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Grape juice

Plain old grape juice isn't as popular as fermented grape juice (aka wine). However, grape juice does contain phytochemicals like wine does, although often in lesser amounts. Grape juice has been tested in a small number of trials for endurance exercise, antioxidant capacity, and inflammation.

Our evidence-based analysis on grape juice features 8 unique references to scientific papers.

Research analysis led by Kamal Patel .
Reviewed by
Examine.com Team
Last Updated:

Grape juice Summary

How does grape juice compare to wine or grapes, for health benefits?

There haven't been trials directly comparing wine to grape juice (outside of studies in animals such as hamsters[1]), so the comparitive benefits are theoretical. Grape juice is different enough from grapes, due to lack of fiber and consequent effects on gut bacteria and other factors, that the results of whole grape trials aren't transferable to grape juice.

Wine contains alcohol (duh!), and alcohol in moderate amounts may help relax blood vessels and increase HDL.[2] Wine also has higher amounts of certain phytochemicals than grape juice does, but similar amounts of other ones.

It's important to note that there are very very few trials on grape juice, compared to on wine. So the reliability of the total body of evidence is somewhat low.

How does grape juice compare to wine, for health DETRIMENTS?

Grape juice doesn't contain alcohol. Consuming alcohol in moderate amounts can turn into consuming alcohol in large amounts, whether chronically or even on occasion.

Even in moderate amounts over time, alcohol may not be that healthy. Some researchers believe the evidence for benefits is mixed enough, and potential detriment large enough, that health benefits should not be trumpeted.[3][4]

Grape juice however, and fruit juices in general, are linked to tooth erosion and dental carries.[5] However, the trials on this typically use conditions that don't fully reflect real-life juice drinking. Grape juice in amounts that are clinically effective may also contribute excessive calories into your diet, as juices are much easier to consume than whole fruits.[6]

What type of grape juice is used in clinical trials?

Often but not always purple grape juice, at 100% purity (in other words, not mixed fruit juice, or sugar-added juice). Occasionally, white grape juice is used.

How does grape juice compared to other fruit juices for health benefits?

Trials haven't been conducted which compare different fruit juices against each other. We'd love to know, but the financial incentive isn't there (What if none of the fruit juices did better than the other ones? That certainly wouldn't encourage further funding by the losing juice's industry.

That being said, grape juice doesn't appear to help memory and cognition quite like blueberry juice can. Unfortunately for the consumer, blueberry juice is much more expensive than grape juice.

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Things To Know & Note

Do Not Confuse With

wine, resveratrol, grape sugar

How to Take Grape juice

Recommended dosage, active amounts, other details

First, make sure you use 100% grape juice, rather than a juice with added sugar or other juices mixed in.

There are relatively few trials on grape juice. The most commonly used dose was 10 ml of grape juice per kilogram of bodyweight, per day. For a 70 kg person, that would amount to 700 mg, or nearly 24 ounces.

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Human Effect Matrix

The Human Effect Matrix looks at human studies (it excludes animal and in vitro studies) to tell you what effects grape juice has on your body, and how strong these effects are.
Grade Level of Evidence
Robust research conducted with repeated double-blind clinical trials
Multiple studies where at least two are double-blind and placebo controlled
Single double-blind study or multiple cohort studies
Uncontrolled or observational studies only
Level of Evidence
? The amount of high quality evidence. The more evidence, the more we can trust the results.
Outcome Magnitude of effect
? The direction and size of the supplement's impact on each outcome. Some supplements can have an increasing effect, others have a decreasing effect, and others have no effect.
Consistency of research results
? Scientific research does not always agree. HIGH or VERY HIGH means that most of the scientific research agrees.
grade-d Notable Very High See 2 studies
A very small amount of evidence suggests an increase in aerobic exercise capacity through increased time to exhaustion.
grade-d Notable - See study
A notable increase in uric acid (nearly 30%) after a month of grape juice supplementation.
grade-d Minor Very High See 2 studies
In limited evidence after a one-time aerobic exercise bout, total antioxidant capacity (TAC) increased, while malondialdehyde (MDA) did not change.
grade-d - - See study
No change in anaerobic threshold after a month of grape juice supplementation.

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