Last Updated: September 28 2022

Punicalagins are really big molecules found in pomegranate juice that are somehow absorbed; they are potent anti-oxidants, and alongside punicic acid confer many of the benefits associated with pomegranates, of which many studies conducted with are here.

Punicalagins is most often used for


Punicalagins are large molecules (ellagitannins) found in Pomegranates and Pomegranate Juice.

They themselves are very potent anti-oxidants, and they can be metabolized into other compounds (ellagic acid, urolithins) that themselves have anti-oxidant capabilities (although lesser). This large anti-oxidant value of punicalagins, about thrice that of red wine and green tea, is what brought Pomegranates to fame. That being said, the overall amount of punicalagins that get into the bloodstream after oral ingestion is quite small (6% is the highest noted and was in rats, sometimes human studies don't even notice punicalagins in the blood).

The ellagic acid and urolithins still confer a lot of health benefits, but their anti-oxidant capabilities are on par with green tea and red wine if not a bit less potent.

There is a very high variation between individuals, and like daidzein (one of the soy isoflavones) it may be genetically dependent on what intestinal microflora one possesses.

What else is Punicalagins known as?
Note that Punicalagins is also known as:
  • Pomegranate Extract
  • Punica Granatum L.
  • Pomegranate Juice
Dosage information

Anti-oxidant potential of the blood increases at an oral dose of 800mg Pomegranate Extract (318mg punicalagins), which may be a good starting point for a bioactive dose. The optimal dose is currently not known.

Join our supplement information course

Examine Database: Punicalagins
What works and what doesn't?

