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Punicalagins

Punicalagins are really big molecules found in pomegranate juice that are somehow absorbed; they are potent anti-oxidants, and alongside punicic acid confer many of the benefits associated with pomegranates, of which many studies conducted with are here.

Our evidence-based analysis on punicalagins features 47 unique references to scientific papers.

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Summary of Punicalagins

Primary information, health benefits, side effects, usage, and other important details

Punicalagins are large molecules (ellagitannins) found in Pomegranates and Pomegranate Juice.

They themselves are very potent anti-oxidants, and they can be metabolized into other compounds (ellagic acid, urolithins) that themselves have anti-oxidant capabilities (although lesser). This large anti-oxidant value of punicalagins, about thrice that of red wine and green tea, is what brought Pomegranates to fame. That being said, the overall amount of punicalagins that get into the bloodstream after oral ingestion is quite small (6% is the highest noted and was in rats, sometimes human studies don't even notice punicalagins in the blood).

The ellagic acid and urolithins still confer a lot of health benefits, but their anti-oxidant capabilities are on par with green tea and red wine if not a bit less potent.

There is a very high variation between individuals, and like daidzein (one of the soy isoflavones) it may be genetically dependent on what intestinal microflora one possesses.

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How to Take

Medical Disclaimer

Recommended dosage, active amounts, other details

Anti-oxidant potential of the blood increases at an oral dose of 800mg Pomegranate Extract (318mg punicalagins), which may be a good starting point for a bioactive dose. The optimal dose is currently not known.

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Human Effect Matrix

Unlocked for Examine Plus members

The Human Effect Matrix summarizes human studies to tell you what effects Punicalagins has on your body, how much evidence there is, and how strong these effects are.

Full details are available to Examine Plus members.
Grade Level of Evidence
Robust research conducted with repeated double-blind clinical trials
Multiple studies where at least two are double-blind and placebo controlled
Single double-blind study or multiple cohort studies
Uncontrolled or observational studies only
Level of Evidence
? The amount of high quality evidence. The more evidence, the more we can trust the results.
Outcome Magnitude of effect
? The direction and size of the supplement's impact on each outcome. Some supplements can have an increasing effect, others have a decreasing effect, and others have no effect.
Consistency of research results
? Scientific research does not always agree. HIGH or VERY HIGH means that most of the scientific research agrees.
Notes
grade-d Notable Very High See 2 studies
Notable as consumption of pomegranate juice is associated with a prolongation in the time require for PSA (biomarker of prostate cancer) to double, from 15 months to 54 months
grade-d Minor - See study
A decrease in general oxidation has been noted with punicalagins
grade-d Minor - See study
A decrease in lipid peroxidation has been noted
grade-d Minor - See study
An increase in metabolites of nitric oxide metabolism have been noted and thought to be indicative of increased nitric oxide production
grade-d Minor Very High See 2 studies
Does not appear to be able to reduce PSA levels outright, although it can attenuate the rate of which PSA increases over time (relative to untreated control, this is a reduction)
grade-d - - See study
No significant influence on estrogen
grade-d - - See study
No significant influence on testosterone levels in men at risk for prostate cancer

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Things to Note

Also Known As

Pomegranate Extract, Punica Granatum L., Pomegranate Juice

  • There is a large inter-individual difference of ellagic acid and urolithins (punicalagin derivatives) in the blood, due to varying levels of colonic bacteria capable of producing them

  • Commercial juices tend to have more punicalagins than do naturally pressed juices, as commerical juices have less overall time before packaging for punicalagins to hydroylze into ellagic acid

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Click here to see all 47 references.