Nitric Oxide

    Last Updated: August 17, 2022

    Nitric oxide (NO) is composed of nitrogen (N) and oxygen (O). The human body creates NO from dietary arginine and nitrate. NO plays a major signaling role in vascular relaxation, and elevated levels are associated with better blood flow and lower blood pressure.


    The human body converts nitrate to nitric oxide (NO), which is a signaling molecule associated with several physiological functions involving blood pressure regulation, cardiovascular health, mitochondria production, calcium transport, oxidative stress, and skeletal muscle repair.[23] It plays a prominent role as a vasodilator, which means it relaxes blood vessels and improves blood flow.

    Nitrate supplementation, whether in its pure form (e.g. sodium/potassium nitrate), or via foods (e.g. beetroot juice/powder), may temporarily reduce the body’s oxygen demand during exercise. A decrease in oxygen demand may result in improved exercise and muscular performance.[24][25]

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    Examine Database References

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    3. Arginine - Stephen J. Bailey, Paul G. Winyard, Anni Vanhatalo, Jamie R. Blackwell, Fred J. DiMenna, Daryl Paul Wilkerson, and Andrew M. JonesAcute L-arginine supplementation reduces the O2 cost of moderate-intensity exercise and enhances high-intensity exercise toleranceJournal of Applied Physiology.()
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    8. Arginine - Schwedhelm E, Maas R, Freese R, Jung D, Lukacs Z, Jambrecina A, Spickler W, Schulze F, Böger RHPharmacokinetic and pharmacodynamic properties of oral L-citrulline and L-arginine: impact on nitric oxide metabolismBr J Clin Pharmacol.(2008 Jan)
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    13. Ginkgo Biloba - Rodríguez M, Ringstad L, Schäfer P, Just S, Hofer HW, Malmsten M, Siegel GReduction of atherosclerotic nanoplaque formation and size by Ginkgo biloba (EGb 761) in cardiovascular high-risk patientsAtherosclerosis.(2007 Jun)
    14. Arginine - Böger RH, Bode-Böger SM, Thiele W, Creutzig A, Alexander K, Frölich JCRestoring vascular nitric oxide formation by L-arginine improves the symptoms of intermittent claudication in patients with peripheral arterial occlusive diseaseJ Am Coll Cardiol.(1998 Nov)
    15. Cocoa Extract - Verawati Sudarma, Sri Sukmaniah, Parlindungan SiregarEffect of dark chocolate on nitric oxide serum levels and blood pressure in prehypertension subjectsActa Med Indones.(2011 Oct)
    16. Astaxanthin - Petyaev IM, Klochkov VA, Chalyk NE, Pristensky DV, Chernyshova MP, Kyle NH, Bashmakov YKMarkers of Hypoxia and Oxidative Stress in Aging Volunteers Ingesting Lycosomal Formulation of Dark Chocolate Containing AstaxanthinJ Nutr Health Aging.(2018)
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    19. L-Carnitine - Hamid Reza Talari, Zeinab Jafari Azad, Yaser Hamidian, Mansooreh Samimi, Hamid Reza Gilasi, Faraneh Ebrahimi Afshar, Vahidreza Ostadmohammadi, Zatollah AsemiEffects of Carnitine Administration on Carotid Intima-media Thickness and Inflammatory Factors in Patients with Polycystic Ovary Syndrome: A Randomized, Double-blind, Placebo-controlled TrialInt J Prev Med.(2019 Jun 7)
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    39. Folic Acid (Vitamin B9) - Asbaghi O, Ghanavati M, Ashtary-Larky D, Bagheri R, Rezaei Kelishadi M, Nazarian B, Nordvall M, Wong A, Dutheil F, Suzuki K, Alavi Naeini AEffects of Folic Acid Supplementation on Oxidative Stress Markers: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.Antioxidants (Basel).(2021-May-28)