Schisandra

Last Updated: January 21 2022

Schizandra berries have been used traditionally as performance enhancers and as an adaptogen. Lots of human evidence from many decades ago in Russia that cannot be accessed, and limited Western evidence. Appears to also reduce anxiety and cortisol, with a tart taste.

Schisandra is most often used for

What else is Schisandra known as?
Note that Schisandra is also known as:
  • Omija
  • Omija Cha
  • Gomishi
  • Repnihat
  • Wuweizi
  • Lemonwood
  • Northern Magnolia Vine
  • Chinese Magnolia Vine
  • Matsbouza
  • Schisandra Chinensis
Schisandra should not be confused with:
  • Schizandrol A (bioactive component)
  • Schisandra sphenanthera (same genera
  • different species)
Dosage information

Clinical trials done in the West are lacking or confounded, and thus optimum doses cannot really be extrapolated from these. The best estimate at this moment in time may be falling back on traditional preparation methods, which are various:

  • Dried fruit extract in a 1:6 w/v ratio against liquid (95% ethanol) and administered at 20-30 drops daily
  • Dried fruit extract in a 1:20 w/v ratio against water, 150mL drank twice a day with meals
  • Eating the powdered fruit or fruit extract (this is what is usually found in pills) at 1-3g daily, with meals

Schisandra Chinensis fruits can be brewed into wines or teas as well.

Examine Database
References
4.^Lu Y, Chen DFAnalysis of Schisandra chinensis and Schisandra sphenantheraJ Chromatogr A.(2009 Mar 13)
7.^Liang Y, Zhou YY, Liu YN, Guan TY, Zheng X, Dai C, Xing L, Rao T, Xie L, Wang GJStudy on the plasma protein binding rate of Schisandra lignans based on the LC-IT-TOF/MS technique with relative quantitative analysisChin J Nat Med.(2013 Jul)
8.^Liu H, Lai H, Jia X, Liu J, Zhang Z, Qi Y, Zhang J, Song J, Wu C, Zhang B, Xiao PComprehensive chemical analysis of Schisandra chinensis by HPLC-DAD-MS combined with chemometricsPhytomedicine.(2013 Sep 15)
9.^Lee IS, Jung KY, Oh SR, Kim DS, Kim JH, Lee JJ, Lee HK, Lee SH, Kim EH, Cheong CPlatelet-activating factor antagonistic activity and(13)C NMR assignment of pregomisin and chamigrenal fromSchisandra chinensisArch Pharm Res.(1997 Dec)
10.^Huang SX, Li RT, Liu JP, Lu Y, Chang Y, Lei C, Xiao WL, Yang LB, Zheng QT, Sun HDIsolation and characterization of biogenetically related highly oxygenated nortriterpenoids from Schisandra chinensisOrg Lett.(2007 May 24)
11.^Huang SX, Yang J, Huang H, Li LM, Xiao WL, Li RT, Sun HDStructural characterization of schintrilactone, a new class of nortriterpenoids from Schisandra chinensisOrg Lett.(2007 Oct 11)
12.^Huang SX, Yang LB, Xiao WL, Lei C, Liu JP, Lu Y, Weng ZY, Li LM, Li RT, Yu JL, Zheng QT, Sun HDWuweizidilactones A-F: novel highly oxygenated nortriterpenoids with unusual skeletons isolated from Schisandra chinensisChemistry.(2007)
13.^Lee SK, Kim SD, Lee HY, Baek SH, Ko MJ, Son BG, Park S, Choi YW, Bae YSα-Iso-cubebene, a natural compound isolated from Schisandra chinensis fruit, has therapeutic benefit against polymicrobial sepsisBiochem Biophys Res Commun.(2012 Sep 21)
