steel pans are similar in function, but around 25% lighter. Plus they’re a bit smoother, which makes them slightly more non-stick than cast iron, unless you sand down your cast iron pan like some cooking fanatics do. But cast iron isn’t actually a very good heat conductor, so it’s prone to developing hot-spots and cold-spots. Not good if you want even cooking. And since carbon steel is thinner, it’s even more prone to uneven heating.
Another con has to do with our old enemy (or friend if you’re anemic), leached iron. If you make a tomato sauce using a cast iron pan, and it tastes weird, there’s a chance the leached iron is the culprit. Again, seasoned pans are your friend, both for non-stick purposes and for avoiding off-tastes in cooked food.
These cons can be mitigated by using more than one type of pan. Different pans are good at different things, so having more than one pan around might be a good idea if you’re into cooking. Even the much-hated Teflon pan is often used by discerning chefs to make eggs. It doesn’t leach anything under normal heat conditions, and even ingesting tiny amounts of Teflon shouldn’t really harm you, since it’s inert. Heating a Teflon pan under high heat for long periods though … those toxic fumes aren’t great for your health and especially your bird’s health.[reference|url=https://pubmed.ncbi.nlm.nih.gov/15638009|title=PTFE toxicity in birds|published=2004 Dec 11|authors=Woodhall S, Stamford M|journal=Vet Rec|][reference|url=https://pubmed.ncbi.nlm.nih.gov/25971706|title=Polytetrafluoroethylene fume-induced pulmonary edema: a case report and review of the literature|published=2015 May 14|authors=Hamaya R, Ono Y, Chida Y, Inokuchi R, Kikuchi K, Tameda T, Tase C, Shinohara K|journal=J Med Case Rep|]
Even with all the options available, there is no perfect pan, given the wide variety of factors people look at. These include non-stickiness, searing ability, ease of use, even heating, and so on and so on. Cast iron does well with some of these and poorly with others.
We might never know the exact health effects of cast iron pans. Eating bits of oxidized oil every day might seem unwise, but a perhaps more likely detriment is getting too much iron, especially when using a newer or less-seasoned pan.
The decision to choose cast iron or a different cooking material depends on a variety of personal preferences, including risk aversion, what you enjoy cooking with, and what you already own. Trying out more than one type of pan may be wise, or even using more than one type of pan on a regular basis, depending on what’s best suited for the job at hand.