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Bromelain

Bromelain is an enzyme extracted from pineapples. It can reduce heart burn and act as a nasal decongestant.

Our evidence-based analysis on bromelain features 69 unique references to scientific papers.

Kamal Patel
Research analysis led by .
Reviewed by
Examine.com Team
Last Updated:
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Summary of Bromelain

Primary information, health benefits, side effects, usage, and other important details

Bromelain, also called ‘pineapple extract,’ is a combination of several compounds, including a large amount of a special protein-digesting enzyme. This enzyme is able to be digested and thus affect the blood and body, rather than just the stomach and intestines.

When Bromelain is in the stomach, it will help the body break down and digest protein. Supplementation of bromelain can also reduce nasal inflammation, meaning it acts as a decongestant.

If taken between meals, bromelain can benefit the immune system and protect the body from cancer. Bromelain’s effects on fat cells are also under investigation, with promising preliminary evidence.

Bromelain’s anti-inflammatory properties are responsible for several of its effects, including its ability to decongest the nasal cavity. Further research is needed to determine the mechanism through which bromelain survives the digestive system.

There are many anecdotes that say bromelain supplementation will cause semen to taste like pineapple, but no studies have tested this claim.

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How to Take

Medical Disclaimer

Recommended dosage, active amounts, other details

The standard dose for bromelain depends on the goal of supplementation. If the goal is to aid digestion, the standard dose is between 200 – 2,000mg, taken with a meal.

If the goal of supplementation is not digestion related, does range from 200 - 800mg.

Bromelain is typically taken between meals to avoid potential degradation in the stomach. The large range for the standard dose is due to the variations in the enzymatic potential of bromelain, which is standardized by milk clotting units (MCU), or gelatin dissolving units (GDU).

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Human Effect Matrix

The Human Effect Matrix looks at human studies (it excludes animal and in vitro studies) to tell you what effects bromelain has on your body, and how strong these effects are.
Grade Level of Evidence
Robust research conducted with repeated double-blind clinical trials
Multiple studies where at least two are double-blind and placebo controlled
Single double-blind study or multiple cohort studies
Uncontrolled or observational studies only
Level of Evidence
? The amount of high quality evidence. The more evidence, the more we can trust the results.
Outcome Magnitude of effect
? The direction and size of the supplement's impact on each outcome. Some supplements can have an increasing effect, others have a decreasing effect, and others have no effect.
Consistency of research results
? Scientific research does not always agree. HIGH or VERY HIGH means that most of the scientific research agrees.
Notes
grade-c
Muscle Soreness
Minor - See 2 studies
It is possible bromelain might reduce muscle soreness, but currently the evidence does not support this claim (although the trial to note a failure of bromelain also noted a failure with Ibuprofen, a known active drug)
grade-c
Incidence of Type 1 Diabetes
- - See study
grade-c
Symptoms of Osteoarthritis
- - See study
No significant influence on symptoms of osteoarthritis when tested
grade-d
Inflammation
Minor - See study
Requires more evidence, but at the moment appears somewhat effective
grade-d
Nasal Congestion
Minor - See study
The potency at this moment in time does not appear remarkable.
grade-d
Subjective Well-Being
Minor - See study
Minor improvements in well being secondary to reducing joint pain

Studies Excluded from Consideration

  • Confounded with Trypsin and Rutin (as rutoside dihydrate)[1][2][3][4]

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Things to Note

Is a Form Of

Other Functions:

Primary Function:

Also Known As

Pineapple extract

Goes Well With

  • Certain anti-biotics (see Nutrient-Nutrient Interactions), may increase bioavailability

  • Dietary protein (if suffering from dyspepsia)

  • Pineapple makes semen taste like pineapple according to anecdotes; Bromelain contains pineapple aromatics and may do this as well

  • Depending on why you are supplementing Bromelain, you may want to take it with a meal or without; please take note of the 'How to Take' section for dosing

  • If left in solution for too long, Bromelain might auto-digest. It would not be advisable to mix it into a drink and leave it alone for prolonged periods of time

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Research Breakdown on Bromelain

1Source and Composition

1.1Sources

1.2Composition

1.3Processing

2Pharmacokinetics

2.1Intestinal Absorption

2.2Circulating in Serum

2.3Cytology

3Digestion and the Intestinal Tract

3.1Gastric

3.2Intestinal

3.3Colonic

4Interactions with Immunology and Inflammation

4.1Mechanisms

4.2Efficacy and Potency

4.3Inflammation and Exercise

4.4Type 1 Diabetes Risk

5Interactions with Cancer Metabolism

5.1Mechanisms

6Interactions with Cardiovascular Health

6.1Blood Flow

6.2Cardioprotection

6.3Atherogenesis

7Interactions with Neurology

7.1Beta-amyloid

8Interactions with Obesity and Fat cells

9Interactions with Sinuses

10Nutrient-Nutrient Interactions

10.1Intestinal transport

10.2Phlogenzym

11Seminal Implications

12Safety and Toxicity

12.1General

12.2Clinical
Click here to see all 69 references.

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This page is regularly updated, to include the most recently available clinical trial evidence.

Each member of our research team is required to have no conflicts of interest, including with supplement manufacturers, food companies, and industry funders. The team includes nutrition researchers, registered dietitians, physicians, and pharmacists. We have a strict editorial process.

This page features 69 references. All factual claims are followed by specifically-applicable references. Click here to see the full set of research information and references for Bromelain.

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