14.^Kim JE, Kim SG, Goo JS, Park DJ, Lee YJ, Hwang IS, Lee HR, Choi SI, Lee YJ, Oh CH, Choi YW, Hwang DYThe α-iso-cubebenol compound isolated from Schisandra chinensis induces p53-independent pathway-mediated apoptosis in hepatocellular carcinoma cellsOncol Rep.(2012 Jun 19)
15.^Lee YJ, Shim JW, Lee YJ, Park YH, Lee HY, Kim SD, Choi YW, Bae YSIdentification of a novel compound that stimulates intracellular calcium increase and CXCL8 production in human neutrophils from Schisandra chinensisBiochem Biophys Res Commun.(2009 Feb 20)
17.^Li L, Xiao Y, Yu D, Ma Y, Huang W, Tian G, Chen LDetermination of three organic acids in Schisandrae Chinensis Fructus by HPLCZhongguo Zhong Yao Za Zhi.(2011 Dec)
18.^Chen G, Huo Y, Tan DX, Liang Z, Zhang W, Zhang YMelatonin in Chinese medicinal herbsLife Sci.(2003 May 23)
19.^Chen Y, Tang J, Wang X, Sun F, Liang SAn immunostimulatory polysaccharide (SCP-IIa) from the fruit of Schisandra chinensis (Turcz.) BaillInt J Biol Macromol.(2012 Apr 1)
28.^Cui YY, Wang MZAspects of schizandrin metabolism in vitro and in vivoEur J Drug Metab Pharmacokinet.(1993 Apr-Jun)
32.^Ryu EY, Park SY, Kim SG, Park da J, Kang JS, Kim YH, Seetharaman R, Choi YW, Lee SJAnti-inflammatory effect of heme oxygenase-1 toward Porphyromonas gingivalis lipopolysaccharide in macrophages exposed to gomisins A, G, and JJ Med Food.(2011 Dec)
35.^Panossian AG, Oganessian AS, Ambartsumian M, Gabrielian ES, Wagner H, Wikman GEffects of heavy physical exercise and adaptogens on nitric oxide content in human salivaPhytomedicine.(1999 Mar)
36.^Park JY, Shin HK, Lee YJ, Choi YW, Bae SS, Kim CDThe mechanism of vasorelaxation induced by Schisandra chinensis extract in rat thoracic aortaJ Ethnopharmacol.(2009 Jan 12)
37.^Park JY, Lee SJ, Yun MR, Seo KW, Bae SS, Park JW, Lee YJ, Shin WJ, Choi YW, Kim CDGomisin A from Schisandra chinensis induces endothelium-dependent and direct relaxation in rat thoracic aortaPlanta Med.(2007 Dec)
38.^Aslanyan G, Amroyan E, Gabrielyan E, Nylander M, Wikman G, Panossian ADouble-blind, placebo-controlled, randomised study of single dose effects of ADAPT-232 on cognitive functionsPhytomedicine.(2010 Jun)
39.^Egashira N, Kurauchi K, Iwasaki K, Mishima K, Orito K, Oishi R, Fujiwara MSchizandrin reverses memory impairment in ratsPhytother Res.(2008 Jan)
40.^Chen XM, Li JS, Li W, Han L, Liu XH, Di LQ, Cai BCIntestinal absorption of the effective components of Schisandra chinensis Baill by rats single-pass perfusion in situYao Xue Xue Bao.(2010 May)
43.^Guan J, Zhu HY, Zhang XR, Zhao Y, Sun DYPharmacokinetics and tissue distribution of Schisandra chinensis extract in miceZhong Yao Cai.(2011 Dec)
44.^Ono H, Matsuzaki Y, Wakui Y, Takeda S, Ikeya Y, Amagaya S, Maruno MDetermination of schizandrin in human plasma by gas chromatography-mass spectrometryJ Chromatogr B Biomed Appl.(1995 Dec 15)
45.^Matsuzaki Y, Matsuzaki T, Takeda S, Koguchi S, Ikeya Y, Mitsuhashi H, Sasaki H, Aburada M, Hosoya E, Oyama TStudies on the metabolic fate of gomisin A (TJN-101). I. Absorption in ratsYakugaku Zasshi.(1991 Sep)
46.^Matsuzaki Y, Ishibashi E, Koguchi S, Wakui Y, Takeda S, Aburada M, Oyama TDetermination of gomisin A (TJN-101) and its metabolite in rat serum by gas chromatography-mass spectrometryYakugaku Zasshi.(1991 Oct)