Unlock the full potential of Examine

Get started

Don't miss out on the latest research

1.^Gil MI, Tomás-Barberán FA, Hess-Pierce B, Holcroft DM, Kader AAAntioxidant activity of pomegranate juice and its relationship with phenolic composition and processingJ Agric Food Chem.(2000 Oct)
4.^Marzouk MS, El-Toumy SA, Moharram FA, Shalaby NM, Ahmed AAPharmacologically active ellagitannins from Terminalia myriocarpaPlanta Med.(2002 Jun)
5.^Cerdá B, Llorach R, Cerón JJ, Espín JC, Tomás-Barberán FAEvaluation of the bioavailability and metabolism in the rat of punicalagin, an antioxidant polyphenol from pomegranate juiceEur J Nutr.(2003 Jan)
6.^Larrosa M, González-Sarrías A, García-Conesa MT, Tomás-Barberán FA, Espín JCUrolithins, ellagic acid-derived metabolites produced by human colonic microflora, exhibit estrogenic and antiestrogenic activitiesJ Agric Food Chem.(2006 Mar 8)
7.^Saruwatari A, Okamura S, Nakajima Y, Narukawa Y, Takeda T, Tamura HPomegranate juice inhibits sulfoconjugation in Caco-2 human colon carcinoma cellsJ Med Food.(2008 Dec)
12.^Cerdá B, Periago P, Espín JC, Tomás-Barberán FAIdentification of urolithin a as a metabolite produced by human colon microflora from ellagic acid and related compoundsJ Agric Food Chem.(2005 Jul 13)
14.^Lai S, Zhou Q, Zhang Y, Shang J, Yu TEffects of pomegranate tannins on experimental gastric damagesZhongguo Zhong Yao Za Zhi.(2009 May)
15.^Ajaikumar KB, Asheef M, Babu BH, Padikkala JThe inhibition of gastric mucosal injury by Punicagranatum L. (pomegranate) methanolic extractJ Ethnopharmacol.(2005 Jan 4)
16.^Pérez-Vicente A, Gil-Izquierdo A, García-Viguera CIn vitro gastrointestinal digestion study of pomegranate juice phenolic compounds, anthocyanins, and vitamin CJ Agric Food Chem.(2002 Apr 10)
17.^Larrosa M, González-Sarrías A, Yáñez-Gascón MJ, Selma MV, Azorín-Ortuño M, Toti S, Tomás-Barberán F, Dolara P, Espín JCAnti-inflammatory properties of a pomegranate extract and its metabolite urolithin-A in a colitis rat model and the effect of colon inflammation on phenolic metabolismJ Nutr Biochem.(2010 Aug)
18.^Bialonska D, Ramnani P, Kasimsetty SG, Muntha KR, Gibson GR, Ferreira DThe influence of pomegranate by-product and punicalagins on selected groups of human intestinal microbiotaInt J Food Microbiol.(2010 Jun 15)
19.^Rosillo MA, Sanchez-Hidalgo M, Cárdeno A, de la Lastra CAProtective effect of ellagic acid, a natural polyphenolic compound, in a murine model of Crohn's diseaseBiochem Pharmacol.(2011 Oct 1)
20.^Hollebeeck S, Winand J, Hérent MF, During A, Leclercq J, Larondelle Y, Schneider YJAnti-inflammatory effects of pomegranate (Punica granatum L.) husk ellagitannins in Caco-2 cells, an in vitro model of human intestineFood Funct.(2012 Aug 25)
21.^González-Sarrías A, Larrosa M, Tomás-Barberán FA, Dolara P, Espín JCNF-kappaB-dependent anti-inflammatory activity of urolithins, gut microbiota ellagic acid-derived metabolites, in human colonic fibroblastsBr J Nutr.(2010 Aug)
23.^Rodríguez-Fragoso L, Martínez-Arismendi JL, Orozco-Bustos D, Reyes-Esparza J, Torres E, Burchiel SWPotential Risks Resulting from Fruit/Vegetable-Drug Interactions: Effects on Drug-Metabolizing Enzymes and Drug TransportersJ Food Sci.(2011 May)
24.^Cayır K, Karadeniz A, Simşek N, Yıldırım S, Karakuş E, Kara A, Akkoyun HT, Sengül EPomegranate seed extract attenuates chemotherapy-induced acute nephrotoxicity and hepatotoxicity in ratsJ Med Food.(2011 Oct)
25.^Xu KZ, Zhu C, Kim MS, Yamahara J, Li YPomegranate flower ameliorates fatty liver in an animal model of type 2 diabetes and obesityJ Ethnopharmacol.(2009 Jun 22)
27.^Bishayee A, Bhatia D, Thoppil RJ, Darvesh AS, Nevo E, Lansky EPPomegranate-mediated chemoprevention of experimental hepatocarcinogenesis involves Nrf2-regulated antioxidant mechanismsCarcinogenesis.(2011 Jun)
28.^Vroegrijk IO, van Diepen JA, van den Berg S, Westbroek I, Keizer H, Gambelli L, Hontecillas R, Bassaganya-Riera J, Zondag GC, Romijn JA, Havekes LM, Voshol PJPomegranate seed oil, a rich source of punicic acid, prevents diet-induced obesity and insulin resistance in miceFood Chem Toxicol.(2011 Jun)
29.^Bishayee A, Thoppil RJ, Darvesh AS, Ohanyan V, Meszaros JG, Bhatia DPomegranate phytoconstituents blunt the inflammatory cascade in a chemically induced rodent model of hepatocellular carcinogenesisJ Nutr Biochem.(2012 Jul 25)
31.^de Nigris F, Williams-Ignarro S, Sica V, Lerman LO, D'Armiento FP, Byrns RE, Casamassimi A, Carpentiero D, Schiano C, Sumi D, Fiorito C, Ignarro LJ, Napoli CEffects of a pomegranate fruit extract rich in punicalagin on oxidation-sensitive genes and eNOS activity at sites of perturbed shear stress and atherogenesisCardiovasc Res.(2007 Jan 15)
33.^Kitiyakara C, Wilcox CSAntioxidants for hypertensionCurr Opin Nephrol Hypertens.(1998 Sep)
34.^Galley HF, Thornton J, Howdle PD, Walker BE, Webster NRCombination oral antioxidant supplementation reduces blood pressureClin Sci (Lond).(1997 Apr)
37.^Pantuck AJ, Leppert JT, Zomorodian N, Aronson W, Hong J, Barnard RJ, Seeram N, Liker H, Wang H, Elashoff R, Heber D, Aviram M, Ignarro L, Belldegrun APhase II study of pomegranate juice for men with rising prostate-specific antigen following surgery or radiation for prostate cancerClin Cancer Res.(2006 Jul 1)
38.^Paller CJ, Ye X, Wozniak PJ, Gillespie BK, Sieber PR, Greengold RH, Stockton BR, Hertzman BL, Efros MD, Roper RP, Liker HR, Carducci MAA randomized phase II study of pomegranate extract for men with rising PSA following initial therapy for localized prostate cancerProstate Cancer Prostatic Dis.(2012 Jun 12)
40.^Somu CA, Ravindra S, Ajith S, Ahamed MGEfficacy of a herbal extract gel in the treatment of gingivitis: A clinical studyJ Ayurveda Integr Med.(2012 Apr)
42.^Senthilkumaran S, Balamurugan N, Suresh P, Thirumalaikolundusubramanian PPriapism, pomegranate juice, and sildenafil: Is there a connectionUrol Ann.(2012 May)
43.^Nagata M, Hidaka M, Sekiya H, Kawano Y, Yamasaki K, Okumura M, Arimori KEffects of pomegranate juice on human cytochrome P450 2C9 and tolbutamide pharmacokinetics in ratsDrug Metab Dispos.(2007 Feb)
44.^Warrington JS, Shader RI, von Moltke LL, Greenblatt DJIn vitro biotransformation of sildenafil (Viagra): identification of human cytochromes and potential drug interactionsDrug Metab Dispos.(2000 Apr)
45.^Meerts IA, Verspeek-Rip CM, Buskens CA, Keizer HG, Bassaganya-Riera J, Jouni ZE, van Huygevoort AH, van Otterdijk FM, van de Waart EJToxicological evaluation of pomegranate seed oilFood Chem Toxicol.(2009 Jun)
46.^Vidal A, Fallarero A, Peña BR, Medina ME, Gra B, Rivera F, Gutierrez Y, Vuorela PMStudies on the toxicity of Punica granatum L. (Punicaceae) whole fruit extractsJ Ethnopharmacol.(2003 Dec)
47.^Patel C, Dadhaniya P, Hingorani L, Soni MGSafety assessment of pomegranate fruit extract: acute and subchronic toxicity studiesFood Chem Toxicol.(2008 Aug)