Grape juice Summary
There haven't been trials directly comparing wine to grape juice (outside of studies in animals such as hamsters), so the comparitive benefits are theoretical. Grape juice is different enough from grapes, due to lack of fiber and consequent effects on gut bacteria and other factors, that the results of whole grape trials aren't transferable to grape juice.
Wine contains alcohol (duh!), and alcohol in moderate amounts may help relax blood vessels and increase HDL. Wine also has higher amounts of certain phytochemicals than grape juice does, but similar amounts of other ones.
It's important to note that there are very very few trials on grape juice, compared to on wine. So the reliability of the total body of evidence is somewhat low.
Grape juice doesn't contain alcohol. Consuming alcohol in moderate amounts can turn into consuming alcohol in large amounts, whether chronically or even on occasion.
Even in moderate amounts over time, alcohol may not be that healthy. Some researchers believe the evidence for benefits is mixed enough, and potential detriment large enough, that health benefits should not be trumpeted.
Grape juice however, and fruit juices in general, are linked to tooth erosion and dental carries. However, the trials on this typically use conditions that don't fully reflect real-life juice drinking. Grape juice in amounts that are clinically effective may also contribute excessive calories into your diet, as juices are much easier to consume than whole fruits.
Often but not always purple grape juice, at 100% purity (in other words, not mixed fruit juice, or sugar-added juice). Occasionally, white grape juice is used.
Trials haven't been conducted which compare different fruit juices against each other. We'd love to know, but the financial incentive isn't there (What if none of the fruit juices did better than the other ones? That certainly wouldn't encourage further funding by the losing juice's industry.
That being said, grape juice doesn't appear to help memory and cognition quite like blueberry juice can. Unfortunately for the consumer, blueberry juice is much more expensive than grape juice.
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Things To Know & Note
Do Not Confuse With
wine, resveratrol, grape sugar
Caution NoticeExamine.com Medical Disclaimer
How to Take Grape juice
Recommended dosage, active amounts, other details
First, make sure you use 100% grape juice, rather than a juice with added sugar or other juices mixed in.
There are relatively few trials on grape juice. The most commonly used dose was 10 ml of grape juice per kilogram of bodyweight, per day. For a 70 kg person, that would amount to 700 mg, or nearly 24 ounces.
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Human Effect Matrix
The Human Effect Matrix looks at human studies (it excludes animal and in vitro studies) to tell you what effects grape juice has on your body, and how strong these effects are.
|Grade||Level of Evidence [show legend]|
|Robust research conducted with repeated double-blind clinical trials|
|Multiple studies where at least two are double-blind and placebo controlled|
|Single double-blind study or multiple cohort studies|
|Uncontrolled or observational studies only|
Level of Evidence
? The amount of high quality evidence. The more evidence, the more we can trust the results.
Magnitude of effect
? The direction and size of the supplement's impact on each outcome. Some supplements can have an increasing effect, others have a decreasing effect, and others have no effect.
Consistency of research results
? Scientific research does not always agree. HIGH or VERY HIGH means that most of the scientific research agrees.
|Notable||Very High See 2 studies|
|Notable||- See study|
|Minor||Very High See 2 studies|
|-||- See study|
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- Vinson JA, Teufel K, Wu N. Red wine, dealcoholized red wine, and especially grape juice, inhibit atherosclerosis in a hamster model. Atherosclerosis. (2001)
- De Oliveira E Silva ER, et al. Alcohol consumption raises HDL cholesterol levels by increasing the transport rate of apolipoproteins A-I and A-II. Circulation. (2000)
- Meister KA, Whelan EM, Kava R. The health effects of moderate alcohol intake in humans: an epidemiologic review. Crit Rev Clin Lab Sci. (2000)
- Burton R, Sheron N. No level of alcohol consumption improves health. Lancet. (2018)
- Liska D, Kelley M, Mah E. 100% Fruit Juice and Dental Health: A Systematic Review of the Literature. Front Public Health. (2019)
- Flood-Obbagy JE, Rolls BJ. The effect of fruit in different forms on energy intake and satiety at a meal. Appetite. (2009)
- de Lima Tavares Toscano L, et al. A single dose of purple grape juice improves physical performance and antioxidant activity in runners: a randomized, crossover, double-blind, placebo study. Eur J Nutr. (2019)
- Toscano LT, et al. Potential ergogenic activity of grape juice in runners. Appl Physiol Nutr Metab. (2015)