47.^Mu Y, Zhang J, Zhang S, Zhou HH, Toma D, Ren S, Huang L, Yaramus M, Baum A, Venkataramanan R, Xie WTraditional Chinese medicines Wu Wei Zi (Schisandra chinensis Baill) and Gan Cao (Glycyrrhiza uralensis Fisch) activate pregnane X receptor and increase warfarin clearance in ratsJ Pharmacol Exp Ther.(2006 Mar)
48.^Xie W, Barwick JL, Downes M, Blumberg B, Simon CM, Nelson MC, Neuschwander-Tetri BA, Brunt EM, Guzelian PS, Evans RMHumanized xenobiotic response in mice expressing nuclear receptor SXRNature.(2000 Jul 27)
49.^Blumberg B, Sabbagh W Jr, Juguilon H, Bolado J Jr, van Meter CM, Ong ES, Evans RMSXR, a novel steroid and xenobiotic-sensing nuclear receptorGenes Dev.(1998 Oct 15)
50.^Chen Y, Ferguson SS, Negishi M, Goldstein JAInduction of human CYP2C9 by rifampicin, hyperforin, and phenobarbital is mediated by the pregnane X receptorJ Pharmacol Exp Ther.(2004 Feb)
51.^Iwata H, Tezuka Y, Kadota S, Hiratsuka A, Watabe TIdentification and characterization of potent CYP3A4 inhibitors in Schisandra fruit extractDrug Metab Dispos.(2004 Dec)
52.^Li WL, Xin HW, Su MW, Xiong LInhibitory effects of schisandrin A and schisandrin B on CYP3A activityMethods Find Exp Clin Pharmacol.(2010 Apr)
54.^Pan Q, Lu Q, Zhang K, Hu XDibenzocyclooctadiene lingnans: a class of novel inhibitors of P-glycoproteinCancer Chemother Pharmacol.(2006 Jul)
56.^Wan CK, Zhu GY, Shen XL, Chattopadhyay A, Dey S, Fong WFGomisin A alters substrate interaction and reverses P-glycoprotein-mediated multidrug resistance in HepG2-DR cellsBiochem Pharmacol.(2006 Sep 28)
57.^Fong WF, Wan CK, Zhu GY, Chattopadhyay A, Dey S, Zhao Z, Shen XLSchisandrol A from Schisandra chinensis reverses P-glycoprotein-mediated multidrug resistance by affecting Pgp-substrate complexesPlanta Med.(2007 Mar)
58.^Yoo HH, Lee M, Lee MW, Lim SY, Shin J, Kim DHEffects of Schisandra lignans on P-glycoprotein-mediated drug efflux in human intestinal Caco-2Planta Med.(2007 May)
59.^Jin J, Bi H, Hu J, Zhong G, Zhao L, Huang Z, Huang MEnhancement of oral bioavailability of paclitaxel after oral administration of Schisandrol B in ratsBiopharm Drug Dispos.(2010 May)
60.^Fan L, Mao XQ, Tao GY, Wang G, Jiang F, Chen Y, Li Q, Zhang W, Lei HP, Hu DL, Huang YF, Wang D, Zhou HHEffect of Schisandra chinensis extract and Ginkgo biloba extract on the pharmacokinetics of talinolol in healthy volunteersXenobiotica.(2009 Mar)
61.^Goldstein JA, de Morais SMBiochemistry and molecular biology of the human CYP2C subfamilyPharmacogenetics.(1994 Dec)
66.^Park SY, Park SJ, Park TG, Rajasekar S, Lee SJ, Choi YWSchizandrin C exerts anti-neuroinflammatory effects by upregulating phase II detoxifying/antioxidant enzymes in microgliaInt Immunopharmacol.(2013 Oct)
67.^Hu D, Li C, Han N, Miao L, Wang D, Liu Z, Wang H, Yin JDeoxyschizandrin Isolated from the Fruits of Schisandra chinensis Ameliorates Aβ1-42-induced Memory Impairment in MicePlanta Med.(2012 Jul 6)
68.^Giridharan VV, Thandavarayan RA, Sato S, Ko KM, Konishi TPrevention of scopolamine-induced memory deficits by schisandrin B, an antioxidant lignan from Schisandra chinensis in miceFree Radic Res.(2011 Aug)
71.^Tang SH, He RR, Huang T, Wang CZ, Cao YF, Zhang Y, Kurihara HThe protective effect of schisandra lignans on stress-evoked hepatic metastases of P815 tumor cells in restraint miceJ Ethnopharmacol.(2011 Mar 8)
72.^Huang F, Xiong Y, Xu L, Ma S, Dou CSedative and hypnotic activities of the ethanol fraction from Fructus Schisandrae in mice and ratsJ Ethnopharmacol.(2007 Apr 4)
79.^Park EJ, Chun JN, Kim SH, Kim CY, Lee HJ, Kim HK, Park JK, Lee SW, So I, Jeon JHSchisandrin B suppresses TGFβ1 signaling by inhibiting Smad2/3 and MAPK pathwaysBiochem Pharmacol.(2012 Feb 1)
80.^Lin X, Duan X, Liang YY, Su Y, Wrighton KH, Long J, Hu M, Davis CM, Wang J, Brunicardi FC, Shi Y, Chen YG, Meng A, Feng XHPPM1A functions as a Smad phosphatase to terminate TGFbeta signalingCell.(2006 Jun 2)
81.^Park JY, Choi YW, Yun JW, Bae JU, Seo KW, Lee SJ, Park SY, Kim CDGomisin J from Schisandra chinensis induces vascular relaxation via activation of endothelial nitric oxide synthaseVascul Pharmacol.(2012 Jun 20)
82.^Park JY, Shin HK, Choi YW, Lee YJ, Bae SS, Han J, Kim CDGomisin A induces Ca2+-dependent activation of eNOS in human coronary artery endothelial cellsJ Ethnopharmacol.(2009 Sep 7)
84.^Han DH, Lee JH, Kim H, Ko MK, Chae MR, Kim HK, So I, Jeon JH, Park JK, Lee SWEffects of Schisandra chinensis extract on the contractility of corpus cavernosal smooth muscle (CSM) and Ca2+ homeostasis in CSM cellsBJU Int.(2012 May)
85.^Pan SY, Dong H, Han YF, Li WY, Zhao XY, Ko KMA novel experimental model of acute hypertriglyceridemia induced by schisandrin BEur J Pharmacol.(2006 May 10)
86.^Pan SY, Dong H, Zhao XY, Xiang CJ, Fang HY, Fong WF, Yu ZL, Ko KMSchisandrin B from Schisandra chinensis reduces hepatic lipid contents in hypercholesterolaemic miceJ Pharm Pharmacol.(2008 Mar)
93.^Van Damme J, Wuyts A, Froyen G, Van Coillie E, Struyf S, Billiau A, Proost P, Wang JM, Opdenakker GGranulocyte chemotactic protein-2 and related CXC chemokines: from gene regulation to receptor usageJ Leukoc Biol.(1997 Nov)
94.^Zhu S, Wang Y, Chen M, Jin J, Qiu Y, Huang M, Huang ZProtective Effect of Schisandrin B Against Cyclosporine A-Induced Nephrotoxicity In Vitro and In VivoAm J Chin Med.(2012 2012)
96.^Stacchiotti A, Li Volti G, Lavazza A, Schena I, Aleo MF, Rodella LF, Rezzani RDifferent role of Schisandrin B on mercury-induced renal damage in vivo and in vitroToxicology.(2011 Aug 15)
97.^Karalliedde J, Viberti GProteinuria in diabetes: bystander or pathway to cardiorenal diseaseJ Am Soc Nephrol.(2010 Dec)
98.^Bae H, Kim R, Kim Y, Lee E, Jin Kim H, Pyo Jang Y, Jung SK, Kim JEffects of Schisandra chinensis Baillon (Schizandraceae) on lipopolysaccharide induced lung inflammation in miceJ Ethnopharmacol.(2012 Jun 26)
99.^Pu HJ, Cao YF, He RR, Zhao ZL, Song JH, Jiang B, Huang T, Tang SH, Lu JM, Kurihara HCorrelation between Antistress and Hepatoprotective Effects of Schisandra Lignans Was Related with Its Antioxidative Actions in Liver CellsEvid Based Complement Alternat Med.(2012)
103.^Bao L, Abe K, Tsang P, Xu JK, Yao XS, Liu HW, Kurihara HBilberry extract protect restraint stress-induced liver damage through attenuating mitochondrial dysfunctionFitoterapia.(2010 Dec)
105.^Cyong JC, Ki SM, Iijima K, Kobayashi T, Furuya MClinical and pharmacological studies on liver diseases treated with Kampo herbal medicineAm J Chin Med.(2000)
107.^Chiu HF, Chen TY, Tzeng YT, Wang CKImprovement of Liver Function in Humans Using a Mixture of Schisandra Fruit Extract and SesaminPhytother Res.(2012 May 21)
108.^Seo EJ, Kuete V, Kadioglu O, Krusche B, Schröder S, Greten HJ, Arend J, Lee IS, Efferth TAntiangiogenic activity and pharmacogenomics of medicinal plants from traditional korean medicineEvid Based Complement Alternat Med.(2013)
109.^Kang JI, Kim SC, Hyun JH, Kang JH, Park DB, Lee YJ, Yoo ES, Kang HKPromotion effect of Schisandra nigra on the growth of hairEur J Dermatol.(2009 Mar-Apr)
110.^Schutgens FW, Neogi P, van Wijk EP, van Wijk R, Wikman G, Wiegant FAThe influence of adaptogens on ultraweak biophoton emission: a pilot-experimentPhytother Res.(2009 Aug)
111.^Narimanian M, Badalyan M, Panosyan V, Gabrielyan E, Panossian A, Wikman G, Wagner HImpact of Chisan (ADAPT-232) on the quality-of-life and its efficacy as an adjuvant in the treatment of acute non-specific pneumoniaPhytomedicine.(2005 Nov)
112.^Chan SWPanax ginseng, Rhodiola rosea and Schisandra chinensisInt J Food Sci Nutr.(2012 Mar)
113.^Panossian A, Wikman G, Kaur P, Asea AAdaptogens exert a stress-protective effect by modulation of expression of molecular chaperonesPhytomedicine.(2009 Jun)
114.^Panossian A, Wikman G, Kaur P, Asea AAdaptogens stimulate neuropeptide y and hsp72 expression and release in neuroglia cellsFront Neurosci.(2012)
115.^Deng X, Chen X, Yin R, Shen Z, Qiao L, Bi KDetermination of deoxyschizandrin in rat plasma by LC-MSJ Pharm Biomed Anal.(2008 Jan 7)
117.^Yao HT, Chang YW, Chen CT, Chiang MT, Chang L, Yeh TKShengmai San reduces hepatic lipids and lipid peroxidation in rats fed on a high-cholesterol dietJ Ethnopharmacol.(2008 Feb 28)
118.^Kamei T, Kumano H, Iwata K, Nariai Y, Matsumoto TThe effect of a traditional Chinese prescription for a case of lung carcinomaJ Altern Complement Med.(2000 Dec)
119.^Takano F, Ohta Y, Tanaka T, Sasaki K, Kobayashi K, Takahashi T, Yahagi N, Yoshizaki F, Fushiya S, Ohta TOral Administration of Ren-Shen-Yang-Rong-Tang 'Ninjin'yoeito' Protects Against Hematotoxicity and Induces Immature Erythroid Progenitor Cells in 5-Fluorouracil-induced AnemiaEvid Based Complement Alternat Med.(2009 Jun)
123.^Kobayashi J, Seiwa C, Sakai T, Gotoh M, Komatsu Y, Yamamoto M, Fukutake M, Matsuno K, Sakurai Y, Kawano Y, Asou HEffect of a traditional Chinese herbal medicine, Ren-Shen-Yang-Rong-Tang (Japanese name: Ninjin-Youei-To), on oligodendrocyte precursor cells from aged-rat brainInt Immunopharmacol.(2003 Jul)
124.^Yamasaki A, Sugahara K, Takemoto T, Ikeda T, Yamashita HEffect of Ninjin-yoei-to (Rensheng-Yangrong-Tang) on olfactory behavior after olfactory nerve transectionPhytomedicine.(2008 May)
125.^Akimoto K, Kitagawa Y, Akamatsu T, Hirose N, Sugano M, Shimizu S, Yamada HProtective effects of sesamin against liver damage caused by alcohol or carbon tetrachloride in rodentsAnn Nutr Metab.(1993)